JP2018524400A - 活性成分のためのペトロラタムベースの送達システム - Google Patents
活性成分のためのペトロラタムベースの送達システム Download PDFInfo
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- JP2018524400A JP2018524400A JP2018518566A JP2018518566A JP2018524400A JP 2018524400 A JP2018524400 A JP 2018524400A JP 2018518566 A JP2018518566 A JP 2018518566A JP 2018518566 A JP2018518566 A JP 2018518566A JP 2018524400 A JP2018524400 A JP 2018524400A
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Abstract
【選択図】なし
Description
本出願は、2015年6月19日に出願された米国仮特許出願第62/182,034号、2016年4月7日に出願された米国仮特許出願第62/319,449号、2016年4月22日に出願された米国仮特許出願第62/326,150号、及び2016年5月19日に出願された米国仮特許出願第62/338,995号に対する優先権を主張し、これらのそれぞれは、本明細書に全体として参照により組み込まれる。
本開示は広く、活性成分のための懸濁マトリックスとしてのペトロラタムベース組成物に関する。本開示はまた、ペトロラタム中の活性成分の安定なエマルションを形成するためのプロセスに関する。
本開示は、ペトロラタムベースの組成物を提供する。ペトロラタムベース組成物は、主にペトロラタムで構成される。ペトロラタムベース組成物の特徴は、少量のペトロラタムのみを含有する組成物とは異なる。一部の実施形態では、ペトロラタムベース組成物は、約80%超のペトロラタムである。他の実施形態では、ペトロラタムベース組成物は、約81%を超えるペトロラタム、約82%を超えるペトロラタム、約83%を超えるペトロラタム、約84%を超えるペトロラタム、約85%を超えるペトロラタム、約86%を超えるペトロラタム、約87%を超えるペトロラタム、約88%を超えるペトロラタム、約89%を超えるペトロラタム、約90%を超えるペトロラタム、約91%を超えるペトロラタム、約92%を超えるペトロラタム、約93%を超えるペトロラタム、約94%を超えるペトロラタム、約95%を超えるペトロラタム、約96%を超えるペトロラタム、約97%を超えるペトロラタム、約98%を超えるペトロラタム、または約99%を超えるペトロラタムである。ペトロラタムは、好ましくは、医療グレードのペトロラタムである。
yrospermum parkii、Buxus chinensis、C10〜30コレステロール/ラノステロールエステル、C12〜15アルキルベンゾアート、C12〜18酸トリグリセリド、C13〜14イソパラフィン、C18〜36酸トリグリセリド、C20〜40パレス−40、コーヒー酸、カフェイン、カユプテ油、カラミン、アスコルビン酸カルシウム、炭酸カルシウム、カルシウムd−パンテテイン−s−スルホナート、グルコン酸カルシウム、カルシウムパンテテインスルホナート、パントテン酸カルシウム、キンセンカ抽出物、Calendula officinalis花抽出物、Calluna vulgaris花抽出物、Calophyllum inophyllum種子油、Camellia japonica、Camellia oleifera、Camellia sinensis、カンファー、カナンガ抽出物、Cananga odorata、キャンデリラワックス、Cannabis sativa L.油、キャノーラ油、カプロイルテトラペプチド−3、カプリル酸/カプリン酸トリグリセリド、カプリリルグリコール、カプリリルメチコン、カプサイシン、トウガラシ、トウガラシ脂油、キャラメル、カルボマー、カーボポール、カルボン酸、カルダモン、カーマイン、カルナバワックス、カルニチン、カルノシン酸、カルノシン、カルノソール酸、カラギーナン、人参油、Carthamus tinctorius油、カルボン、Carya illinoensis油、カゼイン、Castanea sativa種子抽出物、トウゴマイソステアラートイソステアラート、ヒマシ油、カタラーゼ、Caulerpa taxifolia抽出物、シダーウッド、Cedrus atlantica樹皮抽出物、クサノオウ、細胞対話成分、セルロース、セルロースガム、Centaurea cyanus、Centella asiatica、ケファリン、白蝋、微結晶ワックス、セラミドAP、セラミドEOP、セラミドNP、セラミドNS、セラミド、セレシン、セテアレス−20、セテアリルアルコール、セテアリルエチルヘキサノアート、セテアリルグルコシド、セテアリルオクタノアート、セチルアセテート、セチルアルコール、セチルジメチコーン、セチルジメチコーンコポリオール、セチルエステル、セチルヒドロキシエチルセルロース、セチルパルミテート、セチルPEG/PPG−10/1−ジメチコン、カモミール、Chamomilla recutita花抽出物、チャパラル抽出物、木炭、ダイフウシノキ油、キレート剤、サクランボ抽出物、チャイナクレイ、キトサン、クロレラ、クロルヘキシジン、クロロフェン、クロロキシレノール、クロルフェネシン、コレカルシフェロール、コレステロール、コリン、コンドロイチンスルファート、Chondrus crispus、水酸化クロムグリーン、酸化クロムグリーン、キク抽出物、Chrysanthemum parthenium抽出物、Cichorium intybus、Cimicifuga racemosa根抽出物、Cinnamomum、Cinnamomum camphora、桂皮、シンナミルアルコール、クエン酸、シトロネロール、Citrullus colocynthis、Citrus amara、Citrus aurantifolia、Citrus aurantium、Citrus aurantium抽出物、Citrus medica limonium、Citrus unshiu、Citrus unshiu果皮抽出物、サルビア油、クレイ、クローブ葉、丁子油、クローバー花、クローバー葉油、コカミドDEA及びMEA、コカミドプロピルベタイン、コカミドプロピルジメチルアミン、コカミドプロピルヒドロキシスルタイン、ココ−グルコシド、カカオバター、カカオ抽出物、ココグリセリド、ココナッツ、ココナッツ油、Cocus nucifera、Codium tomentosum抽出物、コエンザイムQ10、Coffea arabica(コーヒー)種子油、Coffea arabica抽出物、Cola acuminata種子抽出物、Coleus barbatus、コラーゲン、コラーゲンアミノ酸、コロイド状オートミール、コロイド状銀、初乳、フキタンポポ、コンフリー抽出物、Commiphora myrrha抽出物、コーンフラワー、Copaifera officinalis、Copernicia ceriferaワックス、グルコン酸銅、リシン酸/プロリン酸銅、銅PCA、銅ペプチド、硫酸銅、Corallina officinalis抽出物、コエンドロ、トウモロコシ油、ヤグルマギク、コーンミント、コーンスターチ、Cornus抽出物、Corylus americana、Corylus avellana、クマリン、反対刺激剤、クランベリー種子抽出物、クランベリー種子油、Crataegus monogina抽出物、クレアチン、クレアチニン、キュウリ抽出物、Cucumis melo(メロン)果実抽出物、Cucumis sativus抽出物、Cucurbita pepo種子抽出物、Cucurbitea peponis、Curcuma longa根、クルクミン、Cyamopsis tetragonoloba、シアノコバラミン、シクラメンアルデヒド、シクロヘキサシロキサン、シクロメチコン、シクロペンタシロキサン、シクロテトラシロキサン、Cymbopogon citrates、Cymbopogon martini、システイン、シスチン、シトクロム、サイトカイン、D&C、D&C着色剤、d−α−トコフェロール、デイジー花抽出物、タンポポ抽出物、Daucus carota、DEA、DEAオレス−10ホスファート、死海ミネラル、デカルボキシカルノシンHCL、デシルグルコシド、デシルオレアート、デシレングリコール、デヒドロ酢酸、デヒドロエピアンドロステロン、脱イオン/脱塩水、変性アルコール、デオキシリボ核酸、洗剤洗浄剤、酸化ジューテリウム、デキストラン、デキストリン、DHA、DHEA、ジ−PPG−3ミリスチルエーテルアジパート、珪藻土、ジアゾリジニル尿素、フタル酸ジブチル、ジカプリリルカルボナート、ジセチルホスファート、ジエタノールアミン、ジエチルヘキシルカルボナート、ジエチルヘキシルマラート、ジエチルヘキシルシリンギリデンマロナート、Differin、ジヒドロコレス−30、ジヒドロキシアセトン、ジイソプロピルアジパート、ジイソプロピル二量体ジリノラート、ジイソステアロイルトリメチロールプロパンシロキシシリケート、ダイマージリノール酸ジイソステアリル、ジイソステアリルマラート、イノンド抽出物、ダイマージリノール酸ダイマージリノレイル、ジメチコン、ジメチコンコポリオール、ジメチコンクロスポリマー、ジメチコン/PEG−10/15クロスポリマー、ジメチコン/ビニルジメチコンクロスポリマー、ジメチコノール、ジメチルカプラミド、ジメチルエーテル、ジメチルイソソルビド、ジメチルMEA、ジメチルアミノエタノール(DMAE)、Dioscorea villosa抽出物、ジペンタエリスリチルヘキサカプリラート/ヘキサカプラート、グリチルリチン酸二カリウム、グリチルリチン酸二カリウム、ジプロピレングリコール、ココアンホジ酢酸ニナトリウム、ココイルグルタミン酸ニナトリウム、ジグリセリルリン酸ニナトリウム、EDTA二ナトリウム、グリセリルリン酸二ナトリウム、ラウラミノプロピオン酸二ナトリウム、ラウラミノプロピオン酸二ナトリウムリン酸トコフェリルリン酸ニナトリウム、ルチニル二硫酸二ナトリウム、ジステアルジモニウムヘクトライト、DMAE、DMDMヒダントイン、DNA、ドコサヘキサエン酸、ヨーロッパノイバラ、ハナミズキ、カラトウキ、Dromiceius油、紅藻、ドリアン、Durvillaea antarctica抽出物、エカムスル、Echium plantagineum種子油、エクトイン、EDTA、卵黄、エイコサペンタエン酸、Elaeis guineensis、エラスチン、ニワトコ、オオグルマ、エラグ酸、皮膚軟化剤、エミュー油、乳化剤、セイヨウキヅタ抽出物、エンスリゾール、Enteromorpha compressa抽出物、酵素、上皮成長因子(EGF)、エピガロカテキンガラート、Epilobium angustifolium抽出物、Equisetum arvense、エルゴカルシフェロール、エルゴチオネイン、Eriobotrya japonica、エリスロポエチン(Epo)、エリスルロース、エスキン、エスクリン、エッセンシャル油、エステル、エステル−C、エストラジオール、エタノール、エトキシジグリコール、エチルアルコール、エチルマカダミアート、エチルバニリン、エチルヘキシルメトキシシンナマート、エチルヘキシルパルミテート、エチルヘキシルステアラート、エチルヘキシルグリセリン、エチルパラベン、ユーカリ抽出物、ユーカリ油、Eugenia aromatica、Eugenia caryophyllus、オイゲノール、Euphorbia ceriferaワックス、Euphrasia officinalis、Euterpe oleraca、オオマツヨイグサ油、Evodia rutaecarpa抽出物、Ext. D&C、コゴメグサ、Faex、Fagus sylvatica抽出物、ファルネソール、ファルネシルアセタート、脂肪酸、脂肪アルコール、FD&C、FD&C着色剤、ウイキョウ油、ウイキョウ種子抽出物、フェロシアン化第二鉄アンモニウム、フェロシアン化第二鉄、Ferula foetida、Ferula galbaniflua、フェルラ酸、ナツシロギク抽出物、線維芽細胞成長因子(FGF)、フィブロネクチン、Ficus carica果実抽出物、イチジク、Filipendula glaberrima、Filipendula rubra、被膜形成剤、ファーニードル油、火跡地雑草抽出物、魚軟骨抽出物、フラボノイド、香料、亜麻、フラックスシード油、フローラルオゾン、Foeniculum vulgare抽出物、葉酸、ホルムアルデヒド放出防腐剤、防腐剤、芳香剤抽出物、フリーラジカル損傷、フルクトース、フルーツ酸、Fu ling、Fucus vesiculosus抽出物、フラー土、フマル酸、GABA、ガラクトアラビナン、ガルバヌム、γリノレン酸(GFA)、Ganoderma lucidum抽出物、Gardenia florida抽出物、ゼラチン、Gellidiela acerosa抽出物、ゲニステイン、Gentiana lutea(ゲンチアナ根)根抽出物、ゲラニオール、ゼラニウム抽出物、ゼラニウム油、ゼラニウムプラテンセ、Germaben II、ショウガ抽出物、ショウガ油、Ginkgo biloba葉抽出物、朝鮮人参、GLA、グラブリジン、グルコノラクトン、グルコサミンHCL、グルコース、グルコースオキシダーゼ、グルコースチロシナート、グルコシルヘスペリジン、グルタミン酸、グルタミン、グルタチオン、グルテン成分、グリセレス−26、グリセレス−26ホスファート、グリセレス−6ラウラート、グリセリン、グリセリン、グリセロール、グリセロールモノステアラート、グリセロールトリアセテート、グリセロールトリオレアート、グリセリルベヘナート、グリセリルココアート、グリセリルジベヘナート、グリセリルジパルミテート、グリセリルジステアラート、グリセリルエステル、グリセリルイソパルミテート、グリセリルイソステアラート、グリセリルミリスタート、グリセリルオレアート、グリセリルパルミテート、グリセリルポリメタクリラート、グリセリルステアラート、グリセリルステアラートSE、グリシン、Glycine soja油、Glycine soja種子抽出物、Glycine sojaステロール、グリコーゲン、グリコールステアラート、グリコール酸、糖脂質、糖タンパク質、グリコサミノグリカン、グリコスフィンゴリピド、グリシレチン酸、Glycyrrhiza g
labra、Glycyrrhiza uralensis根抽出物、ゴジ果実抽出物、金、ヒドラスチス、Gossypium herbacuem種子油、ゴツコラ、ブドウ種子抽出物、ブドウ種子油、グレープフルーツ油、グレープフルーツ果皮抽出物、グレープフルーツ種子抽出物、緑茶、ムラサキ、ガイアックウッド、Guaiacum officinale、グアールガム、グアーヒドロキシプロピルトリモニウムクロライド、ガラナ、ガム、Haematococcus pluvialis抽出物、Hamamelis virginiana、ハマメリタンニン、Haslea ostrearia抽出物、サンザシ抽出物、ヘイフラワー抽出物、ハシバミ油、重水、Hedera helix、ヘディオン、Helianthus annuus種子油、Helianthus油、タイマ種子油、肝細胞成長因子(HGF)、ヘスペリジン、ヘスペリジンメチルカルコン、ヘキシルシンナマル、ヘキシルラウラート、ヘキシルデカノール、ヘキシレングリコール、ヘキシルレゾルシノール、ハイビスカス、Himanthalia elongate抽出物、Hippophae rhamnoides、ヒスチジン、ブクリョウ、ホモサラート、蜂蜜、蜂蜜抽出物、スイカズラ花抽出物、ホップ、Hordeum vulgare抽出物、セイヨウトチノキ抽出物、ホースエルダー(horse elder)、セイヨウワサビ、トクサ抽出物、Hortonia floribunda葉抽出物、Huang qi、ヒト成長因子、湿潤剤、Humulus lupulus抽出物、ヒアルロン酸、Hydnocarpus anthelmintica、Hydrastis canadenis、ヒドロコルチゾン、ヒドロコチル抽出物、過酸化水素、水添ココ−グリセリド、水添ジデセン、水添レシチン、水添オリーブ油、水添ヤシグリセリド、水添ポリデセン、水添ポリイソブテン、水添大豆油、水添植物性グリセリドシトラート、加水分解コラーゲン、加水分解コーンスターチ、加水分解グリコサミノグリカン、加水分解ホホバエステル、加水分解ホホバタンパク質、加水分解シルク、加水分解植物性タンパク質、加水分解小麦タンパク質、ヒドロキノン、ヒドロキシエチルアクリラート/アクリロイルジメチルタウリン酸ナトリウムコポリマー、ヒドロキシエチルセルロース、加水分解レシチン、ヒドロキシプロリン、ヒドロキシプロピルグアー、ヒドロキシプロピルデンプンホスファート、Hypericum抽出物、低アレルギー誘発性、ヒソップ、イデベノン、Ilexパラギアリスシス、Illicium vernum、イミダゾリジニル尿素、不活性成分、イノシトール、インスリン様成長因子(IGF)、細胞間マトリックス、インターロイキン(IL)、Inula helenium、ヨードプロピニルブチルカルバメート、Iris florentina抽出物、トチャカ抽出物、酸化鉄、鉄粉、蜜蝋、イソブチルアセテート、イソブチルパラベン、イソセチルサリチラート、イソドデカン、イソフラボン、イソヘキサデカン、イソロイシン、イソノニルイソナノアート、イソパラフィン、イソプロピルアルコール、イソプロピルクロプロステナート、イソプロピルイソステアラート、イソプロピルラノラート、イソプロピルミリスタート、ミリスチン酸イソプロピル、イソプロピルチタントリイソステアラート/トリエトキシカプリリルシランクロスポリマー、イソステアラミドDEA、イソステアリン酸、イソトレチノイン、ツタ抽出物、木蝋、ジャスミン油、Jasminium grandiflorum、ホウセンカ、ホホババター、ホホバエステル、ホホバ油、ホホバワックス、キズイセン抽出物、Ju hua、ナツメ果実抽出物、ジュニパーベリー、Juniperus communis、カオリン、カトンCG、カバ−カバ抽出物、カバ抽出物、ケルプ抽出物、Kigelia africana抽出物、キネチン、キーウィ果実抽出物、コウジ酸、コジクジパルミテート、コーラナッツ、クズ根、ククイナッツオイル油、L−アスコルビン酸、L−カルニチン、L−システイン、乳酸、Lactobacillus bifidus、ラクトビオナート、ラクトビオン酸、ラクトペルオキシダーゼ、レディスマントル抽出物、レディスシスル(オオアザミ)抽出物、Lagerstroemia indica抽出物、Laminaria digitata、Laminaria longicruris、Laminaria ochroleuca抽出物、Laminaria saccharine、Lamium album花抽出物、ラノリン、ラノリンアルコール、ゴボウ抽出物、Larrea divaricata抽出物、Larrea tridentata、Latisse、ラウランポカルボキシグリシナート、ラウディモニウムヒドロキシプロピル加水分解大豆タンパク質、ラウジモニウムヒドロキシプロピル加水分解小麦タンパク質、ラウレス−23、ラウレス−4、ラウレス−7、ラウレス、ラウリン酸、ラウロイルリシン、Laurus nobilis、ラウリルアルコール、ラウリルグルコシド、ラウリルラクテート、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラバンジン油、Lavandula angustifolia、Lavandula officinalis、ラベンダー抽出物及び油、レシチン、レモン、レモンバーム、レモンジュース、レモン油、レモングラス抽出物、レモングラス油、レンズマメ果実抽出物、Lentinus edodes抽出物、Leontopodium alpinum抽出物、Leptospermum scoparium油、ロイシン、Levisticum officinale根抽出物、カンゾウ抽出物、カンゾウ根、Lilium candidum球根抽出物、ライム油及び抽出物、Limnanthes alba、Limnanthes alba種子油、リモネン、リナロール、シナノキ花抽出物、リノール酸、リノレン酸、亜麻仁油、Linum usitatissimum抽出物、脂質、リポソーム、リチウムマグネシウムケイ酸ナトリウム、Lithospermum erythrorhizon、Litsea cubeba、イナゴマメ、Lonicera caprifolium花抽出物、Lonicera japonica、Lonicera japonica花抽出物、ビワ抽出物、ハス種子抽出物、ロベージ根抽出物、Luffa cylindrica種子油または抽出物、ハウチワマメ、ハウチワマメ油、Lupinus albus抽出物、ルテイン、Lycium barbarum果実抽出物、リコピン、灰汁、リシン、マカデミアナッツ油、狂牛病、マデカソシド、マグネシウム、ケイ酸アルミニウムマグネシウム、アスコルビン酸パルミチン酸マグネシウム、アスコルビン酸リン酸マグネシウム、炭酸マグネシウム、グルコン酸マグネシウム、水酸化マグネシウム、マグネシウムラウレススルファート、マグネシウムオレススルファート、ステアリン酸マグネシウム、硫酸マグネシウム、リンゴ酸、ゼニアオイ、Malva sylvestris抽出物、アオイ抽出物、マンダリンオレンジ油または抽出物、マンデル酸、グルコン酸マンガン、マンガンバイオレット、Mangifera indica(マンゴー)種子バター、Mangifera indica根、ネズモドキ油、センジュギク、マリオンベリー、マヨラナ、ウスベニタチアオイ、Mastocarpus stellatus、マテ抽出物、シカギク花抽出物、シカギク油、マトリックスメタロプロテアーゼ、MEA、メドウフォーム種子油、メドウフォーム抽出物、Medicago sativa、Melaleuca alternifolia、Melaleuca cajeputi油、Melia azadirachta、メリビオース、Melissa officinalis、Mentha arvensis、Mentha piperita、Mentha spicata、Mentha viridis、メントール、メントン、メントキシプロパンジオール、メンチルアントラニラート、メンチルラクタート、メラジマート(meradmiate)、メタノール、メチコン、メチオニン、メチルグルセス−20、メチルグルコースセスキステアラート、メチルトリメチコン、メチルクロロイソチアゾリノン、メチルジブロモグルタロニトリル、メチルジヒドロジャスモナート、メチルオイゲノール、メチルグルコシドホスファート、メチルイソチアゾリノン、メチルパラベン、メチルプロパンジオール、メチルシラノールマンヌロナート、メチルシラノールPEG−7グリセリルココアート、メチルスルホニルスルファート、メチルスルホニルメタン、Mexoryl SX、雲母、ミクロクリスタリンワックス、Microcystis aeruginosa、乳タンパク質、レンゲ根、キビ種子抽出物、オジギソウ油または抽出物、鉱油、ミント、Mitracarpe scaber抽出物、混合果実抽出物、モンタンワックス、モンモリロナイト、Morinda citrifolia、Morus bombycis根抽出物、Morus nigra根抽出物、ムコ多糖、Mucor miehei抽出物、ヨモギ抽出物、クワ抽出物、ムルムル種子バター、ミリスチン酸、ミリスチルミリスタート、ミリスチルニコチナート、ミルラ、ギンバイカ抽出物、Myrtus communis抽出物、N−アセチル−Lチロシン、N6−フルフリルアデニン、ナノ粒子、ナノテクノロジー、NaPCA、Narcissus poeticusワックス、Nardostachys jatamansi、Nasturtium officinale抽出物、納豆ガム、天然成分、天然保湿因子(NMF)、インドセンダン抽出物または油、ネオペンチルグリコールジカプリラート/ジカプラート、ネオペンチルグリコールジヘプタノアート、橙花、橙花油、イラクサ抽出物、ナイアシン、ナイアシンアミド、ニコチンアミド、ニコチン酸、窒素、ノニジュース、ノノキシノール、ノルジヒドログアヤレット酸、ナイロン−12、Nymphaea tetragona、o−シメン−5−オール、オーク根抽出物、オートムギβ−グルカン、オートムギフスマ抽出物、オートムギ種子抽出物、オートミール、オクチノキサート、オクチサラート、オクトクリレン、オクチルメトキシシンナマート、オクチルパルミテート、オクチルサリチラート、オクチルサリチラート、オクチルドデカノール、オクチルドデシルミリスタート、オクチルドデシルネオペンタノアート、Oenothera biennis油、Olea europaea果実油、Olea europaea油不けん化物、オレアノール酸、オレイン酸、オレス−10、オレス、オレイルエルカート、オリバナム抽出物、オリーブ油/オリーブ果実油、アヘンケシ種子、オレンジ花、Orbignya martiana、Orbignya oleifera、ラン、オレガノ、Origanum majorana、Origanum vulgare花抽出物、ニオイイリス根、オルトトリ−シクレン、Oryza sativa蝋、Oryza sativa油、オリザノール、オキシドリダクターゼ、オキシベンゾン、酸素、オゾケライト、P. elisabethae、PABA、パジマートO、Padina pavonica抽出物、Paeonia albiflora抽出物、Paeonia suffruticosa抽出物、パーム種子酸、パーム油、Palmaria palmata抽出物、パルマローザ油、パルミチン酸、パルミトイルヘキサペプチド−12、パルミトイルオリゴペプチド、パルミトイルペンタペプチド−3、パルミトイルテトラペプチド−7、パルミトイルトリペプチド−1、Palmitoyl Tripeptide−38、パルミトイルトリペプチド−5、Panax ginseng根抽出物、Panicum miliaceum、パンジー抽出物、パンテチン、パンテノール、パントテン酸、パパイン、Papaver somniferu
m種子、パパイヤ抽出物、パラアミノ安息香酸(PABA)、パラベン、パラフィン、Paraffinum liquidum、Parsol 1789、Passiflora edulis抽出物、Passiflora edulis種子油、パッションフルーツ抽出物、パチューリ、Paullinia cupana種子抽出物、パパイヤ抽出物、ピーナッツ油、ペカン油、ペクチン、PEG 90M、PEG化合物、PEG−10ジメチコン、PEG−10ジメチコン/ビニルジメチコンクロスポリマー、PEG−10ナタネステロール、PEG−100ステアラート、PEG−12ジメチコン、PEG−120メチルグルコースジオレアート、PEG−14、PEG−150ジステアラート、PEG−20メチルグルコースセスキステアラート、PEG−32、PEG−33、PEG−40水添ヒマシ油、PEG−40ステアラート、PEG−60アーモンドグリセリド、PEG−60水添ヒマシ油、PEG−7グリセリルココアート、PEG−75シアバターグリセリド、PEG−8、PEG−8ジメチコン、PEG−80ソルビタンラウラート、PEG/PPG−17/6コポリマー、PEG/PPG−18/18ジメチコン、PEG/PPG−18/4コポリマー、PEG/PPG−20/15ジメチコン、PEG、Pelargonium graveolens油、ヒカゲミズ、ペンタデカラクトン、ペンタエリスリチルテトライソステアラート、ペンタエリスリチルテトラオクタノアート、ペンタペプチド、ペンテン酸ペンタナトリウム、ペンチレングリコール、ボタン花、ボタン根抽出物、ペパーミント、ペプチド、ペルフルオロカーボン、Perilla ocymoides、Persea gratissima油、Persicaria hydropiper、プチグレンマンダリン、ペトロラタム、PHA、フェノキシエタノール、フェノキシイソプロパノール、フェニルトリメチコン、フェニルアラニン、フェニルエチルレゾルシノール、フロレチン、ホスファチジルコリン、ホスファチジルエタノールアミン、リン脂質、リン酸、光増感剤、フタラート、Phyllanthus emblica果実抽出物、フィタントリオール、フィチン酸、フィトエストロゲン、フィトナジオン、フィトスフィンゴシン、フィトステロール、Picea abies抽出物、マツ油、パイナップル抽出物、松毬抽出物、Pinus lambertiana木材抽出物、Pinus sylvestris抽出物、Piper nigrum、ピスタチオ種子油、Pistacia vera種子油、Pisum sativum、プランクトン抽出物、可塑剤、Plectranthus barbatus抽出物、プラム抽出物、プラム種子油、Pogostemon cablin、ポロキサマー184、ポロキサマー407、ポロキサマー、ポリアクリルアミド、ポリアクリラート−17、ポリアミノプロピルビグアニド、ポリブテン、ポリカプロラクトン、ポリエチレン、ポリエチレングリコール、ポリグルクロン酸、ポリグリセロールモノステアラート、ポリグリセリル2トリイソステアラート、ポリグリセリルメタクリラート、ポリグリセリル−3蜜蝋、ポリグリセリル−3メチルグルコースジステアラート、ポリグリセリル−4イソステアラート、ポリグリセリル−6イソステアラート、イタドリ根抽出物、ポリヒドロキシ酸、ポリヒドロキシステアリン酸、ポリイソブテン、ポリマー、ポリメチルメタクリラート、ポリメチルシルセスキオキサン、ポリプロピレングリコール、ポリクオタニウム−10、ポリクオタニウム、多糖類、ポリシリコーン−11、ポリソルベート20、ポリソルベート60、ポリソルベート80、ポリソルベート、ポリビニルアルコール、ポリビニルピロリドン、ザクロ抽出物、Poria cocos抽出物、Porphyridium cruentum抽出物、Portulaca oleracea抽出物、カリウム、アスコルビルトコフェリルリン酸塩カリウム、セチルリン酸カリウム、水酸化カリウム、ミリスチン酸カリウム、リン酸カリウム、ソルビン酸カリウム、PPG−12ブテス−16、PPG−12/SMDIコポリマー、PPG−14ブチルエーテル、PPG−2ミリスチルエーテルプロピオナート、PPG−2−デセス−30、PPG−20メチルグルコースエーテル、PPG−26−ブテス−26、PPG−3ベンジルエーテルミリスタート、プレグネノロンアセタート、防腐剤、プロゲステロンUSP、プロリン、プロパンジオール、プロポリス、プロピレンカルボナート、プロピレングリコール、プロピレングリコールジカプリラート/ジカプラート、プロピレングリコールイソステアラート、プロピレングリコールラウラート、プロピレングリコールステアラート、プロピルパラベン、プロスタグランジンアナログ、プロテアーゼ、タンパク質、Prunella vulgaris、Prunus americana、Prunus amygdalus dulcis、Prunus armeniaca、Prunus domestica種子抽出物、Prunus domestica種子油、Prunus dulcis、Pseudopterogorgia elisabethae、Pueraria lobata、プルラン、カボチャ、カボチャ種子抽出物、Punica granatum抽出物、精製水、PVM/MAデカジエンクロスポリマー、PVP、PVPコポリマー、PVP/ジメチルアミノエチルメタクリラート、ピクノジェノール、ピリドキシン塩酸塩(HCL)、Pyrus cydonia、Pyrus malus、クオタニウムアンモニウム化合物、クオタニウム−15、クオタニウム−18ヘクトライト、ケルセチン、シロオーク、Quercus infectoria抽出物、セッケンボク抽出物、マルメロ種子、キノア油、Ranunculus ficaria抽出物、ナタネ油、キイチゴ種子抽出物、キイチゴ種子油、赤27レーキ、赤33、赤6レーキ、紅藻類、アカツメクサ、アメリカアカミキイチゴ抽出物、コウキシタン、還元剤、Renova、レゾルシノール、レスベラトロール、Retin−A、レチノイド、レチノール、レチニルアスコルバート、レチニルパルミテート、レチニルレチノアート、リボフラビン、米糠油、米油、米デンプン、リシノレアート、Ricinus communis、RNA、Robinia pseudacacia抽出物、Rosa canina、Rosa centifolia、Rosa centifolia花、Rosa damascena油、Rosa eglanteria、Rosa gallica花抽出物、Rosa mosqueta、Rosa roxburghii抽出物、Rosa rubiginosa、バラ花、バラ花油、バラの実、バラの実油、バラ油、ローズマリー抽出物、ローズマリー油、ローズウッド油、Rosmarinus officinalis抽出物、ロイヤルゼリー、Rubus idaeus、Rubus occidentalis、Rubus ursinus、Rubus ursinus x idaeus、Rubus villoscus、ルスコゲニン、Ruscus aculeatus、ルチン、異性化糖、サッカリド、Saccharomycesカルシウム発酵素、Saccharomyces cerevisiae、Saccharomyces銅発酵素、Saccharomyces鉄発酵素、Saccharomyces溶解物、Saccharomycesマグネシウム発酵素、Saccharomycesマンガン発酵素、Saccharomyces officinarum発酵素、Saccharomycesカリウム発酵素、saccharomycesセレン発酵素、Saccharomycesケイ素発酵素、Saccharomyces亜鉛発酵素、ベニバナ種子油、サルビア抽出物、サリシン、サリチル酸、Salix alba抽出物、Salix nigra(ヤナギ)樹皮抽出物、Salvia officinalis、Sambucus canadensis、Sambucus cerulea、Sambucus nigra、ビャクダン油、Santalum album種子抽出物、Sapindus mukurossi果皮抽出物、Saponaria officinalis抽出物、サポニン、Sargassum filipendula抽出物、モッコウ油、ノコギリヤシ抽出物、Saxifraga sarmentosa抽出物、スクラレオリド、Sclerocarya birrea、スクレロチウムガム、Scutellaria baicalensis抽出物、SDアルコール、SDアルコール40−2、シーバックソーン、海塩、ムチサンゴ抽出物、Seamollient、海藻、セバシン酸、セレン、セイヨウウツボグサ、Serenoa serrulata抽出物、セリシン、セリン、ゴマ油、Sesamum indicum、セスキオレアート、Shao−yao、シアバター、Siegesbeckia orientalis、シリカ、シリカジメチルシリラート、シリケート、シリコーン、シルク、シルクパウダー、シルクプロテイン、シロキサン、砂泥、銀、塩化銀、スルファジアジン銀、シルバーティップ白茶葉抽出物、Silybum marianum抽出物、シメチコン、Simmondsia chinensis、サーチュイン、皮膚呼吸因子、皮膚同一成分、皮膚修復成分、スカルキャップ抽出物、スリップ剤、スリッパリーエルム樹皮、セッケン、ムクロジ抽出物、シャボンソウ、酢酸ナトリウム、アクリル酸ナトリウム/アクリロイルジメチルタウラートコポリマー、アスコルビン酸ナトリウム、アスコルビルリン酸ナトリウム、安息香酸ナトリウム、亜硫酸水素ナトリウム、ホウ酸ナトリウム、ナトリウムC14〜16オレフィンスルホナート、ナトリウムカルボマー、炭酸ナトリウム、カルボキシメチルβ−グルカンナトリウム、セテアリル硫酸ナトリウム、塩化ナトリウム、コンドロイチン硫酸ナトリウム、クエン酸ナトリウム、ココアンホ酢酸ナトリウム、ヤシ脂肪酸ナトリウム、ココイルアミノ酸ナトリウム、ココイルグルタミン酸ナトリウム、ココイルイセチオン酸ナトリウム、デヒドロ酢酸ナトリウム、ジラウロイルグルタミン酸リシンナトリウム、ヘキサメタリン酸ナトリウム、ヒアルロン酸ナトリウム、水酸化ナトリウム、ヒドロキシメチルグリシン酸ナトリウム、乳酸ナトリウム、ラクトビオン酸ナトリウム、ラウレス硫酸ナトリウム、ラウレス−13カルボン酸ナトリウム、ラウロアンホ酢酸ナトリウム、ラウロイルラクチル酸ナトリウム、ラウロイルサルコシン酸ナトリウム、ラウロイルグルコースカルボン酸ナトリウム、ラウリル硫酸ナトリウム、メタ重亜硫酸ナトリウム、メチルココイルタウリン酸ナトリウム、メチルタウリン酸ナトリウム、ミレス硫酸ナトリウム、パーム核脂肪酸ナトリウム、パルミチン酸ナトリウム、ナトリウムPCA、ナトリウムPEG−7オリーブ油カルボキシラート、フィチン酸ナトリウム、ポリアクリル酸ナトリウム、サリチル酸ナトリウム、ケイ酸ナトリウム、亜硫酸ナトリウム、牛脂脂肪酸ナトリウム、チオグリコール酸ナトリウム、トリデセス硫酸ナトリウム、Solanum lycopersicum抽出物、Solanum tuberosum抽出物、可溶性フィッシュコラーゲン、溶媒、Sonojell、ソルビン酸、ソルビタンオレアート、ソルビタンセスキオレアート、ソルビタンステアラート、ソルビトール、大豆抽出物、大豆イソフラボン、大豆油、大豆タンパク質、大豆ステロール、スペアミント油、SPF、スフィンゴ脂質、カンショウ、Spiraea ulmaria、スピルリナ、スクアラン、スクワラン、セントジョーンズワート、トウシキミ、塩化ステアピリウム、塩化ステアラルコニウム、ステアラルコニウムヘクトライト、ステアラート、ステアレス−20、ステアリン酸、ステアリルアルコール、ステアリルジメチコン、ステアリルグリチルリチナート、ステアリルメチコン、幹細胞、トロベリーベゴニア、エゴノ
キベンゾイン、スチレン/アクリラートコポリマー、サブチリシン、スクロース、サトウキビ抽出物、スルファート、イオウ、日光阻止因子、ヒマワリ種子油、日焼け止め、スーパーオキシドジスムターゼ、界面活性剤、スイートアーモンド、スイートアーモンド油、Symphytum officinale抽出物、Szechuan peppercorn、タルク、タロー、タマヌ油、Tamarindus indica種子抽出物、Tanacetum parthenium、タンジェリン油、タンニン酸、タンニン、Taraktogenos kurzii、Taraxacum officinale、酒石酸、Tazorac、TEA、チャノキ油、TEA−ラウリルスルファート、テプレノン、テレフタル酸ジクラムスルホン酸スルホン酸、Terminalia catappa、Terminalia sericea、Terminalia sericea抽出物、テトラジブチルペンタリリスリチルヒドロキシヒドロキシシンナマート、テトラヘキシルデシルアスコルバート、テトラヒドロビスデメトキシクルクミン、テトラヒドロビスデメトキシジフェルロイルメタン、テトラヒドロデメトキシクルクミン、テトラヒドロデメトキシジフェルロイルメタン、テトラヒドロジフェルロイルメタン、テトラヒドロメトキシクルクミン、テトラヒドロキシプロピルエチレンジアミン、EDTA四ナトリウム、エチドロン酸四ナトリウム、Theobroma cacao種子バター、チアミンHCL、増粘剤、チオクト酸、チオジプロピオン酸、チオグリコラート、チオタウリン、スレオニン、タイム抽出物、タイム油、胸腺加水分解物、Thymus serpillum抽出物、Thymus vulgaris、Thymus vulgaris油、Tilia cordata、Tinosorb M、Tinosorb S、組織呼吸因子(TRF)、二酸化チタン、トコフェロール、トコフェロールアセタート、トコフェリルアセタート、トコフェリルリネオラート(lineolate)、トコトリエノール、トマト抽出物、イワキンバイ抽出物、トルマリン、トラガント、トラネキサム酸、トランスフォーミング成長因子(TGF)、トレハロース、トレチノイン、トリベヘニン、トリベヘニンPEG−20エステル、トリカプリリン、トリクロサン、トリデシルサリチラート、トリデシルステアラート、トリデシルトリメリタート、トリエタノールアミン、トリエトキシカプリリルシラン、トリエトキシカプリリルシランクロスポリマー、トリエトキシシリルエチルポリジメチルシロキシエチルヘキシルジメチコン、Trifolium pratense、トリグリセリド、トリゴネラフォエヌムグラエクム種子抽出物、トリイソセチルシトラート、トリラウリン、トリメチルシロキシシリケート、トリオクラノリン(trioclanolin)、トリオクタノイントリオクチルドデシルシトラート、トリペプチド−32、EDTA三ナトリウム、Triticum vulgare(小麦)胚芽抽出物、Triticum vulgare油、トロクセルチン、トリプトファン、ウコン、Tussilago farfara、チロシナーゼ、チロシン、ユビキノン、Ulmus fulva樹皮抽出物、ウルトラマリン、Ulva lactuca抽出物、Uncaria tomentosa抽出物、Undaria pinnatifida、尿素、Urtica dioica、UVA、Uva ursi抽出物、UVB、VA/クロトナート、VA/クロトナートコポリマー、Vaccinium macrocarpon果実抽出物、Vaccinium myrtillus、バリン、Vanilla planifolia果実抽出物、血管内皮成長因子(VEGF)、ビジョザクラ抽出物、ベチベルソウ油または抽出物、ビニルジメチコン/メチコンシルセスキオキサンクロスポリマー、Viola tricolor抽出物、Visnaga vera抽出物、ビタミンA、ビタミンBl、ビタミンB12、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンC、ビタミンD、ビタミンE、ビタミンF、ビタミンH、ビタミンK、ヨーロッパブドウ、Vitreoscilla発酵素、揮発性油、VP/エイコセンコポリマー、VP/ヘキサデセンコポリマー、クルミ抽出物、クルミ油、クルミ殻粉末、水、オランダガラシ抽出物、スイカ果実抽出物、小麦アミノ酸、小麦粉芽グリセリド、小麦粉芽油、小麦タンパク質、乳清、乳清タンパク質、シロイラクサ、シロカシ樹皮抽出物、白茶葉抽出物、セイヨウシロヤナギ、カナダサイシン、野生ヤマノイモ抽出物、ヤナギ樹皮、ヤナギハーブ、ヒメコウジ油、マンサク、キサンタンガム、キサントフィル、Xi xin、Ximenia americana油、キシリトール、キシロース、キシメニン酸、セイヨウノコギリソウ抽出物、酵母、酵母抽出物、黄5、黄6レーキ、イェルバマテ抽出物、イランイラン、ヨーグルト、ユッカ抽出物、Yucca schidigera、Zanthoxylum piperitum、ゼオライト、亜鉛、炭酸亜鉛、グルコン酸亜鉛、酸化亜鉛、亜鉛PCA、フェノールスルホン酸亜鉛、ステアリン酸亜鉛、硫酸亜鉛、Zingiber officinale roscoe、Zingiber zerumbet、Zingiberaceae、ならびにZizyphus jujuba果実抽出物が挙げられる。さらに別の実施形態では、成分は、防腐剤、例えば、次亜塩素酸ナトリウム、第4級アンモニウム化合物、アルコール、ベタジン、ヨウ素であってよい。別の実施形態では、成分は、金、銀、PHMB、または次亜塩素酸ナトリウムなどの保存剤であってよい。水溶性ではない成分の場合、溶媒の適切な使用により、本発明に従って非水溶性成分が使用されることが可能になることを、当業者は理解する。
本開示は、セクション(I)に記載の組成物を作製するための方法も提供する。より具体的には、活性成分を含む送達系は、(a)溶媒に活性成分を溶解させて、活性成分溶液を得ること;(b)融解したペトロラタムを得るのに十分な温度にペトロラタムを加熱すること、及びペトロラタムの温度よりも高い温度に活性成分溶液を加熱して、加熱された活性成分溶液を得ること;(c)融解したペトロラタム及び加熱された活性成分溶液を混合して融解した混合物を得ること;ならびに、(D)融解した混合物を冷却して、ペトロラタムベース組成物を得ることを含む方法で調製される。ステップ(a)〜(d)は順番に行われる。
別の態様では、本発明は、所望の部位に活性成分を送達する方法を包含する。
SOPプロトコールに従って洗浄し滅菌したタンクに2540.3ポンドの白色ペトロラタムを添加することにより、「製剤1」(図1)を調製した。タンク中では、ペトロラタムを110℃〜113°Fに加熱してペトロラタムを融解させた。別個の清浄な浄化された容器では、133.70ポンドの水及び所望の量のBZK及びPHMBを加え、122°Fに加熱した。両方の相が同じ温度である時、混合しながら、溶液相を、ペトロラタムに徐々に添加した。熱は96〜104°Fに徐々に減少させた。生成物を、品質コントロールのために試験して、ポリプロピレンドラムに移した。得られた組成物は、外観に光沢があり、白色からわずかに黄色であった。25℃での比重は、0.830〜0.910の時の仕様と一致する。25℃、TFで10rpmでの粘度値は、約225,000〜300,000cpsである場合に仕様に適合する。最終製剤は、重量パーセントの以下の成分を含有した:95%のペトロラタム;0.13%のBZK、0.2%のPHMB、及び4.67%の水。
皮膚感作性を評価するために、本明細書で「製剤1」と呼ばれる実施例1の製剤について試験を行った。製剤1を含むパッチを、18〜63歳の年齢範囲及び5つの皮膚の種類を表す53名のヒト研究参加者の皮膚に直接適用した。表1は、参加者の人口統計を示す。パッチは、最初の適用後の48時間、所定位置にとどまった。参加者に、予定された訪問の48時間前にパッチを取り外さないように指示した。その後、対象に、パッチを24時間取り外すように指示した。この手順を、一連の9連続まで繰り返し、24時間の曝露を、週3回3週間連続で行った。試験部位を、熟練した従事者が評価した。10〜14日間の休息期間の後、再試験/チャレンジ用量を、以前に未曝露の試験部位に1回適用した。試験部位を、熟練した職員が、適用の48時間後及び96時間後に評価した。部位を、表2に提示されるようなInternational Contact Dermatitis Research Group scoring scale (Rietschel, Fowler, Ed., Fisher’s Contact Dermatitis (fourth ed.)Baltimore, Williams & Wilkins, 1995)に基づいて採点した。
USP51に従って、抗菌効力試験を行った。5つの微生物を試験した。各生体を、細菌1グラム当たり1×106コロニー形成単位(CFU)または酵母及びカビ1グラム当たり1×105CFUの接種レベルで接種した。次に、接種した試料を、20〜25℃で28日間保存した。各微生物の集団を、2、7、14、21、及び28日目のプレートカウントにより決定した。プレートカウントを、希釈剤としての改変Letheen Brothを使用して1:10の開始希釈で実施して、Tryptic Soyアガー及びSabouraud Dextroseアガー上にプレーティングした。
試験を、(培養で成長させた)哺乳動物細胞の、製剤1のアガー拡散性要素への生物学的反応性を評価するために行った。
皮膚刺激を引き起こす製剤1の刺激可能性を評価するために、試験を行った。
製剤1を含む抗菌液体懸濁液中のMRSAの集団における変化を評価するための試験を行った。メチシリン耐性Staphylococcus aureus(MRSA)は、ペニシリン誘導体抗生物質メチシリンに対して耐性がある球菌形状の好気性菌である。MRSAは、厄介な感染を引き起こし得、その迅速な複製及び抗生物質への耐性により、処置がより困難になる。MRSA細菌は、乾燥に耐性を示し、それ故、長期間、表面及び繊維上で生存することができ、それ故、この細菌を、表面上の抗菌効力試験の優れた代表例にする。
56歳の黒人男性が、足ならびに第2趾及び第3趾の右背側及び底側の表面に静脈潰瘍の主訴を伴ってクリニックを訪れた。患者は、慢性リンパ浮腫、DM、HTN、高脂血症、右側の残存不全麻痺を伴うCVA、車椅子に縛られ、タバコ依存、発作性障害、うつ病、及び喘息の重大な既往歴を有していた。患者は過去に、クリング、エース、及びコバンラップを用いるブタジエンガーゼラップ及びIodasorbで過去に処置を受けていたが、改善はほとんどなかった。創傷ケアを毎週2回行った。
76歳の白人女性が、右脛に1.0×5.0×0.1mmの裂傷を受けた24時間後に、クリニックを訪れた。患者は、木材の山の近くで立っていたその時、いくつかの木材が落下して、患者を切断したと話した。X線写真では、骨折については否定され、超音波検査では、異物が残っているという証拠は見つからなかった。創傷は、骨にプローブしなかった。患者の破傷風の状態は、これまでに提示されていた。創傷は、滅菌生理食塩水で清浄した後、縁を再び近づけて、地元ERにおいて、保持縫合糸及び単純閉鎖縫合糸で閉じた。
51歳の女性が肛門周囲膿瘍の管理のために入院した。患者は、6ヶ月前に肛門周囲膿瘍の病歴があり、ヨードアレルギーがあった。以前の膿瘍は、ベッドサイドI&D及び経口抗生物質により処置されていた。感染の再発で、痔瘻の存在について懸念が生じ、患者は、評価及び介入のためのSIRS基準下で入院させた。
共存症のない22歳の健康な男性が、更衣室での傷害による第2度の擦過傷で緊急治療室に入院した。患者の破傷風状態に対処し、傷口を清浄して、トリプル抗生物質軟膏、滅菌ガーゼ、及び含浸銀メッシュでドレッシングした。患者及びその両親は、退院時にこのドレッシングコースBIDを継続するよう指示された。
長期間の喫煙及びDVTの病歴を有する70歳の白人男性が、PEに進行していた。病院での過程は、抗凝固療法及びIVFの留置を含んでいた。入院後に、患者は、両下肢静脈潰瘍を発症し、低アルブミンレベルと診断された。プロテインサプリメントを、ハニーシート、ウナブーツ、コバン、及びエースラップを用いる積極的なドレッシング交換と共に週1回に進む週2回から開始した。急性期のために、月2回の足治療により患者をフォローした。アルブミンレベルが正常化し、ゆっくりとした改善を伴い、ドレッシング交換を継続し、この時点で、許容される治癒が生じ、患者が圧迫ストッキングに移行させた。
重大な既往歴のない9歳の少年が、左側方の顎に感染病変を伴ってクリニックを訪れた。患者の父親は、少年が、空手中にマットの上に落ちた時に、物理的な擦傷火傷を受けたと報告している。両親はバシトラシンで局所的に傷を7日間処置したが、軽度の化膿性排液を伴った、患部の紅斑、浮腫、及び、局所的な熱感の悪化を報告した。患者は触診に対する圧痛を訴えた。診療所でとられた培養物により、単純ヘルペス1型及びメチシリン耐性Staphylococcus aureus(MRSA)が明らかになった。
刺激性おむつ皮膚炎は、乳児及び幼児に一般に見られる皮膚刺激の広範に見られる形態である。刺激物に皮膚を長時間曝露すると、これらの攻撃が悪化する。このような刺激物は、数の少ないおむつ交換、下痢、及び接触性アレルギーを含む。局所皮膚pHの変化は、表皮の破壊を引き起こして、臀部の最も目立った領域に疼痛を伴う紅斑性の発疹をもたらす
放射線皮膚炎の処置のための証明に基づいたプロトコールは少なく、これらの症例の病院管理が一貫性を欠いているという、研究上の表れである。2010年の文献レビューは、いずれの1つの治療選択肢を支持するエビデンスも不十分であると結論づけた。加えて、以前の研究では、放射線療法を受けている患者における紅斑反応の発生率が80〜90%、湿性落屑の発生率が10〜15%であることを報告し、この状態が放射線療法の広く見られる副作用であることを示した。ここで、製剤1での処置を実施した放射線皮膚炎の症例を報告する。
潰瘍が6ヶ月間あった、心血管疾患及び十分に管理された糖尿病の72歳の男性が、クリニックを訪れた。潰瘍は3.2cm×1.9cm×0.2cmの測定値であり、Wagnerグレード2として病期分類した。患者は、結婚して、3人の成人した子供があり、喫煙をせず、社交上のアルコールを飲み、種々の内分泌障害の家族歴があった。患者は、以前の潰瘍を否定し、潰瘍を「虫の咬傷」と考えていた。患者の創傷の過去の処置は、創傷床へのベタジン、シルバデン、及びヒドロゲルを含んでいた。訪問の際、患者は、乾いた滅菌ドレッシングを用いてシルバデンを一日おきに塗布していたが、創傷の測定は、不十分な治癒を示した。患者の薬物療法は、メトホルミン、クロピドグレル、メプロプロロール、低用量アスピリン、ならびにACE阻害剤、ペニシリン、及びサルファ剤に対しアレルギーのあるシンバスタチンであった。
皮膚裂傷は、ヒト皮膚の2つの主な層である表皮及び真皮の分離に起因する。それらは、高齢者に影響を与える主要な問題であり、14%及び24%の間の有病率を有する。アルツハイマー病、低アルブミン、PVD、高血圧症、及び甲状腺機能低下症の病歴を有する88歳の白人女性が、複雑な皮膚裂傷を管理しようとして、4ヶ月間不成功の処置を受けていた。銀及び局所抗生物質を含む多くのドレッシング技術が最小限の進歩で試みられていた。式Iの薄層を、創傷領域及びその周囲に適用した。次に、非粘着性のガーゼシートを、続いて、エースラップ(圧迫用)を適用した。このドレッシングを、毎週交換した。各ドレッシングの交換時に、脚を生理食塩水で清浄した。数週間以内に、創傷は安定化し、2週間以内に完全に上皮化した。顕著な治癒を見ることができ、第11週まで続く。さらに、非付着性レジメンが常に使用されていたが、ドレッシング交換は、患者にとって痛みを伴い、これは、創傷部位からのドレッシング材料の除去に対する視覚的及び聴覚的応答により示される。製剤1を使用する間、ドレッシング交換の間の不快感/疼痛応答はなかった。製剤1は、追加の保護の非接着層を加えて、治癒を刺激するしながら不快感を減少させ、最終的に再上皮化をもたらした。ドレッシング交換プロトコール中の製剤1の使用は、治癒を刺激し、追加の物理的外傷から部位を保護し、ドレッシング交換中の疼痛を低減させた。このような非外来患者の場合、四肢欠損及び感染のリスクが非常に高く、このような複雑で困難な創傷の治癒は、大成功を表す。
重大な既往歴のない38歳の女性が、限局性浮腫及び紅斑性を伴う紅斑性小胞水疱性プラークの2日の病歴を伴って訪れた。患者は掻痒感を否定したが、関連する灼熱感を認めた。病変の発症の前に、患者は自宅近くでハイキングをし、その間に、見つけた樹木からオレンジを採取した。試験時に、患者は、患者が自宅で排液を認めた小胞/水疱が散在した4.1cm×3.4cmの中心プラークを有する。2つの二次的な斑点があり:1つは、0.9cmであり、もう1つは、4mmである。病変は、左前脛に位置する。それらは、浮腫性及び紅斑性であるが、反対側と比較して測定可能な温度変化はない。
試験管内にパッケージ化された製剤Iを、加速安定性試験に供した。製剤Iを、40℃±2℃/75%±5%の相対湿度(RH)の貯蔵チャンバー内に横向きに置き、異なる間隔が3ヶ月の期間を経た。製品を、物理的及び分析的特性について評価した。40℃±2℃/75%±5%(RH)で保存した時、ベンジルアルコニウムクロライドは、表15に示すように安定であった。
創傷及び周囲の組織に薄層の製剤1を適用することにより、8人の患者の新しい創傷を処置した。創傷を、圧迫ドレッシングでドレッシングし、このドレッシング、一週間創傷と接触したままにした。創傷を処置前に綿棒で採取し、次に、1週間後にドレッシングを取り除いた時の処置終了時に、再度綿棒で採取した。綿棒試料のバイオバーデン分析を、合計微生物数及びStaphylococcus数について実施した。
疼痛低減のためのトロラミンサリチラートの10%水相、疼痛低減のためのリドカインの4%水相、感染コントロールのための次亜塩素酸ナトリウムの0.125%水相、及びグルコン酸クロルヘキシジンの4%水相を含む異なる活性成分で、実施例1を、繰り返した。
カチオン性殺生物剤の代わりにネオマイシンを用いることを除いて、実施例1に開示したプロセスを繰り返す。結果は、ペトロラタム中に分散されたネオマイシンナノ液滴の安定した製剤となるであろう。
Claims (15)
- ペトロラタムベース組成物であって、ペトロラタム及び活性成分を含み、前記活性成分が、前記ペトロラタム全体にナノ液滴として分散されている、前記ペトロラタムベース組成物。
- 前記ナノ液滴の寸法が、約10nm〜約10,000nmの範囲である、請求項1に記載の組成物。
- 前記活性成分が、前記ペトロラタムベース組成物に対して1重量%未満の量で前記組成物に提供される、請求項1に記載の組成物。
- 前記組成物が、90重量%を超えるペトロラタムである、請求項1に記載の組成物。
- 前記組成物が、乳化剤を含有しない、請求項1に記載の組成物。
- 前記活性成分が、前記組成物全体に均一に分散されている、請求項1に記載の組成物。
- 前記組成物が、水をさらに含む、請求項1に記載の組成物。
- 前記活性成分が、ビタミン若しくはサプリメント、医薬品、生物学的製剤、または化粧品成分から選択される、請求項1に記載の組成物。
- 前記組成物が、TGF−α、TGF−β(TGFβ1、TGFβ2、TGFβ3)、血小板由来成長因子(PDGF)、上皮成長因子(EGF)、ケラチノサイト成長因子とも称される線維芽細胞成長因子(FGF1、FGF2、FGF4、FGF7)、血管内皮成長因子(VEGF)、インスリン様成長因子(IGF)、結合組織成長因子(CTGF)、アクチビン、インターロイキン−1(IL1α、IL1β)、TNFα、及びGM−CSFからなる群より選択される1つ以上の化合物をさらに含む、請求項8に記載の組成物。
- ペトロラタム及び活性成分を含むペトロラタムベース組成物を調製するためのプロセスであって、前記プロセスは、
a)溶媒に前記活性成分を溶解させて、活性成分溶液を得ること;
b)前記ペトロラタムを融解させるのに十分な温度に前記ペトロラタムを加熱して、融解したペトロラタムを得ること、及び前記融解したペトロラタムよりも高い温度に前記活性成分溶液を加熱して、加熱された活性成分溶液を得ること;
c)前記融解したペトロラタム及び前記加熱された活性成分溶液を混合して、融解した混合物を得ること;ならびに、
d)前記融解された混合物を冷却して、前記ペトロラタムベース組成物を得ること
を含む、前記プロセス。 - 乳化剤が使用されない、請求項10に記載のプロセス。
- 前記加熱された活性成分溶液が、前記融解したペトロラタムの前記温度よりも約1℃〜約10℃高い温度を有する、請求項10に記載のプロセス。
- 前記加熱された活性成分溶液が、前記融解したペトロラタムの前記温度よりも約1℃〜約5°C高い温度を有する、請求項10に記載のプロセス。
- 前記活性成分が、ビタミン若しくはサプリメント、医薬品、生物学的製剤、または化粧品成分から選択される、請求項10に記載のプロセス。
- ペトロラタムベース組成物であって、ペトロラタム及び活性成分を含み、
a)溶媒に前記活性成分を溶解させて、活性成分溶液を得ること;
b)前記ペトロラタムを融解させるのに十分な温度に前記ペトロラタムを加熱して、融解したペトロラタムを得ること、及び融解したペトロラタムよりも高い温度に前記活性成分溶液を加熱して、加熱された活性成分溶液を得ること;
c)前記融解したペトロラタム及び前記加熱された活性成分溶液を混合して、融解した混合物を得ること;ならびに、
d)前記融解された混合物を冷却して、前記ペトロラタムベース組成物を得ること
を含むステップで調製される、前記ペトロラタムベース組成物。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102563718B1 (ko) * | 2022-11-30 | 2023-08-08 | 에이앤펩주식회사 | 펩타이드 및 천연 발효물을 포함하는 피부염증 완화용 조성물 |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016126982A1 (en) * | 2015-02-05 | 2016-08-11 | Marc Selner | Ionic nanovesicle suspension and biocide prepared therefrom |
CN108136027A (zh) * | 2015-06-19 | 2018-06-08 | 全球健康方案有限责任公司 | 用于活性成分的基于凡士林的递送系统 |
US10463601B1 (en) * | 2016-06-17 | 2019-11-05 | Lorita Dillon | Topical cosmetic composition |
US10496949B2 (en) * | 2017-01-04 | 2019-12-03 | Christopher Zoumalan | Compositions and methods for treating cutaneous conditions |
WO2019074617A2 (en) * | 2017-09-14 | 2019-04-18 | Kilman Clarke Lewis | NEUPANEX ®: NEUROGENESIS, NEUROREGENERATIONAL AND NEUROPROTECTIVE SUPPLEMENT SUPPLEMENT COMBINATION |
CA3000495A1 (en) * | 2018-04-06 | 2019-10-06 | Exzell Pharma Inc. | Pharmaceutical compositions containing cannabis, uses thereof and methods for improving energy levels and/or alleviating fatigue |
CN108813246A (zh) * | 2018-05-31 | 2018-11-16 | 陕西顾森健康科技有限公司 | 一种易吸收防流失的胶原蛋白肽抗衰组合物及其制备工艺 |
KR101938877B1 (ko) * | 2018-08-20 | 2019-01-16 | 안디바 주식회사 | 수딩크림 조성물 및 그의 제조방법 |
US10933087B2 (en) * | 2018-09-25 | 2021-03-02 | Global Health Solutions, Llc | Methods and compositions for eye care |
WO2020069222A1 (en) * | 2018-09-26 | 2020-04-02 | Global Health Solutions Llc | Topical neurotoxin compositions |
WO2020069225A1 (en) * | 2018-09-26 | 2020-04-02 | Global Health Solutions Llc | Phmb compositions and methods of treatment for skin cancer |
CN109288117B (zh) * | 2018-10-22 | 2022-06-17 | 福建中烟工业有限责任公司 | 一种组合物及其在卷烟中的应用 |
WO2020117550A1 (en) * | 2018-12-03 | 2020-06-11 | International Flavors & Fragrances Inc. | White pine bark extract for decreasing endothelin-1 secretion, stem cell factor synthesis and protein carbonylation |
KR102031885B1 (ko) * | 2019-01-08 | 2019-10-15 | 안디바 주식회사 | 마카 추출물을 함유한 수딩크림 조성물 |
CA3127079A1 (en) * | 2019-01-16 | 2020-07-23 | Global Health Solutions Llc | Petrolatum-based phmb compositions and methods of treatment for onychomycosis |
WO2020150532A1 (en) * | 2019-01-16 | 2020-07-23 | Global Health Solutions Llc | Compositions and methods for the control and treatment of candida auris |
CA3126985A1 (en) * | 2019-01-21 | 2020-07-30 | Food For Future S.R.L. Societa Benefit | Methylation process |
CN109738252B (zh) * | 2019-01-23 | 2021-03-09 | 深圳天辰医疗科技有限公司 | 25-羟基-维生素d解离液 |
CN109696435B (zh) * | 2019-01-25 | 2021-03-09 | 深圳天辰医疗科技有限公司 | 维生素d的测定方法 |
CN109568563B (zh) * | 2019-02-02 | 2023-01-17 | 北京胜泰生物医药科技有限公司 | 一种沸石负载天然提取物的组合物及其制备方法 |
SE544407C2 (en) * | 2019-02-27 | 2022-05-10 | Aquammodate Ab | Stabilized filtration device |
KR102026995B1 (ko) | 2019-03-18 | 2019-09-30 | 에이앤에이치 인터내셔널 코스메틱스 | 수용화가 가능한 페트롤라툼 화장료 조성물의 제조방법 |
KR102096204B1 (ko) * | 2019-05-31 | 2020-04-02 | 최명석 | 국소지방 파괴 방법 및 국소지방 파괴용 저장성 용액 |
CN110604719A (zh) * | 2019-06-19 | 2019-12-24 | 青岛华澳现代医疗美容有限公司 | 自体修复激活组合物及其制备方法 |
CN110339399A (zh) * | 2019-07-09 | 2019-10-18 | 上海市第六人民医院 | 一种仿生人工骨及其制备方法 |
CN110353883A (zh) * | 2019-07-10 | 2019-10-22 | 重庆市人民医院 | 用于治疗褥疮的复合敷料层及带有复合敷料层的褥疮贴 |
KR102055098B1 (ko) * | 2019-07-26 | 2019-12-12 | (주)티이엔 | 여드름 피부 예방, 개선 및 치료용 조성물 |
CN110917380A (zh) * | 2019-08-01 | 2020-03-27 | 安徽省小山卫生材料有限公司 | 一种皮肤创面用聚硅酮敷料的制备方法 |
CN110339115B (zh) * | 2019-08-15 | 2021-11-16 | 广东芭薇生物科技股份有限公司 | 一种修护精华液及其制备方法 |
CN110540305B (zh) * | 2019-08-30 | 2021-01-29 | 福建闽泰交通工程有限公司 | 小流域河道修复方法 |
US11633368B2 (en) | 2019-09-03 | 2023-04-25 | Milton D. Moore | Enhanced moisturizing lotion compositions |
CN110859791B (zh) * | 2019-11-05 | 2022-12-20 | 广州梵之容化妆品有限公司 | 美白肌肤组合物及其应用、美白肌肤面膜 |
CN110840776B (zh) * | 2019-11-19 | 2022-08-19 | 上海中翊日化有限公司 | 一种化妆品试剂 |
CN115154342A (zh) * | 2019-12-31 | 2022-10-11 | 新生活化妆品科技(上海)有限公司 | 外用添加剂及其应用、皮肤外用制品 |
CN111084783A (zh) * | 2020-01-13 | 2020-05-01 | 深圳市生命谷生命科技研究院 | 鱼类体表多糖及鱼类体表消化多糖的应用 |
CN110946770A (zh) * | 2020-01-16 | 2020-04-03 | 厦门泽本健康管理有限公司 | 一种具液晶结构的祛痘霜及其制备方法 |
US20210259964A1 (en) * | 2020-02-25 | 2021-08-26 | Michael K. Hoskins | Antiviral preparation for treating human skin |
CN111346027A (zh) * | 2020-03-12 | 2020-06-30 | 广州品域美妆创新科技有限公司 | 一种含有乳糖酸的控油毛孔收缩组合物及其应用 |
CN115666501A (zh) * | 2020-05-19 | 2023-01-31 | 第八日实验室有限责任公司 | 具有蛋白质基质的皮肤护理产品 |
KR102149954B1 (ko) * | 2020-05-28 | 2020-09-01 | 김홍중 | 토르말린과 복합 천연물을 포함하는 통증완화용 조성물 |
CN111617775B (zh) * | 2020-06-12 | 2021-06-08 | 中国石油大学(北京) | 用于电化学制备过氧化氢的纳米催化剂及其制法和应用 |
CN111617021B (zh) * | 2020-07-07 | 2022-07-22 | 上海芒歌科技有限公司 | 抗口腔幽门螺杆菌的牙膏 |
CN111658567A (zh) * | 2020-07-20 | 2020-09-15 | 广州葆雀化妆品有限公司 | 一种美颜六胜肽原液 |
CN111662143B (zh) * | 2020-07-22 | 2022-05-31 | 中国农业科学院特产研究所 | 黄芪专用肥、提高黄芪产量的施肥方法 |
CN111920018A (zh) * | 2020-08-14 | 2020-11-13 | 江西师范大学 | 一种即食高钙鱼肠的制作方法 |
CN111903708B (zh) * | 2020-08-19 | 2023-07-21 | 宁夏农林科学院植物保护研究所(宁夏植物病虫害防治重点实验室) | 一种含硅藻土的矿物源农药制剂及其应用 |
US11524040B2 (en) | 2020-08-24 | 2022-12-13 | Charlotte's Web, Inc. | Composition for the treatment of acne |
CN112088777B (zh) * | 2020-08-28 | 2022-02-22 | 上海辰山植物园 | 一种牡丹组培苗离体生根方法 |
CN112210445B (zh) * | 2020-09-30 | 2022-01-11 | 山东华熙海御生物医药有限公司 | 一种透明质酸清洗液及其制备方法 |
CN112220706B (zh) * | 2020-11-06 | 2022-10-25 | 泉后(广州)生物科技研究院有限公司 | 一种抗衰老组合物、面霜及其制备方法 |
CN112274687B (zh) * | 2020-11-25 | 2023-05-30 | 广州润虹医药科技股份有限公司 | 一种稳定的水胶体油纱及其制备方法 |
CN112574890B (zh) * | 2020-11-26 | 2022-03-15 | 浙江工业大学 | 总状毛霉sy5-47及其在桑叶黄酮提取中的应用 |
CN112741929B (zh) * | 2020-12-28 | 2022-06-24 | 河南亚都实业有限公司 | 一种医用外伤止血复合敷料 |
US20220202761A1 (en) * | 2020-12-31 | 2022-06-30 | Melaleuca, Inc. | Diaper cream |
KR102468645B1 (ko) * | 2021-01-25 | 2022-11-21 | 클라쏜 주식회사 | 정전기 방지 기능이 우수한 당구대 천 조성물 |
US11565020B2 (en) * | 2021-01-31 | 2023-01-31 | Global Health Solutions, Inc. | Powdered collagen wound care compositions |
CN113144276B (zh) * | 2021-03-16 | 2022-08-23 | 中山大学 | 复合载药骨水泥及其制备方法和应用 |
CN115245470A (zh) * | 2021-04-27 | 2022-10-28 | 山东本真化妆品有限公司 | 水包油乳液及其在对抗婴儿湿疹中的用途 |
US11633425B2 (en) | 2021-05-13 | 2023-04-25 | Ahava—Dead Sea Laboratories Ltd. | Anti-glycation compositions |
CN113243446B (zh) * | 2021-05-20 | 2022-11-08 | 山西大学 | 一种谷糠蛋白提取物及其制备方法和应用 |
US11642305B2 (en) | 2021-06-03 | 2023-05-09 | Melissa Kadzai | Composition for a skin and hair product |
CN113350241B (zh) * | 2021-06-30 | 2022-11-08 | 广州市科能化妆品科研有限公司 | 榄仁树叶提取物的用途、舒敏组合物及其应用 |
CN113508880A (zh) * | 2021-07-21 | 2021-10-19 | 海南丰席树诺丽产业有限责任公司 | 一种抗氧化、提高免疫力的诺丽果汁及其制备方法 |
CN113775030A (zh) * | 2021-10-14 | 2021-12-10 | 山东路德新材料股份有限公司 | 一种排水格栅及其制造方法 |
WO2023064390A1 (en) * | 2021-10-17 | 2023-04-20 | ELEVAI Labs, Inc. | Exosome-based skincare product |
CN114045284B (zh) * | 2021-11-11 | 2023-12-15 | 中国农业科学院农业质量标准与检测技术研究所 | 一种提取生物组织样品中核酸的方法 |
CN113968774B (zh) * | 2021-11-23 | 2024-01-30 | 辽宁中医药大学 | 马齿苋中一种多芳基化合物及其提取分离方法 |
CN114015573B (zh) * | 2021-12-09 | 2023-06-27 | 绵阳市农业科学研究院 | 一种乳酸杆菌保护剂及其应用 |
CN114264744A (zh) * | 2021-12-23 | 2022-04-01 | 南京天嘉检测服务有限公司 | 一种基于茴香醛特征标志物鉴别枇杷蜂蜜的方法 |
WO2023129625A1 (en) * | 2021-12-30 | 2023-07-06 | Aravai Global Llc | Formulations and methods of making and using the same |
CN114487083B (zh) * | 2022-01-19 | 2024-05-07 | 中国地质大学(北京) | 一种磁性羟基纳米材料Fe3O4@COFs及其在磺胺质谱检测领域的应用 |
CN114224759B (zh) * | 2022-01-25 | 2023-02-10 | 广州臻颜化妆品有限公司 | 一种亚微米凡士林组合物及亚微米凡士林沐浴精华乳 |
WO2023149769A1 (ko) * | 2022-02-07 | 2023-08-10 | 전동욱 | 자외선에 의한 피부 손상 예방, 개선 또는 치료를 위한 조성물 및 이를 이용한 피부보호 방법 |
KR102435823B1 (ko) * | 2022-02-16 | 2022-08-23 | 조동혁 | 로션 및 모이스쳐밤이 통합된 하이브리드 화장품 |
CN114456246A (zh) * | 2022-02-25 | 2022-05-10 | 瀚科(浙江)生物科技有限责任公司 | 一种提高刺梨蛋白抑菌活性和热稳定性的方法和应用 |
CN114617813A (zh) * | 2022-03-11 | 2022-06-14 | 广州市南方医康生物科技有限公司 | 一种具有抗皱嫩肤效果的化妆品制作方法 |
CN114652820B (zh) * | 2022-03-22 | 2024-02-06 | 中国药科大学 | 一种阳离子脂质体纳米粒及其制备方法和应用 |
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KR102551642B1 (ko) * | 2022-06-27 | 2023-07-11 | 주식회사 넥스텍인터내셔널 | 살리실산, 오레가노추출물, 오이풀추출물 및 월계수잎추출물을 함유하는 여드름성 피부 개선용 화장료 조성물 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05184655A (ja) * | 1991-07-03 | 1993-07-27 | Lab D Hygiene & De Dietetique Lhd | 治療用包帯 |
JPH08336555A (ja) * | 1995-03-02 | 1996-12-24 | Johnson & Johnson Consumer Prod Inc | 構造化絆創膏 |
US6093414A (en) * | 1997-08-11 | 2000-07-25 | Christopher C. Capelli | Silver-based antimicrobial compositions |
CN1771937A (zh) * | 2005-11-04 | 2006-05-17 | 沈阳明华制药有限公司 | 鬼臼毒素外用膏剂及制备方法 |
WO2011010732A1 (ja) * | 2009-07-23 | 2011-01-27 | 株式会社 イギス | 皮膚外用剤組成物 |
CN103182070A (zh) * | 2013-04-12 | 2013-07-03 | 江苏迪沃生物制品有限公司 | 一种外用组合物、制剂及其应用 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2640801A (en) | 1950-04-08 | 1953-06-02 | American Cyanamid Co | Aureomycin ointment |
US3758686A (en) | 1971-12-07 | 1973-09-11 | American Cyanamid Co | Method of using steroid acetonides |
US4929442A (en) * | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
US4895452A (en) | 1988-03-03 | 1990-01-23 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
CA2064331C (en) * | 1991-03-28 | 2003-02-18 | Marvin L. Bayne | Vascular endothelial cell growth factor c subunit |
US5387417A (en) | 1991-08-22 | 1995-02-07 | Dow Corning Corporation | Non-greasy petrolatum emulsion |
US5346886A (en) * | 1993-11-15 | 1994-09-13 | John Lezdey | Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin |
UA39965C2 (uk) | 1993-12-03 | 2001-07-16 | Лайфор Леборетріз Лтд | Вірусоцидний, бактерицидний та руйнуючий сперматозоїди вагінальний засіб і вагінальний супозиторій ( варіанти ) |
US5420106A (en) * | 1994-03-22 | 1995-05-30 | Bristol-Myers Squibb Company | Method and composition having enhanced alpha-hydroxy acid skin permeation and retention |
DE19627498A1 (de) * | 1996-07-08 | 1998-01-15 | Nat Starch Chem Invest | Stärkehaltige Reinigungs- und Pflegemittel |
EP1035832B1 (en) * | 1997-12-03 | 2002-09-11 | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | Skin care composition with improved skin hydration capability |
US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
US6309664B1 (en) | 1999-09-15 | 2001-10-30 | Igen, Incorporated | Methods, uses and compositions of fluid petrolatum |
DE10042894A1 (de) | 2000-08-31 | 2002-03-14 | Thor Chemie Gmbh | Synergistische Biozidzusammensetzung mit 2-Methylisothiazolin-3-on |
US6800301B2 (en) | 2001-04-09 | 2004-10-05 | Sadie N. Smith | Multi-purpose skin balm including skin balm for psoriasis |
US10117812B2 (en) * | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US7074459B2 (en) | 2003-05-23 | 2006-07-11 | Stockel Richard F | Method for preserving wood |
US20050048020A1 (en) * | 2003-07-07 | 2005-03-03 | Wille John J. | Novel topical delivery system for plant derived anti-irritants |
CA2532730C (en) | 2003-07-17 | 2013-02-26 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
US20090312524A1 (en) * | 2003-11-28 | 2009-12-17 | Alternative Sourced Collagen, Llc | Compositions and methods comprising collagen |
US9028852B2 (en) * | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
WO2006099359A2 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
CA2600175A1 (en) | 2005-03-24 | 2006-03-20 | Avanir Pharmaceuticals | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors |
ES2415362T3 (es) | 2005-04-08 | 2013-07-25 | Mie University | Agente externo para tratar heridas |
JP2007039416A (ja) | 2005-08-05 | 2007-02-15 | Shiseido Co Ltd | ワセリン含有水中油型乳化組成物 |
US20070048345A1 (en) | 2005-08-31 | 2007-03-01 | Kimberly-Clark Worldwide, Inc. | Antimicrobial composition |
US8128973B2 (en) * | 2005-09-07 | 2012-03-06 | Noreen Mulvanerty | Medicated skin care preparation for promoting wound healing |
US20070141091A1 (en) | 2005-12-21 | 2007-06-21 | Erning Xia | Biguanide ointment and method of treatment and prevention of infections |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US7723278B2 (en) | 2007-05-15 | 2010-05-25 | Conopco Inc. | Stable, substantially surfactant-free liquid compositions comprising hydrophobic phase |
JP2009029791A (ja) * | 2007-06-26 | 2009-02-12 | Kowa Co | ステロイドを含有するo/w型乳化製剤 |
US8784659B2 (en) | 2007-08-08 | 2014-07-22 | General Electric Company | Method for controlling microbial biofilm in aqueous systems |
US7691419B2 (en) * | 2007-12-20 | 2010-04-06 | Dileva Rose Marie | Compositions and methods for treating skin conditions in mammals |
GB0803026D0 (en) | 2008-02-20 | 2008-03-26 | Enviroquest Group Ltd | External surface treatment system |
US7977289B2 (en) * | 2008-05-06 | 2011-07-12 | Conopco, Inc. | Substantially surfactant free in-shower gel compositions comprising hydrophilic and hydrophobic benefit agents |
US20100092526A1 (en) | 2008-09-26 | 2010-04-15 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
WO2010087964A2 (en) * | 2009-01-28 | 2010-08-05 | Nanobio Corporation | Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof |
US20100233224A1 (en) | 2009-02-23 | 2010-09-16 | Epir Technologies, Inc. | Photolytic release of biocides for high efficiency decontamination through phospholipid nanoparticles |
WO2011039638A2 (en) * | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Topical tetracycline compositions |
KR20130041803A (ko) * | 2010-04-07 | 2013-04-25 | 알러간, 인코포레이티드 | 안과 조성물을 위한 보존제의 조합 |
US9402770B2 (en) | 2011-12-09 | 2016-08-02 | Covidien | Antimicrobial non-adherent dressings and related methods therefor |
US20150246087A1 (en) * | 2012-06-11 | 2015-09-03 | Regenera Pharma Ltd. | Extracts and therapeutic uses thereof |
US8969649B2 (en) * | 2012-08-10 | 2015-03-03 | Ethicon, Inc. | Integrated dressing device |
EP2976095B1 (en) * | 2013-03-15 | 2020-12-23 | 3M Innovative Properties Company | Wound healing compositions |
ES2709324T3 (es) * | 2013-05-15 | 2019-04-16 | Euroresearch Srl | Polvo de colágeno, composición y uso |
CN106163542A (zh) | 2014-02-05 | 2016-11-23 | 雷波内制药有限公司 | 用于促进皮肤溃疡和伤口愈合的组合物 |
WO2016126982A1 (en) | 2015-02-05 | 2016-08-11 | Marc Selner | Ionic nanovesicle suspension and biocide prepared therefrom |
CN108136027A (zh) * | 2015-06-19 | 2018-06-08 | 全球健康方案有限责任公司 | 用于活性成分的基于凡士林的递送系统 |
-
2016
- 2016-05-27 CN CN201680046347.7A patent/CN108136027A/zh active Pending
- 2016-05-27 KR KR1020187001752A patent/KR102132544B1/ko active IP Right Grant
- 2016-05-27 CA CA2990201A patent/CA2990201A1/en not_active Abandoned
- 2016-05-27 US US15/167,099 patent/US10722461B2/en active Active
- 2016-05-27 AU AU2016278853A patent/AU2016278853A1/en not_active Abandoned
- 2016-05-27 RU RU2018102133A patent/RU2018102133A/ru not_active Application Discontinuation
- 2016-05-27 JP JP2018518566A patent/JP6869974B2/ja active Active
- 2016-05-27 EP EP16812128.3A patent/EP3310391A4/en active Pending
- 2016-05-27 EP EP16812129.1A patent/EP3310392A4/en active Pending
- 2016-05-27 AU AU2016278854A patent/AU2016278854A1/en not_active Abandoned
- 2016-05-27 CA CA2990170A patent/CA2990170A1/en not_active Abandoned
- 2016-05-27 JP JP2018518565A patent/JP2018517786A/ja active Pending
- 2016-05-27 US US15/167,044 patent/US10675243B2/en active Active
- 2016-05-27 WO PCT/US2016/034740 patent/WO2016204958A1/en active Application Filing
- 2016-05-27 KR KR1020187001751A patent/KR102132543B1/ko active IP Right Grant
- 2016-05-27 BR BR112017027490-6A patent/BR112017027490A2/pt not_active Application Discontinuation
- 2016-05-27 RU RU2018102137A patent/RU2018102137A/ru not_active Application Discontinuation
- 2016-05-27 CN CN201680045690.XA patent/CN108136026A/zh active Pending
- 2016-05-27 WO PCT/US2016/034747 patent/WO2016204959A1/en active Application Filing
-
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- 2017-08-08 US US15/672,197 patent/US20170333346A1/en active Pending
-
2020
- 2020-05-11 US US16/872,178 patent/US10874608B2/en active Active
- 2020-06-30 US US16/917,846 patent/US10966927B2/en active Active
- 2020-12-28 US US17/135,646 patent/US20210186874A1/en active Pending
-
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- 2021-04-05 US US17/222,061 patent/US20210220268A1/en active Pending
- 2021-09-09 US US17/470,971 patent/US20210401744A1/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05184655A (ja) * | 1991-07-03 | 1993-07-27 | Lab D Hygiene & De Dietetique Lhd | 治療用包帯 |
JPH08336555A (ja) * | 1995-03-02 | 1996-12-24 | Johnson & Johnson Consumer Prod Inc | 構造化絆創膏 |
US6093414A (en) * | 1997-08-11 | 2000-07-25 | Christopher C. Capelli | Silver-based antimicrobial compositions |
CN1771937A (zh) * | 2005-11-04 | 2006-05-17 | 沈阳明华制药有限公司 | 鬼臼毒素外用膏剂及制备方法 |
WO2011010732A1 (ja) * | 2009-07-23 | 2011-01-27 | 株式会社 イギス | 皮膚外用剤組成物 |
CN103182070A (zh) * | 2013-04-12 | 2013-07-03 | 江苏迪沃生物制品有限公司 | 一种外用组合物、制剂及其应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102563718B1 (ko) * | 2022-11-30 | 2023-08-08 | 에이앤펩주식회사 | 펩타이드 및 천연 발효물을 포함하는 피부염증 완화용 조성물 |
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