JP2009280595A5 - - Google Patents
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- JP2009280595A5 JP2009280595A5 JP2009168271A JP2009168271A JP2009280595A5 JP 2009280595 A5 JP2009280595 A5 JP 2009280595A5 JP 2009168271 A JP2009168271 A JP 2009168271A JP 2009168271 A JP2009168271 A JP 2009168271A JP 2009280595 A5 JP2009280595 A5 JP 2009280595A5
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- JP
- Japan
- Prior art keywords
- medicament according
- dihydro
- salt
- benzofuran
- methylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 15
- BZCALJIHZVNMGJ-HSZRJFAPSA-N 2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid Chemical compound CC1=CC(OCCCS(C)(=O)=O)=CC(C)=C1C1=CC=CC(COC=2C=C3OC[C@@H](CC(O)=O)C3=CC=2)=C1 BZCALJIHZVNMGJ-HSZRJFAPSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 3
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 3
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 3
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N diguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 3
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- WPGGHFDDFPHPOB-BBWFWOEESA-N Mitiglinide Chemical compound C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)O)C1=CC=CC=C1 WPGGHFDDFPHPOB-BBWFWOEESA-N 0.000 claims 2
- OELFLUMRDSZNSF-BRWVUGGUSA-N Nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims 2
- 229960000698 Nateglinide Drugs 0.000 claims 2
- ZQNPDAVSHFGLIQ-UHFFFAOYSA-N calcium;hydrate Chemical compound O.[Ca] ZQNPDAVSHFGLIQ-UHFFFAOYSA-N 0.000 claims 2
- 229960003365 mitiglinide Drugs 0.000 claims 2
- ZSBOMTDTBDDKMP-OAHLLOKOSA-N Alogliptin Chemical group C=1C=CC=C(C#N)C=1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1 ZSBOMTDTBDDKMP-OAHLLOKOSA-N 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 229960004580 GLIBENCLAMIDE Drugs 0.000 claims 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N Glibenclamide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 1
- WIGIZIANZCJQQY-RUCARUNLSA-N Glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 claims 1
- 229960003105 Metformin Drugs 0.000 claims 1
- HYAFETHFCAUJAY-UHFFFAOYSA-N Pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 1
- 229960005095 Pioglitazone Drugs 0.000 claims 1
- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical group OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 claims 1
- 229960001667 alogliptin Drugs 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-M benzoate Chemical compound [O-]C(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-M 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960004346 glimepiride Drugs 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229940086735 succinate Drugs 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229960001729 voglibose Drugs 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
Description
[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸をエタノール−水から再結晶して、表題化合物を無色結晶として得た。収率 85%。
1 H NMR (CDCl3) δ: 1.99 (6H, s), 2.29-2.41(2H, m), 2.61(1H, dd, J=16.9, 9.2Hz), 2.81(1H, dd, J=16.9, 5.5Hz), 2.97(3H, s), 3.23-3.31(2H, m), 3.75-3.87(1H, m), 4.13(2H, t, J=5.8Hz), 4.28(1H, dd, J=9.1, 6.0Hz), 4.76(1H, t, J=9.1Hz), 5.06(2H, s), 6.44-6.52(2H, m), 6.64(2H, s), 7.02-7.10(2H, m), 7.16(1H, s), 7.35-7.46(2H, m)。
1 H NMR (CDCl3) δ: 1.99 (6H, s), 2.29-2.41(2H, m), 2.61(1H, dd, J=16.9, 9.2Hz), 2.81(1H, dd, J=16.9, 5.5Hz), 2.97(3H, s), 3.23-3.31(2H, m), 3.75-3.87(1H, m), 4.13(2H, t, J=5.8Hz), 4.28(1H, dd, J=9.1, 6.0Hz), 4.76(1H, t, J=9.1Hz), 5.06(2H, s), 6.44-6.52(2H, m), 6.64(2H, s), 7.02-7.10(2H, m), 7.16(1H, s), 7.35-7.46(2H, m)。
Claims (15)
- (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)インスリン製剤、PPAR機能調節剤、α−グルコシダーゼ阻害剤、ビグアナイド剤、スルホニルウレア剤、ミチグリニドまたはそのカルシウム塩水和物、ナテグリニド、またはジペプチジルぺプチダーゼIV阻害剤とを組み合わせてなる医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)ジペプチジルぺプチダーゼIV阻害剤とを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)PPAR機能調節剤とを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)α−グルコシダーゼ阻害剤とを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)ビグアナイド剤とを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)スルホニルウレア剤とを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)ミチグリニドまたはそのカルシウム塩水和物、またはナテグリニドとを組み合わせてなる、請求項1記載の医薬。 - (1)[(3S)-6-({2',6'-ジメチル-4'-[3-(メチルスルホニル)プロポキシ]ビフェニル-3-イル}メトキシ)-2,3-ジヒドロ-1-ベンゾフラン-3-イル]酢酸またはその塩と、
(2)インスリン製剤とを組み合わせてなる、請求項1記載の医薬。 - ジペプチジルぺプチダーゼIV阻害剤がアログリプチンまたはその安息香酸塩である、請求項2記載の医薬。
- ジペプチジルぺプチダーゼIV阻害剤が2−[[6−[(3R)−3−アミノ−1−ピペリジニル]−3,4−ジヒドロ−3−メチル−2,4−ジオキソ−1(2H)−ピリミジニル]メチル]−4−フルオロベンゾニトリルまたはそのコハク酸塩である、請求項2記載の医薬。
- PPAR機能調節剤がピオグリタゾンまたはその塩酸塩である、請求項3記載の医薬。
- α−グルコシダーゼ阻害剤がボグリボースである、請求項4記載の医薬。
- ビグアナイド剤がメトホルミンまたはその塩酸塩である、請求項5記載の医薬。
- スルホニルウレア剤がグリベンクラミドまたはグリメピリドである、請求項6記載の医薬。
- 糖尿病の治療剤である、請求項1記載の医薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009168271A JP4917634B2 (ja) | 2006-06-27 | 2009-07-16 | 縮合環化合物 |
Applications Claiming Priority (3)
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---|---|---|---|
JP2006177099 | 2006-06-27 | ||
JP2006177099 | 2006-06-27 | ||
JP2009168271A JP4917634B2 (ja) | 2006-06-27 | 2009-07-16 | 縮合環化合物 |
Related Parent Applications (1)
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JP2008554357A Division JP4401428B2 (ja) | 2006-06-27 | 2007-06-26 | 縮合環化合物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011269300A Division JP5409757B2 (ja) | 2006-06-27 | 2011-12-08 | 縮合環化合物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009280595A JP2009280595A (ja) | 2009-12-03 |
JP2009280595A5 true JP2009280595A5 (ja) | 2012-02-02 |
JP4917634B2 JP4917634B2 (ja) | 2012-04-18 |
Family
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008554357A Expired - Fee Related JP4401428B2 (ja) | 2006-06-27 | 2007-06-26 | 縮合環化合物 |
JP2009168271A Expired - Fee Related JP4917634B2 (ja) | 2006-06-27 | 2009-07-16 | 縮合環化合物 |
JP2011269300A Expired - Fee Related JP5409757B2 (ja) | 2006-06-27 | 2011-12-08 | 縮合環化合物 |
Family Applications Before (1)
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---|---|---|---|
JP2008554357A Expired - Fee Related JP4401428B2 (ja) | 2006-06-27 | 2007-06-26 | 縮合環化合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011269300A Expired - Fee Related JP5409757B2 (ja) | 2006-06-27 | 2011-12-08 | 縮合環化合物 |
Country Status (37)
Country | Link |
---|---|
US (5) | US7732626B2 (ja) |
EP (4) | EP2248812B1 (ja) |
JP (3) | JP4401428B2 (ja) |
KR (1) | KR101058772B1 (ja) |
CN (4) | CN103070854A (ja) |
AR (1) | AR061644A1 (ja) |
AT (1) | ATE543815T1 (ja) |
AU (1) | AU2007265966B2 (ja) |
BR (1) | BRPI0713378A8 (ja) |
CA (2) | CA2656003C (ja) |
CL (1) | CL2007001873A1 (ja) |
CO (1) | CO6160234A2 (ja) |
CR (1) | CR10564A (ja) |
CY (2) | CY1112705T1 (ja) |
DK (2) | DK2248812T5 (ja) |
ES (2) | ES2450081T3 (ja) |
GE (1) | GEP20115359B (ja) |
HK (1) | HK1131126A1 (ja) |
HR (2) | HRP20120333T1 (ja) |
IL (1) | IL195947A (ja) |
JO (1) | JO2969B1 (ja) |
MA (1) | MA30537B1 (ja) |
ME (1) | ME00535B (ja) |
MX (1) | MX2008016274A (ja) |
MY (1) | MY154798A (ja) |
NO (1) | NO20090235L (ja) |
NZ (1) | NZ574038A (ja) |
PE (1) | PE20080993A1 (ja) |
PL (2) | PL2041123T3 (ja) |
PT (2) | PT2248812E (ja) |
RS (2) | RS53230B (ja) |
RU (1) | RU2444521C2 (ja) |
SI (2) | SI2041123T1 (ja) |
TW (1) | TWI354668B (ja) |
UA (1) | UA95296C2 (ja) |
WO (1) | WO2008001931A2 (ja) |
ZA (1) | ZA200900154B (ja) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2009048527A1 (en) | 2007-10-10 | 2009-04-16 | Amgen Inc. | Substituted biphenyl gpr40 modulators |
WO2009111056A1 (en) * | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
WO2009117421A2 (en) * | 2008-03-17 | 2009-09-24 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
JP2012503595A (ja) | 2008-07-28 | 2012-02-09 | シダンスク ユニバーシティ | 代謝病の治療用の化合物 |
TW201014850A (en) | 2008-09-25 | 2010-04-16 | Takeda Pharmaceutical | Solid pharmaceutical composition |
EP2358656B1 (en) | 2008-10-15 | 2014-01-01 | Amgen, Inc | Spirocyclic gpr40 modulators |
US8501804B2 (en) | 2008-10-27 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
JPWO2010076884A1 (ja) | 2008-12-29 | 2012-06-21 | 武田薬品工業株式会社 | 新規縮合環化合物およびその用途 |
US20100190747A1 (en) | 2009-01-27 | 2010-07-29 | Hideo Suzuki | Fused ring compound and use thereof |
EP2423176A4 (en) | 2009-04-22 | 2012-11-07 | Astellas Pharma Inc | CARBOXYLIC ACID COMPOUND |
WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
EP2460523B1 (en) | 2009-07-28 | 2017-01-04 | Takeda Pharmaceutical Company Limited | Tablet |
CA2779398A1 (en) | 2009-10-30 | 2011-05-05 | Mochida Phamaceutical Co., Ltd. | Novel 3-hydroxy-5-arylisoxazole derivative |
CN102712610B (zh) | 2009-12-25 | 2015-03-04 | 持田制药株式会社 | 新的3-羟基-5-芳基异噻唑衍生物 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
UY33354A (es) | 2010-04-27 | 2011-12-01 | Takeda Pharmaceutical | Compuesto biciclico como inhibidor acc |
SG186223A1 (en) | 2010-06-16 | 2013-01-30 | Takeda Pharmaceutical | Crystal of amide compound |
US8299117B2 (en) | 2010-06-16 | 2012-10-30 | Metabolex Inc. | GPR120 receptor agonists and uses thereof |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
EP2617726A4 (en) | 2010-09-17 | 2014-05-14 | Takeda Pharmaceutical | DIABETES THERAPEUTIC |
US9040525B2 (en) | 2010-10-08 | 2015-05-26 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
AR084032A1 (es) | 2010-11-30 | 2013-04-17 | Takeda Pharmaceutical | Compuesto biciclico |
DK2646425T3 (en) | 2010-12-01 | 2015-08-24 | Boehringer Ingelheim Int | Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome. |
WO2014011926A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
SG192645A1 (en) | 2011-02-17 | 2013-09-30 | Takeda Pharmaceutical | Production method of optically active dihydrobenzofuran derivative |
WO2012136221A1 (en) | 2011-04-08 | 2012-10-11 | Syddansk Universitet | Ortho-fluoro substituted compounds for the treatment of metabolic diseases |
NZ617409A (en) | 2011-04-27 | 2015-08-28 | Mochida Pharm Co Ltd | Novel 3-hydroxyisothiazole 1-oxide derivative |
AU2012248627A1 (en) | 2011-04-28 | 2013-11-14 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN103012343B (zh) * | 2011-09-26 | 2015-04-08 | 上海恒瑞医药有限公司 | 稠合环类衍生物、其制备方法及其在医药上的应用 |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013061962A1 (ja) | 2011-10-24 | 2013-05-02 | 武田薬品工業株式会社 | 二環性化合物 |
CN103429581B (zh) * | 2012-01-12 | 2015-08-26 | 江苏恒瑞医药股份有限公司 | 多环类衍生物、其制备方法及其在医药上的应用 |
US9365540B2 (en) | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
GB2498968A (en) * | 2012-02-01 | 2013-08-07 | Prosidion Ltd | Pharmaceutical combination of a GPR119 agonist and a GPR40 agonist |
US9382188B2 (en) | 2012-02-13 | 2016-07-05 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
JP6121339B2 (ja) * | 2012-02-13 | 2017-04-26 | 武田薬品工業株式会社 | 芳香環化合物 |
EP2814466B1 (en) | 2012-02-15 | 2018-12-26 | Takeda Pharmaceutical Company Limited | Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof |
ES2640258T3 (es) * | 2012-02-24 | 2017-11-02 | Takeda Pharmaceutical Company Limited | Compuesto anular aromático como inhibidor de grelina o-aciltransferasa |
WO2013128378A1 (en) * | 2012-02-28 | 2013-09-06 | Piramal Enterprises Limited | Phenyl alkanoic acid derivatives as gpr agonists |
US8642585B2 (en) | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
JPWO2013147026A1 (ja) | 2012-03-29 | 2015-12-14 | 武田薬品工業株式会社 | 芳香環化合物 |
US8809376B2 (en) | 2012-04-30 | 2014-08-19 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
EP2848622A4 (en) | 2012-05-10 | 2015-11-04 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
EP2848621A4 (en) | 2012-05-10 | 2016-06-01 | Takeda Pharmaceutical | AROMATIC CYCLIC COMPOUND |
KR102145641B1 (ko) | 2012-06-05 | 2020-08-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 고형 제제 |
JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
LT2894151T (lt) | 2012-09-04 | 2021-09-10 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Imidazolino dariniai, jų gamybos būdai ir jų naudojimas medicinoje |
IN2015DN03795A (ja) | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
TWI692469B (zh) | 2012-11-09 | 2020-05-01 | 南韓商Lg化學股份有限公司 | Gpr40受體促效劑,製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
UY35143A (es) | 2012-11-16 | 2014-05-30 | Bristol Myers Squibb Co | Derivados de dihidropirazol como moduladores del receptor acoplado a la proteína gpr40 g |
KR20150088878A (ko) | 2012-11-28 | 2015-08-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 인다닐옥시디하이드로벤조푸라닐아세트산 |
JP6283862B2 (ja) * | 2012-12-07 | 2018-02-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規インダニルオキシジヒドロベンゾフラニル酢酸 |
WO2014122067A1 (en) | 2013-02-06 | 2014-08-14 | Boehringer Ingelheim International Gmbh | New indanyloxydihydrobenzofuranylacetic acids |
US9840512B2 (en) | 2013-02-22 | 2017-12-12 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
JP6387023B2 (ja) * | 2013-02-28 | 2018-09-05 | ティウムバイオ カンパニー、リミテッドTiumBio Co., Ltd. | 三環式化合物およびその使用 |
CN103145663B (zh) * | 2013-03-01 | 2016-03-23 | 上海高准医药有限公司 | (s)-2-(2,3-二氢苯并呋喃-3-基)乙酸衍生物,其制备方法及其在医药上的应用 |
US9605000B2 (en) | 2013-03-14 | 2017-03-28 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as SSTR antagonists |
CN104059039B (zh) * | 2013-03-22 | 2017-03-15 | 正大天晴药业集团股份有限公司 | 具有gpr40受体功能调节作用的稠环化合物 |
US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
WO2014170842A2 (en) | 2013-04-17 | 2014-10-23 | Piramal Enterprises Limited | Substituted alkyl carboxylic acid derivatives as gpr agonists |
CN104870429B (zh) * | 2013-05-22 | 2017-05-03 | 四川海思科制药有限公司 | 苯并呋喃衍生物、其制备方法及其在医药上的应用 |
CN104250238B (zh) * | 2013-06-25 | 2017-12-26 | 南京圣和药业股份有限公司 | Gpr40激动剂及其应用 |
CN104250239B (zh) * | 2013-06-29 | 2016-09-07 | 山东轩竹医药科技有限公司 | 芳香多环羧酸衍生物 |
WO2015000412A1 (zh) * | 2013-07-02 | 2015-01-08 | 四川海思科制药有限公司 | 苯并环丁烯类衍生物、其制备方法及其在医药上的应用 |
UY35650A (es) | 2013-07-09 | 2015-02-27 | Takeda Pharmaceutical | Compuesto heterocíclico |
EP3031799B1 (en) | 2013-08-09 | 2018-04-04 | Takeda Pharmaceutical Company Limited | Aromatic compound |
CN104370864B (zh) * | 2013-08-14 | 2016-04-13 | 成都苑东生物制药股份有限公司 | 一种2-(6-羟基-2,3-二氢苯并呋喃-3-基)乙腈化合物和以该化合物制备tak-875药物的方法 |
CN105246875A (zh) * | 2013-09-03 | 2016-01-13 | 四川海思科制药有限公司 | 茚满衍生物及其制备方法和在医药上的应用 |
JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2015062486A1 (en) * | 2013-10-31 | 2015-05-07 | Sunshine Lake Pharma Co., Ltd. | Biphenyl compounds and uses thereof |
EA201690888A1 (ru) | 2013-11-14 | 2016-10-31 | Кадила Хелзкэр Лимитед | Новые гетероциклические соединения |
ES2747973T3 (es) | 2013-11-15 | 2020-03-12 | Merck Sharp & Dohme | Compuestos tricíclicos antidiabéticos |
CN104650055A (zh) * | 2013-11-22 | 2015-05-27 | 山东轩竹医药科技有限公司 | 芳香多环羧酸衍生物 |
US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN105001212B (zh) * | 2014-04-16 | 2018-01-16 | 江苏柯菲平医药股份有限公司 | 稠环化合物及其制备方法和应用 |
WO2015176267A1 (en) | 2014-05-22 | 2015-11-26 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2016019587A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [7, 6]-fused bicyclic antidiabetic compounds |
EP3177287B1 (en) | 2014-08-08 | 2022-02-23 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
US10662171B2 (en) | 2014-08-08 | 2020-05-26 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
US10100042B2 (en) | 2014-08-08 | 2018-10-16 | Merck Sharp & Dohme Corp. | [5,6]—fused bicyclic antidiabetic compounds |
CN104193731B (zh) * | 2014-08-27 | 2017-03-15 | 广东东阳光药业有限公司 | 一种脲取代联苯类化合物及其组合物及用途 |
CN104177320B (zh) * | 2014-08-27 | 2016-03-02 | 广东东阳光药业有限公司 | 一种脲取代联苯类化合物及其组合物及用途 |
AU2015331074B2 (en) | 2014-10-17 | 2018-11-15 | Hyundai Pharm Co., Ltd. | Composite preparation, containing novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
CN105418563B (zh) * | 2015-12-28 | 2017-11-10 | 山东大学 | Tak‑875类似物及其制备方法与应用 |
WO2017172505A1 (en) | 2016-03-29 | 2017-10-05 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
US10793530B2 (en) | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
CN110177773B (zh) | 2017-01-26 | 2023-08-25 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途 |
CN110312714B (zh) | 2017-01-26 | 2022-12-09 | 勃林格殷格翰国际有限公司 | 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途 |
EP3573953A1 (en) | 2017-01-26 | 2019-12-04 | Boehringer Ingelheim International GmbH | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
JOP20180029A1 (ar) | 2017-03-30 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب حلقي غير متجانس |
WO2018181847A1 (ja) | 2017-03-31 | 2018-10-04 | 武田薬品工業株式会社 | 芳香環化合物 |
AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
EP3709995A4 (en) | 2017-11-16 | 2021-04-14 | Merck Sharp & Dohme Corp. | BICYCLIC ANTIDIABETIC COMPOUNDS |
FI3737470T3 (fi) | 2018-01-08 | 2023-03-19 | Celon Pharma Sa | 3-fenyyli-4-heksyylihappojohdannaisia GPR40-agonisteina |
TWI796596B (zh) | 2018-02-13 | 2023-03-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
CN110294744A (zh) * | 2018-03-21 | 2019-10-01 | 中国医学科学院药物研究所 | Gpr40受体激动剂、其制法和其药物组合物与用途 |
EA202092269A1 (ru) | 2018-03-23 | 2020-12-14 | Кармот Терапьютикс, Инк. | Модуляторы сопряженных с g-белком рецепторов |
KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
CN112399874B (zh) | 2018-07-13 | 2024-03-22 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
AR116019A1 (es) | 2018-08-27 | 2021-03-25 | Scohia Pharma Inc | Derivados de guanidinobenzoilo como inhibidores de enteropeptidasa |
EP3856768A2 (en) | 2018-09-24 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
US20220016215A1 (en) | 2018-09-24 | 2022-01-20 | Takeda Phaarmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
CN112955435A (zh) | 2018-10-24 | 2021-06-11 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
CA3130282A1 (en) * | 2019-02-13 | 2020-08-20 | Gexval Inc. | Pharmaceutical composition for preventing or treating bone diseases |
WO2022034664A1 (ja) * | 2020-08-12 | 2022-02-17 | 株式会社ジェクスヴァル | 骨疾患の予防または治療用の医薬組成物 |
KR20230005184A (ko) | 2020-03-25 | 2023-01-09 | 다케다 야쿠힌 고교 가부시키가이샤 | Gip 수용체 작용제 펩티드 화합물의 qd 투약 및 이의 용도 |
PE20221727A1 (es) | 2020-03-25 | 2022-11-04 | Takeda Pharmaceuticals Co | Dosificacion qw de compuestos peptidicos agonistas del receptor de gip y sus usos |
WO2022133111A1 (en) * | 2020-12-16 | 2022-06-23 | Regents Of The University Of Minnesota | Cubanyl biguanide compounds |
EP4337682A2 (en) | 2021-05-13 | 2024-03-20 | Carmot Therapeutics Inc. | Modulators of g-protein coupled receptors |
WO2023169456A1 (en) | 2022-03-09 | 2023-09-14 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
WO2023179542A1 (en) | 2022-03-21 | 2023-09-28 | Gasherbrum Bio , Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
WO2023198140A1 (en) | 2022-04-14 | 2023-10-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9309324D0 (en) * | 1993-05-06 | 1993-06-16 | Bayer Ag | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
US5489586A (en) | 1994-03-07 | 1996-02-06 | Warner-Lambert Company | Method for treating inflammatory disease in humans |
US5612330A (en) | 1994-03-07 | 1997-03-18 | Warner-Lambert Company | Methods for inhibiting and controlling viral growth |
WO1997010224A1 (en) | 1995-09-13 | 1997-03-20 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
RU6023U1 (ru) | 1997-01-20 | 1998-02-16 | АО "Автоэлектроника" | Устройство управления для экономайзера принудительного холостого хода |
US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
WO1999022735A1 (en) | 1997-10-30 | 1999-05-14 | Merck & Co., Inc. | Somatostatin agonists |
DE60027420T2 (de) | 1999-04-28 | 2006-11-16 | Aventis Pharma Deutschland Gmbh | Tri-aryl-säurederivate als ppar rezeptor liganden |
RU11297U1 (ru) | 1999-06-16 | 1999-09-16 | Курзанов Евгений Владимирович | Установка для выборочного измерения производительности нефтяных источников при групповом учете |
AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
IL148084A0 (en) | 1999-08-26 | 2002-09-12 | Aventis Pharm Prod Inc | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans |
EP1227090A4 (en) | 1999-10-07 | 2002-11-20 | Tadeka Chemical Ind Ltd | AMIN DERIVATIVES |
EP1228067B1 (en) | 1999-11-10 | 2004-07-14 | Takeda Chemical Industries, Ltd. | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
AU2223501A (en) * | 1999-12-24 | 2001-07-09 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
DK1285651T3 (da) | 2000-04-28 | 2010-12-13 | Takeda Pharmaceutical | Melanin-koncentrerende hormon-antagonister |
US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
US6429223B1 (en) * | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6613776B2 (en) * | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1318997B1 (en) * | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
RU2340611C2 (ru) | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
US6610677B2 (en) * | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
WO2002068471A2 (en) * | 2000-12-21 | 2002-09-06 | Bristol-Myers Squibb Company | Nucleic acid molecules and polypeptides for a human cation channel polypeptide |
IL156368A0 (en) * | 2000-12-21 | 2004-01-04 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
PT1373259E (pt) * | 2001-03-30 | 2005-03-31 | Pfizer Prod Inc | Inibidores piridazinona de aldose reductase |
TWI311133B (en) * | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
TW522326B (en) * | 2001-08-03 | 2003-03-01 | Inventec Corp | Real-time data customer service system and method thereof |
US6701066B2 (en) * | 2001-10-11 | 2004-03-02 | Micron Technology, Inc. | Delivery of solid chemical precursors |
WO2003042204A1 (fr) | 2001-10-19 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Derive d'amine |
JP4166024B2 (ja) | 2002-03-07 | 2008-10-15 | 独立行政法人科学技術振興機構 | 2環式化合物およびその製造方法 |
BR0309546A (pt) * | 2002-04-26 | 2005-02-15 | Hoffmann La Roche | Composto, composição farmacêutica que compreende o mesmo, processo para a sua preparação e utilização e método para tratamento profilático ou terapêutico de diabetes do tipo ii |
JPWO2004011469A1 (ja) * | 2002-07-26 | 2005-11-24 | 協和醗酵工業株式会社 | 細胞分化誘導剤 |
CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
US7572910B2 (en) * | 2003-02-20 | 2009-08-11 | Pfizer, Inc. | Pyridazinone aldose reductase inhibitors |
WO2004080943A1 (ja) * | 2003-03-11 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤 |
US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
EP1630152A4 (en) * | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONNECTION WITH CONDENSED RING |
PE20050444A1 (es) * | 2003-10-31 | 2005-08-09 | Takeda Pharmaceutical | Compuestos de piridina como inhibidores de la peptidasa |
RU2353617C2 (ru) | 2003-10-31 | 2009-04-27 | Такеда Фармасьютикал Компани Лимитед | Производные пиридина в качестве ингибиторов дипептидилпептидазы iv |
WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
CA2551610A1 (en) * | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | 3−(4−ベンジルオキシフェニル)プロパン酸誘導体 |
EP1698624B1 (en) | 2003-12-26 | 2012-06-27 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
CA2560111A1 (en) * | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
JP4859665B2 (ja) * | 2004-03-30 | 2012-01-25 | 武田薬品工業株式会社 | アルコキシフェニルプロパン酸誘導体 |
UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
TW200609219A (en) * | 2004-06-17 | 2006-03-16 | Neurogen Corp | Aryl-substituted piperazine derivatives |
JP3689711B1 (ja) | 2004-12-24 | 2005-08-31 | 極東鋼弦コンクリート振興株式会社 | 真空グラウト注入方法 |
TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
ZA200708144B (en) * | 2005-02-25 | 2008-11-26 | Takeda Pharmaceutical | Pyridyl acetic acid compounds |
PE20080344A1 (es) * | 2006-06-27 | 2008-06-09 | Sanofi Aventis | Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1 |
PE20080212A1 (es) * | 2006-06-27 | 2008-04-25 | Sanofi Aventis | Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1) |
TW200815418A (en) * | 2006-06-27 | 2008-04-01 | Astrazeneca Ab | New compounds I |
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