JP2015527889A - 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用 - Google Patents

誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用 Download PDF

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JP2015527889A
JP2015527889A JP2015524358A JP2015524358A JP2015527889A JP 2015527889 A JP2015527889 A JP 2015527889A JP 2015524358 A JP2015524358 A JP 2015524358A JP 2015524358 A JP2015524358 A JP 2015524358A JP 2015527889 A JP2015527889 A JP 2015527889A
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domain
tale
histone
dna
crispr
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フェン・ジャン
マーク・ブリガム
レ・コン
シルヴァーナ・コナーマン
ネヴィル・エスピ・サンジャナ
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Harvard University
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Harvard University
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2015524358A 2012-07-25 2013-07-21 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用 Pending JP2015527889A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261675778P 2012-07-25 2012-07-25
US61/675,778 2012-07-25
US201261721283P 2012-11-01 2012-11-01
US61/721,283 2012-11-01
US201261736465P 2012-12-12 2012-12-12
US61/736,465 2012-12-12
US201361794458P 2013-03-15 2013-03-15
US61/794,458 2013-03-15
US201361835973P 2013-06-17 2013-06-17
US61/835,973 2013-06-17
PCT/US2013/051418 WO2014018423A2 (en) 2012-07-25 2013-07-21 Inducible dna binding proteins and genome perturbation tools and applications thereof

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JP2017249186A Division JP2018082709A (ja) 2012-07-25 2017-12-26 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用

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JP2015527889A true JP2015527889A (ja) 2015-09-24

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JP2017249186A Pending JP2018082709A (ja) 2012-07-25 2017-12-26 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用

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US (4) US20150291966A1 (https=)
EP (3) EP3494997B1 (https=)
JP (2) JP2015527889A (https=)
KR (2) KR102530118B1 (https=)
CN (2) CN105188767A (https=)
AU (3) AU2013293270B2 (https=)
CA (1) CA2879997A1 (https=)
DK (1) DK3494997T3 (https=)
ES (1) ES2757623T3 (https=)
PL (1) PL3494997T3 (https=)
PT (1) PT3494997T (https=)
WO (1) WO2014018423A2 (https=)

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JP2016517549A (ja) * 2013-02-07 2016-06-16 ザ ジェネラル ホスピタル コーポレイション Ｔａｌｅ転写活性化因子
JP2018082709A (ja) * 2012-07-25 2018-05-31 ザ ブロード インスティテュート， インコーポレイテッド 誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
JP2018531013A (ja) * 2015-10-16 2018-10-25 アストラゼネカ アクチボラグ 細胞ゲノムの誘導性改変
US10273271B2 (en) 2011-07-15 2019-04-30 The General Hospital Corporation Methods of transcription activator like effector assembly
WO2020091069A1 (ja) * 2018-11-01 2020-05-07 国立大学法人東京大学 ２分割されたＣｐｆ１タンパク質
JP2020519258A (ja) * 2017-05-09 2020-07-02 ウルトラジェニックス ファーマシューティカル インコーポレイテッド トランスフェクション試薬を生成するための拡大可能な方法
US10894950B2 (en) 2012-05-29 2021-01-19 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
WO2021065155A1 (ja) * 2019-09-30 2021-04-08 国立研究開発法人産業技術総合研究所 Ｃａｓ９ヌクレアーゼのＤＮＡ切断活性を制御する方法
JP2022531809A (ja) * 2019-05-14 2022-07-11 デューク ユニバーシティ ＡＴＰａｓｅ媒介性疾患の処置のための組成物および方法
WO2023038020A1 (ja) 2021-09-07 2023-03-16 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法
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