EA201491011A1 - Способы лечения с помощью ингибитора гамма-интерферона - Google Patents

Способы лечения с помощью ингибитора гамма-интерферона

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Publication number
EA201491011A1
EA201491011A1 EA201491011A EA201491011A EA201491011A1 EA 201491011 A1 EA201491011 A1 EA 201491011A1 EA 201491011 A EA201491011 A EA 201491011A EA 201491011 A EA201491011 A EA 201491011A EA 201491011 A1 EA201491011 A1 EA 201491011A1
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EA
Eurasian Patent Office
Prior art keywords
ifn
methods
treatment
gamma interferon
interferon inhibitor
Prior art date
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EA201491011A
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English (en)
Inventor
Эндрю А. Уэлчер
Майкл Дж. Бодигхаймер
Джеймс Б. Чанг
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Амген Инк.
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Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201491011A1 publication Critical patent/EA201491011A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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  • Health & Medical Sciences (AREA)
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Abstract

Изобретение относится к способам лечения заболеваний, опосредованных гамма-интерфероном (ИФН-γ) с применением ингибиторов ИФН-γ, например, антител против ИФН-γ человека, причем перед введением и/или после введения ингибитора ИФН-γ определяют уровни экспрессии одного или более биомаркеров. Кроме того, рассматриваются способы лечения с применением конкретных фармакодинамически эффективных доз антитела против ИФН-γ человека.
EA201491011A 2011-11-23 2012-11-21 Способы лечения с помощью ингибитора гамма-интерферона EA201491011A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161563357P 2011-11-23 2011-11-23
US201261616846P 2012-03-28 2012-03-28
US201261651900P 2012-05-25 2012-05-25
PCT/US2012/066348 WO2013078378A1 (en) 2011-11-23 2012-11-21 Methods of treatment using an antibody against interferon gamma

Publications (1)

Publication Number Publication Date
EA201491011A1 true EA201491011A1 (ru) 2014-09-30

Family

ID=47295210

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491011A EA201491011A1 (ru) 2011-11-23 2012-11-21 Способы лечения с помощью ингибитора гамма-интерферона

Country Status (17)

Country Link
US (4) US20130142809A1 (ru)
EP (2) EP2791168A1 (ru)
JP (2) JP2015505300A (ru)
KR (1) KR20140097336A (ru)
CN (1) CN104159919A (ru)
AU (1) AU2012340624B2 (ru)
BR (1) BR112014012607A2 (ru)
CA (1) CA2854921A1 (ru)
CL (1) CL2014001345A1 (ru)
EA (1) EA201491011A1 (ru)
HK (1) HK1203519A1 (ru)
IL (1) IL232510A0 (ru)
MX (1) MX2014006241A (ru)
PH (1) PH12014501122A1 (ru)
SG (1) SG11201402490XA (ru)
WO (1) WO2013078378A1 (ru)
ZA (1) ZA201403451B (ru)

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