DE602007009663D1 - Pyridonsulfonamide und pyridonsulfamide als mek-hemmer - Google Patents
Pyridonsulfonamide und pyridonsulfamide als mek-hemmerInfo
- Publication number
- DE602007009663D1 DE602007009663D1 DE602007009663T DE602007009663T DE602007009663D1 DE 602007009663 D1 DE602007009663 D1 DE 602007009663D1 DE 602007009663 T DE602007009663 T DE 602007009663T DE 602007009663 T DE602007009663 T DE 602007009663T DE 602007009663 D1 DE602007009663 D1 DE 602007009663D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridenesulfamides
- sulphonamides
- pyridone
- mek inhibitors
- mek
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 PYRIDONE SULPHONAMIDES Chemical class 0.000 title abstract 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XSJZFXKWCCMFKJ-UHFFFAOYSA-N O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 Chemical class O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 XSJZFXKWCCMFKJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79312906P | 2006-04-18 | 2006-04-18 | |
PCT/US2007/066894 WO2007121481A2 (en) | 2006-04-18 | 2007-04-18 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007009663D1 true DE602007009663D1 (de) | 2010-11-18 |
Family
ID=38610466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007009663T Active DE602007009663D1 (de) | 2006-04-18 | 2007-04-18 | Pyridonsulfonamide und pyridonsulfamide als mek-hemmer |
Country Status (16)
Country | Link |
---|---|
US (2) | US7897624B2 (de) |
EP (1) | EP2012786B1 (de) |
JP (1) | JP5269762B2 (de) |
KR (1) | KR101391461B1 (de) |
CN (1) | CN101454004B (de) |
AT (1) | ATE483463T1 (de) |
AU (1) | AU2007237901B2 (de) |
BR (1) | BRPI0710817A2 (de) |
CA (1) | CA2649122C (de) |
DE (1) | DE602007009663D1 (de) |
EA (1) | EA016674B1 (de) |
ES (1) | ES2354182T3 (de) |
HK (1) | HK1128617A1 (de) |
IL (1) | IL194595A (de) |
MX (1) | MX2008013097A (de) |
WO (1) | WO2007121481A2 (de) |
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US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
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US8648116B2 (en) * | 2005-07-21 | 2014-02-11 | Ardea Biosciences, Inc. | Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same |
WO2007121269A2 (en) | 2006-04-11 | 2007-10-25 | Ardea Biosciences, Inc. | N-aryl-n'alkyl sulfamides as mek inhibitors |
JP5269762B2 (ja) | 2006-04-18 | 2013-08-21 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Mek阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド |
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PE20100747A1 (es) * | 2008-04-21 | 2010-11-03 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
BRPI0916566B8 (pt) | 2008-08-04 | 2021-05-25 | Merck Patent Ges Mit Beschraenkter Haftung | isonicotinamida fenilamina, seu uso, composição farmacêutica, e kit |
EP2370568B1 (de) | 2008-12-10 | 2017-07-19 | Dana-Farber Cancer Institute, Inc. | Mek mutanten mit resistenz gegen mek inhibitoren |
UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
CN106478496A (zh) * | 2009-03-27 | 2017-03-08 | 阿迪生物科学公司 | 作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺 |
CN102459188A (zh) * | 2009-06-15 | 2012-05-16 | 凯美隆(北京)药业技术有限公司 | 新型6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
TWI524890B (zh) | 2009-07-24 | 2016-03-11 | 亞德生化公司 | (r)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺及(s)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺之製備 |
US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
KR20120094165A (ko) | 2009-10-13 | 2012-08-23 | 알로스팀 테라퓨틱스 엘엘씨 | 질병의 치료에 유용한 신규 mek 억제제 |
BR112012010519A2 (pt) | 2009-11-04 | 2017-12-05 | Novartis Ag | derivados de sulfonamida heterocíclicos |
AU2011221227B2 (en) | 2010-02-25 | 2015-07-09 | Dana-Farber Cancer Institute, Inc. | BRAF mutations conferring resistance to BRAF inhibitors |
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CN102358730A (zh) * | 2011-08-24 | 2012-02-22 | 济南赛文医药技术有限公司 | 一种小分子mek蛋白激酶抑制剂 |
CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
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- 2007-04-18 AT AT07760859T patent/ATE483463T1/de not_active IP Right Cessation
- 2007-04-18 MX MX2008013097A patent/MX2008013097A/es active IP Right Grant
- 2007-04-18 AU AU2007237901A patent/AU2007237901B2/en not_active Ceased
- 2007-04-18 EP EP07760859A patent/EP2012786B1/de active Active
- 2007-04-18 EA EA200870446A patent/EA016674B1/ru not_active IP Right Cessation
- 2007-04-18 ES ES07760859T patent/ES2354182T3/es active Active
- 2007-04-18 WO PCT/US2007/066894 patent/WO2007121481A2/en active Application Filing
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Also Published As
Publication number | Publication date |
---|---|
ATE483463T1 (de) | 2010-10-15 |
US8716318B2 (en) | 2014-05-06 |
HK1128617A1 (en) | 2009-11-06 |
EA200870446A1 (ru) | 2009-04-28 |
ES2354182T3 (es) | 2011-03-10 |
EP2012786A4 (de) | 2010-02-24 |
AU2007237901B2 (en) | 2012-07-05 |
CA2649122A1 (en) | 2007-10-25 |
US20070244164A1 (en) | 2007-10-18 |
CN101454004A (zh) | 2009-06-10 |
BRPI0710817A2 (pt) | 2011-08-23 |
AU2007237901A1 (en) | 2007-10-25 |
EP2012786A2 (de) | 2009-01-14 |
WO2007121481A8 (en) | 2008-10-16 |
US7897624B2 (en) | 2011-03-01 |
KR101391461B1 (ko) | 2014-05-07 |
WO2007121481A3 (en) | 2008-05-22 |
CN101454004B (zh) | 2013-12-04 |
KR20090005193A (ko) | 2009-01-12 |
IL194595A (en) | 2015-04-30 |
WO2007121481A2 (en) | 2007-10-25 |
EP2012786B1 (de) | 2010-10-06 |
MX2008013097A (es) | 2008-10-27 |
US20110112152A1 (en) | 2011-05-12 |
JP5269762B2 (ja) | 2013-08-21 |
EA016674B1 (ru) | 2012-06-29 |
CA2649122C (en) | 2015-06-30 |
JP2009534408A (ja) | 2009-09-24 |
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