MX2020004063A - Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados. - Google Patents

Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados.

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Publication number
MX2020004063A
MX2020004063A MX2020004063A MX2020004063A MX2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A
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MX
Mexico
Prior art keywords
systems
methods
selected antibodies
produce
genetically modified
Prior art date
Application number
MX2020004063A
Other languages
English (en)
Inventor
Howell F Moffett
Justin J Taylor
Original Assignee
Hutchinson Fred Cancer Res
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Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of MX2020004063A publication Critical patent/MX2020004063A/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
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    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
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    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
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    • C07K16/089—Cytomegalovirus
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    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

Se describen sistemas y métodos para modificar genéticamente linfocitos B para que expresen anticuerpos seleccionados. Los sistemas y métodos pueden usarse para: evitar la necesidad de vacunas clásicas; proporcionar protección contra agentes infecciosos para los cuales no hay vacunas disponibles en la actualidad; proporcionar protección contra agentes infecciosos cuando los pacientes se encuentran inmunodeprimidos por otras cuestiones; y/o proporcionar un beneficio proporcionado por un anticuerpo terapéutico, tal como en el tratamiento de trastornos autoinmunitarios.
MX2020004063A 2017-10-20 2018-10-19 Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados. MX2020004063A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762575275P 2017-10-20 2017-10-20
US201762580303P 2017-11-01 2017-11-01
US201862623371P 2018-01-29 2018-01-29
PCT/US2018/056789 WO2019079772A1 (en) 2017-10-20 2018-10-19 SYSTEMS AND METHODS FOR GENETICALLY MODIFIED B-LYMPHOCYTES FOR EXPRESSING SELECTED ANTIBODIES

Publications (1)

Publication Number Publication Date
MX2020004063A true MX2020004063A (es) 2020-10-05

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MX2020004063A MX2020004063A (es) 2017-10-20 2018-10-19 Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados.

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US (2) US11578118B2 (es)
EP (1) EP3697895A4 (es)
JP (2) JP7383607B2 (es)
KR (1) KR20200085781A (es)
CN (1) CN111479916A (es)
AU (1) AU2018351072A1 (es)
BR (1) BR112020007823A2 (es)
CA (1) CA3079681A1 (es)
IL (1) IL274082A (es)
MX (1) MX2020004063A (es)
SG (1) SG11202003024WA (es)
WO (1) WO2019079772A1 (es)

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BR112020007823A2 (pt) 2020-10-27
US20230250159A1 (en) 2023-08-10
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