CY1114978T1 - Συντηγμενες κυκλικες ενωσεις ως ρυθμιστες υποδοχεα gpr40 - Google Patents

Συντηγμενες κυκλικες ενωσεις ως ρυθμιστες υποδοχεα gpr40

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Publication number
CY1114978T1
CY1114978T1 CY20141100213T CY141100213T CY1114978T1 CY 1114978 T1 CY1114978 T1 CY 1114978T1 CY 20141100213 T CY20141100213 T CY 20141100213T CY 141100213 T CY141100213 T CY 141100213T CY 1114978 T1 CY1114978 T1 CY 1114978T1
Authority
CY
Cyprus
Prior art keywords
functional circuits
inhibitor
gpr40 receptors
gpr40
receptors
Prior art date
Application number
CY20141100213T
Other languages
English (en)
Inventor
Tsuneo Yasuma
Nobuyuki Negoro
Masayuki Yamashita
Masahiro Itou
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of CY1114978T1 publication Critical patent/CY1114978T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Ophthalmology & Optometry (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει φαρμακευτική σύνθεση περιλαμβάνουσα μια ένωση που αντιπροσωπεύεται από τον τύπο (I): όπου έκαστο σύμβολο είναι όπως ορίζεται στην περιγραφή ή άλας αυτής, σε συνδυασμό με αναστολέα διπεπτιδύλ πεπτιδάσης IV, παρασκεύασμα ινσουλίνης, ρυθμιστή λειτουργίας PPAR, αναστολέα α-γλυκοσιδάσης, διγουανίδιο, σουλφονυλουρία, μιτιγλινίδιο ή ένυδρο άλας ασβεστίου αυτού ή νατεγλινίδιο.
CY20141100213T 2006-06-27 2014-03-18 Συντηγμενες κυκλικες ενωσεις ως ρυθμιστες υποδοχεα gpr40 CY1114978T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006177099 2006-06-27
EP10172951.5A EP2248812B1 (en) 2006-06-27 2007-06-26 Fused cyclic compounds as gpr40 receptor modulators

Publications (1)

Publication Number Publication Date
CY1114978T1 true CY1114978T1 (el) 2016-12-14

Family

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CY20121100396T CY1112705T1 (el) 2006-06-27 2012-04-25 Συντηγμενες κυκλικες ενωσεις
CY20141100213T CY1114978T1 (el) 2006-06-27 2014-03-18 Συντηγμενες κυκλικες ενωσεις ως ρυθμιστες υποδοχεα gpr40

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US (5) US7732626B2 (el)
EP (4) EP2743268A3 (el)
JP (3) JP4401428B2 (el)
KR (1) KR101058772B1 (el)
CN (4) CN103083307A (el)
AR (1) AR061644A1 (el)
AT (1) ATE543815T1 (el)
AU (1) AU2007265966B2 (el)
BR (1) BRPI0713378A8 (el)
CA (2) CA2656003C (el)
CL (1) CL2007001873A1 (el)
CO (1) CO6160234A2 (el)
CR (1) CR10564A (el)
CY (2) CY1112705T1 (el)
DK (2) DK2041123T3 (el)
ES (2) ES2450081T3 (el)
GE (1) GEP20115359B (el)
HK (1) HK1131126A1 (el)
HR (2) HRP20120333T1 (el)
IL (1) IL195947A (el)
JO (1) JO2969B1 (el)
MA (1) MA30537B1 (el)
ME (1) ME00535B (el)
MX (1) MX2008016274A (el)
MY (1) MY154798A (el)
NO (1) NO20090235L (el)
NZ (1) NZ574038A (el)
PE (1) PE20080993A1 (el)
PL (2) PL2248812T3 (el)
PT (2) PT2041123E (el)
RS (2) RS52307B (el)
RU (1) RU2444521C2 (el)
SI (2) SI2041123T1 (el)
TW (1) TWI354668B (el)
UA (1) UA95296C2 (el)
WO (1) WO2008001931A2 (el)
ZA (1) ZA200900154B (el)

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CN101616913A (zh) 2009-12-30
EP2743268A2 (en) 2014-06-18
SI2041123T1 (sl) 2012-05-31
UA95296C2 (uk) 2011-07-25
DK2041123T3 (da) 2012-05-07
BRPI0713378A2 (pt) 2012-04-03
PT2041123E (pt) 2012-04-09
CA2656003C (en) 2014-03-25
EP2431367A3 (en) 2012-07-04
CA2656003A1 (en) 2008-01-03

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