CY1121236T1 - Ανθρωπινα αντισωματα εναντι της pcsk9 για χρηση σε μεθοδους θεραπειας συγκεκριμενων ομαδων ατομων - Google Patents

Ανθρωπινα αντισωματα εναντι της pcsk9 για χρηση σε μεθοδους θεραπειας συγκεκριμενων ομαδων ατομων

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Publication number
CY1121236T1
CY1121236T1 CY20181100645T CY181100645T CY1121236T1 CY 1121236 T1 CY1121236 T1 CY 1121236T1 CY 20181100645 T CY20181100645 T CY 20181100645T CY 181100645 T CY181100645 T CY 181100645T CY 1121236 T1 CY1121236 T1 CY 1121236T1
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CY
Cyprus
Prior art keywords
pcsk9
treatment
fragments
present
antibodies
Prior art date
Application number
CY20181100645T
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English (en)
Inventor
Corinne Hanotin
Laurence BESSAC
Umesh CHAUDHARI
Original Assignee
Sanofi Biotechnology
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45529125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121236(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP11305088.4A external-priority patent/EP2650016A1/en
Priority claimed from EP11305089A external-priority patent/EP2481758A1/en
Application filed by Sanofi Biotechnology filed Critical Sanofi Biotechnology
Publication of CY1121236T1 publication Critical patent/CY1121236T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
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Abstract

Η παρούσα εφεύρεση σχετίζεται με μεθόδους για τη θεραπεία ασθενειών ή παθήσεων στις οποίες η έκφραση ή δραστικότητα της προπρωτεΐνης κονβερτάσης σουμπτιλισίνης/κεξίνης τύπου 9 (PCSK9) προκαλεί επίπτωση με χορήγηση ειδικών αντισωμάτων έναντι της PCSK9 ή θραυσμάτων αυτών δέσμευσης αντιγόνου και κατά προτίμηση με επιπρόσθετη χορήγηση αναστολέα της 3-υδροξυ-3-μεθυλ-γλουταρυλ-CoA αναγωγάσης (HMG-CoA αναγωγάση). Η παρούσα εφεύρεση σχετίζεται περαιτέρω με ειδικά αντισώματα έναντι της PCSK9 ή θραύσματα αυτών πρόσδεσης αντιγόνο για χρήση στη θεραπεία ασθενειών ή παθήσεων στις οποίες η έκφραση ή η δραστικότητα PCSK9 προκαλεί επίπτωση. Η παρούσα εφεύρεση αναφέρεται επίσης σε κατασκευές που περιλαμβάνουν υλικά συσκευασίας, ειδικά αντισώματα έναντι της PCSK9 ή θραύσματα αυτών δέσμευσης αντιγόνου και μια ετικέτα ή ένα ένθετο συσκευασίας που δείχνει ποιες ομάδες ασθενών μπορούν να υποβληθούν σε αγωγή με τα εν λόγω αντισώματα ή θραύσματα, ποιες ομάδες ασθενών δεν πρέπει να υποβληθούν σε θεραπεία με τα αναφερθέντα αντισώματα ή θραύσματα και ποια δοσολογία θα πρέπει να χρησιμοποιηθεί. Η παρούσα εφεύρεση σχετίζεται περαιτέρω με μεθόδους ελέγχου της αποτελεσματικότητας των ειδικών για την PCSK9 αντισωμάτων ή θραυσμάτων αυτών δέσμευσης αντιγόνου για τη θεραπεία ορισμένων ασθενειών ή παθήσεων και για τη θεραπεία συγκεκριμένων υποομάδων ασθενών.
CY20181100645T 2011-01-28 2018-06-21 Ανθρωπινα αντισωματα εναντι της pcsk9 για χρηση σε μεθοδους θεραπειας συγκεκριμενων ομαδων ατομων CY1121236T1 (el)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
EP11305088.4A EP2650016A1 (en) 2011-01-28 2011-01-28 Human antibodies to PSCK9 for use in methods of treatment based on particular dosage regimens (11565)
EP11305089A EP2481758A1 (en) 2011-01-28 2011-01-28 Human antibodies to PSCK9 for use in methods of treating particular groups of subjects (11566)
EP11305514 2011-04-29
EP11305513 2011-04-29
EP11306040 2011-08-12
EP11306039 2011-08-12
EP11306202 2011-09-22
EP11306201 2011-09-22
EP11306449 2011-11-08
EP11306450 2011-11-08
EP12701742.4A EP2668212B1 (en) 2011-01-28 2012-01-27 Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
PCT/EP2012/051320 WO2012101252A2 (en) 2011-01-28 2012-01-27 Human antibodies to pcsk9 for use in methods of treating particular groups of subjects

Publications (1)

Publication Number Publication Date
CY1121236T1 true CY1121236T1 (el) 2020-05-29

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CY20181100645T CY1121236T1 (el) 2011-01-28 2018-06-21 Ανθρωπινα αντισωματα εναντι της pcsk9 για χρηση σε μεθοδους θεραπειας συγκεκριμενων ομαδων ατομων

Country Status (39)

Country Link
US (6) US9682013B2 (el)
EP (4) EP3326648B1 (el)
JP (8) JP6375113B2 (el)
KR (6) KR20140012075A (el)
CN (4) CN107899010A (el)
AR (3) AR084937A1 (el)
AU (5) AU2012210480B2 (el)
BR (2) BR112013018877A2 (el)
CA (2) CA2825778A1 (el)
CL (2) CL2013002162A1 (el)
CO (2) CO6751277A2 (el)
CR (1) CR20130406A (el)
CY (1) CY1121236T1 (el)
DK (1) DK2668212T3 (el)
DO (1) DOP2013000170A (el)
EC (1) ECSP13012792A (el)
ES (3) ES2674600T3 (el)
GT (1) GT201300186A (el)
HK (1) HK1255729A1 (el)
HR (1) HRP20180959T1 (el)
HU (1) HUE039258T2 (el)
IL (5) IL227658A0 (el)
LT (1) LT2668212T (el)
MA (1) MA34923B1 (el)
MX (4) MX367075B (el)
MY (2) MY165159A (el)
NI (1) NI201300064A (el)
NZ (1) NZ792724A (el)
PE (2) PE20181052A1 (el)
PH (1) PH12021500018A1 (el)
PL (3) PL3326648T3 (el)
PT (1) PT2668212T (el)
RS (1) RS57339B1 (el)
RU (4) RU2016142273A (el)
SG (2) SG192117A1 (el)
SI (1) SI2668212T1 (el)
TW (3) TW201242613A (el)
WO (3) WO2012101251A1 (el)
ZA (2) ZA201305524B (el)

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KR20140012075A (ko) 2014-01-29
JP2014511361A (ja) 2014-05-15
EP2668212B1 (en) 2018-03-21
WO2012101252A3 (en) 2012-11-15
TW201711698A (zh) 2017-04-01
AU2012210480A1 (en) 2013-08-22
LT2668212T (lt) 2018-07-10
TWI635870B (zh) 2018-09-21
AR084938A1 (es) 2013-07-10

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