JP2009530022A - 制御された治療薬送達のためのナノ多孔性コーティングを有する医療器具 - Google Patents
制御された治療薬送達のためのナノ多孔性コーティングを有する医療器具 Download PDFInfo
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Abstract
【選択図】図1
Description
Claims (26)
- 植え込み又は挿入可能な医療器具であり、
(a)陥没部を含む領域と、
(b)前記陥没部内の、第1治療薬を含む治療薬収容領域と、
(c)陥没部の上に配置され、陥没部と器具外部との間での分子種の輸送を調節するナノ多孔性領域とを含み、
前記医療器具が治療薬貯蔵部としてのその機能を超えた治療的役割を提供する医療器具。 - 前記領域が複数の陥没部を含む、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部が貫通孔又はスロットである、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部がめくら穴又は溝部である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部の最小横方向寸法が1000μm未満である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部の最小横方向寸法が100μm未満である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 陥没部が1より大きい又は1に等しいアスペクト比を有している、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部を含む前記領域が金属領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部を含む前記領域が高分子領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部を含む前記領域がシリコン領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記陥没部を含む前記領域がセラミック領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性領域がナノ多孔性高分子領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性領域がナノ多孔性金属領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性領域がナノ多孔性セラミック領域である、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性セラミック領域が、ナノ多孔性アルミナ領域、ナノ多孔性チタニア領域、及びナノ多孔性シリカ領域から選択される、請求項14に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性領域が平行な細孔構造を含む、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記ナノ多孔性領域が相互連結型細孔構造を含む、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記治療的機能が、機械的機能、電気的機能、熱的機能及び磁気的機能から選択される、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記器具が、カテーテル、ガイドワイヤ、バルーン、フィルタ、ステント、グラフト、ステントグラフト、血管アクセスポート、塞栓形成器具、心筋プラグ、パッチ、ペースメーカー、ペースメーカーリード、左心室補助器具、完全人工心臓、心臓弁、血管弁、吻合クリップ及びリング、及び組織再生工学スカホールドから選択される、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記医療器具が、冠血管系、末梢血管系、食道、気管、結腸、胆道、泌尿生殖器系、又は脳への植え込み又は挿入用に適合されている、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記医療器具がステントであり、前記陥没部を含む前記領域がステントストラットである、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記第1治療薬に加えて、更に材料を前記治療薬収容領域に含む、請求項1に記載の植え込み又は挿入可能な医療器具。
- 第2治療薬を前記治療薬収容領域に更に含む、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記治療薬が前記器具から放出される、請求項1に記載の植え込み又は挿入可能な医療器具。
- 前記放出がゼロ次放出である、請求項24に記載の植え込み又は挿入可能な医療器具。
- 前記治療薬が、抗血栓剤、抗増殖剤、抗炎症薬、抗遊走薬、細胞外基質産生及び組織化に影響する薬剤、抗腫瘍薬、抗有糸分裂薬、麻酔薬、抗血液凝固剤、血管細胞成長促進剤、血管細胞成長阻害薬、コレステロール降下薬、血管拡張剤、TGF−β上昇剤、及び内因性血管作動機構阻害剤から成る群の1つ以上から選択される、請求項1に記載の植え込み又は挿入可能な医療器具。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US11/388,604 | 2006-03-24 | ||
US11/388,604 US20070224235A1 (en) | 2006-03-24 | 2006-03-24 | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
PCT/US2007/004704 WO2007111801A2 (en) | 2006-03-24 | 2007-02-26 | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
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Publication Number | Publication Date |
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JP2009530022A true JP2009530022A (ja) | 2009-08-27 |
JP5424865B2 JP5424865B2 (ja) | 2014-02-26 |
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JP2009501430A Expired - Fee Related JP5424865B2 (ja) | 2006-03-24 | 2007-02-26 | 制御された治療薬送達のためのナノ多孔性コーティングを有する医療器具 |
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US (2) | US20070224235A1 (ja) |
EP (1) | EP2010241A2 (ja) |
JP (1) | JP5424865B2 (ja) |
CA (1) | CA2661456A1 (ja) |
WO (1) | WO2007111801A2 (ja) |
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Also Published As
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US20100233238A1 (en) | 2010-09-16 |
US20070224235A1 (en) | 2007-09-27 |
WO2007111801A2 (en) | 2007-10-04 |
EP2010241A2 (en) | 2009-01-07 |
CA2661456A1 (en) | 2007-10-04 |
WO2007111801A3 (en) | 2008-06-19 |
US8574615B2 (en) | 2013-11-05 |
JP5424865B2 (ja) | 2014-02-26 |
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