JP2017526370A5 - - Google Patents

Info

Publication number

JP2017526370A5

JP2017526370A5 JP2017511691A JP2017511691A JP2017526370A5 JP 2017526370 A5 JP2017526370 A5 JP 2017526370A5 JP 2017511691 A JP2017511691 A JP 2017511691A JP 2017511691 A JP2017511691 A JP 2017511691A JP 2017526370 A5 JP2017526370 A5 JP 2017526370A5

Authority

JP

Japan

Prior art keywords

seq

antibody

cdr

amino acid

fragment

Prior art date

2015-08-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 182
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 22
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
• 239000000427 antigen Substances 0.000 claims description 15
• 102000036639 antigens Human genes 0.000 claims description 15
• 108091007433 antigens Proteins 0.000 claims description 15
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 14
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 14
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• 208000035475 disorder Diseases 0.000 claims description 10
• 230000004068 intracellular signaling Effects 0.000 claims description 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 9
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 9
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 9
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 7
• 101100383038 Homo sapiens CD19 gene Proteins 0.000 claims description 7
• 210000004027 cell Anatomy 0.000 claims description 7
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 6
• 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 6
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 6
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• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
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• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 3
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• 229910052757 nitrogen Inorganic materials 0.000 description 9
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