CO6351740A2 - Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido - Google Patents
Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosidoInfo
- Publication number
- CO6351740A2 CO6351740A2 CO11032140A CO11032140A CO6351740A2 CO 6351740 A2 CO6351740 A2 CO 6351740A2 CO 11032140 A CO11032140 A CO 11032140A CO 11032140 A CO11032140 A CO 11032140A CO 6351740 A2 CO6351740 A2 CO 6351740A2
- Authority
- CO
- Colombia
- Prior art keywords
- macrociclic
- hcv
- nucleoside
- inhibitor
- synergic combinations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con una combinación sinérgica del compuesto de la fórmula (I):o una de sus sales farmacéuticamente aceptables, y el compuesto de la fórmula (II):o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08164612 | 2008-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6351740A2 true CO6351740A2 (es) | 2011-12-20 |
Family
ID=40076811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11032140A CO6351740A2 (es) | 2008-09-18 | 2011-03-15 | Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido |
Country Status (20)
Country | Link |
---|---|
US (1) | US20110171174A1 (es) |
EP (1) | EP2341907A1 (es) |
JP (1) | JP2012502956A (es) |
KR (1) | KR20110054056A (es) |
CN (1) | CN102164602A (es) |
AP (1) | AP2011005608A0 (es) |
AR (1) | AR073603A1 (es) |
AU (1) | AU2009294622A1 (es) |
BR (1) | BRPI0919404A2 (es) |
CA (1) | CA2737835A1 (es) |
CO (1) | CO6351740A2 (es) |
EA (1) | EA201170456A1 (es) |
EC (1) | ECSP11010902A (es) |
IL (1) | IL211599A0 (es) |
MX (1) | MX2011002896A (es) |
PA (1) | PA8842901A1 (es) |
TW (1) | TW201023858A (es) |
UY (1) | UY32128A (es) |
WO (1) | WO2010031829A1 (es) |
ZA (1) | ZA201102047B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI454476B (zh) | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作c型肝炎病毒抑制劑之巨環吲哚衍生物 |
WO2010033443A1 (en) | 2008-09-17 | 2010-03-25 | Boehringer Ingelheim International Gmbh | Combination of hcv ns3 protease inhibitor with interferon and ribavirin |
CN102596201A (zh) | 2009-10-30 | 2012-07-18 | 贝林格尔.英格海姆国际有限公司 | 包含BI201335、干扰素α和利巴韦林的HCV组合治疗的用药方案 |
SG184524A1 (en) * | 2010-04-13 | 2012-11-29 | Janssen Pharmaceuticals Inc | Combination of a macrocyclic inhibitor of hcv, a non-nucleoside and a nucleoside |
WO2011153712A1 (en) * | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
WO2012040124A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
MX2013003060A (es) * | 2010-09-30 | 2013-05-30 | Boehringer Ingelheim Int | Terapia de combinacion para tratar infeccion por hcv. |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8466159B2 (en) * | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) * | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
BR112015007879A2 (pt) | 2012-10-19 | 2017-07-04 | Bristol Myers Squibb Co | inibidores do vírus da hepatite c |
EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EP2914598B1 (en) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
KR102168621B1 (ko) * | 2012-12-21 | 2020-10-22 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
JP6342922B2 (ja) | 2013-03-07 | 2018-06-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤 |
WO2018017989A1 (en) * | 2016-07-22 | 2018-01-25 | Janssen Pharmaceuticals, Inc. | Combination therapy regimen for treatment of selected hcv genotypes |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
CA2641859A1 (en) * | 2006-02-09 | 2007-08-16 | Schering Corporation | Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto |
AR059430A1 (es) * | 2006-02-09 | 2008-04-09 | Schering Corp | Novedosas combinaciones y metodos de inhibidores del vhc |
JP2010505902A (ja) * | 2006-10-10 | 2010-02-25 | メディヴィル・アクチエボラーグ | Hcvヌクレオシド阻害剤 |
-
2009
- 2009-09-17 TW TW098131308A patent/TW201023858A/zh unknown
- 2009-09-17 AR ARP090103573A patent/AR073603A1/es not_active Application Discontinuation
- 2009-09-18 MX MX2011002896A patent/MX2011002896A/es not_active Application Discontinuation
- 2009-09-18 WO PCT/EP2009/062096 patent/WO2010031829A1/en active Application Filing
- 2009-09-18 JP JP2011527331A patent/JP2012502956A/ja active Pending
- 2009-09-18 US US13/119,466 patent/US20110171174A1/en not_active Abandoned
- 2009-09-18 BR BRPI0919404A patent/BRPI0919404A2/pt not_active Application Discontinuation
- 2009-09-18 EP EP09783155A patent/EP2341907A1/en not_active Withdrawn
- 2009-09-18 CN CN2009801373764A patent/CN102164602A/zh active Pending
- 2009-09-18 EA EA201170456A patent/EA201170456A1/ru unknown
- 2009-09-18 AU AU2009294622A patent/AU2009294622A1/en not_active Abandoned
- 2009-09-18 PA PA20098842901A patent/PA8842901A1/es unknown
- 2009-09-18 UY UY0001032128A patent/UY32128A/es unknown
- 2009-09-18 AP AP2011005608A patent/AP2011005608A0/xx unknown
- 2009-09-18 KR KR1020117008646A patent/KR20110054056A/ko not_active Application Discontinuation
- 2009-09-18 CA CA2737835A patent/CA2737835A1/en not_active Abandoned
-
2011
- 2011-03-07 IL IL211599A patent/IL211599A0/en unknown
- 2011-03-15 CO CO11032140A patent/CO6351740A2/es not_active Application Discontinuation
- 2011-03-17 EC EC2011010902A patent/ECSP11010902A/es unknown
- 2011-03-17 ZA ZA2011/02047A patent/ZA201102047B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010031829A1 (en) | 2010-03-25 |
AU2009294622A1 (en) | 2010-03-25 |
TW201023858A (en) | 2010-07-01 |
EP2341907A1 (en) | 2011-07-13 |
US20110171174A1 (en) | 2011-07-14 |
AP2011005608A0 (en) | 2011-04-30 |
EA201170456A1 (ru) | 2011-08-30 |
MX2011002896A (es) | 2011-08-15 |
ZA201102047B (en) | 2012-08-29 |
BRPI0919404A2 (pt) | 2015-12-15 |
UY32128A (es) | 2010-03-26 |
AR073603A1 (es) | 2010-11-17 |
CN102164602A (zh) | 2011-08-24 |
PA8842901A1 (es) | 2010-04-21 |
JP2012502956A (ja) | 2012-02-02 |
KR20110054056A (ko) | 2011-05-24 |
ECSP11010902A (es) | 2011-06-30 |
CA2737835A1 (en) | 2010-03-25 |
IL211599A0 (en) | 2011-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |