BR112017012222A2 - métodos para derivar um biomarcador de assinatura gênica e para tratar um paciente que tem um tumor, método e sistema para testar uma amostra de tumor removida de um paciente, e, kit. - Google Patents
métodos para derivar um biomarcador de assinatura gênica e para tratar um paciente que tem um tumor, método e sistema para testar uma amostra de tumor removida de um paciente, e, kit.Info
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- BR112017012222A2 BR112017012222A2 BR112017012222A BR112017012222A BR112017012222A2 BR 112017012222 A2 BR112017012222 A2 BR 112017012222A2 BR 112017012222 A BR112017012222 A BR 112017012222A BR 112017012222 A BR112017012222 A BR 112017012222A BR 112017012222 A2 BR112017012222 A2 BR 112017012222A2
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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Abstract
trata-se de uma plataforma de expressão gênica que é uma combinação de um conjunto de genes que são correlacionados à resposta a um antagonista de pd-1 em múltiplos tipos de tumor e um conjunto de genes de normalização. um método e sistema para usar a plataforma de expressão gênica para derivar biomarcadores de assinatura gênica de resposta antitumoral a um antagonista de pd-1 e para testar amostras de paciente para biomarcadores de assinatura gênica preditivos também são revelados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462089538P | 2014-12-09 | 2014-12-09 | |
US201562160284P | 2015-05-12 | 2015-05-12 | |
PCT/US2015/064445 WO2016094377A1 (en) | 2014-12-09 | 2015-12-08 | System and methods for deriving gene signature biomarkers of response to pd-1 antagonists |
Publications (1)
Publication Number | Publication Date |
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BR112017012222A2 true BR112017012222A2 (pt) | 2018-01-30 |
Family
ID=56108044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017012222A BR112017012222A2 (pt) | 2014-12-09 | 2015-12-08 | métodos para derivar um biomarcador de assinatura gênica e para tratar um paciente que tem um tumor, método e sistema para testar uma amostra de tumor removida de um paciente, e, kit. |
Country Status (11)
Country | Link |
---|---|
US (1) | US11377693B2 (pt) |
EP (1) | EP3230498B1 (pt) |
JP (1) | JP2018505658A (pt) |
KR (1) | KR20170086661A (pt) |
CN (1) | CN107109700A (pt) |
AU (2) | AU2015360736A1 (pt) |
BR (1) | BR112017012222A2 (pt) |
CA (1) | CA2968406A1 (pt) |
MX (1) | MX2017007535A (pt) |
RU (1) | RU2017123117A (pt) |
WO (1) | WO2016094377A1 (pt) |
Families Citing this family (28)
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AP2911A (en) | 2005-12-02 | 2014-05-31 | Sinai School Medicine | Chimeric Viruses presenting non-native surface proteins and uses thereof |
PL2170959T3 (pl) | 2007-06-18 | 2014-03-31 | Merck Sharp & Dohme | Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1 |
PE20151921A1 (es) | 2013-03-14 | 2015-12-26 | Icahn School Med Mount Sinai | Virus de la enfermedad de newcastle y usos de los mismos |
ME03527B (me) | 2013-12-12 | 2020-04-20 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antitijelo, njegov fragment koji se vezuje na antigen, i njegova medicinska primjena |
CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
JP6767096B2 (ja) * | 2014-12-11 | 2020-10-14 | リティックス バイオファーマ エイエス | 免疫チェックポイント阻害剤の組み合わせ |
EP3283882B1 (en) | 2015-04-17 | 2020-12-16 | Merck Sharp & Dohme Corp. | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
US10438699B2 (en) * | 2016-05-10 | 2019-10-08 | Macau University Of Science And Technology | Method and system for determining an association of biological features with a medical condition |
CA3039402A1 (en) | 2016-10-07 | 2018-04-12 | Omniseq, Inc. | Methods and systems for determining personalized therapies |
JP7235508B2 (ja) * | 2016-11-24 | 2023-03-08 | 第一三共株式会社 | Pd-1免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法 |
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JP2021521439A (ja) * | 2018-04-13 | 2021-08-26 | エックス4 ファーマシューティカルズ, インコーポレイテッド | がん血清バイオマーカーおよびその使用方法 |
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JP7401460B2 (ja) | 2018-05-14 | 2023-12-19 | メルク・シャープ・アンド・ドーム・エルエルシー | レンバチニブ及びpd-1アンタゴニストを含む組み合わせ療法のためのバイオマーカー |
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WO2020005068A2 (en) * | 2018-06-29 | 2020-01-02 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Gene signatures and method for predicting response to pd-1 antagonists and ctla-4 antagonists, and combination thereof |
EP3891185A2 (en) * | 2018-12-05 | 2021-10-13 | F. Hoffmann-La Roche AG | Diagnostic methods and compositions for cancer immunotherapy |
EP3976832A1 (en) * | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
EP4010022A4 (en) * | 2019-08-09 | 2024-01-17 | The Regents Of Univ Of California | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BLADDER CANCER |
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CN111088360A (zh) * | 2020-01-17 | 2020-05-01 | 暨南大学 | Pd1-ctla4和/或pdl2-ctla4在制备预测aml预后试剂盒中的应用 |
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CA2905798C (en) | 2013-03-15 | 2023-01-24 | Genentech, Inc. | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
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-
2015
- 2015-12-08 MX MX2017007535A patent/MX2017007535A/es unknown
- 2015-12-08 CN CN201580072918.XA patent/CN107109700A/zh active Pending
- 2015-12-08 CA CA2968406A patent/CA2968406A1/en not_active Abandoned
- 2015-12-08 AU AU2015360736A patent/AU2015360736A1/en not_active Abandoned
- 2015-12-08 BR BR112017012222A patent/BR112017012222A2/pt not_active Application Discontinuation
- 2015-12-08 US US15/533,769 patent/US11377693B2/en active Active
- 2015-12-08 RU RU2017123117A patent/RU2017123117A/ru not_active Application Discontinuation
- 2015-12-08 KR KR1020177018558A patent/KR20170086661A/ko not_active Application Discontinuation
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- 2015-12-08 JP JP2017530266A patent/JP2018505658A/ja active Pending
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2020
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EP3230498A4 (en) | 2018-08-01 |
US11377693B2 (en) | 2022-07-05 |
RU2017123117A (ru) | 2019-01-10 |
CA2968406A1 (en) | 2016-06-16 |
US20180327848A1 (en) | 2018-11-15 |
EP3230498A1 (en) | 2017-10-18 |
AU2015360736A1 (en) | 2017-06-01 |
MX2017007535A (es) | 2017-08-10 |
EP3230498B1 (en) | 2023-01-18 |
JP2018505658A (ja) | 2018-03-01 |
RU2017123117A3 (pt) | 2019-07-17 |
WO2016094377A1 (en) | 2016-06-16 |
AU2020204557A1 (en) | 2020-07-30 |
KR20170086661A (ko) | 2017-07-26 |
CN107109700A (zh) | 2017-08-29 |
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