HK1128617A1 - Pyridone sulfonamides and pyridone sulfamides as mek inhibitors - Google Patents
Pyridone sulfonamides and pyridone sulfamides as mek inhibitorsInfo
- Publication number
- HK1128617A1 HK1128617A1 HK09106325.4A HK09106325A HK1128617A1 HK 1128617 A1 HK1128617 A1 HK 1128617A1 HK 09106325 A HK09106325 A HK 09106325A HK 1128617 A1 HK1128617 A1 HK 1128617A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyridone
- sulfonamides
- sulfamides
- mek inhibitors
- mek
- Prior art date
Links
- -1 Pyridone sulfonamides Chemical class 0.000 title abstract 2
- PDXBRFRMFLTHPE-UHFFFAOYSA-N 1H-pyridin-2-one sulfamide Chemical class NS(N)(=O)=O.O=C1C=CC=CN1 PDXBRFRMFLTHPE-UHFFFAOYSA-N 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XSJZFXKWCCMFKJ-UHFFFAOYSA-N O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 Chemical class O=S(=O)NC1=CC=CNC1NC1=CC=CC=C1 XSJZFXKWCCMFKJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79312906P | 2006-04-18 | 2006-04-18 | |
PCT/US2007/066894 WO2007121481A2 (en) | 2006-04-18 | 2007-04-18 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1128617A1 true HK1128617A1 (en) | 2009-11-06 |
Family
ID=38610466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09106325.4A HK1128617A1 (en) | 2006-04-18 | 2009-07-14 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
Country Status (16)
Country | Link |
---|---|
US (2) | US7897624B2 (de) |
EP (1) | EP2012786B1 (de) |
JP (1) | JP5269762B2 (de) |
KR (1) | KR101391461B1 (de) |
CN (1) | CN101454004B (de) |
AT (1) | ATE483463T1 (de) |
AU (1) | AU2007237901B2 (de) |
BR (1) | BRPI0710817A2 (de) |
CA (1) | CA2649122C (de) |
DE (1) | DE602007009663D1 (de) |
EA (1) | EA016674B1 (de) |
ES (1) | ES2354182T3 (de) |
HK (1) | HK1128617A1 (de) |
IL (1) | IL194595A (de) |
MX (1) | MX2008013097A (de) |
WO (1) | WO2007121481A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003295324B2 (en) * | 2002-08-23 | 2008-08-28 | Ardea Biosciences,Inc. | Non-nucleoside reverse transcriptase inhibitors |
US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
WO2007121269A2 (en) | 2006-04-11 | 2007-10-25 | Ardea Biosciences, Inc. | N-aryl-n'alkyl sulfamides as mek inhibitors |
ATE483463T1 (de) | 2006-04-18 | 2010-10-15 | Ardea Biosciences Inc | Pyridonsulfonamide und pyridonsulfamide als mek- hemmer |
US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
JP5479337B2 (ja) * | 2007-07-30 | 2014-04-23 | アルディア バイオサイエンス,インク. | Mek阻害剤およびrafキナーゼ阻害剤の組み合わせ、ならびにその使用 |
AR071587A1 (es) * | 2008-04-21 | 2010-06-30 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
UA107183C2 (uk) | 2008-08-04 | 2014-12-10 | Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань | |
JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Mek阻害剤に対する耐性を付与するmek突然変異 |
UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
US8673919B2 (en) | 2009-03-27 | 2014-03-18 | Ardea Biosciences, Inc. | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors |
CN102459188A (zh) * | 2009-06-15 | 2012-05-16 | 凯美隆(北京)药业技术有限公司 | 新型6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
TWI524890B (zh) * | 2009-07-24 | 2016-03-11 | 亞德生化公司 | (r)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺及(s)-n-(3,4-二氟-2-(2-氟-4-碘苯胺基)-6-甲氧基苯基)-1-(2,3-二羥丙基)環丙烷-1-磺醯胺之製備 |
US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
EP2488507B1 (de) | 2009-10-13 | 2014-12-17 | Allostem Therapeutics LLC | Neue mek-hemmer zur behandlung von diabetes |
EP2496575B1 (de) | 2009-11-04 | 2014-04-30 | Novartis AG | Heterocyclische sulfonamidderivate als mek-hemmer |
US8637246B2 (en) | 2010-02-25 | 2014-01-28 | Dana-Farber Cancer Institute, Inc. | BRAF mutations conferring resistance to BRAF inhibitors |
ES2714875T3 (es) | 2010-03-09 | 2019-05-30 | Dana Farber Cancer Inst Inc | Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer |
CA2806734A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
CN102358730A (zh) * | 2011-08-24 | 2012-02-22 | 济南赛文医药技术有限公司 | 一种小分子mek蛋白激酶抑制剂 |
CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
EP3249054A1 (de) | 2012-12-20 | 2017-11-29 | Biomatrica, INC. | Formulierungen und verfahren zur stabilisierung von pcr-reagenzien |
WO2015002729A2 (en) | 2013-06-13 | 2015-01-08 | Biomatrica, Inc. | Cell stabilization |
ES2786373T3 (es) | 2014-06-10 | 2020-10-09 | Biomatrica Inc | Estabilización de trombocitos a temperaturas ambiente |
WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
BR112018011639A2 (pt) | 2015-12-08 | 2018-11-27 | Biomatrica Inc | redução de taxa de sedimentação de eritrócitos |
US10366774B2 (en) | 2016-09-27 | 2019-07-30 | Spin Memory, Inc. | Device with dynamic redundancy registers |
US10489245B2 (en) | 2017-10-24 | 2019-11-26 | Spin Memory, Inc. | Forcing stuck bits, waterfall bits, shunt bits and low TMR bits to short during testing and using on-the-fly bit failure detection and bit redundancy remapping techniques to correct them |
US10411185B1 (en) | 2018-05-30 | 2019-09-10 | Spin Memory, Inc. | Process for creating a high density magnetic tunnel junction array test platform |
BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5596008A (en) * | 1995-02-10 | 1997-01-21 | G. D. Searle & Co. | 3,4-Diaryl substituted pyridines for the treatment of inflammation |
US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
ES2153031T4 (es) | 1995-04-20 | 2001-05-16 | Pfizer | Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf. |
PT780386E (pt) | 1995-12-20 | 2003-02-28 | Hoffmann La Roche | Inibidores de metaloprotease de matriz |
EP0818442A3 (de) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclische Sulphonderivate als Metalloproteinase-Inhibitoren und zur Hemmung der Produktion von Tumornekrosefaktor |
DK0923585T3 (da) | 1996-07-18 | 2002-07-01 | Pfizer | Phosphinatbaserede inhibitorer af matrixmetalloproteinaser |
BR9711223A (pt) | 1996-08-23 | 1999-08-17 | Pfizer | Derivados de cido arilsulfonilamino-hidrox mico |
DE69730151T2 (de) | 1997-01-06 | 2005-08-04 | Pfizer Inc. | Cyclische sulfonderivate |
DE69817801T2 (de) | 1997-02-03 | 2004-03-11 | Pfizer Products Inc., Groton | Arylsulfonylhydroxamsäurederivate |
AU5493598A (en) | 1997-02-07 | 1998-08-26 | Pfizer Inc. | N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases |
HUP0000657A3 (en) | 1997-02-11 | 2000-10-30 | Pfizer | N-arylsulfonyl-piperidine, -morpholine hydroxamic acid derivatives and pharmaceutical compositions containing them |
US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
DE69822839T2 (de) | 1997-08-08 | 2004-08-19 | Pfizer Products Inc., Groton | Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
DE69915004T2 (de) | 1998-11-05 | 2004-09-09 | Pfizer Products Inc., Groton | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate |
US6511993B1 (en) * | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
GB9912961D0 (en) | 1999-06-03 | 1999-08-04 | Pfizer Ltd | Metalloprotease inhibitors |
NZ525016A (en) * | 2000-09-15 | 2004-10-29 | Vertex Pharma | Isoxazoles and their use as inhibitors of ERK |
JP2004514718A (ja) * | 2000-11-02 | 2004-05-20 | アストラゼネカ アクチボラグ | 抗癌剤としての置換キノリン類 |
TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
ES2335276T3 (es) * | 2002-03-13 | 2010-03-24 | Array Biopharma, Inc. | Derivados de bencimidazol alquilado n3 como inhibidores de mek. |
US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
WO2004011461A1 (en) * | 2002-07-25 | 2004-02-05 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
JP2005162727A (ja) * | 2003-03-18 | 2005-06-23 | Sankyo Co Ltd | スルファミド誘導体及びその医薬組成物 |
MXPA06005657A (es) * | 2003-11-19 | 2006-08-23 | Array Biopharma Inc | Inhibidores heterociclicos de mek y metodos para usarlos. |
JP2006083137A (ja) * | 2004-09-17 | 2006-03-30 | Sankyo Co Ltd | 免疫抑制剤 |
JP2006083133A (ja) * | 2004-09-17 | 2006-03-30 | Sankyo Co Ltd | スルファミド誘導体医薬組成物 |
US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
ATE483463T1 (de) | 2006-04-18 | 2010-10-15 | Ardea Biosciences Inc | Pyridonsulfonamide und pyridonsulfamide als mek- hemmer |
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2007
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- 2008-11-18 KR KR1020087028158A patent/KR101391461B1/ko not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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CA2649122C (en) | 2015-06-30 |
WO2007121481A8 (en) | 2008-10-16 |
JP2009534408A (ja) | 2009-09-24 |
EP2012786A2 (de) | 2009-01-14 |
EP2012786B1 (de) | 2010-10-06 |
CN101454004B (zh) | 2013-12-04 |
US8716318B2 (en) | 2014-05-06 |
EA016674B1 (ru) | 2012-06-29 |
WO2007121481A3 (en) | 2008-05-22 |
EP2012786A4 (de) | 2010-02-24 |
WO2007121481A2 (en) | 2007-10-25 |
ES2354182T3 (es) | 2011-03-10 |
US20070244164A1 (en) | 2007-10-18 |
MX2008013097A (es) | 2008-10-27 |
KR101391461B1 (ko) | 2014-05-07 |
US20110112152A1 (en) | 2011-05-12 |
CA2649122A1 (en) | 2007-10-25 |
EA200870446A1 (ru) | 2009-04-28 |
DE602007009663D1 (de) | 2010-11-18 |
US7897624B2 (en) | 2011-03-01 |
IL194595A (en) | 2015-04-30 |
AU2007237901A1 (en) | 2007-10-25 |
ATE483463T1 (de) | 2010-10-15 |
JP5269762B2 (ja) | 2013-08-21 |
AU2007237901B2 (en) | 2012-07-05 |
BRPI0710817A2 (pt) | 2011-08-23 |
KR20090005193A (ko) | 2009-01-12 |
CN101454004A (zh) | 2009-06-10 |
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