IL162796A0 - Medicinal compositions containing ghrelin - Google Patents
Medicinal compositions containing ghrelinInfo
- Publication number
- IL162796A0 IL162796A0 IL16279603A IL16279603A IL162796A0 IL 162796 A0 IL162796 A0 IL 162796A0 IL 16279603 A IL16279603 A IL 16279603A IL 16279603 A IL16279603 A IL 16279603A IL 162796 A0 IL162796 A0 IL 162796A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions containing
- medicinal compositions
- containing ghrelin
- ghrelin
- medicinal
- Prior art date
Links
- 102000012004 Ghrelin Human genes 0.000 title 1
- 101800001586 Ghrelin Proteins 0.000 title 1
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002146155 | 2002-05-21 | ||
PCT/JP2003/006349 WO2003097083A1 (fr) | 2002-05-21 | 2003-05-21 | Compositions medicinales contenant de la ghreline |
Publications (1)
Publication Number | Publication Date |
---|---|
IL162796A0 true IL162796A0 (en) | 2005-11-20 |
Family
ID=29545111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16279603A IL162796A0 (en) | 2002-05-21 | 2003-05-21 | Medicinal compositions containing ghrelin |
IL162796A IL162796A (en) | 2002-05-21 | 2004-06-30 | Medicinal compositions containing ghrelin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL162796A IL162796A (en) | 2002-05-21 | 2004-06-30 | Medicinal compositions containing ghrelin |
Country Status (11)
Country | Link |
---|---|
US (3) | US20060166871A1 (xx) |
EP (1) | EP1506786B1 (xx) |
JP (1) | JP5000848B2 (xx) |
KR (1) | KR20050012224A (xx) |
CN (1) | CN100411683C (xx) |
AU (1) | AU2003235401B2 (xx) |
BR (1) | BR0306685A (xx) |
CA (1) | CA2471879C (xx) |
ES (1) | ES2615484T3 (xx) |
IL (2) | IL162796A0 (xx) |
WO (1) | WO2003097083A1 (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE552031T1 (de) | 2001-12-18 | 2012-04-15 | Alize Pharma Sas | Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz |
US7666833B2 (en) | 2001-12-18 | 2010-02-23 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
IL162796A0 (en) | 2002-05-21 | 2005-11-20 | Kenji Kangawa | Medicinal compositions containing ghrelin |
CA2496687A1 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
EP1694355A4 (en) * | 2003-10-24 | 2009-07-29 | Alize Pharma Sas | USE OF GHRELINE AND NON-ACYLATED GHRELINE COMPOSITIONS IN INSULIN RELATED DISEASES |
CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
US20080269116A1 (en) * | 2004-05-11 | 2008-10-30 | Taub Dennis D | Methods of Inhibiting Proinflammatory Cytokine Expression Using Ghrelin |
CA2576915A1 (en) * | 2004-08-18 | 2006-03-02 | Elixir Pharmaceuticals, Inc. | Growth-hormone secretagogues |
CN101022822B (zh) * | 2004-08-24 | 2012-06-27 | 第一三共株式会社 | 生理学活性肽的液体制剂 |
WO2006053383A1 (en) * | 2004-11-22 | 2006-05-26 | Anadis Ltd | Bioactive compositions |
EP1875928A4 (en) * | 2005-04-15 | 2012-03-21 | Univ Shinshu | NEW METHOD FOR THE USE OF TRIACETIN AND TOOLS FOR DIAGNOSTIC ULTRASOUND EXAMINATION |
JP5033798B2 (ja) * | 2005-07-02 | 2012-09-26 | アレコー・リミテッド | タンパク質を含む安定水系 |
AU2006316100B2 (en) * | 2005-11-21 | 2011-12-01 | Daiichi Sankyo Company, Limited | Therapeutic agent for skin or skin repair-promoting agent comprising ghrelin, derivative thereof or substance capable of acting on GHS-R1a as active ingredient |
WO2007088681A1 (ja) | 2006-01-31 | 2007-08-09 | National University Corporation Hokkaido University | グレリン産生促進剤 |
US20100227806A1 (en) * | 2006-03-10 | 2010-09-09 | Tulipano Giovanni | Use Of A Ghrelin Agonist To Improve Catabolic Effects Of Glucocorticoid Treatment |
KR101201055B1 (ko) * | 2006-03-13 | 2012-11-15 | 리아트 민쯔 | 악액질 및/또는 식욕감퇴 및/또는 식욕감퇴-악액질 및/또는영양장애 및/또는 지방이영양증 및/또는 근육 쇠약 및/또는 식욕-자극의 치료를 위한 그렐린 스플라이스 변이체의 용도 |
US7763707B2 (en) | 2006-03-13 | 2010-07-27 | Liat Mintz | Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation |
US8299022B2 (en) * | 2006-09-27 | 2012-10-30 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the N-terminal |
GB0700523D0 (en) * | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
CN101678084B (zh) | 2007-05-31 | 2015-01-21 | 阿利兹药物股份有限公司 | 未酰基化的生长素释放肽作为治疗代谢紊乱中的治疗剂 |
US8318664B2 (en) | 2007-05-31 | 2012-11-27 | Alize Pharma Sas | Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity |
WO2009033773A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent |
CN102066401A (zh) | 2008-05-01 | 2011-05-18 | 艾瑞克有限公司 | 蛋白质制品 |
US8476408B2 (en) | 2008-06-13 | 2013-07-02 | Alize Pharma Sas | Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
EP2328607A1 (en) | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
CA2774999A1 (en) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products |
JP2015505300A (ja) | 2011-11-23 | 2015-02-19 | アムジエン・インコーポレーテツド | インターフェロンγに対する抗体を使用した治療方法 |
JP6031121B2 (ja) | 2011-12-15 | 2016-11-24 | アリゼ ファーマ エスアーエス | 非アシル化グレリンを使用したグレリンレベル及びグレリン/非アシル化グレリン比の調節 |
US9657062B2 (en) | 2012-02-03 | 2017-05-23 | Zealand Pharma A/S | Ghrelin analogues |
FR2987268B1 (fr) * | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
WO2015017123A1 (en) | 2013-07-16 | 2015-02-05 | Liat Mintz | Ghrelin splice variant for treating neuronal damage,neurodegenerative disease, parkinsons disease, alzheimers disease, and/or depression |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
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JPH0651637B2 (ja) * | 1985-03-28 | 1994-07-06 | エーザイ株式会社 | ペプタイドの吸着防止組成物 |
JPS62238298A (ja) * | 1986-04-08 | 1987-10-19 | Sanraku Inc | 新規アントラサイクリン抗生物質dcp−1及び2 |
JPH0669956B2 (ja) * | 1988-09-30 | 1994-09-07 | 旭化成工業株式会社 | ポリペプタイド類の吸着防止剤 |
DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
SE9300105D0 (sv) | 1993-01-15 | 1993-01-15 | Kabi Pharmacia Ab | Stable protein solution |
US5482931A (en) * | 1993-06-29 | 1996-01-09 | Ferring Ab | Stabilized pharmaceutical peptide compositions |
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IL162796A0 (en) | 2002-05-21 | 2005-11-20 | Kenji Kangawa | Medicinal compositions containing ghrelin |
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2003
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- 2003-05-21 BR BR0306685-1A patent/BR0306685A/pt not_active IP Right Cessation
- 2003-05-21 EP EP03752939.3A patent/EP1506786B1/en not_active Expired - Lifetime
- 2003-05-21 AU AU2003235401A patent/AU2003235401B2/en not_active Expired
- 2003-05-21 JP JP2004505079A patent/JP5000848B2/ja not_active Expired - Lifetime
- 2003-05-21 US US10/500,561 patent/US20060166871A1/en not_active Abandoned
- 2003-05-21 CA CA2471879A patent/CA2471879C/en not_active Expired - Lifetime
- 2003-05-21 ES ES03752939.3T patent/ES2615484T3/es not_active Expired - Lifetime
- 2003-05-21 KR KR10-2004-7010362A patent/KR20050012224A/ko not_active Application Discontinuation
- 2003-05-21 WO PCT/JP2003/006349 patent/WO2003097083A1/ja active Application Filing
- 2003-05-21 CN CNB038028301A patent/CN100411683C/zh not_active Expired - Lifetime
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US20060166871A1 (en) | 2006-07-27 |
CN1622822A (zh) | 2005-06-01 |
CA2471879C (en) | 2014-02-25 |
EP1506786A1 (en) | 2005-02-16 |
CN100411683C (zh) | 2008-08-20 |
KR20050012224A (ko) | 2005-01-31 |
US20080081787A1 (en) | 2008-04-03 |
US20120264691A1 (en) | 2012-10-18 |
JP5000848B2 (ja) | 2012-08-15 |
IL162796A (en) | 2011-01-31 |
EP1506786A4 (en) | 2009-07-29 |
CA2471879A1 (en) | 2003-11-27 |
AU2003235401B2 (en) | 2008-09-25 |
JPWO2003097083A1 (ja) | 2005-10-06 |
EP1506786B1 (en) | 2016-11-23 |
BR0306685A (pt) | 2005-04-26 |
AU2003235401A1 (en) | 2003-12-02 |
US8518893B2 (en) | 2013-08-27 |
US8440628B2 (en) | 2013-05-14 |
WO2003097083A1 (fr) | 2003-11-27 |
ES2615484T3 (es) | 2017-06-07 |
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