JP2008533127A5 - - Google Patents

Info

Publication number

JP2008533127A5

JP2008533127A5 JP2008501452A JP2008501452A JP2008533127A5 JP 2008533127 A5 JP2008533127 A5 JP 2008533127A5 JP 2008501452 A JP2008501452 A JP 2008501452A JP 2008501452 A JP2008501452 A JP 2008501452A JP 2008533127 A5 JP2008533127 A5 JP 2008533127A5

Authority

JP

Japan

Prior art keywords

formulation

metformin

release

dosage

pharmaceutically acceptable

Prior art date

2006-03-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 claims 38
• 239000000203 mixture Substances 0.000 claims 38
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 20
• 229960003105 metformin Drugs 0.000 claims 20
• 239000004615 ingredient Substances 0.000 claims 5
• 206010010774 Constipation Diseases 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000003826 tablet Substances 0.000 claims 4
• 230000001684 chronic effect Effects 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 230000003111 delayed effect Effects 0.000 claims 3
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
• 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
• XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims 2
• 229960002632 acarbose Drugs 0.000 claims 2
• XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims 2
• 238000004090 dissolution Methods 0.000 claims 2
• 239000007912 modified release tablet Substances 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• 238000013270 controlled release Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000001198 duodenum Anatomy 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 210000003405 ileum Anatomy 0.000 claims 1
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
• 210000001630 jejunum Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000002784 stomach Anatomy 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1