BR112017005336A2 - método de tratamento de cânceres sólidos e/ou metástases dos mesmos, medicamentos com essa finalidade e método para prever o resultado clínico de tratamento de cânceres sólidos e/ou metástases dos mesmos - Google Patents
método de tratamento de cânceres sólidos e/ou metástases dos mesmos, medicamentos com essa finalidade e método para prever o resultado clínico de tratamento de cânceres sólidos e/ou metástases dos mesmosInfo
- Publication number
- BR112017005336A2 BR112017005336A2 BR112017005336A BR112017005336A BR112017005336A2 BR 112017005336 A2 BR112017005336 A2 BR 112017005336A2 BR 112017005336 A BR112017005336 A BR 112017005336A BR 112017005336 A BR112017005336 A BR 112017005336A BR 112017005336 A2 BR112017005336 A2 BR 112017005336A2
- Authority
- BR
- Brazil
- Prior art keywords
- metastases
- solid cancers
- treating solid
- predicting
- drugs
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
a presente invenção refere-se a um novo método de tratamento de câncer colorretal (crc) e metástases do mesmo em indivíduos, e de preferência também de outros cânceres sólidos e metástases dos mesmos em indivíduos, em que o referido método depende preferencialmente de se o paciente apresenta certos níveis de proteínas específicos em um ou mais fluidos corporais, antes ou durante o tratamento, em que o referido tratamento compreende a administração de pelo menos um inibidor da integrina pan av a um paciente, um medicamento para uso nos referidos novos métodos, e um método de previsão do resultado de um tratamento com pelo menos um inibidor da integrina pan av, com base nos referidos níveis de proteínas específicas em um ou mais fluidos corporais do paciente
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051530P | 2014-09-17 | 2014-09-17 | |
| PCT/EP2015/001699 WO2016041614A1 (en) | 2014-09-17 | 2015-08-18 | A method of treating solid cancers and/or metastases thereof, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017005336A2 true BR112017005336A2 (pt) | 2017-12-12 |
Family
ID=53969334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017005336A BR112017005336A2 (pt) | 2014-09-17 | 2015-08-18 | método de tratamento de cânceres sólidos e/ou metástases dos mesmos, medicamentos com essa finalidade e método para prever o resultado clínico de tratamento de cânceres sólidos e/ou metástases dos mesmos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11415581B2 (pt) |
| EP (1) | EP3193927B1 (pt) |
| JP (2) | JP7372025B2 (pt) |
| KR (1) | KR20170052690A (pt) |
| CN (1) | CN107073111A (pt) |
| AU (2) | AU2015317409A1 (pt) |
| BR (1) | BR112017005336A2 (pt) |
| CA (1) | CA2961421C (pt) |
| ES (1) | ES2856348T3 (pt) |
| IL (1) | IL251078B (pt) |
| MX (1) | MX2017003015A (pt) |
| RU (1) | RU2017112998A (pt) |
| SG (1) | SG11201702135PA (pt) |
| WO (1) | WO2016041614A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017113001A (ru) | 2014-09-17 | 2018-10-17 | Мерк Патент Гмбх | Способ лечения метастазов в кости, предназначенные для этого медикаменты, и способ прогнозирования клинического исхода лечения метастазов в кости |
| CN108957014A (zh) * | 2018-09-27 | 2018-12-07 | 郑州大学第附属医院 | 结直肠癌血清标志物、表达评估方法、试剂盒及应用 |
| CN113015747A (zh) * | 2018-10-19 | 2021-06-22 | 默克专利股份公司 | 用于治疗结肠直肠癌的阿比妥单抗 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281142B6 (sk) | 1991-03-06 | 2000-12-11 | Merck Patent Gesellschaft Mit Beschr�Nkter Haftung | Humanizovaná monoklonálna protilátka, expresné vektory a farmaceutický prostriedok |
| DK0719859T3 (da) | 1994-12-20 | 2003-10-20 | Merck Patent Gmbh | Anti-alfa V-integrin monoklonalt antistof |
| US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| MXPA03010007A (es) | 2001-05-02 | 2004-02-12 | Novartis Ag | USO DE BISFOSFONATOS EN EL TRATAMIENTO DE METASTASIS DE HUESO ASOCIADO CON CANCER DE PRoSTATA. |
| JP2004002321A (ja) | 2002-03-11 | 2004-01-08 | Takeda Chem Ind Ltd | 性ホルモン依存性疾患治療剤 |
| WO2003075958A1 (fr) | 2002-03-11 | 2003-09-18 | Takeda Chemical Industries, Ltd. | Medicaments permettant de traiter une maladie dependant d'une hormone sexuelle |
| EP1613966A2 (en) | 2003-04-08 | 2006-01-11 | Colotech A/S | A method for detection of colorectal cancer in human samples |
| EP1973569B1 (en) | 2006-01-18 | 2013-05-22 | Merck Patent GmbH | Specific therapy using integrin ligands for treating cancer |
| WO2007103116A2 (en) * | 2006-03-02 | 2007-09-13 | Laboratory Corporation Of America Holdings | Methods and systems for evaluating health risk factors by measurement of dna damage and dna repair |
| EP2526967A1 (en) | 2007-07-17 | 2012-11-28 | Merck Patent GmbH | Engineered anti-alpha v-integrin hybrid antibodies |
| JP5403534B2 (ja) * | 2008-10-29 | 2014-01-29 | インフォコム株式会社 | 食道癌の予後予測のための情報を提供する方法 |
| SG172355A1 (en) * | 2008-12-23 | 2011-07-28 | Genentech Inc | Methods and compositions for diagnostic use in cancer patients |
| AU2009331955B2 (en) | 2008-12-23 | 2015-09-24 | Merck Patent Gmbh | Biomarkers for inhibitors with anti-angiogenic activity |
| US20120039805A1 (en) * | 2009-02-20 | 2012-02-16 | Pangea Biosciences, Inc. | Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample |
| AU2010262133B2 (en) * | 2009-06-19 | 2016-02-25 | Merck Patent Gmbh | Biomarkers and methods for determining efficacy of anti-EGFR antibodies in cancer therapy |
| WO2011033006A1 (en) | 2009-09-17 | 2011-03-24 | F. Hoffmann-La Roche Ag | Methods and compositions for diagnostics use in cancer patients |
| EP2606349A4 (en) | 2010-08-20 | 2014-04-30 | Univ Jefferson | AGENTS FOR CANCER DIAGNOSIS AND CANCER THERAPY |
| JP6320042B2 (ja) | 2011-02-11 | 2018-05-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 前立腺癌治療のための抗アルファ−ｖインテグリン抗体 |
| JP2014516531A (ja) * | 2011-05-25 | 2014-07-17 | ノバルティス アーゲー | 肺癌に対するバイオマーカー |
| WO2012167028A2 (en) | 2011-06-02 | 2012-12-06 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to cell growth inhibition |
| SG11201406184XA (en) | 2012-03-30 | 2014-10-30 | Genentech Inc | Diagnostic methods and compositions for treatment of cancer |
| WO2013152313A1 (en) * | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| RU2017113001A (ru) | 2014-09-17 | 2018-10-17 | Мерк Патент Гмбх | Способ лечения метастазов в кости, предназначенные для этого медикаменты, и способ прогнозирования клинического исхода лечения метастазов в кости |
-
2015
- 2015-08-18 KR KR1020177010415A patent/KR20170052690A/ko unknown
- 2015-08-18 AU AU2015317409A patent/AU2015317409A1/en not_active Abandoned
- 2015-08-18 MX MX2017003015A patent/MX2017003015A/es unknown
- 2015-08-18 ES ES15753899T patent/ES2856348T3/es active Active
- 2015-08-18 RU RU2017112998A patent/RU2017112998A/ru not_active Application Discontinuation
- 2015-08-18 WO PCT/EP2015/001699 patent/WO2016041614A1/en active Application Filing
- 2015-08-18 CA CA2961421A patent/CA2961421C/en active Active
- 2015-08-18 SG SG11201702135PA patent/SG11201702135PA/en unknown
- 2015-08-18 US US15/511,993 patent/US11415581B2/en active Active
- 2015-08-18 BR BR112017005336A patent/BR112017005336A2/pt not_active IP Right Cessation
- 2015-08-18 EP EP15753899.2A patent/EP3193927B1/en active Active
- 2015-08-18 CN CN201580049728.6A patent/CN107073111A/zh active Pending
- 2015-08-18 JP JP2017514914A patent/JP7372025B2/ja active Active
-
2017
- 2017-03-09 IL IL251078A patent/IL251078B/en active IP Right Grant
-
2020
- 2020-09-18 JP JP2020157433A patent/JP7242617B2/ja active Active
-
2021
- 2021-05-24 AU AU2021203352A patent/AU2021203352A1/en active Pending
-
2022
- 2022-06-17 US US17/807,465 patent/US20220334117A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170298134A1 (en) | 2017-10-19 |
| AU2015317409A1 (en) | 2017-04-27 |
| JP2021009154A (ja) | 2021-01-28 |
| CA2961421C (en) | 2024-01-30 |
| JP7372025B2 (ja) | 2023-10-31 |
| SG11201702135PA (en) | 2017-04-27 |
| RU2017112998A3 (pt) | 2019-03-28 |
| ES2856348T3 (es) | 2021-09-27 |
| RU2017112998A (ru) | 2018-10-17 |
| EP3193927A1 (en) | 2017-07-26 |
| CA2961421A1 (en) | 2016-03-24 |
| AU2021203352A1 (en) | 2021-06-24 |
| JP2017535516A (ja) | 2017-11-30 |
| US11415581B2 (en) | 2022-08-16 |
| JP7242617B2 (ja) | 2023-03-20 |
| MX2017003015A (es) | 2017-05-23 |
| CN107073111A (zh) | 2017-08-18 |
| KR20170052690A (ko) | 2017-05-12 |
| IL251078B (en) | 2021-05-31 |
| IL251078A0 (en) | 2017-04-30 |
| EP3193927B1 (en) | 2020-11-25 |
| WO2016041614A1 (en) | 2016-03-24 |
| US20220334117A1 (en) | 2022-10-20 |
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