EA200601874A1 - Жидкий состав гормона роста - Google Patents

Жидкий состав гормона роста

Info

Publication number
EA200601874A1
EA200601874A1 EA200601874A EA200601874A EA200601874A1 EA 200601874 A1 EA200601874 A1 EA 200601874A1 EA 200601874 A EA200601874 A EA 200601874A EA 200601874 A EA200601874 A EA 200601874A EA 200601874 A1 EA200601874 A1 EA 200601874A1
Authority
EA
Eurasian Patent Office
Prior art keywords
growth hormone
metal salt
liquid composition
alkaline earth
earth metal
Prior art date
Application number
EA200601874A
Other languages
English (en)
Other versions
EA010626B1 (ru
Inventor
Тьюдор Арвинт
Карин Люэ Клебер
Original Assignee
Арес Трейдинг С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арес Трейдинг С.А. filed Critical Арес Трейдинг С.А.
Publication of EA200601874A1 publication Critical patent/EA200601874A1/ru
Publication of EA010626B1 publication Critical patent/EA010626B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение относится к жидкому составу, содержащему гормон роста или вещество, которое стимулирует высвобождение или потенцирует активность эндогенного hGH; полипропилен-полиэтилен гликоля; цитрат/буфер фосфата, соль щелочного металла и соль щелочно-земельного металла или соль псевдощелочно-земельного металла, и к способу его получения.
EA200601874A 2004-04-07 2005-03-30 Жидкий состав гормона роста EA010626B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101444 2004-04-07
PCT/EP2005/051448 WO2005105148A2 (en) 2004-04-07 2005-03-30 Liquid growth hormone formulation

Publications (2)

Publication Number Publication Date
EA200601874A1 true EA200601874A1 (ru) 2007-02-27
EA010626B1 EA010626B1 (ru) 2008-10-30

Family

ID=34928942

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601874A EA010626B1 (ru) 2004-04-07 2005-03-30 Жидкий состав гормона роста

Country Status (24)

Country Link
US (1) US7662393B2 (ru)
EP (1) EP1740213B9 (ru)
JP (1) JP4991522B2 (ru)
KR (1) KR101120879B1 (ru)
CN (1) CN100574801C (ru)
AT (1) ATE547121T1 (ru)
AU (1) AU2005237775B2 (ru)
BR (1) BRPI0508798A (ru)
CA (1) CA2559918A1 (ru)
CY (1) CY1113834T1 (ru)
DK (1) DK1740213T3 (ru)
EA (1) EA010626B1 (ru)
ES (1) ES2383994T3 (ru)
HK (1) HK1098708A1 (ru)
HR (1) HRP20120235T1 (ru)
IL (1) IL178416A (ru)
MX (1) MXPA06011029A (ru)
NO (1) NO337249B1 (ru)
PL (1) PL1740213T3 (ru)
PT (1) PT1740213E (ru)
RS (1) RS52310B (ru)
SI (1) SI1740213T1 (ru)
UA (1) UA89781C2 (ru)
WO (1) WO2005105148A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1174457B1 (en) * 1999-12-03 2004-12-22 Toray Industries, Inc. Biaxially stretched polyester film for forming
EP2142207A4 (en) * 2007-04-04 2013-01-16 Theratechnologies Inc PHARMACEUTICAL FORMULATIONS OF GHRH MOLECULES
EP2525833A2 (en) 2010-01-22 2012-11-28 Novo Nordisk Health Care AG Stable growth hormone compounds
CN106139158A (zh) 2010-01-22 2016-11-23 诺沃—诺迪斯克保健股份有限公司 体内功效延长的生长激素
EP2417982A1 (en) * 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
US20140194356A1 (en) 2011-07-25 2014-07-10 Sandoz Ag Aqueous formulation comprising at least a neutral salt and a biopharmaceutical protein
US8871713B2 (en) * 2013-03-01 2014-10-28 Theratechnologies Inc. Formulations of growth hormone releasing factor (GRF) molecules with improved stability
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
EP3431508A4 (en) * 2016-03-14 2019-08-14 JCR Pharmaceuticals Co., Ltd. SERUM ALBUMIN-20-K-GROWTH HORMONE FUSION PROTEIN
US20200237652A1 (en) * 2017-08-08 2020-07-30 Csl Behring Ag Hemopexin formulations
WO2024026224A1 (en) 2022-07-29 2024-02-01 University Of Rochester Methods for improving muscle mass, strength, or function with a combination of testosterone and growth hormone

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3325223A1 (de) * 1983-07-13 1985-01-24 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
JPS60123426A (ja) * 1983-12-07 1985-07-02 Eisai Co Ltd 経鼻投与用セクレチン製剤
DE3584560D1 (de) * 1984-04-09 1991-12-05 Du Pont Arzneimittelzusammensetzung geeignet zur behandlung oder prophylaxe von herzstoerungen.
PT83095B (en) * 1985-07-30 1987-12-23 Int Minerals & Chem Corp Method for the stabilization of growth promoting hormones using polyoxyethylene-polyoxypropylene copolymers
US5681814A (en) * 1990-06-07 1997-10-28 Genentech, Inc. Formulated IGF-I Composition
HUT67319A (en) * 1991-08-30 1995-03-28 Life Medical Sciences Inc Compositions for treating wounds
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
ATE359824T1 (de) * 1992-07-31 2007-05-15 Genentech Inc Wässrige formulierung enthaltend menschliches wachstumshormon
JPH0892125A (ja) * 1994-09-21 1996-04-09 Nippon Chem Res Kk 水性医薬組成物
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
US20020077461A1 (en) * 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
US6759393B1 (en) * 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
JP2003504346A (ja) * 1999-07-12 2003-02-04 グランデイス・バイオテツク・ゲー・エム・ベー・ハー 成長ホルモン製剤
EP1309312A2 (en) * 2000-08-07 2003-05-14 Inhale Therapeutic Systems, Inc. Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
CA2466642C (en) * 2001-11-14 2011-01-18 Guohua Chen Injectable depot composition
AR040526A1 (es) * 2002-07-09 2005-04-13 Grandis Biotech Gmbh Formulaciuones de hgh en alta concentracion que contienen fenol
WO2004082707A2 (en) * 2003-03-18 2004-09-30 Ares Trading Sa Stabilisation of growth hormones in solution

Also Published As

Publication number Publication date
PL1740213T3 (pl) 2012-08-31
RS52310B (en) 2012-12-31
KR20070005628A (ko) 2007-01-10
NO337249B1 (no) 2016-02-22
EP1740213B1 (en) 2012-02-29
WO2005105148A3 (en) 2006-07-20
SI1740213T1 (sl) 2012-04-30
EP1740213B9 (en) 2012-06-13
UA89781C2 (ru) 2010-03-10
BRPI0508798A (pt) 2007-09-04
AU2005237775B2 (en) 2010-03-04
HK1098708A1 (en) 2007-07-27
WO2005105148A2 (en) 2005-11-10
KR101120879B1 (ko) 2012-02-27
WO2005105148A8 (en) 2005-12-08
IL178416A0 (en) 2007-02-11
JP4991522B2 (ja) 2012-08-01
ES2383994T3 (es) 2012-06-28
AU2005237775A1 (en) 2005-11-10
EA010626B1 (ru) 2008-10-30
IL178416A (en) 2012-12-31
CN100574801C (zh) 2009-12-30
US20080038292A1 (en) 2008-02-14
PT1740213E (pt) 2012-03-21
MXPA06011029A (es) 2007-01-25
NO20065097L (no) 2007-01-02
CA2559918A1 (en) 2005-11-10
DK1740213T3 (da) 2012-04-10
US7662393B2 (en) 2010-02-16
JP2007532515A (ja) 2007-11-15
EP1740213A2 (en) 2007-01-10
CN1946427A (zh) 2007-04-11
CY1113834T1 (el) 2016-07-27
ATE547121T1 (de) 2012-03-15
HRP20120235T1 (hr) 2012-04-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU