JP2010529230A5 - - Google Patents
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- JP2010529230A5 JP2010529230A5 JP2010510483A JP2010510483A JP2010529230A5 JP 2010529230 A5 JP2010529230 A5 JP 2010529230A5 JP 2010510483 A JP2010510483 A JP 2010510483A JP 2010510483 A JP2010510483 A JP 2010510483A JP 2010529230 A5 JP2010529230 A5 JP 2010529230A5
- Authority
- JP
- Japan
- Prior art keywords
- silk fibroin
- gelation
- solution
- concentration
- salt solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108010022355 Fibroins Proteins 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 49
- 238000001879 gelation Methods 0.000 claims description 37
- 238000000527 sonication Methods 0.000 claims description 22
- 239000012266 salt solution Substances 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 19
- 239000000499 gel Substances 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 239000012620 biological material Substances 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 229910001414 potassium ion Inorganic materials 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 description 5
- 238000000692 Student's t-test Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002983 circular dichroism Methods 0.000 description 2
- 238000013382 DNA quantification Methods 0.000 description 1
- ZYFVNVRFVHJEIU-UHFFFAOYSA-N PicoGreen Chemical compound CN(C)CCCN(CCCN(C)C)C1=CC(=CC2=[N+](C3=CC=CC=C3S2)C)C2=CC=CC=C2N1C1=CC=CC=C1 ZYFVNVRFVHJEIU-UHFFFAOYSA-N 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000010850 salt effect Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94055407P | 2007-05-29 | 2007-05-29 | |
| PCT/US2008/065076 WO2008150861A1 (en) | 2007-05-29 | 2008-05-29 | Method for silk fibroin gelation using sonication |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015053556A Division JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529230A JP2010529230A (ja) | 2010-08-26 |
| JP2010529230A5 true JP2010529230A5 (cg-RX-API-DMAC7.html) | 2011-05-06 |
Family
ID=40094093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510483A Withdrawn JP2010529230A (ja) | 2007-05-29 | 2008-05-29 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
| JP2015053556A Active JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015053556A Active JP6091540B2 (ja) | 2007-05-29 | 2015-03-17 | 音波処理を用いた絹フィブロインのゲル化のための方法 |
Country Status (20)
Families Citing this family (111)
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