JP2014508142A - Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 - Google Patents

Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 Download PDF

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JP2014508142A
JP2014508142A JP2013550892A JP2013550892A JP2014508142A JP 2014508142 A JP2014508142 A JP 2014508142A JP 2013550892 A JP2013550892 A JP 2013550892A JP 2013550892 A JP2013550892 A JP 2013550892A JP 2014508142 A JP2014508142 A JP 2014508142A
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antibody
antigen
binding fragment
pharmaceutical composition
dose
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JP2013550892A
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JP2014508142A5 (enExample
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コリンヌ・アノタン
ロランス・ベサッキ
ウーメッシュ・シャウダーリ
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Sanofi SA
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Sanofi SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45529125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2014508142(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP11305089A external-priority patent/EP2481758A1/en
Priority claimed from EP11305088.4A external-priority patent/EP2650016A1/en
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JP2014508142A publication Critical patent/JP2014508142A/ja
Publication of JP2014508142A5 publication Critical patent/JP2014508142A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Obesity (AREA)
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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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JP2013550892A 2011-01-28 2012-01-27 Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 Pending JP2014508142A (ja)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
EP11305089A EP2481758A1 (en) 2011-01-28 2011-01-28 Human antibodies to PSCK9 for use in methods of treating particular groups of subjects (11566)
EP11305088.4A EP2650016A1 (en) 2011-01-28 2011-01-28 Human antibodies to PSCK9 for use in methods of treatment based on particular dosage regimens (11565)
EP11305089.2 2011-01-28
EP11305088.4 2011-01-28
EP11305514 2011-04-29
EP11305513 2011-04-29
EP11305513.1 2011-04-29
EP11305514.9 2011-04-29
EP11306039 2011-08-12
EP11306040 2011-08-12
EP11306039.6 2011-08-12
EP11306040.4 2011-08-12
EP11306201 2011-09-22
EP11306201.2 2011-09-22
EP11306202.0 2011-09-22
EP11306202 2011-09-22
EP11306450 2011-11-08
EP11306449.7 2011-11-08
EP11306450.5 2011-11-08
EP11306449 2011-11-08
PCT/EP2012/051321 WO2012101253A1 (en) 2011-01-28 2012-01-27 Pharmaceutical compositions comprising human antibodies to pcsk9

Related Child Applications (1)

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JP2017000850A Division JP2017095491A (ja) 2011-01-28 2017-01-06 Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物

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JP2014508142A true JP2014508142A (ja) 2014-04-03
JP2014508142A5 JP2014508142A5 (enExample) 2015-03-19

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Family Applications (8)

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JP2013550892A Pending JP2014508142A (ja) 2011-01-28 2012-01-27 Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物
JP2013550891A Active JP6375113B2 (ja) 2011-01-28 2012-01-27 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2017000850A Pending JP2017095491A (ja) 2011-01-28 2017-01-06 Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物
JP2017000849A Pending JP2017095490A (ja) 2011-01-28 2017-01-06 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2018168406A Active JP6730388B2 (ja) 2011-01-28 2018-09-10 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2020114604A Active JP7140800B2 (ja) 2011-01-28 2020-07-02 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2022116860A Pending JP2022141869A (ja) 2011-01-28 2022-07-22 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2024112158A Pending JP2024138473A (ja) 2011-01-28 2024-07-12 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体

Family Applications After (7)

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JP2013550891A Active JP6375113B2 (ja) 2011-01-28 2012-01-27 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2017000850A Pending JP2017095491A (ja) 2011-01-28 2017-01-06 Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物
JP2017000849A Pending JP2017095490A (ja) 2011-01-28 2017-01-06 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2018168406A Active JP6730388B2 (ja) 2011-01-28 2018-09-10 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2020114604A Active JP7140800B2 (ja) 2011-01-28 2020-07-02 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2022116860A Pending JP2022141869A (ja) 2011-01-28 2022-07-22 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体
JP2024112158A Pending JP2024138473A (ja) 2011-01-28 2024-07-12 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体

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US (7) US9561155B2 (enExample)
EP (4) EP2668212B1 (enExample)
JP (8) JP2014508142A (enExample)
KR (6) KR20220136466A (enExample)
CN (4) CN107899010A (enExample)
AR (3) AR084938A1 (enExample)
AU (5) AU2012210481B2 (enExample)
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CA (2) CA2825778A1 (enExample)
CL (2) CL2013002162A1 (enExample)
CO (2) CO6751276A2 (enExample)
CR (1) CR20130406A (enExample)
CY (1) CY1121236T1 (enExample)
DK (1) DK2668212T3 (enExample)
DO (1) DOP2013000170A (enExample)
EC (1) ECSP13012792A (enExample)
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GT (1) GT201300186A (enExample)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017145256A (ja) * 2011-07-14 2017-08-24 ファイザー・インク 抗ｐｃｓｋ９抗体を用いた処置
JP2018511596A (ja) * 2015-03-20 2018-04-26 オーフス ウニベルシテット リポタンパク質代謝障害の治療のためのｐｃｓｋ９阻害剤
JP2021515772A (ja) * 2018-03-06 2021-06-24 サノフィ・バイオテクノロジー 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用
US12083176B2 (en) 2011-01-28 2024-09-10 Sanofi Biotechnology Human antibodies to PCSK9 for use in methods of treating particular groups of subjects
US12269897B2 (en) 2008-12-15 2025-04-08 Regeneron Pharmaceuticals, Inc. Anti-PCSK9 antibodies
US12606638B2 (en) 2013-11-12 2026-04-21 Sanofi Biotechnology Dosing regimens for use with PCSK9 inhibitors
US12612466B2 (en) 2011-07-28 2026-04-28 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-PCSK9 antibodies

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20080381B1 (ar) * 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
NZ617779A (en) 2009-03-18 2015-08-28 Resverlogix Corp Novel anti-inflammatory agents
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
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