JP2018030854A5 - - Google Patents

Info

Publication number

JP2018030854A5

JP2018030854A5 JP2017174408A JP2017174408A JP2018030854A5 JP 2018030854 A5 JP2018030854 A5 JP 2018030854A5 JP 2017174408 A JP2017174408 A JP 2017174408A JP 2017174408 A JP2017174408 A JP 2017174408A JP 2018030854 A5 JP2018030854 A5 JP 2018030854A5

Authority

JP

Japan

Prior art keywords

asbti

pediatric

use according

bile acid

cholestasis

Prior art date

2017-09-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 206010008635 Cholestasis Diseases 0.000 claims 15
• 239000003613 bile acid Substances 0.000 claims 15
• 201000002150 Progressive familial intrahepatic cholestasis Diseases 0.000 claims 12
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 10
• 210000002966 serum Anatomy 0.000 claims 8
• 230000007870 cholestasis Effects 0.000 claims 7
• 231100000359 cholestasis Toxicity 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 7
• 210000004185 liver Anatomy 0.000 claims 7
• 230000002440 hepatic effect Effects 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 201000011374 Alagille syndrome Diseases 0.000 claims 4
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 4
• 206010010317 Congenital absence of bile ducts Diseases 0.000 claims 4
• 102100021711 Ileal sodium/bile acid cotransporter Human genes 0.000 claims 4
• 108091006614 SLC10A2 Proteins 0.000 claims 4
• 201000005271 biliary atresia Diseases 0.000 claims 4
• 239000003112 inhibitor Substances 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 201000001493 benign recurrent intrahepatic cholestasis Diseases 0.000 claims 3
• 210000003494 hepatocyte Anatomy 0.000 claims 3
• 238000002054 transplantation Methods 0.000 claims 3
• 208000003251 Pruritus Diseases 0.000 claims 2
• 206010048214 Xanthoma Diseases 0.000 claims 2
• 206010048215 Xanthomatosis Diseases 0.000 claims 2
• 230000004596 appetite loss Effects 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 208000001024 intrahepatic cholestasis Diseases 0.000 claims 2
• 230000007872 intrahepatic cholestasis Effects 0.000 claims 2
• 208000019423 liver disease Diseases 0.000 claims 2
• 235000021266 loss of appetite Nutrition 0.000 claims 2
• 208000019017 loss of appetite Diseases 0.000 claims 2
• 230000017074 necrotic cell death Effects 0.000 claims 2
• 230000000414 obstructive effect Effects 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• 208000011580 syndromic disease Diseases 0.000 claims 2
• 208000019256 Benign recurrent intrahepatic cholestasis type 2 Diseases 0.000 claims 1
• 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
• 208000005595 Chronic Idiopathic Jaundice Diseases 0.000 claims 1
• 206010011878 Deafness Diseases 0.000 claims 1
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 201000004943 Dubin-Johnson syndrome Diseases 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 1
• 206010019663 Hepatic failure Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 206010020880 Hypertrophy Diseases 0.000 claims 1
• 208000032571 Infant acute respiratory distress syndrome Diseases 0.000 claims 1
• 208000037112 Intestinal Failure Diseases 0.000 claims 1
• 206010023126 Jaundice Diseases 0.000 claims 1
• 108010012071 Lipoprotein-X Proteins 0.000 claims 1
• 206010067125 Liver injury Diseases 0.000 claims 1
• 206010025476 Malabsorption Diseases 0.000 claims 1
• 208000004155 Malabsorption Syndromes Diseases 0.000 claims 1
• 206010028974 Neonatal respiratory distress syndrome Diseases 0.000 claims 1
• 206010033645 Pancreatitis Diseases 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 235000017284 Pometia pinnata Nutrition 0.000 claims 1
• 240000007653 Pometia tomentosa Species 0.000 claims 1
• 208000001647 Renal Insufficiency Diseases 0.000 claims 1
• 206010041660 Splenomegaly Diseases 0.000 claims 1
• 201000001490 benign recurrent intrahepatic cholestasis 1 Diseases 0.000 claims 1
• 201000001488 benign recurrent intrahepatic cholestasis 2 Diseases 0.000 claims 1
• 208000026586 benign recurrent intrahepatic cholestasis type 1 Diseases 0.000 claims 1
• 210000000941 bile Anatomy 0.000 claims 1
• 239000003833 bile salt Substances 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 239000007910 chewable tablet Substances 0.000 claims 1
• 201000001883 cholelithiasis Diseases 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 235000009508 confectionery Nutrition 0.000 claims 1
• 239000007919 dispersible tablet Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000007938 effervescent tablet Substances 0.000 claims 1
• -1 elixirs Substances 0.000 claims 1
• 208000009866 extrahepatic cholestasis Diseases 0.000 claims 1
• 206010016256 fatigue Diseases 0.000 claims 1
• 208000030304 gastrointestinal bleeding Diseases 0.000 claims 1
• 239000007903 gelatin capsule Substances 0.000 claims 1
• 239000008187 granular material Substances 0.000 claims 1
• 208000037824 growth disorder Diseases 0.000 claims 1
• 230000010370 hearing loss Effects 0.000 claims 1
• 231100000888 hearing loss Toxicity 0.000 claims 1
• 208000016354 hearing loss disease Diseases 0.000 claims 1
• 231100000753 hepatic injury Toxicity 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 208000015525 isolated neonatal sclerosing cholangitis Diseases 0.000 claims 1
• 201000006370 kidney failure Diseases 0.000 claims 1
• 231100000835 liver failure Toxicity 0.000 claims 1
• 208000007903 liver failure Diseases 0.000 claims 1
• 235000011475 lollipops Nutrition 0.000 claims 1
• 239000007937 lozenge Substances 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims 1
• 235000016709 nutrition Nutrition 0.000 claims 1
• 230000035764 nutrition Effects 0.000 claims 1
• 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
• 210000003240 portal vein Anatomy 0.000 claims 1
• 239000002516 radical scavenger Substances 0.000 claims 1
• 230000037390 scarring Effects 0.000 claims 1
• 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
• 230000007863 steatosis Effects 0.000 claims 1
• 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 235000020357 syrup Nutrition 0.000 claims 1
• 239000006188 syrup Substances 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1