JP2010529230A5 - - Google Patents
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- JP2010529230A5 JP2010529230A5 JP2010510483A JP2010510483A JP2010529230A5 JP 2010529230 A5 JP2010529230 A5 JP 2010529230A5 JP 2010510483 A JP2010510483 A JP 2010510483A JP 2010510483 A JP2010510483 A JP 2010510483A JP 2010529230 A5 JP2010529230 A5 JP 2010529230A5
- Authority
- JP
- Japan
- Prior art keywords
- silk fibroin
- gelation
- solution
- concentration
- salt solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108010022355 Fibroins Proteins 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 49
- 238000001879 gelation Methods 0.000 claims description 37
- 238000000527 sonication Methods 0.000 claims description 22
- 239000012266 salt solution Substances 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 19
- 239000000499 gel Substances 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 239000012620 biological material Substances 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 229910001414 potassium ion Inorganic materials 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 description 5
- 238000000692 Student's t-test Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002983 circular dichroism Methods 0.000 description 2
- 238000013382 DNA quantification Methods 0.000 description 1
- ZYFVNVRFVHJEIU-UHFFFAOYSA-N PicoGreen Chemical compound CN(C)CCCN(CCCN(C)C)C1=CC(=CC2=[N+](C3=CC=CC=C3S2)C)C2=CC=CC=C2N1C1=CC=CC=C1 ZYFVNVRFVHJEIU-UHFFFAOYSA-N 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000010850 salt effect Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94055407P | 2007-05-29 | 2007-05-29 | |
| PCT/US2008/065076 WO2008150861A1 (en) | 2007-05-29 | 2008-05-29 | Method for silk fibroin gelation using sonication |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015053556A Division JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529230A JP2010529230A (ja) | 2010-08-26 |
| JP2010529230A5 true JP2010529230A5 (enExample) | 2011-05-06 |
Family
ID=40094093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510483A Withdrawn JP2010529230A (ja) | 2007-05-29 | 2008-05-29 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
| JP2015053556A Active JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015053556A Active JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8187616B2 (enExample) |
| EP (1) | EP2211876B1 (enExample) |
| JP (2) | JP2010529230A (enExample) |
| KR (2) | KR101839659B1 (enExample) |
| CN (2) | CN104013598A (enExample) |
| AU (1) | AU2008260156B2 (enExample) |
| BR (1) | BRPI0813312A2 (enExample) |
| CA (1) | CA2688431C (enExample) |
| CY (1) | CY1116090T1 (enExample) |
| DK (1) | DK2211876T3 (enExample) |
| EA (1) | EA019118B1 (enExample) |
| ES (1) | ES2527125T3 (enExample) |
| HK (1) | HK1201470A1 (enExample) |
| HR (1) | HRP20141265T1 (enExample) |
| IL (1) | IL202354A (enExample) |
| MX (1) | MX2009012978A (enExample) |
| PL (1) | PL2211876T3 (enExample) |
| PT (1) | PT2211876E (enExample) |
| SI (1) | SI2211876T1 (enExample) |
| WO (1) | WO2008150861A1 (enExample) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6092337A (ja) * | 1983-10-26 | 1985-05-23 | Sekisui Plastics Co Ltd | 発泡フエノ−ル樹脂成形物の製造方法 |
| WO2004000915A2 (en) * | 2002-06-24 | 2003-12-31 | Tufts University | Silk biomaterials and methods of use thereof |
| US7842780B2 (en) | 2003-01-07 | 2010-11-30 | Trustees Of Tufts College | Silk fibroin materials and use thereof |
| EP3231846A1 (en) | 2003-04-10 | 2017-10-18 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
| WO2005000483A1 (en) * | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| EP2650907B1 (en) | 2004-06-04 | 2024-10-23 | The Board Of Trustees Of The University Of Illinois | Methods and devices for fabricating and assembling printable semiconductor elements |
| US8574461B2 (en) * | 2006-11-03 | 2013-11-05 | Tufts University | Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same |
| EP2101975A2 (en) | 2006-11-03 | 2009-09-23 | Trustees of Tufts College | Biopolymer sensor and method of manufacturing the same |
| US9969134B2 (en) | 2006-11-03 | 2018-05-15 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| JP2010522583A (ja) | 2007-02-27 | 2010-07-08 | トラスティーズ オブ タフツ カレッジ | 組織工学的に作製された絹製臓器 |
| EA019118B1 (ru) | 2007-05-29 | 2014-01-30 | Трастиз Оф Тафтс Колледж | Способ желатинизации фиброина шелка и регулирования времени желатинизации, способ инкапсуляции по меньшей мере одного компонента в фиброин шелка (варианты) |
| WO2009100280A2 (en) * | 2008-02-07 | 2009-08-13 | Trustees Of Tufts College | 3-dimensional silk hydroxyapatite compositions |
| GB0807868D0 (en) * | 2008-04-30 | 2008-06-04 | Knight David P | Cartilage repair material and a method for the preparation thereof |
| WO2009140588A1 (en) * | 2008-05-15 | 2009-11-19 | Trustees Of Tufts College | Silk polymer-based adenosine release: therapeutic potential for epilepsy |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| US8097926B2 (en) | 2008-10-07 | 2012-01-17 | Mc10, Inc. | Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy |
| US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
| US8372726B2 (en) | 2008-10-07 | 2013-02-12 | Mc10, Inc. | Methods and applications of non-planar imaging arrays |
| US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
| US9289132B2 (en) | 2008-10-07 | 2016-03-22 | Mc10, Inc. | Catheter balloon having stretchable integrated circuitry and sensor array |
| MX2011003618A (es) | 2008-10-09 | 2011-06-16 | Tufts College | Peliculas de seda modificadas que contienen glicerol. |
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| WO2011008842A2 (en) | 2009-07-14 | 2011-01-20 | Trustees Of Tufts College | Electrospun silk material systems for wound healing |
| US8779097B2 (en) * | 2009-07-31 | 2014-07-15 | Council Of Scientific & Industrial Research | Accelerated gelation of regenerated fibroin |
| JP2013506058A (ja) * | 2009-09-28 | 2013-02-21 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 延伸したシルクｅｇｅｌ繊維およびその製造方法 |
| IN2012DN02358A (enExample) | 2009-09-29 | 2015-08-21 | Tufts College | |
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| EP2513953B1 (en) | 2009-12-16 | 2017-10-18 | The Board of Trustees of the University of Illionis | Electrophysiology using conformal electronics |
| US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
| US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
| US9603971B2 (en) | 2010-03-05 | 2017-03-28 | Trustees Of Tufts College | Silk-based ionomeric compositions |
| CN104224171B (zh) | 2010-03-17 | 2017-06-09 | 伊利诺伊大学评议会 | 基于生物可吸收基质的可植入生物医学装置 |
| JP2013533754A (ja) | 2010-04-12 | 2013-08-29 | タフツ・ユニバーシティ | 絹電子部品 |
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- 2008-05-29 KR KR1020157020146A patent/KR101839659B1/ko active Active
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- 2008-05-29 CN CN200880100926.0A patent/CN101772348B/zh active Active
- 2008-05-29 CA CA2688431A patent/CA2688431C/en active Active
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