BR0306685A - Composição farmacêutica contendo grelina - Google Patents

Composição farmacêutica contendo grelina

Info

Publication number
BR0306685A
BR0306685A BR0306685-1A BR0306685A BR0306685A BR 0306685 A BR0306685 A BR 0306685A BR 0306685 A BR0306685 A BR 0306685A BR 0306685 A BR0306685 A BR 0306685A
Authority
BR
Brazil
Prior art keywords
buffer
pharmaceutical composition
ghrelin
phosphate
composition containing
Prior art date
Application number
BR0306685-1A
Other languages
English (en)
Inventor
Yoshiharu Minamitake
Masaru Matsumoto
Original Assignee
Daiichi Suntory Pharma Co Ltd
Kenji Kangawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd, Kenji Kangawa filed Critical Daiichi Suntory Pharma Co Ltd
Publication of BR0306685A publication Critical patent/BR0306685A/pt

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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Abstract

"COMPOSIçãO FARMACêUTICA CONTENDO GRELINA". A presente invenção refere-se uma composição farmacêutica estavelmente contém grelina ou seu derivado, que é um secretagogo de hormónio do crescimento endógeno (GHS) para um receptor de secretagogo de hormónio do crescimento (GHS-R), compreendendo uma solução aquosa contendo as grelinas tendo faixa de pH de 2 a 7, em que a solução aquosa tendo faixa de pH de 2 a 7 é uma solução tampão, especialmente, tampão de cloridrato de glicina, tampão de acetato, tampão de citrato, tampão de lactato, tampão de fosfato, tampão de fosfato - ácido cítrico, tampão de fosfato - acetato - borato ou tampão de ftalato, e a concentração das grelinas na solução é de 0,03 nmol/ml a 6 <109>mol/mL.
BR0306685-1A 2002-05-21 2003-05-21 Composição farmacêutica contendo grelina BR0306685A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002146155 2002-05-21
PCT/JP2003/006349 WO2003097083A1 (fr) 2002-05-21 2003-05-21 Compositions medicinales contenant de la ghreline

Publications (1)

Publication Number Publication Date
BR0306685A true BR0306685A (pt) 2005-04-26

Family

ID=29545111

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0306685-1A BR0306685A (pt) 2002-05-21 2003-05-21 Composição farmacêutica contendo grelina

Country Status (11)

Country Link
US (3) US20060166871A1 (pt)
EP (1) EP1506786B1 (pt)
JP (1) JP5000848B2 (pt)
KR (1) KR20050012224A (pt)
CN (1) CN100411683C (pt)
AU (1) AU2003235401B2 (pt)
BR (1) BR0306685A (pt)
CA (1) CA2471879C (pt)
ES (1) ES2615484T3 (pt)
IL (2) IL162796A0 (pt)
WO (1) WO2003097083A1 (pt)

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EP1506786A1 (en) 2005-02-16
ES2615484T3 (es) 2017-06-07
US8440628B2 (en) 2013-05-14
JP5000848B2 (ja) 2012-08-15
AU2003235401A1 (en) 2003-12-02
IL162796A0 (en) 2005-11-20
WO2003097083A1 (fr) 2003-11-27
US20120264691A1 (en) 2012-10-18
CA2471879C (en) 2014-02-25
CN100411683C (zh) 2008-08-20
KR20050012224A (ko) 2005-01-31
US20060166871A1 (en) 2006-07-27
AU2003235401B2 (en) 2008-09-25
EP1506786B1 (en) 2016-11-23
IL162796A (en) 2011-01-31
CA2471879A1 (en) 2003-11-27
US20080081787A1 (en) 2008-04-03
EP1506786A4 (en) 2009-07-29
CN1622822A (zh) 2005-06-01
US8518893B2 (en) 2013-08-27

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