CN104861071B - 针对pcsk9的全人源单克隆抗体的可变区基因及其应用 - Google Patents
针对pcsk9的全人源单克隆抗体的可变区基因及其应用 Download PDFInfo
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Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105348390B (zh) * | 2015-10-26 | 2018-08-28 | 北京智仁美博生物科技有限公司 | 抗人pcsk9单克隆抗体 |
CA3009904A1 (en) | 2015-12-31 | 2017-07-06 | Jiangsu Hengrui Medicine Co., Ltd. | Pcsk9 antibody, antigen-binding fragment thereof, and medicinal application thereof |
CN105801701B (zh) * | 2016-03-31 | 2019-03-29 | 河北仁博科技有限公司 | 一种pcsk9抗体的重链和轻链可变区及其应用 |
CN107266575B (zh) * | 2016-04-07 | 2021-12-24 | 天士力生物医药股份有限公司 | 前蛋白转化酶枯草溶菌素kexin 9型的结合蛋白及其应用 |
CN107474140B (zh) * | 2016-06-08 | 2022-06-03 | 常州博嘉生物医药科技有限公司 | Pcsk9特异性的结合蛋白mv072及其应用 |
WO2018054241A1 (en) * | 2016-09-20 | 2018-03-29 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-pcsk9 antibodies |
TW201825524A (zh) * | 2016-09-20 | 2018-07-16 | 中國大陸商上海藥明生物技術有限公司 | 新型抗-pcsk9抗體 |
CN109776680B (zh) | 2019-01-25 | 2020-05-12 | 浙江蓝盾药业有限公司 | 抗人pcsk9单克隆抗体及其用途 |
CN111620950B (zh) * | 2020-06-16 | 2023-01-31 | 中国药科大学 | 全人源抗pcsk9抗体、其抗原结合片段及其应用 |
CN114438075A (zh) * | 2022-02-25 | 2022-05-06 | 刘博巽 | 一种枯草芽孢杆菌前蛋白酶9靶向结合蛋白的筛选方法与应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103476797A (zh) * | 2011-01-28 | 2013-12-25 | 赛诺菲 | 包含针对pcsk9的人抗体的药物组合物 |
WO2015054619A2 (en) * | 2013-10-11 | 2015-04-16 | Sanofi | Use of a pcsk9 inhibitor to treat hyperlipidemia |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103476797A (zh) * | 2011-01-28 | 2013-12-25 | 赛诺菲 | 包含针对pcsk9的人抗体的药物组合物 |
WO2015054619A2 (en) * | 2013-10-11 | 2015-04-16 | Sanofi | Use of a pcsk9 inhibitor to treat hyperlipidemia |
Non-Patent Citations (2)
Title |
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PCSK9结构与功能;肖文虎等;《中国生物化学与分子生物学报》;20090331;第25卷(第3期);第213-218页 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structureefunction relation to therapeutic inhibition;G. Tibolla, et al.;《Nutrition, Metabolism & Cardiovascular Diseases 》;20110923;第21卷(第11期);第835-843页 |
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