HK1128617A1 - Pyridone sulfonamides and pyridone sulfamides as mek inhibitors - Google Patents
Pyridone sulfonamides and pyridone sulfamides as mek inhibitorsInfo
- Publication number
- HK1128617A1 HK1128617A1 HK09106325.4A HK09106325A HK1128617A1 HK 1128617 A1 HK1128617 A1 HK 1128617A1 HK 09106325 A HK09106325 A HK 09106325A HK 1128617 A1 HK1128617 A1 HK 1128617A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyridone
- sulfonamides
- sulfamides
- mek inhibitors
- mek
- Prior art date
Links
- -1 Pyridone sulfonamides Chemical class 0.000 title abstract 2
- PDXBRFRMFLTHPE-UHFFFAOYSA-N 1H-pyridin-2-one sulfamide Chemical class NS(N)(=O)=O.O=C1C=CC=CN1 PDXBRFRMFLTHPE-UHFFFAOYSA-N 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XSJZFXKWCCMFKJ-UHFFFAOYSA-N O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 Chemical class O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 XSJZFXKWCCMFKJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79312906P | 2006-04-18 | 2006-04-18 | |
PCT/US2007/066894 WO2007121481A2 (en) | 2006-04-18 | 2007-04-18 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1128617A1 true HK1128617A1 (en) | 2009-11-06 |
Family
ID=38610466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09106325.4A HK1128617A1 (en) | 2006-04-18 | 2009-07-14 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Country Status (16)
Country | Link |
---|---|
US (2) | US7897624B2 (xx) |
EP (1) | EP2012786B1 (xx) |
JP (1) | JP5269762B2 (xx) |
KR (1) | KR101391461B1 (xx) |
CN (1) | CN101454004B (xx) |
AT (1) | ATE483463T1 (xx) |
AU (1) | AU2007237901B2 (xx) |
BR (1) | BRPI0710817A2 (xx) |
CA (1) | CA2649122C (xx) |
DE (1) | DE602007009663D1 (xx) |
EA (1) | EA016674B1 (xx) |
ES (1) | ES2354182T3 (xx) |
HK (1) | HK1128617A1 (xx) |
IL (1) | IL194595A (xx) |
MX (1) | MX2008013097A (xx) |
WO (1) | WO2007121481A2 (xx) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA05002070A (es) * | 2002-08-23 | 2005-07-05 | Ribapharm Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
JP5269762B2 (ja) | 2006-04-18 | 2013-08-21 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Mek阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド |
US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
CA2924418A1 (en) * | 2007-07-30 | 2009-02-05 | Jean-Michel Vernier | Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same |
AR071587A1 (es) * | 2008-04-21 | 2010-06-30 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
ES2560878T3 (es) | 2008-08-04 | 2016-02-23 | Merck Patent Gmbh | Compuestos novedosos de fenilamino-isonicotinamida |
WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
WO2010108652A1 (en) * | 2009-03-27 | 2010-09-30 | Ardea Biosciences Inc. | Dihydropyridin sulfonamides and dihydropyridin sulfamides as mek inhibitors |
CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
CN102459188A (zh) * | 2009-06-15 | 2012-05-16 | 凯美隆(北京)药业技术有限公司 | 新型6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
TWI524890B (zh) | 2009-07-24 | 2016-03-11 | 亞德生化公司 | (r)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺及(s)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺之製備 |
US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
JP5892612B2 (ja) | 2009-10-13 | 2016-03-23 | アロメック セラピューティクス エルエルシーAllomek Therapeutics Llc | 疾患の処置に有用な新規のmek阻害剤 |
ES2487628T3 (es) * | 2009-11-04 | 2014-08-22 | Novartis Ag | Derivados de sulfonamida heterocíclica útiles como inhibidores de MEK |
BR112012021411A2 (pt) | 2010-02-25 | 2017-04-18 | Dana Farber Cancer Inst Inc | mutações braf que conferem resistência a inibidores braf. |
EA030276B1 (ru) | 2010-03-09 | 2018-07-31 | Дана-Фарбер Кэнсер Инститьют, Инк. | Способы идентификации страдающих раком пациентов и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака |
EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
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EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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EP2012786A4 (en) | 2010-02-24 |
BRPI0710817A2 (pt) | 2011-08-23 |
US20110112152A1 (en) | 2011-05-12 |
IL194595A (en) | 2015-04-30 |
EP2012786B1 (en) | 2010-10-06 |
ES2354182T3 (es) | 2011-03-10 |
EP2012786A2 (en) | 2009-01-14 |
AU2007237901A1 (en) | 2007-10-25 |
KR20090005193A (ko) | 2009-01-12 |
ATE483463T1 (de) | 2010-10-15 |
WO2007121481A3 (en) | 2008-05-22 |
EA200870446A1 (ru) | 2009-04-28 |
US7897624B2 (en) | 2011-03-01 |
US20070244164A1 (en) | 2007-10-18 |
DE602007009663D1 (de) | 2010-11-18 |
WO2007121481A2 (en) | 2007-10-25 |
WO2007121481A8 (en) | 2008-10-16 |
CN101454004A (zh) | 2009-06-10 |
KR101391461B1 (ko) | 2014-05-07 |
CA2649122A1 (en) | 2007-10-25 |
MX2008013097A (es) | 2008-10-27 |
JP2009534408A (ja) | 2009-09-24 |
EA016674B1 (ru) | 2012-06-29 |
CN101454004B (zh) | 2013-12-04 |
CA2649122C (en) | 2015-06-30 |
US8716318B2 (en) | 2014-05-06 |
AU2007237901B2 (en) | 2012-07-05 |
JP5269762B2 (ja) | 2013-08-21 |
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