|
CA2478374C
(en)
*
|
2002-03-13 |
2009-01-06 |
Eli M. Wallace |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
US7235537B2
(en)
*
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
AU2003297925A1
(en)
*
|
2002-12-13 |
2004-07-09 |
Smithkline Beecham Corporation |
Thrombopoietin mimetics
|
|
WO2004075915A1
(ja)
*
|
2003-02-26 |
2004-09-10 |
Kowa Co. Ltd. |
アレルギー性接触性皮膚炎治療薬
|
|
WO2005009975A2
(en)
|
2003-07-24 |
2005-02-03 |
Warner-Lambert Company Llc |
Benzimidazole derivatives as mek inhibitors
|
|
US7538120B2
(en)
*
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
US7144907B2
(en)
*
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
NZ545864A
(en)
|
2003-09-22 |
2009-12-24 |
S Bio Pte Ltd |
Benzimidazole derivates: preparation and pharmaceutical applications
|
|
UA84175C2
(ru)
|
2003-11-19 |
2008-09-25 |
Аррей Байофарма Инк. |
Гетероциклические ингибиторы мэк и их применение
|
|
US7517994B2
(en)
*
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7732616B2
(en)
*
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
RU2006121990A
(ru)
|
2003-11-21 |
2007-12-27 |
Эррэй Биофарма Инк. (Us) |
Ингибиторы протеинкиназ акт
|
|
JP2007513967A
(ja)
*
|
2003-12-11 |
2007-05-31 |
セラヴァンス, インコーポレーテッド |
変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
|
|
AR051248A1
(es)
|
2004-10-20 |
2007-01-03 |
Applied Research Systems |
Derivados de 3-arilamino piridina
|
|
AU2005311451A1
(en)
*
|
2004-12-01 |
2006-06-08 |
Merck Serono Sa |
[1,2,4]triazolo[4,3-a]pyridine derivatives for the treatment of hyperproliferative diseases
|
|
US7429667B2
(en)
*
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
|
AU2006299902B2
(en)
|
2005-05-18 |
2012-11-01 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
CA2612419C
(en)
*
|
2005-06-23 |
2017-06-13 |
Array Biopharma Inc. |
Process for preparing benzimidazole compounds
|
|
EP1904061B1
(en)
*
|
2005-06-23 |
2018-12-26 |
Array Biopharma, Inc. |
SNAr PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS
|
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
|
AU2013203939B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
GEP20125456B
(en)
|
2005-10-07 |
2012-03-26 |
Exelixis Inc |
Azetidines as mek inhibitors for the treatment of proliferative diseases
|
|
AU2012261703B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
US7968108B2
(en)
*
|
2005-10-25 |
2011-06-28 |
Metbro Distributing L.P. |
Hydrogen cyanamide pesticide formulations
|
|
US7572460B2
(en)
*
|
2005-10-25 |
2009-08-11 |
Rodrigo Rodriguez-Kabana |
Hydrogen cyanamide pesticide formulations
|
|
TWI405756B
(zh)
*
|
2005-12-21 |
2013-08-21 |
Array Biopharma Inc |
新穎硫酸氫鹽
|
|
RU2418790C3
(ru)
*
|
2005-12-21 |
2022-03-14 |
Астразенека Аб |
Новая гидросульфатная соль
|
|
EP1966155A1
(en)
*
|
2005-12-21 |
2008-09-10 |
AstraZeneca AB |
Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer
|
|
CA2534243A1
(fr)
|
2006-01-25 |
2007-07-25 |
Hydro Quebec |
Particules d'oxyde metallique enrobees a faible taux de dissolution, procedes de preparation et utilisation dans les systemes electrochimiques
|
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
|
US7842836B2
(en)
|
2006-04-11 |
2010-11-30 |
Ardea Biosciences |
N-aryl-N'alkyl sulfamides as MEK inhibitors
|
|
DE602007009663D1
(de)
*
|
2006-04-18 |
2010-11-18 |
Ardea Biosciences Inc |
Pyridonsulfonamide und pyridonsulfamide als mek-hemmer
|
|
JP5231410B2
(ja)
|
2006-07-06 |
2013-07-10 |
アレイ バイオファーマ、インコーポレイテッド |
Aktプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン
|
|
KR101527232B1
(ko)
|
2006-07-06 |
2015-06-09 |
어레이 바이오파마 인크. |
Akt 단백질 키나제 억제제로서의 시클로펜타〔d〕피리미딘
|
|
CA2656364C
(en)
|
2006-07-06 |
2014-11-25 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
US8492378B2
(en)
*
|
2006-08-03 |
2013-07-23 |
Takeda Pharmaceutical Company Limited |
GSK-3β inhibitor
|
|
ZA200901009B
(en)
*
|
2006-08-21 |
2010-05-26 |
Genentech Inc |
Aza-benzothiophenyl compounds and methods of use
|
|
EP2069359B1
(en)
*
|
2006-08-21 |
2014-11-12 |
Genentech, Inc. |
Aza-benzothiophenyl compounds and methods of use
|
|
ATE531720T1
(de)
*
|
2006-08-21 |
2011-11-15 |
Genentech Inc |
Aza-benzofuranylverbindungen und anwendungsverfahren dafür
|
|
WO2008076415A1
(en)
|
2006-12-14 |
2008-06-26 |
Exelixis, Inc. |
Methods of using mek inhibitors
|
|
JO2985B1
(ar)
|
2006-12-20 |
2016-09-05 |
Takeda Pharmaceuticals Co |
مثبطات كينازmapk/erk
|
|
CN101678001A
(zh)
*
|
2007-04-13 |
2010-03-24 |
阿斯利康(瑞典)有限公司 |
包含azd2171和azd6244或mek-抑制剂ⅱ的组合治疗
|
|
US8509487B2
(en)
*
|
2007-04-19 |
2013-08-13 |
Avago Technologies General Ip (Singapore) Pte. Ltd. |
System and method for optically measuring a parameter of an object
|
|
JP5580735B2
(ja)
|
2007-06-12 |
2014-08-27 |
ジェネンテック, インコーポレイテッド |
N−置換アザインドール類及び使用方法
|
|
KR101624361B1
(ko)
*
|
2007-07-05 |
2016-05-25 |
어레이 바이오파마 인크. |
Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
|
|
SG185274A1
(en)
|
2007-07-05 |
2012-11-29 |
Array Biopharma Inc |
Pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
GB0714384D0
(en)
|
2007-07-23 |
2007-09-05 |
Ucb Pharma Sa |
theraputic agents
|
|
EP2217234A2
(en)
*
|
2007-10-15 |
2010-08-18 |
AstraZeneca AB |
Combinations of mek inhibitors with mtor inhibitors
|
|
WO2009064675A1
(en)
|
2007-11-12 |
2009-05-22 |
Takeda Pharmaceutical Company Limited |
Mapk/erk kinase inhibitors
|
|
JP5421925B2
(ja)
|
2007-12-19 |
2014-02-19 |
ジェネンテック, インコーポレイテッド |
5−アニリノイミダゾピリジン及び使用の方法
|
|
DK2231662T3
(da)
|
2007-12-19 |
2011-08-29 |
Genentech Inc |
8-Anilinoimidazopyridiner og deres anvendelse som anticancer- og/eller antiinflammatoriske midler
|
|
JP2011506533A
(ja)
|
2007-12-20 |
2011-03-03 |
エフ.ホフマン−ラ ロシュ アーゲー |
Mekキナーゼ阻害剤としての置換ヒダントイン
|
|
ES2387707T3
(es)
|
2007-12-21 |
2012-09-28 |
Genentech, Inc. |
Azaindolizinas y procedimientos de uso
|
|
KR101624752B1
(ko)
*
|
2008-01-09 |
2016-05-26 |
어레이 바이오파마 인크. |
Akt 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
|
|
KR101624753B1
(ko)
*
|
2008-01-09 |
2016-05-26 |
어레이 바이오파마 인크. |
Akt 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
|
|
WO2009093008A1
(en)
|
2008-01-21 |
2009-07-30 |
Ucb Pharma S.A. |
Thieno-pyridine derivatives as mek inhibitors
|
|
SA109300195B1
(ar)
|
2008-03-28 |
2013-04-20 |
Astrazeneca Ab |
تركيبة صيدلانية جديدة مضادة للسرطان
|
|
GB0811304D0
(en)
|
2008-06-19 |
2008-07-30 |
Ucb Pharma Sa |
Therapeutic agents
|
|
EP2293472A1
(en)
|
2008-06-23 |
2011-03-09 |
Panasonic Corporation |
Wireless communication base station apparatus and reference signal allocation method
|
|
US8492427B2
(en)
*
|
2008-07-01 |
2013-07-23 |
Genentech, Inc. |
Isoindolones derivatives as MEK kinase inhibitors and methods of use
|
|
RU2509078C2
(ru)
|
2008-07-01 |
2014-03-10 |
Дженентек, Инк. |
Бициклические гетероциклы в качестве ингибиторов киназы мек
|
|
UA107183C2
(uk)
|
2008-08-04 |
2014-12-10 |
|
Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань
|
|
CN101653607B
(zh)
*
|
2008-08-19 |
2013-02-13 |
鼎泓国际投资(香港)有限公司 |
含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途
|
|
WO2010051245A1
(en)
*
|
2008-11-03 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Benzimidazole and aza-benzimidazole carboxamides
|
|
CA2742945A1
(en)
|
2008-11-10 |
2010-05-14 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted sulphonamido phenoxybenzamides
|
|
JO3002B1
(ar)
|
2009-08-28 |
2016-09-05 |
Irm Llc |
مركبات و تركيبات كمثبطات كيناز بروتين
|
|
US8242260B2
(en)
|
2009-08-28 |
2012-08-14 |
Novartis Ag |
Compounds and compositions as protein kinase inhibitors
|
|
JP2013508318A
(ja)
|
2009-10-21 |
2013-03-07 |
バイエル・ファルマ・アクチェンゲゼルシャフト |
置換されたベンゾスルホンアミド誘導体
|
|
WO2011047795A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted benzosulphonamides
|
|
CA2777071A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
|
WO2011095807A1
(en)
|
2010-02-07 |
2011-08-11 |
Astrazeneca Ab |
Combinations of mek and hh inhibitors
|
|
WO2011133520A1
(en)
|
2010-04-19 |
2011-10-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
|
EP2560953B1
(en)
|
2010-04-21 |
2016-01-06 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
|
KR20130048293A
(ko)
|
2010-06-25 |
2013-05-09 |
노파르티스 아게 |
단백질 키나제 억제제로서의 헤테로아릴 화합물 및 조성물
|
|
CN103221043B
(zh)
|
2010-08-05 |
2016-04-06 |
卡斯西部储备大学 |
用于治疗神经元连接发育障碍的erk抑制剂
|
|
MY170236A
(en)
|
2010-10-06 |
2019-07-11 |
Glaxosmithkline Llc |
Benzimidazole derivatives as pi3 kinase inhibitors
|
|
CN103282351A
(zh)
|
2010-10-29 |
2013-09-04 |
拜耳知识产权有限责任公司 |
取代的苯氧基吡啶
|
|
CN102020651B
(zh)
|
2010-11-02 |
2012-07-18 |
北京赛林泰医药技术有限公司 |
6-芳基氨基吡啶酮甲酰胺mek抑制剂
|
|
KR20140063501A
(ko)
|
2010-12-22 |
2014-05-27 |
페이트 세러퓨틱스, 인코포레이티드 |
단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
|
|
WO2012085244A1
(fr)
|
2010-12-23 |
2012-06-28 |
Sanofi |
Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique
|
|
PL2694073T3
(pl)
|
2011-04-01 |
2019-06-28 |
Genentech, Inc. |
Kombinacje inhibitorów AKT i MEK do leczenia nowotworu
|
|
KR20140025434A
(ko)
|
2011-04-01 |
2014-03-04 |
제넨테크, 인크. |
Akt 억제제 화합물 및 화학요법제의 조합물, 및 사용 방법
|
|
WO2012145503A1
(en)
|
2011-04-21 |
2012-10-26 |
Novartis Ag |
Pharmaceutical combinations
|
|
WO2012162293A1
(en)
*
|
2011-05-23 |
2012-11-29 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitory compounds with mek inhibitors
|
|
EP2714037B1
(en)
|
2011-05-25 |
2016-07-13 |
Université Paris Descartes |
Erk inhibitors for use in treating spinal muscular atrophy
|
|
US9416132B2
(en)
|
2011-07-21 |
2016-08-16 |
Tolero Pharmaceuticals, Inc. |
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
|
|
SG10201606284UA
(en)
|
2011-08-01 |
2016-09-29 |
Genentech Inc |
Methods Of Treating Cancer Using Pd-1 Axis Binding Antagonists And Mek Inhibitors
|
|
US10813630B2
(en)
|
2011-08-09 |
2020-10-27 |
Corquest Medical, Inc. |
Closure system for atrial wall
|
|
US10307167B2
(en)
|
2012-12-14 |
2019-06-04 |
Corquest Medical, Inc. |
Assembly and method for left atrial appendage occlusion
|
|
US10314594B2
(en)
|
2012-12-14 |
2019-06-11 |
Corquest Medical, Inc. |
Assembly and method for left atrial appendage occlusion
|
|
CA2846454A1
(en)
*
|
2011-08-31 |
2013-05-10 |
Novartis Ag |
Synergistic combinations of pi3k- and mek-inhibitors
|
|
EP2750672A1
(en)
*
|
2011-09-01 |
2014-07-09 |
Novartis AG |
Use of organic compound for the treatment of noonan syndrome
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
US9168254B2
(en)
|
2011-10-14 |
2015-10-27 |
Array Biopharma Inc. |
Polymorphs of ARRY-380, a selective HER 2 inhibitor and pharmaceutical compositions containing them
|
|
US20140286902A1
(en)
|
2011-11-02 |
2014-09-25 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitors with platinum-containing agents
|
|
WO2013067162A1
(en)
|
2011-11-02 |
2013-05-10 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
|
|
US9402831B2
(en)
|
2011-11-14 |
2016-08-02 |
Synta Pharmaceutical Corp. |
Combination therapy of HSP90 inhibitors with BRAF inhibitors
|
|
EP2797957B1
(en)
|
2011-11-23 |
2019-06-19 |
MedImmune, LLC |
Binding molecules specific for her3 and uses thereof
|
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
|
AU2013208720A1
(en)
|
2012-01-09 |
2014-07-24 |
Arrowhead Research Corporation |
RNAi agents to treat Beta-Catenin related diseases
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN103204827B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途
|
|
GB201201332D0
(en)
|
2012-01-26 |
2012-03-14 |
Imp Innovations Ltd |
Method
|
|
CN104487089B
(zh)
*
|
2012-03-20 |
2018-08-28 |
诺华股份有限公司 |
Mek抑制剂和igfir抑制剂的组合疗法
|
|
EP2836873B1
(en)
|
2012-04-09 |
2020-03-11 |
Switch Materials, Inc. |
Switching materials, and compositions and methods for making same
|
|
EP4600727A3
(en)
|
2012-05-29 |
2025-10-22 |
Solutia Canada Inc. |
Optical filter comprising a variable transmittance layer
|
|
US20150267258A1
(en)
|
2012-05-31 |
2015-09-24 |
Bayer Pharma Aktiengesellschaft |
Biomarkers for determining effective response of treatments of hepatocellular carcinoma (hcc) patients
|
|
AR091876A1
(es)
*
|
2012-07-26 |
2015-03-04 |
Novartis Ag |
Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas
|
|
CA2879252C
(en)
|
2012-08-17 |
2017-10-10 |
F. Hoffmann-La Roche Ag |
Combination therapies for melanoma comprising administering cobimetinib and vemurafinib
|
|
JP6530313B2
(ja)
|
2012-10-02 |
2019-06-12 |
エピセラピューティクス アーペーエス |
ヒストン脱メチル化酵素の阻害剤
|
|
ES2671502T3
(es)
|
2012-10-12 |
2018-06-06 |
Exelixis, Inc. |
Proceso novedoso para preparar compuestos para su uso en el tratamiento de cáncer
|
|
WO2014062838A2
(en)
|
2012-10-16 |
2014-04-24 |
Tolero Pharmaceuticals, Inc. |
Pkm2 modulators and methods for their use
|
|
CN109336824B
(zh)
*
|
2012-10-19 |
2022-11-11 |
诺华股份有限公司 |
Mek抑制剂的制备和包含mek抑制剂的制剂
|
|
US20140142689A1
(en)
|
2012-11-21 |
2014-05-22 |
Didier De Canniere |
Device and method of treating heart valve malfunction
|
|
DK2925366T3
(en)
*
|
2012-11-29 |
2018-06-06 |
Novartis Ag |
PHARMACEUTICAL COMBINATIONS
|
|
US9867825B2
(en)
|
2012-12-20 |
2018-01-16 |
Novartis Ag |
Pharmaceutical combination comprising binimetinib
|
|
EP2752191A1
(en)
|
2013-01-07 |
2014-07-09 |
Sanofi |
Compositions and methods using hdm2 antagonist and mek inhibitor
|
|
JP2016508726A
(ja)
|
2013-02-22 |
2016-03-24 |
セルラー ダイナミクス インターナショナル, インコーポレイテッド |
組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生
|
|
JP6465790B2
(ja)
|
2013-02-27 |
2019-02-06 |
第一三共株式会社 |
Mapkシグナル伝達経路を阻害する化合物に対する応答性を予測する方法
|
|
TR201808599T4
(tr)
|
2013-02-27 |
2018-07-23 |
Gilead Sciences Inc |
Histon demetilaz inhibitörleri.
|
|
CA2905993C
(en)
|
2013-03-14 |
2022-12-06 |
Tolero Pharmaceuticals, Inc. |
Substituted 4-amino-pyrimidinyl-2-amino-phenyl derivatives and pharmaceutical compositions thereof for use as jak2 and alk2 inhibitors
|
|
DK2976106T3
(da)
*
|
2013-03-21 |
2021-06-14 |
Array Biopharma Inc |
Kombinationsterapi, som omfatter en b-raf-hæmmer og en anden hæmmer
|
|
AR097617A1
(es)
|
2013-09-13 |
2016-04-06 |
Actelion Pharmaceuticals Ltd |
Derivados antibacterianos del 2h-indazol
|
|
EP3046557A1
(en)
|
2013-09-20 |
2016-07-27 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
US10570204B2
(en)
|
2013-09-26 |
2020-02-25 |
The Medical College Of Wisconsin, Inc. |
Methods for treating hematologic cancers
|
|
US9566443B2
(en)
|
2013-11-26 |
2017-02-14 |
Corquest Medical, Inc. |
System for treating heart valve malfunction including mitral regurgitation
|
|
SG11201605014YA
(en)
|
2013-12-19 |
2016-07-28 |
Actelion Pharmaceuticals Ltd |
Antibacterial 1h-indazole and 1h-indole derivatives
|
|
CA2935804A1
(en)
|
2014-01-14 |
2015-07-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
CN104788365B
(zh)
*
|
2014-01-16 |
2018-08-10 |
上海艾力斯医药科技有限公司 |
异烟酰胺衍生物、其制备方法及应用
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
EP3805369B1
(en)
|
2014-03-04 |
2025-09-03 |
Fate Therapeutics, Inc. |
Improved reprogramming methods and cell culture platforms
|
|
AR099612A1
(es)
|
2014-03-04 |
2016-08-03 |
Actelion Pharmaceuticals Ltd |
Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
|
|
PH12016501545B1
(en)
|
2014-03-14 |
2023-12-06 |
Immutep Sas |
Antibody molecules to lag-3 and uses thereof
|
|
AR099890A1
(es)
|
2014-03-31 |
2016-08-24 |
Epitherapeutics Aps |
Inhibidores de histona demetilasas
|
|
US20170107486A1
(en)
|
2014-04-21 |
2017-04-20 |
Cellular Dynamics International, Inc. |
Hepatocyte production via forward programming by combined genetic and chemical engineering
|
|
CN106458931A
(zh)
|
2014-05-16 |
2017-02-22 |
埃科特莱茵药品有限公司 |
抗菌的喹唑啉‑4(3h)‑酮衍生物
|
|
US10023879B2
(en)
|
2014-06-04 |
2018-07-17 |
Fate Therapeutics, Inc. |
Minimal volume reprogramming of mononuclear cells
|
|
CN106573060A
(zh)
|
2014-07-15 |
2017-04-19 |
豪夫迈·罗氏有限公司 |
使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物
|
|
MA40470A
(fr)
|
2014-08-27 |
2016-03-03 |
Gilead Sciences Inc |
Composés et procédés d'inhibition des histones déméthylases
|
|
CN107206071A
(zh)
|
2014-09-13 |
2017-09-26 |
诺华股份有限公司 |
Alk抑制剂的联合疗法
|
|
AU2015327868A1
(en)
|
2014-10-03 |
2017-04-20 |
Novartis Ag |
Combination therapies
|
|
US20170248603A1
(en)
|
2014-10-06 |
2017-08-31 |
Dana-Farber Cancer Institute, Inc. |
Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
CA2964367C
(en)
|
2014-10-14 |
2024-01-30 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
US10842626B2
(en)
|
2014-12-09 |
2020-11-24 |
Didier De Canniere |
Intracardiac device to correct mitral regurgitation
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
NZ731664A
(en)
|
2014-12-23 |
2024-02-23 |
Novartis Ag |
Triazolopyrimidine compounds and uses thereof
|
|
EP3250680A4
(en)
|
2015-01-26 |
2018-12-05 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
CN105566225A
(zh)
*
|
2015-02-16 |
2016-05-11 |
苏州晶云药物科技有限公司 |
一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法
|
|
JP2016155776A
(ja)
*
|
2015-02-24 |
2016-09-01 |
学校法人兵庫医科大学 |
抗腫瘍効果増強剤および抗腫瘍剤
|
|
HK1248603A1
(zh)
|
2015-03-10 |
2018-10-19 |
Aduro Biotech, Inc. |
用於活化"干扰素基因的刺激剂"依懒性信号传导的组合物和方法
|
|
RU2017134379A
(ru)
|
2015-03-25 |
2019-04-03 |
Новартис Аг |
Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4
|
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
|
EP4378957A3
(en)
|
2015-07-29 |
2024-08-07 |
Novartis AG |
Combination therapies comprising antibody molecules to pd-1
|
|
AR105646A1
(es)
|
2015-08-11 |
2017-10-25 |
Actelion Pharmaceuticals Ltd |
Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
|
|
US20190008859A1
(en)
|
2015-08-21 |
2019-01-10 |
Acerta Pharma B.V. |
Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
|
|
RU2740091C2
(ru)
|
2015-08-28 |
2021-01-11 |
Новартис Аг |
Ингибиторы mdm2 и их комбинации
|
|
AR105889A1
(es)
|
2015-09-03 |
2017-11-22 |
Actelion Pharmaceuticals Ltd |
Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
|
|
CN108291237B
(zh)
|
2015-10-16 |
2023-11-21 |
菲特治疗公司 |
用于诱导和维护基态多能性的平台
|
|
JP2019500893A
(ja)
|
2015-11-03 |
2019-01-17 |
ヤンセン バイオテツク,インコーポレーテツド |
Pd−1及びtim−3に特異的に結合する抗体及びそれらの使用
|
|
AU2016348342B2
(en)
|
2015-11-04 |
2023-07-06 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
EP3371314B1
(en)
|
2015-11-04 |
2023-07-05 |
Fate Therapeutics, Inc. |
Genomic engineering of pluripotent cells
|
|
KR102833068B1
(ko)
|
2015-12-17 |
2025-07-14 |
노파르티스 아게 |
Pd-1에 대한 항체 분자 및 그의 용도
|
|
WO2017127755A1
(en)
|
2016-01-20 |
2017-07-27 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
WO2017127729A1
(en)
|
2016-01-20 |
2017-07-27 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
KR20180118719A
(ko)
|
2016-03-04 |
2018-10-31 |
다이호야쿠힌고교 가부시키가이샤 |
악성 종양 치료용 제제 및 조성물
|
|
US11883404B2
(en)
|
2016-03-04 |
2024-01-30 |
Taiho Pharmaceuticals Co., Ltd. |
Preparation and composition for treatment of malignant tumors
|
|
AR108257A1
(es)
|
2016-05-02 |
2018-08-01 |
Mei Pharma Inc |
Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
|
|
PT3463345T
(pt)
|
2016-06-03 |
2023-01-06 |
Array Biopharma Inc |
Combinações farmacêuticas
|
|
EP3472166A1
(en)
|
2016-06-20 |
2019-04-24 |
Novartis AG |
Imidazopyrimidine compounds useful for the treatment of cancer
|
|
US10689378B2
(en)
|
2016-06-20 |
2020-06-23 |
Novartis Ag |
Triazolopyridine compounds and uses thereof
|
|
ES2975263T3
(es)
|
2016-06-20 |
2024-07-04 |
Novartis Ag |
Formas cristalinas de un compuesto triazolopirimidínico
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
WO2018065924A1
(en)
*
|
2016-10-04 |
2018-04-12 |
Sun Pharmaceutical Industries Limited |
Intermediates of mitogen-activated protein kinase kinase (map2k or mek) inhibitors and process for their preparation
|
|
WO2018092064A1
(en)
|
2016-11-18 |
2018-05-24 |
Novartis Ag |
Combinations of mdm2 inhibitors and bcl-xl inhibitors
|
|
CN108084078B
(zh)
*
|
2016-11-24 |
2021-07-30 |
中山大学 |
一种治疗银屑病性关节炎疾病的药物阿普斯特的合成方法
|
|
US11932870B2
(en)
|
2016-12-05 |
2024-03-19 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
EP3372624A1
(en)
|
2017-03-06 |
2018-09-12 |
Henkel AG & Co. KGaA |
One component composition based on compounds with at least two exo-vinylene cyclic carbonate units
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
US12116348B2
(en)
|
2017-11-14 |
2024-10-15 |
Shenzhen Targetrx, Inc. |
Substituted benzimidazole compound and composition comprising same
|
|
BR112020008888A2
(pt)
|
2017-11-16 |
2020-10-20 |
Novartis Ag |
terapias de combinação
|
|
TW201938165A
(zh)
|
2017-12-18 |
2019-10-01 |
美商輝瑞股份有限公司 |
治療癌症的方法及組合療法
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
BR112020018697A2
(pt)
|
2018-03-19 |
2020-12-29 |
Taiho Pharmaceutical Co., Ltd. |
Composição farmacêutica incluindo alquilsulfato de sódio
|
|
CA3096984A1
(en)
|
2018-04-05 |
2019-10-10 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Axl kinase inhibitors and use of the same
|
|
CN112513085B
(zh)
|
2018-05-24 |
2024-06-18 |
詹森生物科技公司 |
Psma结合剂及其用途
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
WO2020021465A1
(en)
|
2018-07-25 |
2020-01-30 |
Advanced Accelerator Applications (Italy) S.R.L. |
Method of treatment of neuroendocrine tumors
|
|
HRP20250912T1
(hr)
|
2018-07-25 |
2025-09-26 |
Advanced Accelerator Applications S.A. |
Stabilne, koncentrirane otopine radionuklidnih kompleksa
|
|
JP2021530554A
(ja)
|
2018-07-26 |
2021-11-11 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
異常なacvr1発現を伴う疾患を処置するための方法およびそこで使用するためのacvr1阻害剤
|
|
PL3837256T3
(pl)
|
2018-08-17 |
2023-07-10 |
Novartis Ag |
Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy
|
|
JP7358484B2
(ja)
|
2018-09-25 |
2023-10-10 |
アドヴァンスド・アクセラレーター・アプリケーションズ・(イタリー)・エッセエッレエッレ |
併用療法
|
|
MA55141A
(fr)
|
2018-11-20 |
2021-09-29 |
Nflection Therapeutics Inc |
Composés cyanoaryl-aniline pour le traitement d'affections de la peau
|
|
CN117551073A
(zh)
|
2018-11-20 |
2024-02-13 |
恩福莱克逊治疗有限公司 |
用于治疗皮肤疾病噻吩基苯胺化合物
|
|
WO2020106308A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Naphthyridinone-aniline compounds for treatment of dermal disorders
|
|
AU2019402189B2
(en)
|
2018-12-20 |
2023-04-13 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
SG11202106635WA
(en)
|
2018-12-21 |
2021-07-29 |
Daiichi Sankyo Co Ltd |
Combination of antibody-drug conjugate and kinase inhibitor
|
|
EP3924351B1
(en)
|
2019-02-12 |
2025-05-21 |
Sumitomo Pharma America, Inc. |
Crystalline form of the hydrochloride salt of 2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
|
|
US20220144807A1
(en)
|
2019-02-15 |
2022-05-12 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
BR112021015672A2
(pt)
|
2019-02-15 |
2021-10-05 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos
|
|
EP3942045A1
(en)
|
2019-03-21 |
2022-01-26 |
Onxeo |
A dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
|
US11712433B2
(en)
|
2019-03-22 |
2023-08-01 |
Sumitomo Pharma Oncology, Inc. |
Compositions comprising PKM2 modulators and methods of treatment using the same
|
|
WO2020212832A1
(en)
*
|
2019-04-16 |
2020-10-22 |
Alembic Pharmaceuticals Limited |
Process of preparation of benzimidazole compounds
|
|
MA55717A
(fr)
|
2019-04-19 |
2022-02-23 |
Janssen Biotech Inc |
Méthodes de traitement du cancer de la prostate avec un anticorps anti-psma/cd3
|
|
TWI817018B
(zh)
|
2019-06-28 |
2023-10-01 |
美商艾瑞生藥股份有限公司 |
用於治療braf相關的疾病和失調症之化合物
|
|
CN114302878A
(zh)
|
2019-07-03 |
2022-04-08 |
大日本住友制药肿瘤公司 |
酪氨酸激酶非受体1(tnk1)抑制剂及其用途
|
|
CN114746414B
(zh)
|
2019-09-26 |
2024-10-18 |
诺华公司 |
氮杂-喹啉化合物及其用途
|
|
JP2023500906A
(ja)
|
2019-11-08 |
2023-01-11 |
インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) |
キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
|
|
WO2021116901A1
(en)
*
|
2019-12-09 |
2021-06-17 |
Biocon Limited |
Forms of binimetinib and process for preparation thereof
|
|
EP4076660A1
(en)
|
2019-12-20 |
2022-10-26 |
Novartis AG |
Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
CN115380026B
(zh)
*
|
2020-03-17 |
2023-11-07 |
南京明德新药研发有限公司 |
蛋白降解调节剂与其使用方法
|
|
TW202200146A
(zh)
|
2020-04-10 |
2022-01-01 |
日商大鵬藥品工業股份有限公司 |
使用有3,5-二取代苯炔基化合物與mek抑制劑之癌症治療法
|
|
WO2021250521A1
(en)
|
2020-06-09 |
2021-12-16 |
Array Biopharma Inc. |
4-oxo-3,4-dihydroquinazolinon compounds for the treatment of braf-associated diseases and disorders
|
|
JP2023531676A
(ja)
|
2020-06-23 |
2023-07-25 |
ノバルティス アーゲー |
3-(1-オキソイソインドリン-2-イル)ピぺリジン-2,6-ジオン誘導体を含む投与レジメン
|
|
AR123185A1
(es)
|
2020-08-10 |
2022-11-09 |
Novartis Ag |
Compuestos y composiciones para inhibir ezh2
|
|
EP4204021A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
WO2022043556A1
(en)
|
2020-08-31 |
2022-03-03 |
Novartis Ag |
Stable radiopharmaceutical composition
|
|
US20230338587A1
(en)
|
2020-08-31 |
2023-10-26 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
MX2023003867A
(es)
|
2020-10-05 |
2023-04-18 |
Pf Medicament |
Combinacion de encorafenib y binimetinib a manera de tratamiento adyuvante contra melanoma resecado en etapa ii.
|
|
TW202237119A
(zh)
|
2020-12-10 |
2022-10-01 |
美商住友製藥腫瘤公司 |
Alk﹘5抑制劑和彼之用途
|
|
CN112759552A
(zh)
*
|
2020-12-31 |
2021-05-07 |
武汉九州钰民医药科技有限公司 |
司美替尼的合成方法
|
|
CN112679438A
(zh)
*
|
2020-12-31 |
2021-04-20 |
武汉九州钰民医药科技有限公司 |
制备司美替尼的方法
|
|
US12141240B2
(en)
|
2021-01-20 |
2024-11-12 |
Rutgers, The State University Of New Jersey |
Method of calibration using master calibration function
|
|
CA3205523A1
(en)
*
|
2021-01-21 |
2022-07-28 |
Michael Houghton |
Processes for preparing pyrrolopyridine-aniline compounds
|
|
KR20230137393A
(ko)
|
2021-01-28 |
2023-10-04 |
얀센 바이오테크 인코포레이티드 |
Psma 결합 단백질 및 이의 용도
|
|
CN117794929A
(zh)
|
2021-02-02 |
2024-03-29 |
法国施维雅药厂 |
选择性bcl-xl protac化合物及使用方法
|
|
CN117321418A
(zh)
|
2021-03-18 |
2023-12-29 |
诺华股份有限公司 |
癌症生物标志物及其使用方法
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
KR102868758B1
(ko)
|
2021-04-13 |
2025-10-14 |
뉴베일런트, 아이엔씨. |
Egfr 돌연변이를 지니는 암을 치료하기 위한 아미노-치환된 헤테로사이클
|
|
US20240207257A1
(en)
*
|
2021-04-15 |
2024-06-27 |
Ideaya Biosciences, Inc. |
Combination therapy comprising a pkc inhibitor and a mek inhibitor
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
US12280055B2
(en)
|
2021-05-27 |
2025-04-22 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
IL307964A
(en)
|
2021-06-09 |
2023-12-01 |
Chugai Pharmaceutical Co Ltd |
Combined treatment for cancer
|
|
WO2022262699A1
(zh)
*
|
2021-06-17 |
2022-12-22 |
深圳市塔吉瑞生物医药有限公司 |
取代的苯并咪唑类化合物及包含该化合物的组合物及其用途
|
|
EP4367112A1
(en)
|
2021-07-09 |
2024-05-15 |
Plexium, Inc. |
Aryl compounds and pharmaceutical compositions that modulate ikzf2
|
|
CN118201615A
(zh)
|
2021-11-04 |
2024-06-14 |
豪夫迈·罗氏有限公司 |
喹唑啉酮化合物用于治疗癌症的新用途
|
|
WO2023084489A1
(en)
|
2021-11-15 |
2023-05-19 |
Pfizer Inc. |
Methods of treating coronavirus disease 2019
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|
|
CA3256012A1
(en)
|
2022-05-20 |
2023-11-23 |
Les Laboratoires Servier |
ANTIBODY-DRUG CONJUGATES, MET INHIBITORS BCL-XL, AND THEIR METHODS OF USE
|
|
EP4525925A1
(en)
|
2022-05-20 |
2025-03-26 |
Novartis AG |
Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
WO2023238000A1
(en)
*
|
2022-06-06 |
2023-12-14 |
Glenmark Life Sciences Limited |
Process for preparation of selumetinib and salts thereof
|
|
WO2024105144A1
(en)
|
2022-11-18 |
2024-05-23 |
F. Hoffmann-La Roche Ag |
Quinazolinone compound as braf inhibitor for the treatment of advanced solid cancer or metastases
|
|
KR20250160354A
(ko)
|
2023-03-10 |
2025-11-12 |
노파르티스 아게 |
Panras 억제제 항체-약물 콘쥬게이트 및 이의 사용 방법
|
|
JPWO2024209717A1
(show.php)
|
2023-04-06 |
2024-10-10 |
|
|
|
WO2025073765A1
(en)
|
2023-10-03 |
2025-04-10 |
Institut National de la Santé et de la Recherche Médicale |
Methods of prognosis and treatment of patients suffering from melanoma
|
|
WO2025111450A1
(en)
|
2023-11-22 |
2025-05-30 |
Les Laboratoires Servier |
Anti-cd74 antibody-drug conjugates and methods of use thereof
|
|
FR3159741A1
(fr)
|
2024-03-04 |
2025-09-05 |
Pierre Fabre Medicament |
Formulation topique comprenant du binimetinib
|
|
WO2025215536A1
(en)
|
2024-04-10 |
2025-10-16 |
Novartis Ag |
Macrocyclic panras inhibitors for the treatment of cancer
|
|
PL248506B1
(pl)
*
|
2025-01-27 |
2025-12-22 |
Lubelska Polt |
Kompozytowa konstrukcja przekładkowa
|
|
PL451046A1
(pl)
*
|
2025-01-27 |
2025-06-09 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451050A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451047A1
(pl)
*
|
2025-01-27 |
2025-08-18 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451049A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451048A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|