JP2009502115A - 小細胞肺癌の診断方法 - Google Patents
小細胞肺癌の診断方法 Download PDFInfo
- Publication number
- JP2009502115A JP2009502115A JP2008503310A JP2008503310A JP2009502115A JP 2009502115 A JP2009502115 A JP 2009502115A JP 2008503310 A JP2008503310 A JP 2008503310A JP 2008503310 A JP2008503310 A JP 2008503310A JP 2009502115 A JP2009502115 A JP 2009502115A
- Authority
- JP
- Japan
- Prior art keywords
- lung cancer
- sclc
- genes
- gene
- small cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010041067 Small cell lung cancer Diseases 0.000 title claims abstract description 559
- 208000000587 small cell lung carcinoma Diseases 0.000 title claims abstract description 529
- 238000002405 diagnostic procedure Methods 0.000 title abstract description 6
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 675
- 230000014509 gene expression Effects 0.000 claims abstract description 328
- 238000000034 method Methods 0.000 claims abstract description 221
- 208000020816 lung neoplasm Diseases 0.000 claims abstract description 156
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims abstract description 153
- 201000005202 lung cancer Diseases 0.000 claims abstract description 153
- 238000002512 chemotherapy Methods 0.000 claims abstract description 78
- 230000000694 effects Effects 0.000 claims abstract description 77
- 239000003550 marker Substances 0.000 claims abstract description 77
- 238000011282 treatment Methods 0.000 claims abstract description 61
- 238000012216 screening Methods 0.000 claims abstract description 47
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims abstract description 44
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims abstract description 44
- 210000004027 cell Anatomy 0.000 claims description 255
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 166
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 153
- 229920001184 polypeptide Polymers 0.000 claims description 149
- 102000004169 proteins and genes Human genes 0.000 claims description 131
- 150000007523 nucleic acids Chemical group 0.000 claims description 128
- 238000012360 testing method Methods 0.000 claims description 122
- 150000001875 compounds Chemical class 0.000 claims description 121
- 102000039446 nucleic acids Human genes 0.000 claims description 112
- 108020004707 nucleic acids Proteins 0.000 claims description 112
- 108020004459 Small interfering RNA Proteins 0.000 claims description 96
- 239000004055 small Interfering RNA Substances 0.000 claims description 85
- 239000000203 mixture Substances 0.000 claims description 73
- 239000000523 sample Substances 0.000 claims description 65
- 230000001105 regulatory effect Effects 0.000 claims description 64
- 239000002773 nucleotide Substances 0.000 claims description 63
- 125000003729 nucleotide group Chemical group 0.000 claims description 63
- 101000976649 Homo sapiens Zinc finger protein ZIC 5 Proteins 0.000 claims description 45
- 102100023494 Zinc finger protein ZIC 5 Human genes 0.000 claims description 45
- 230000000692 anti-sense effect Effects 0.000 claims description 43
- 239000003795 chemical substances by application Substances 0.000 claims description 39
- 102000040430 polynucleotide Human genes 0.000 claims description 37
- 108091033319 polynucleotide Proteins 0.000 claims description 37
- 239000002157 polynucleotide Substances 0.000 claims description 37
- 230000027455 binding Effects 0.000 claims description 30
- 239000013598 vector Substances 0.000 claims description 30
- 238000001514 detection method Methods 0.000 claims description 29
- 239000012634 fragment Substances 0.000 claims description 29
- 239000012472 biological sample Substances 0.000 claims description 28
- 230000000295 complement effect Effects 0.000 claims description 25
- 108091034117 Oligonucleotide Proteins 0.000 claims description 24
- 229960005486 vaccine Drugs 0.000 claims description 24
- 230000004071 biological effect Effects 0.000 claims description 23
- 230000001965 increasing effect Effects 0.000 claims description 22
- 108020004999 messenger RNA Proteins 0.000 claims description 21
- 230000007423 decrease Effects 0.000 claims description 20
- 108020004414 DNA Proteins 0.000 claims description 19
- 230000005809 anti-tumor immunity Effects 0.000 claims description 19
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 18
- 108091028664 Ribonucleotide Proteins 0.000 claims description 17
- 239000002336 ribonucleotide Substances 0.000 claims description 17
- 125000002652 ribonucleotide group Chemical group 0.000 claims description 17
- 108700008625 Reporter Genes Proteins 0.000 claims description 15
- 108091081021 Sense strand Proteins 0.000 claims description 15
- 210000002919 epithelial cell Anatomy 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 14
- 230000001939 inductive effect Effects 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 11
- 101000883798 Homo sapiens Probable ATP-dependent RNA helicase DDX53 Proteins 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 102100038236 Probable ATP-dependent RNA helicase DDX53 Human genes 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 230000003247 decreasing effect Effects 0.000 claims description 9
- 238000013518 transcription Methods 0.000 claims description 9
- 230000035897 transcription Effects 0.000 claims description 9
- 101100545268 Homo sapiens ZIC5 gene Proteins 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 8
- 230000002103 transcriptional effect Effects 0.000 claims description 7
- 238000001890 transfection Methods 0.000 claims description 6
- 108700026220 vif Genes Proteins 0.000 claims description 4
- 108091026890 Coding region Proteins 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 106
- 239000003814 drug Substances 0.000 abstract description 45
- 229940124597 therapeutic agent Drugs 0.000 abstract description 17
- 238000011269 treatment regimen Methods 0.000 abstract description 3
- 230000002411 adverse Effects 0.000 abstract description 2
- 201000011510 cancer Diseases 0.000 description 74
- 210000001519 tissue Anatomy 0.000 description 56
- 239000000047 product Substances 0.000 description 34
- 230000002401 inhibitory effect Effects 0.000 description 32
- 239000002299 complementary DNA Substances 0.000 description 27
- 229940079593 drug Drugs 0.000 description 26
- 230000001225 therapeutic effect Effects 0.000 description 24
- 239000000427 antigen Substances 0.000 description 20
- 108091007433 antigens Proteins 0.000 description 20
- 102000036639 antigens Human genes 0.000 description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- 238000004458 analytical method Methods 0.000 description 18
- 230000010261 cell growth Effects 0.000 description 18
- 229920002477 rna polymer Polymers 0.000 description 18
- 238000002493 microarray Methods 0.000 description 17
- 238000009472 formulation Methods 0.000 description 16
- 238000009396 hybridization Methods 0.000 description 16
- 208000024891 symptom Diseases 0.000 description 16
- 230000006870 function Effects 0.000 description 15
- 210000004072 lung Anatomy 0.000 description 15
- 210000001744 T-lymphocyte Anatomy 0.000 description 14
- 150000001413 amino acids Chemical class 0.000 description 14
- 239000002246 antineoplastic agent Substances 0.000 description 14
- 210000004443 dendritic cell Anatomy 0.000 description 14
- 201000010099 disease Diseases 0.000 description 14
- 239000007924 injection Substances 0.000 description 14
- 238000002347 injection Methods 0.000 description 14
- 238000002560 therapeutic procedure Methods 0.000 description 14
- 239000003826 tablet Substances 0.000 description 13
- 238000009169 immunotherapy Methods 0.000 description 12
- 238000004393 prognosis Methods 0.000 description 12
- 238000003757 reverse transcription PCR Methods 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 11
- 238000011161 development Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 10
- 238000004422 calculation algorithm Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 239000003112 inhibitor Substances 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 108090000994 Catalytic RNA Proteins 0.000 description 9
- 102000053642 Catalytic RNA Human genes 0.000 description 9
- 239000000074 antisense oligonucleotide Substances 0.000 description 9
- 238000012230 antisense oligonucleotides Methods 0.000 description 9
- 238000003556 assay Methods 0.000 description 9
- 238000000338 in vitro Methods 0.000 description 9
- 238000001727 in vivo Methods 0.000 description 9
- 230000006698 induction Effects 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 230000002829 reductive effect Effects 0.000 description 9
- 108091092562 ribozyme Proteins 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 238000000636 Northern blotting Methods 0.000 description 8
- 238000013459 approach Methods 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000002775 capsule Substances 0.000 description 8
- 238000002372 labelling Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000001531 micro-dissection Methods 0.000 description 8
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 7
- 239000013604 expression vector Substances 0.000 description 7
- 210000005265 lung cell Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 7
- 210000001550 testis Anatomy 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 108700020796 Oncogene Proteins 0.000 description 6
- 239000000556 agonist Substances 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 230000001413 cellular effect Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 239000002502 liposome Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 6
- 230000000750 progressive effect Effects 0.000 description 6
- 230000000069 prophylactic effect Effects 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 210000004881 tumor cell Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 229940041181 antineoplastic drug Drugs 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000004663 cell proliferation Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000013068 control sample Substances 0.000 description 5
- 238000012258 culturing Methods 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 5
- 102000037865 fusion proteins Human genes 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 5
- 238000001114 immunoprecipitation Methods 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000014616 translation Effects 0.000 description 5
- 201000009030 Carcinoma Diseases 0.000 description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- 101000873629 Homo sapiens Secretory carrier-associated membrane protein 5 Proteins 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 102100035894 Secretory carrier-associated membrane protein 5 Human genes 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 229940127089 cytotoxic agent Drugs 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 210000002865 immune cell Anatomy 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000007918 intramuscular administration Methods 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000000955 neuroendocrine Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 230000002062 proliferating effect Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- -1 small molecule compound Chemical class 0.000 description 4
- 210000003802 sputum Anatomy 0.000 description 4
- 208000024794 sputum Diseases 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 238000010561 standard procedure Methods 0.000 description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 238000013519 translation Methods 0.000 description 4
- 238000010396 two-hybrid screening Methods 0.000 description 4
- 108010085238 Actins Proteins 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 102100022812 DNA-binding protein RFX2 Human genes 0.000 description 3
- 102100032038 EH domain-containing protein 3 Human genes 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 3
- 102100024412 GTPase IMAP family member 4 Human genes 0.000 description 3
- 102100034230 Grainyhead-like protein 3 homolog Human genes 0.000 description 3
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 description 3
- 101000756799 Homo sapiens DNA-binding protein RFX2 Proteins 0.000 description 3
- 101000921212 Homo sapiens EH domain-containing protein 3 Proteins 0.000 description 3
- 101000833375 Homo sapiens GTPase IMAP family member 4 Proteins 0.000 description 3
- 101001069926 Homo sapiens Grainyhead-like protein 3 homolog Proteins 0.000 description 3
- 101001135094 Homo sapiens LIM domain transcription factor LMO4 Proteins 0.000 description 3
- 101001071230 Homo sapiens PHD finger protein 20 Proteins 0.000 description 3
- 101000650344 Homo sapiens RecQ-mediated genome instability protein 1 Proteins 0.000 description 3
- 101000800583 Homo sapiens Transcription factor 20 Proteins 0.000 description 3
- 102100033494 LIM domain transcription factor LMO4 Human genes 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 108060001084 Luciferase Proteins 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 102100036878 PHD finger protein 20 Human genes 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 102100027431 RecQ-mediated genome instability protein 1 Human genes 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 102100030838 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L Human genes 0.000 description 3
- 101710192270 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L Proteins 0.000 description 3
- 108091023040 Transcription factor Proteins 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 3
- 102100033142 Transcription factor 20 Human genes 0.000 description 3
- 238000001042 affinity chromatography Methods 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000007621 cluster analysis Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 238000001476 gene delivery Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000016784 immunoglobulin production Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 238000001001 laser micro-dissection Methods 0.000 description 3
- 208000037841 lung tumor Diseases 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 238000011275 oncology therapy Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000010839 reverse transcription Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000004565 tumor cell growth Effects 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 210000005253 yeast cell Anatomy 0.000 description 3
- 238000010600 3H thymidine incorporation assay Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- 102100026189 Beta-galactosidase Human genes 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 102000010792 Chromogranin A Human genes 0.000 description 2
- 108010038447 Chromogranin A Proteins 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 230000033616 DNA repair Effects 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
- 108700039887 Essential Genes Proteins 0.000 description 2
- 102100039556 Galectin-4 Human genes 0.000 description 2
- 102100025564 Glutamate-rich protein 3 Human genes 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 description 2
- 101001056890 Homo sapiens Glutamate-rich protein 3 Proteins 0.000 description 2
- 101001033715 Homo sapiens Insulinoma-associated protein 1 Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102100039091 Insulinoma-associated protein 1 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- 239000012097 Lipofectamine 2000 Substances 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 108091058545 Secretory proteins Proteins 0.000 description 2
- 102000040739 Secretory proteins Human genes 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 108091008874 T cell receptors Proteins 0.000 description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 108091023045 Untranslated Region Proteins 0.000 description 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
- HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 238000009566 cancer vaccine Methods 0.000 description 2
- 229940022399 cancer vaccine Drugs 0.000 description 2
- 229960004562 carboplatin Drugs 0.000 description 2
- YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 229960004316 cisplatin Drugs 0.000 description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 238000002224 dissection Methods 0.000 description 2
- 238000007459 endoscopic retrograde cholangiopancreatography Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000002991 immunohistochemical analysis Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 208000028830 lung neuroendocrine neoplasm Diseases 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 238000010208 microarray analysis Methods 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 208000029522 neoplastic syndrome Diseases 0.000 description 2
- 201000011519 neuroendocrine tumor Diseases 0.000 description 2
- 230000004766 neurogenesis Effects 0.000 description 2
- 238000003499 nucleic acid array Methods 0.000 description 2
- 102000026415 nucleotide binding proteins Human genes 0.000 description 2
- 108091014756 nucleotide binding proteins Proteins 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 230000002018 overexpression Effects 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 238000001558 permutation test Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 229960004641 rituximab Drugs 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 108091005703 transmembrane proteins Proteins 0.000 description 2
- 102000035160 transmembrane proteins Human genes 0.000 description 2
- 239000000439 tumor marker Substances 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 102000019719 zinc ion binding proteins Human genes 0.000 description 2
- 108091016308 zinc ion binding proteins Proteins 0.000 description 2
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- 108020005075 5S Ribosomal RNA Proteins 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 102100022142 Achaete-scute homolog 1 Human genes 0.000 description 1
- 102100022385 Activity-dependent neuroprotector homeobox protein Human genes 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- BMFMQGXDDJALKQ-BYPYZUCNSA-N Argininic acid Chemical compound NC(N)=NCCC[C@H](O)C(O)=O BMFMQGXDDJALKQ-BYPYZUCNSA-N 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091032955 Bacterial small RNA Proteins 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 102100024503 Centrosomal protein of 41 kDa Human genes 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 241001559589 Cullen Species 0.000 description 1
- 208000033485 Cushing syndrome due to ectopic ACTH secretion Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
- 108700020911 DNA-Binding Proteins Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101710202200 Endolysin A Proteins 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000195619 Euglena gracilis Species 0.000 description 1
- 244000059224 Gaultheria adenothrix Species 0.000 description 1
- 235000001721 Gaultheria adenothrix Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 101150009006 HIS3 gene Proteins 0.000 description 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 1
- 108010075704 HLA-A Antigens Proteins 0.000 description 1
- 108010013476 HLA-A24 Antigen Proteins 0.000 description 1
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 1
- 101000901099 Homo sapiens Achaete-scute homolog 1 Proteins 0.000 description 1
- 101000755474 Homo sapiens Activity-dependent neuroprotector homeobox protein Proteins 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101000981059 Homo sapiens Centrosomal protein of 41 kDa Proteins 0.000 description 1
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 1
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108010002586 Interleukin-7 Proteins 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 101100238610 Mus musculus Msh3 gene Proteins 0.000 description 1
- 206010028424 Myasthenic syndrome Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 102000003945 NF-kappa B Human genes 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010052399 Neuroendocrine tumour Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 101000622060 Photinus pyralis Luciferin 4-monooxygenase Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 102000014450 RNA Polymerase III Human genes 0.000 description 1
- 108010078067 RNA Polymerase III Proteins 0.000 description 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 238000010240 RT-PCR analysis Methods 0.000 description 1
- 241000269435 Rana <genus> Species 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 102100022056 Serum response factor Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 108020004688 Small Nuclear RNA Proteins 0.000 description 1
- 102000039471 Small Nuclear RNA Human genes 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 230000010632 Transcription Factor Activity Effects 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 108010004977 Vasopressins Proteins 0.000 description 1
- 102000002852 Vasopressins Human genes 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000037842 advanced-stage tumor Diseases 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229960004424 carbon dioxide Drugs 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 208000002458 carcinoid tumor Diseases 0.000 description 1
- 101150055766 cat gene Proteins 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 239000012568 clinical material Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 230000005757 colony formation Effects 0.000 description 1
- 238000010293 colony formation assay Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000010968 computed tomography angiography Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000006552 constitutive activation Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
- 230000009274 differential gene expression Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 201000002091 ectopic Cushing syndrome Diseases 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- 230000030279 gene silencing Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229940022353 herceptin Drugs 0.000 description 1
- 238000007417 hierarchical cluster analysis Methods 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000013090 high-throughput technology Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 102000053563 human MYC Human genes 0.000 description 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
- 229960001101 ifosfamide Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical class C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000011532 immunohistochemical staining Methods 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 101150066555 lacZ gene Proteins 0.000 description 1
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000002794 lymphocyte assay Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 238000011242 molecular targeted therapy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000002887 multiple sequence alignment Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 description 1
- 208000016065 neuroendocrine neoplasm Diseases 0.000 description 1
- 230000007658 neurological function Effects 0.000 description 1
- 230000003955 neuronal function Effects 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000001225 nuclear magnetic resonance method Methods 0.000 description 1
- 238000007826 nucleic acid assay Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 238000010397 one-hybrid screening Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 229960001309 procaine hydrochloride Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 230000022983 regulation of cell cycle Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- 108010008790 ribosomal phosphoprotein P1 Proteins 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000009131 signaling function Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 238000011255 standard chemotherapy Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003696 structure analysis method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000003160 two-hybrid assay Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- WQAJKOXBERTWBK-UHFFFAOYSA-N verdine Natural products CC1CNC2C(C1)OC3(CCC4C5CCC6(O)CC(O)CC(O)C6(C)C5C(=O)C4=C3C)C2C WQAJKOXBERTWBK-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70319205P | 2005-07-27 | 2005-07-27 | |
| US79996106P | 2006-05-11 | 2006-05-11 | |
| PCT/JP2006/315254 WO2007013665A2 (en) | 2005-07-27 | 2006-07-26 | Method of diagnosing small cell lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502115A true JP2009502115A (ja) | 2009-01-29 |
| JP2009502115A5 JP2009502115A5 (enExample) | 2009-09-10 |
Family
ID=37398410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503310A Ceased JP2009502115A (ja) | 2005-07-27 | 2006-07-26 | 小細胞肺癌の診断方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090317392A1 (enExample) |
| EP (6) | EP2336316A1 (enExample) |
| JP (1) | JP2009502115A (enExample) |
| CN (1) | CN101283106A (enExample) |
| WO (1) | WO2007013665A2 (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012522488A (ja) * | 2009-04-01 | 2012-09-27 | オンコセラピー・サイエンス株式会社 | C6orf167ペプチドおよびそれを含むワクチン |
| JP2014520555A (ja) * | 2011-07-14 | 2014-08-25 | ナショナル ヘルス リサーチ インスティテューツ | Glk介在疾患の治療薬同定方法、および、glk介在疾患判定方法 |
| WO2015012175A1 (ja) * | 2013-07-22 | 2015-01-29 | 学校法人関西医科大学 | 小細胞肺がんの診断薬及び治療薬 |
| JP2015536933A (ja) * | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| JP2016531915A (ja) * | 2013-08-28 | 2016-10-13 | ステムセントリックス, インコーポレイテッド | 部位特異的抗体コンジュゲーション方法および組成物 |
| WO2016178374A1 (ja) * | 2015-05-01 | 2016-11-10 | 国立研究開発法人科学技術振興機構 | 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤 |
| JP2016538318A (ja) * | 2013-08-28 | 2016-12-08 | ステムセントリックス, インコーポレイテッド | 新規sez6モジュレーターおよび使用方法 |
| JP2018525437A (ja) * | 2015-07-25 | 2018-09-06 | ハビブ・フロストHabib FROST | がんおよび他の病的状態における治療または治癒を提供する、システム、デバイスおよび方法 |
| WO2020022361A1 (ja) * | 2018-07-24 | 2020-01-30 | 公立大学法人福島県立医科大学 | 肺癌の予後バイオマーカー |
| WO2021241527A1 (ja) * | 2020-05-25 | 2021-12-02 | 国立大学法人東海国立大学機構 | 非小細胞肺がんの化学療法の効果を予測するための情報を提供する方法および情報提供用キット、非小細胞肺がんの化学療法の効果を予測する方法、非小細胞肺がんの化学療法の効果を予測する予測装置、予測装置のプログラムおよび記録媒体 |
| JP2023504334A (ja) * | 2019-08-26 | 2023-02-03 | リキッド ラング ディーエックス | 肺がんの診断のためのバイオマーカー |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2007099852A1 (ja) * | 2006-02-23 | 2009-07-16 | 国立大学法人金沢大学 | 固形癌のチロシンキナーゼ阻害剤に対する感受性を検査する方法及び検査キット |
| EP2423333A1 (en) * | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| ES2625259T3 (es) * | 2006-08-29 | 2017-07-19 | Oxford Biotherapeutics Ltd | Identificación de proteína asociada con carcinoma hepatocelular, glioblastoma y cáncer de pulmón |
| EP2476699B1 (en) | 2006-10-17 | 2015-06-17 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing DEPDC1 polypeptides |
| TW200908998A (en) * | 2007-06-27 | 2009-03-01 | Oncotherapy Science Inc | Compositions and methods of treating cancer |
| US8598125B2 (en) * | 2007-08-20 | 2013-12-03 | Onco Therapy Science, Inc. | CDCA1 peptide and pharmaceutical agent comprising the same |
| EP4032899A1 (en) | 2007-08-20 | 2022-07-27 | Oncotherapy Science, Inc. | Foxm1 peptide and medicinal agent comprising the same |
| WO2009028581A1 (en) * | 2007-08-24 | 2009-03-05 | Oncotherapy Science, Inc. | Cancer-related genes, cdca5, epha7, stk31 and wdhd1 |
| WO2009028580A1 (en) * | 2007-08-24 | 2009-03-05 | Oncotherapy Science, Inc. | Ebi3, dlx5, nptx1 and cdkn3 for target genes of lung cancer therapy and diagnosis |
| TW201000119A (en) * | 2008-06-10 | 2010-01-01 | Oncotherapy Science Inc | MYBL2 epitope peptides and vaccines containing the same |
| TW201000115A (en) * | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| TWI526219B (zh) * | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Cdca1抗原決定位胜肽及含此胜肽的疫苗 |
| WO2010007791A1 (en) * | 2008-07-16 | 2010-01-21 | Oncotherapy Science, Inc. | Ect2 oncogene as a therapeutic target and prognostic indicator for lung and esophageal cancer |
| TWI466680B (zh) | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Melk抗原決定位胜肽及含此胜肽的疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| JP2012501168A (ja) * | 2008-08-28 | 2012-01-19 | オンコセラピー・サイエンス株式会社 | 腫瘍マーカー及び癌に対する治療標的としてのtbc1d7 |
| CA2735148A1 (en) * | 2008-08-28 | 2010-03-04 | Oncotherapy Science, Inc. | Oip5 as a target gene for cancer therapy and diagnosis |
| US8975086B2 (en) * | 2008-08-28 | 2015-03-10 | Oncotherapy Science, Inc. | Method for treating or preventing bladder cancer using the DEPDC1 polypeptide |
| US10359425B2 (en) | 2008-09-09 | 2019-07-23 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
| CA2741399C (en) | 2008-10-22 | 2016-10-11 | Oncotherapy Science, Inc. | Rab6kifl/kif20a epitope peptide and vaccines containing the same |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
| GB0904382D0 (en) * | 2009-03-13 | 2009-04-29 | Univ Dundee | Treatment of cell proliferation and differentiation disorders |
| TW201102081A (en) | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| TWI507204B (zh) | 2009-05-26 | 2015-11-11 | Oncotherapy Science Inc | Cdc45l胜肽與含此胜肽之疫苗 |
| WO2011021386A1 (en) * | 2009-08-21 | 2011-02-24 | Oncotherapy Science, Inc. | Cstf2 for target genes of lung cancer therapy and diagnosis |
| CN102597235A (zh) * | 2009-08-24 | 2012-07-18 | 肿瘤疗法科学股份有限公司 | 肺癌和食管癌相关基因adamts18 |
| TWI485245B (zh) | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之melk胜肽及含此胜肽之疫苗 |
| TW201627003A (zh) | 2010-04-02 | 2016-08-01 | 腫瘤療法 科學股份有限公司 | Ect2胜肽及含此胜肽之疫苗 |
| CN102243240B (zh) * | 2010-05-11 | 2014-08-27 | 中国科学院上海生命科学研究院 | 非小细胞肺癌分子标志物及其应用 |
| US20130149320A1 (en) * | 2010-05-31 | 2013-06-13 | Centre National De La Recherche Scientifique | Asf1b as a Prognosis Marker and Therapeutic Target in Human Cancer |
| AU2011274422B2 (en) | 2010-07-09 | 2016-02-11 | Somalogic Operating Co., Inc. | Lung cancer biomarkers and uses thereof |
| WO2012016082A1 (en) | 2010-07-30 | 2012-02-02 | Oncotherapy Science, Inc. | Quinoline derivatives and melk inhibitors containing the same |
| MX350533B (es) | 2010-08-13 | 2017-09-08 | Somalogic Inc | Biomarcadores de cancer pancreatico y usos de los mismos. |
| EP2606132A1 (en) * | 2010-08-19 | 2013-06-26 | OncoTherapy Science, Inc. | C6orf167 as a target gene for cancer therapy and diagnosis |
| CA2808859A1 (en) * | 2010-08-20 | 2012-02-23 | Pangea Biosciences, Inc. | Cancer diagnostic and cancer therapeutic |
| SG189278A1 (en) * | 2010-10-21 | 2013-05-31 | Oncotherapy Science Inc | C18orf54 peptides and vaccines including the same |
| US20120245044A1 (en) * | 2011-03-25 | 2012-09-27 | Translational Genomics Research Institute | Methods of determining chemotherapy response in cancer |
| WO2012142656A1 (en) * | 2011-04-18 | 2012-10-26 | Garvan Institute Of Medical Research | Method of diagnosing cancer |
| CN106168624B (zh) * | 2011-10-24 | 2018-03-13 | 私募蛋白质体公司 | 肺癌生物标记及其用途 |
| SG2014012363A (en) | 2011-10-28 | 2014-09-26 | Oncotherapy Science Inc | Topk peptides and vaccines including the same |
| EP2795330B1 (en) * | 2011-12-21 | 2017-07-19 | Integrated Diagnostics Inc. | Methods for diagnosis of lung cancer |
| US11913957B2 (en) | 2011-12-21 | 2024-02-27 | Biodesix, Inc. | Compositions, methods and kits for diagnosis of lung cancer |
| US9304137B2 (en) | 2011-12-21 | 2016-04-05 | Integrated Diagnostics, Inc. | Compositions, methods and kits for diagnosis of lung cancer |
| AU2012366148B2 (en) | 2012-01-19 | 2016-12-01 | Oncotherapy Science, Inc. | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
| WO2014010229A1 (en) | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Cdca1 epitope peptides for th1 cells and vaccines containing the same |
| EP2872530A4 (en) | 2012-07-10 | 2016-04-06 | Oncotherapy Science Inc | KIF20A EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING SAME |
| AU2013202506B2 (en) * | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
| KR101507540B1 (ko) | 2012-10-22 | 2015-04-07 | 사회복지법인 삼성생명공익재단 | 뇌전이암 진단용 조성물 |
| RU2509808C1 (ru) * | 2012-10-30 | 2014-03-20 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | СПОСОБ ОПРЕДЕЛЕНИЯ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК НЕМЕЛКОКЛЕТОЧНОГО РАКА ЛЕГКИХ К ДЕЙСТВИЮ ПРЕПАРАТОВ, РЕАКТИВИРУЮЩИХ БЕЛОК р53 |
| CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
| WO2014138661A1 (en) | 2013-03-08 | 2014-09-12 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Kntc2胜肽及含此胜肽之疫苗 |
| US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| TWI643867B (zh) | 2013-05-24 | 2018-12-11 | 日商腫瘤療法 科學股份有限公司 | 對於th1細胞之imp-3抗原決定位胜肽及含此之疫苗 |
| US9297805B2 (en) | 2013-07-26 | 2016-03-29 | Integrated Diagnostics, Inc. | Compositions, methods and kits for diagnosis of lung cancer |
| EP2876445A1 (en) * | 2013-11-22 | 2015-05-27 | Institut de Cancérologie de l'Ouest | Method for in vitro diagnosing and prognosing of triple negative breast cancer recurrence |
| CN105214077B (zh) * | 2014-06-03 | 2019-02-05 | 浙江阿思科力生物科技有限公司 | Usp33在肿瘤中的应用 |
| CN111925431B (zh) | 2014-08-04 | 2025-04-15 | 肿瘤疗法科学股份有限公司 | Koc1衍生的肽和包含它们的疫苗 |
| WO2016021508A1 (ja) | 2014-08-04 | 2016-02-11 | オンコセラピー・サイエンス株式会社 | Cdca1由来ペプチドおよびそれを含むワクチン |
| CN104198722A (zh) * | 2014-08-11 | 2014-12-10 | 广东药学院 | 一种肺癌新肿瘤标志物gsta1及其筛选方法和应用 |
| EP3186391B1 (en) * | 2014-08-28 | 2020-05-27 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin | Methods and kit for identification of cancer |
| EP3314020A1 (en) * | 2015-06-29 | 2018-05-02 | The Broad Institute Inc. | Tumor and microenvironment gene expression, compositions of matter and methods of use thereof |
| SG10201913592QA (en) | 2015-08-12 | 2020-02-27 | Oncotherapy Science Inc | Depdc1-derived peptide and vaccine containing same |
| JP2018532992A (ja) * | 2015-09-09 | 2018-11-08 | ソマロジック, インコーポレイテッドSomaLogic, Inc. | 個別化薬物治療計画の開発方法、及びプロテオミックプロファイルに基づく標的薬物開発 |
| BR112018005581A2 (pt) | 2015-10-08 | 2018-10-16 | Oncotherapy Science, Inc. | peptídeo derivado de foxm1 e vacina incluindo o mesmo |
| CN105331691B (zh) * | 2015-10-28 | 2018-06-08 | 北京泱深生物信息技术有限公司 | Pzp基因在胆管癌诊断和治疗中的应用 |
| MX2018008358A (es) * | 2016-01-12 | 2018-09-21 | Univ Chiba Nat Univ Corp | Anticuerpo anti cadena ligera reguladora de miosina (anti-myl9). |
| CN105803068A (zh) * | 2016-03-31 | 2016-07-27 | 北京泱深生物信息技术有限公司 | 一种诊治肺腺癌的分子标记物 |
| PT3458074T (pt) * | 2016-05-16 | 2024-08-21 | Univ Texas | Composições para a entrega de trna na forma de nanopartículas e métodos de utilização com os mesmos |
| CN107435062B (zh) * | 2016-05-25 | 2020-10-20 | 上海伯豪医学检验所有限公司 | 甄别肺部微小结节良恶性的外周血基因标志物及其用途 |
| GB201609977D0 (en) * | 2016-06-08 | 2016-07-20 | Cancer Rec Tech Ltd | Chemosensitivity predictive biomarkers |
| CA3026809A1 (en) * | 2016-06-21 | 2017-12-28 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for diagnosing lung cancers using gene expression profiles |
| CN109890963B (zh) | 2016-08-31 | 2023-10-03 | 肿瘤疗法科学股份有限公司 | 针对melk的单克隆抗体及其使用 |
| CN106442995A (zh) * | 2016-09-30 | 2017-02-22 | 四川大学华西医院 | 一种肺癌筛查试剂盒 |
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| NL2020004B1 (en) | 2016-12-09 | 2018-07-02 | Ary Flohil Jacob | Treatment of diffuse intrinsic pontine glioma |
| WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| CN107502659B (zh) * | 2017-08-21 | 2020-09-11 | 桂林医学院 | Vipr1基因在制备肝癌诊断产品和预后预测产品中的应用 |
| CN109423516A (zh) * | 2017-08-25 | 2019-03-05 | 北京市神经外科研究所 | 通过分子标志物检测垂体腺瘤放射治疗敏感性或抵抗性的试剂盒 |
| EP3698144B1 (en) * | 2017-10-18 | 2025-07-09 | Biodesix, Inc. | Compositions, methods and kits for diagnosis of lung cancer |
| CN109777872B (zh) * | 2017-11-15 | 2021-04-02 | 北京大学 | 肺癌中的t细胞亚群及其特征基因 |
| CN109837340B (zh) * | 2017-11-24 | 2023-01-10 | 顾万君 | 用于肺癌无创诊断的外周血基因标记物 |
| EP3728630A4 (en) | 2017-12-19 | 2021-11-17 | The Wistar Institute Of Anatomy And Biology | COMPOSITIONS AND METHODS FOR DIAGNOSING LUNG CANCERS USING GENE EXPRESSION PROFILES |
| TWI846703B (zh) | 2018-06-19 | 2024-07-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
| CN108676888B (zh) * | 2018-07-12 | 2022-01-28 | 吉林大学 | 一种肺部恶性肿瘤易感性预测试剂盒及系统 |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| CN109030835B (zh) * | 2018-09-06 | 2021-06-22 | 江苏省人民医院(南京医科大学第一附属医院) | 一种分析Rab8调节Klotho表达在非小细胞肺癌中的作用的方法 |
| JOP20210115A1 (ar) | 2018-11-21 | 2023-01-30 | Univ Texas | تركيبات وطرق لتعديل نشاط ديهيدروجيناز بسلسلة قصيرة |
| WO2020117715A1 (en) | 2018-12-03 | 2020-06-11 | Board Of Regents, The University Of Texas System | Oligo-benzamide analogs and their use in cancer treatment |
| CN111487408B (zh) * | 2019-01-28 | 2023-04-07 | 中国科学院大连化学物理研究所 | Calb2及定量检测calb2的试剂的应用及工具 |
| WO2020182517A1 (en) * | 2019-03-08 | 2020-09-17 | Oncolab Diagnostics Gmbh | Cancer diagnosis and prognosis |
| CA3140129A1 (en) * | 2019-05-17 | 2020-11-26 | The Regents Of The University Of California | Mps modified peptides and use thereof |
| CN110066871A (zh) * | 2019-06-04 | 2019-07-30 | 中国人民解放军联勤保障部队第九八0医院 | 高血压性脑出血的早期诊断标志物 |
| CN110456061B (zh) * | 2019-07-31 | 2021-10-01 | 四川大学华西医院 | Rundc3a自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| JP7732637B2 (ja) * | 2019-08-27 | 2025-09-02 | 国立大学法人東海国立大学機構 | 胃癌分子標的核酸医薬 |
| CN110632310A (zh) * | 2019-10-25 | 2019-12-31 | 四川大学华西医院 | Map2自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN111084781B (zh) * | 2019-12-12 | 2021-08-17 | 中山大学肿瘤防治中心 | Arhgef19反义核苷酸序列在制备抑制肿瘤细胞生长药物中的应用及其表达载体 |
| CN110951875B (zh) * | 2019-12-13 | 2022-09-13 | 上海市同济医院 | Pafah1b3在制备骨肉瘤的诊断标记物和治疗骨肉瘤药物中的应用 |
| CN111394334B (zh) * | 2020-01-10 | 2022-02-15 | 中山大学 | 抑制ezh2活性的抗肿瘤多肽及其应用 |
| CN111254201B (zh) * | 2020-03-28 | 2020-10-27 | 中国医学科学院北京协和医院 | Dennd1c作为诊治腹主动脉瘤的分子标志物的应用 |
| CN114214422B (zh) * | 2020-03-30 | 2023-06-27 | 中国医学科学院肿瘤医院 | 外泌体miR-106b-3P、ARPC5在肺癌诊断中的应用 |
| CN114277141B (zh) * | 2020-03-30 | 2022-09-02 | 中国医学科学院肿瘤医院 | 外泌体cda、mboat2等在肺癌诊断中的应用 |
| CN111440871A (zh) * | 2020-04-26 | 2020-07-24 | 至本医疗科技(上海)有限公司 | 基因标记物在肺癌预后判断中的应用 |
| CN111500733B (zh) * | 2020-05-27 | 2022-03-08 | 中国人民解放军军事科学院军事医学研究院 | 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物 |
| CN111455058A (zh) * | 2020-05-27 | 2020-07-28 | 深圳市因诺转化医学研究院 | 一种乳腺癌肿瘤相关的肿瘤标志物及应用、试剂盒 |
| CN111893185A (zh) * | 2020-08-10 | 2020-11-06 | 梁嵘 | 表达ntng1基因的细胞株的构建方法和应用 |
| CN114231621B (zh) * | 2020-09-09 | 2024-08-20 | 上海市胸科医院 | Lancl2在制备诊断或者治疗肺癌的药物中的应用 |
| CN112410342B (zh) * | 2020-12-04 | 2022-08-26 | 复旦大学附属中山医院 | 抑制HIST1H2BD基因的siRNA分子 |
| WO2022140386A1 (en) * | 2020-12-21 | 2022-06-30 | The Johns Hopkins University | Detection of lung cancer using cell-free dna fragmentation |
| CN114949217B (zh) * | 2021-02-23 | 2024-06-18 | 中国科学院分子细胞科学卓越创新中心 | 癌症靶标及其应用 |
| CN114558138B (zh) * | 2021-03-15 | 2024-01-12 | 深圳市华晨阳科技有限公司 | 敲低bace2基因表达的物质在抗肿瘤中的应用及bace2抑制剂 |
| CN112980956B (zh) * | 2021-03-19 | 2022-06-14 | 温州医科大学 | 抑制肺癌生长的靶标与诊断标志物uc.336及其应用 |
| CN113881768B (zh) * | 2021-06-15 | 2023-10-03 | 上海长征医院 | 用于骨肉瘤分型和评估骨肉瘤预后的基因及其应用 |
| CN113552357A (zh) * | 2021-07-23 | 2021-10-26 | 燕山大学 | 白三烯a4水解酶作为肺癌早期标志物的应用 |
| US20240238241A1 (en) * | 2021-07-30 | 2024-07-18 | Japan Science And Technology Agency | Pharmaceutical composition for treatment of pancreatic cancer and bile duct cancer |
| CN113499440B (zh) * | 2021-08-23 | 2023-04-28 | 大连医科大学 | 下调rbms1表达的试剂在制备治疗肺癌的药物中的应用 |
| CN113736879B (zh) * | 2021-09-03 | 2023-09-22 | 中国医学科学院肿瘤医院 | 用于小细胞肺癌患者预后的系统及其应用 |
| CN113721020B (zh) * | 2021-09-14 | 2022-06-24 | 大连医科大学附属第二医院 | Ctsf在非小细胞肺癌诊断中的应用 |
| CN115181744B (zh) * | 2021-12-10 | 2024-12-24 | 涟水县人民医院 | 长链非编码rna linc01635在制备抗肺癌药物中的应用 |
| CN114164216B (zh) * | 2021-12-21 | 2023-08-25 | 北京航空航天大学 | 一种基因在促进骨形成中的应用 |
| CN116555423B (zh) * | 2022-01-27 | 2025-12-05 | 四川大学华西医院 | 肺癌甲基化标志物组合、检测产品及其应用 |
| CN114544975A (zh) * | 2022-03-07 | 2022-05-27 | 南京鼓楼医院 | Ehd1蛋白表达量作为检测标志物在预测ivf-et妊娠结局中的应用 |
| CN115015557B (zh) * | 2022-05-30 | 2025-03-25 | 郑州大学第一附属医院 | 用于肺癌检测的生物标志物及其应用 |
| CN115678997A (zh) * | 2022-11-03 | 2023-02-03 | 复旦大学附属肿瘤医院 | 基于小细胞肺癌血浆外泌体长链RNAs的诊断及疗效预测模型 |
| CN115572769B (zh) * | 2022-12-07 | 2023-03-14 | 中国人民解放军军事科学院军事医学研究院 | 用于肝癌患者良性预后预测的基因标志物组合 |
| CN116444680B (zh) * | 2022-12-28 | 2024-05-03 | 杭州凯保罗生物科技有限公司 | 一种ralgds-krt8-aif1融合肿瘤抗原蛋白的制备方法及其应用 |
| CN116287253B (zh) * | 2023-02-22 | 2024-06-28 | 武汉科技大学 | 一种肺癌分子标志物及其应用 |
| CN116359505B (zh) * | 2023-04-12 | 2025-02-07 | 上海秤信生物科技有限公司 | Ralgds截断蛋白在肺癌筛查中的应用 |
| CN116593717B (zh) * | 2023-07-18 | 2023-09-26 | 首都医科大学附属北京口腔医院 | 突触融合蛋白8在检测线粒体损伤中的应用 |
| CN117604111B (zh) * | 2024-01-23 | 2024-04-12 | 杭州华得森生物技术有限公司 | 用于小细胞肺癌诊断和预后判断的生物标志物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076623A2 (en) * | 2003-02-28 | 2004-09-10 | Oncotherapy Science, Inc. | Rna-interference for znfn3a1-gene as a method for inhibiting cancer cell growth |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US20020103360A1 (en) | 1998-09-01 | 2002-08-01 | Yang Pan | Novel protein related to melanoma-inhibiting protein and uses thereof |
| AU3622600A (en) * | 1999-03-08 | 2000-09-28 | Neurocrine Biosciences, Inc. | Metalloproteinases and methods of use therefor |
| EP1259545A2 (en) * | 2000-01-21 | 2002-11-27 | Ludwig Institute For Cancer Research | Small cell lung cancer associated antigens and uses therefor |
| EP1136547A3 (en) * | 2000-03-22 | 2002-09-25 | Pfizer Products Inc. | Adamts polypeptides, nucleic acids encoding them, and uses thereof |
| AU2001259062A1 (en) * | 2000-04-11 | 2001-10-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| SE0002973D0 (sv) * | 2000-08-22 | 2000-08-22 | Astrazeneca Ab | Method |
| ATE368735T1 (de) * | 2000-12-18 | 2007-08-15 | Astellas Pharma Inc | Neue aggrecanase |
| DE60126659T2 (de) * | 2000-12-25 | 2007-10-31 | Astellas Pharma Inc. | Neue protease |
| US20030194764A1 (en) * | 2001-04-05 | 2003-10-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| WO2003029273A2 (en) * | 2001-09-28 | 2003-04-10 | Whitehead Institute For Biomedical Research | Classification of lung carcinomas using gene expression analysis |
| AU2002351945A1 (en) * | 2001-11-13 | 2003-05-26 | Universite De Liege | A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide |
| GB0130955D0 (en) * | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| JP2005532036A (ja) * | 2002-01-09 | 2005-10-27 | 理化学研究所 | 癌プロフィール |
| PL371525A1 (en) * | 2002-01-31 | 2005-06-27 | Wyeth | Aggrecanase molecules |
| US20060234235A1 (en) * | 2002-11-04 | 2006-10-19 | The United States Of America, As Represented By The Secretary, Dept Of Health And Human Services | Methods and compositions for the diagnosis of neuroendocrine lung cancer |
| EP1581812B1 (en) * | 2003-01-06 | 2008-07-16 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
| DE10316701A1 (de) * | 2003-04-09 | 2004-11-04 | Hinzmann, Bernd, Dr. | Humane Nukleinsäuresequenzen aus Bronchialkarzinomen |
| CA2522299A1 (en) * | 2003-04-15 | 2004-10-28 | Avalon Pharmaceuticals, Inc | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
| EP1469082A1 (en) * | 2003-04-16 | 2004-10-20 | Boehringer Ingelheim International GmbH | Method of identifying compounds that specifically inhibit the anaphase promoting complex |
| KR20060031809A (ko) * | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| US20050084880A1 (en) * | 2003-07-11 | 2005-04-21 | Ronald Duman | Systems and methods for diagnosing & treating psychological and behavioral conditions |
| EP2423333A1 (en) * | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| TW200908998A (en) * | 2007-06-27 | 2009-03-01 | Oncotherapy Science Inc | Compositions and methods of treating cancer |
| EP4032899A1 (en) * | 2007-08-20 | 2022-07-27 | Oncotherapy Science, Inc. | Foxm1 peptide and medicinal agent comprising the same |
| WO2009028580A1 (en) * | 2007-08-24 | 2009-03-05 | Oncotherapy Science, Inc. | Ebi3, dlx5, nptx1 and cdkn3 for target genes of lung cancer therapy and diagnosis |
| WO2009028581A1 (en) * | 2007-08-24 | 2009-03-05 | Oncotherapy Science, Inc. | Cancer-related genes, cdca5, epha7, stk31 and wdhd1 |
-
2006
- 2006-07-26 EP EP10010571A patent/EP2336316A1/en not_active Withdrawn
- 2006-07-26 EP EP10010570A patent/EP2298895A1/en not_active Withdrawn
- 2006-07-26 CN CNA2006800357440A patent/CN101283106A/zh active Pending
- 2006-07-26 WO PCT/JP2006/315254 patent/WO2007013665A2/en not_active Ceased
- 2006-07-26 EP EP10010558A patent/EP2295570A1/en not_active Withdrawn
- 2006-07-26 JP JP2008503310A patent/JP2009502115A/ja not_active Ceased
- 2006-07-26 US US11/913,273 patent/US20090317392A1/en not_active Abandoned
- 2006-07-26 EP EP10010566A patent/EP2305811A1/en not_active Withdrawn
- 2006-07-26 EP EP10010569A patent/EP2295571A1/en not_active Withdrawn
- 2006-07-26 EP EP06782127A patent/EP1907581A2/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076623A2 (en) * | 2003-02-28 | 2004-09-10 | Oncotherapy Science, Inc. | Rna-interference for znfn3a1-gene as a method for inhibiting cancer cell growth |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012522488A (ja) * | 2009-04-01 | 2012-09-27 | オンコセラピー・サイエンス株式会社 | C6orf167ペプチドおよびそれを含むワクチン |
| JP2014520555A (ja) * | 2011-07-14 | 2014-08-25 | ナショナル ヘルス リサーチ インスティテューツ | Glk介在疾患の治療薬同定方法、および、glk介在疾患判定方法 |
| JP2015536933A (ja) * | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| WO2015012175A1 (ja) * | 2013-07-22 | 2015-01-29 | 学校法人関西医科大学 | 小細胞肺がんの診断薬及び治療薬 |
| JP2016531915A (ja) * | 2013-08-28 | 2016-10-13 | ステムセントリックス, インコーポレイテッド | 部位特異的抗体コンジュゲーション方法および組成物 |
| JP2016538318A (ja) * | 2013-08-28 | 2016-12-08 | ステムセントリックス, インコーポレイテッド | 新規sez6モジュレーターおよび使用方法 |
| JP2021059550A (ja) * | 2015-05-01 | 2021-04-15 | 国立研究開発法人科学技術振興機構 | 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤 |
| WO2016178374A1 (ja) * | 2015-05-01 | 2016-11-10 | 国立研究開発法人科学技術振興機構 | 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤 |
| JPWO2016178374A1 (ja) * | 2015-05-01 | 2018-02-22 | 国立研究開発法人科学技術振興機構 | 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤 |
| JP7249044B2 (ja) | 2015-05-01 | 2023-03-30 | 国立研究開発法人科学技術振興機構 | 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤 |
| US10669545B2 (en) | 2015-05-01 | 2020-06-02 | Japan Science And Technology Agency | Tumor cell malignant transformation suppressor and anti-tumor agent |
| JP2018525437A (ja) * | 2015-07-25 | 2018-09-06 | ハビブ・フロストHabib FROST | がんおよび他の病的状態における治療または治癒を提供する、システム、デバイスおよび方法 |
| JP7602862B2 (ja) | 2015-07-25 | 2024-12-19 | ハビブ・フロスト | がんおよび他の病的状態における治療または治癒を提供する、システム、デバイスおよび方法 |
| JPWO2020022361A1 (ja) * | 2018-07-24 | 2021-08-05 | 公立大学法人福島県立医科大学 | 肺癌の予後バイオマーカー |
| JP7114112B2 (ja) | 2018-07-24 | 2022-08-08 | 公立大学法人福島県立医科大学 | 肺癌の予後バイオマーカー |
| WO2020022361A1 (ja) * | 2018-07-24 | 2020-01-30 | 公立大学法人福島県立医科大学 | 肺癌の予後バイオマーカー |
| JP2023504334A (ja) * | 2019-08-26 | 2023-02-03 | リキッド ラング ディーエックス | 肺がんの診断のためのバイオマーカー |
| WO2021241527A1 (ja) * | 2020-05-25 | 2021-12-02 | 国立大学法人東海国立大学機構 | 非小細胞肺がんの化学療法の効果を予測するための情報を提供する方法および情報提供用キット、非小細胞肺がんの化学療法の効果を予測する方法、非小細胞肺がんの化学療法の効果を予測する予測装置、予測装置のプログラムおよび記録媒体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101283106A (zh) | 2008-10-08 |
| EP2298895A1 (en) | 2011-03-23 |
| US20090317392A1 (en) | 2009-12-24 |
| WO2007013665A2 (en) | 2007-02-01 |
| EP2295570A1 (en) | 2011-03-16 |
| EP1907581A2 (en) | 2008-04-09 |
| WO2007013665A3 (en) | 2007-07-05 |
| EP2295571A1 (en) | 2011-03-16 |
| EP2305811A1 (en) | 2011-04-06 |
| EP2336316A1 (en) | 2011-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009502115A (ja) | 小細胞肺癌の診断方法 | |
| JP4620670B2 (ja) | 乳癌を診断する方法 | |
| JP4938451B2 (ja) | 非小細胞肺癌の診断のための方法 | |
| US20070054849A1 (en) | Method for diagnosing hepatocellular carcinomas | |
| WO2006085684A9 (en) | Method of diagnosing bladder cancer | |
| US8029981B2 (en) | Hypoxia-inducible protein 2 (HIG2), a diagnostic marker for clear cell renal cell carcinoma | |
| EP1907580A2 (en) | Method for diagnosing and treating renal cell carcinoma | |
| JP2012125248A (ja) | 結腸癌関連遺伝子tom34 | |
| US20070253954A1 (en) | Epha4 As Therapeutic Target Of Prc And Pdaca | |
| US20090142344A1 (en) | Breast cancer related gene znfn3a1 | |
| JP2009505632A (ja) | 膵臓癌関連遺伝子であるcst6およびgabrp | |
| US20080063640A1 (en) | Pin-Prc Transition Genes | |
| WO2012090479A1 (en) | Mcm7 as a target gene for cancer therapy and diagnosis | |
| US8182997B2 (en) | Prostate cancer related gene STYK1 | |
| EP1915462A2 (en) | Cancer related gene rasgef1a | |
| JP2012501169A (ja) | がん関連遺伝子lgn/gpsm2 | |
| HK1115193B (en) | Colon cancer related gene tom34 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090723 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090723 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120227 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120326 |
|
| A045 | Written measure of dismissal of application [lapsed due to lack of payment] |
Free format text: JAPANESE INTERMEDIATE CODE: A045 Effective date: 20120730 |