ES2572001T3 - Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo - Google Patents

Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo

Info

Publication number
ES2572001T3
ES2572001T3 ES12192910T ES12192910T ES2572001T3 ES 2572001 T3 ES2572001 T3 ES 2572001T3 ES 12192910 T ES12192910 T ES 12192910T ES 12192910 T ES12192910 T ES 12192910T ES 2572001 T3 ES2572001 T3 ES 2572001T3
Authority
ES
Spain
Prior art keywords
bisfuran
antiviral
intermediates
derived
protease inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12192910T
Other languages
English (en)
Inventor
Kenneth R Crawford
Eric D Dowdy
Arnold Gutierrez
Richard P Polniaszek
Richard Hung Chiu Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ES2572001T3 publication Critical patent/ES2572001T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4084—Esters with hydroxyaryl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto que tiene la fórmula C:**Fórmula** o una sal farmacéuticamente aceptable del mismo.
ES12192910T 2006-03-29 2007-03-29 Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo Active ES2572001T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78712606P 2006-03-29 2006-03-29

Publications (1)

Publication Number Publication Date
ES2572001T3 true ES2572001T3 (es) 2016-05-27

Family

ID=38323963

Family Applications (2)

Application Number Title Priority Date Filing Date
ES07754134T Active ES2430557T3 (es) 2006-03-29 2007-03-29 Proceso para la preparación de inhibidores de la proteasa del VIH
ES12192910T Active ES2572001T3 (es) 2006-03-29 2007-03-29 Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES07754134T Active ES2430557T3 (es) 2006-03-29 2007-03-29 Proceso para la preparación de inhibidores de la proteasa del VIH

Country Status (24)

Country Link
US (4) US20110065631A1 (es)
EP (2) EP1999133B1 (es)
JP (2) JP5430395B2 (es)
KR (2) KR101429300B1 (es)
CN (2) CN102516259B (es)
AP (2) AP2013006690A0 (es)
AU (1) AU2007245194B2 (es)
BR (1) BRPI0710199A2 (es)
CA (1) CA2647316C (es)
DK (1) DK1999133T3 (es)
EA (2) EA020088B1 (es)
ES (2) ES2430557T3 (es)
HR (2) HRP20140626A2 (es)
IL (2) IL194122A (es)
MX (1) MX2008012398A (es)
NO (2) NO342102B1 (es)
NZ (2) NZ571302A (es)
PL (1) PL1999133T3 (es)
PT (1) PT1999133E (es)
SG (1) SG170794A1 (es)
SI (1) SI1999133T1 (es)
UA (1) UA97241C2 (es)
WO (1) WO2007126812A2 (es)
ZA (1) ZA200808046B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
BR112012018862A2 (pt) 2010-01-28 2015-10-13 Mapi Pharma Ltd processo para a preparação de darunavir e intermediários de darunavir
CN102190638A (zh) * 2010-03-16 2011-09-21 中国科学院上海药物研究所 联芳基醇二胺类化合物、其药物组合物、制备方法及应用
CN102584748B (zh) * 2011-01-13 2015-02-11 浙江九洲药业股份有限公司 夫沙那韦中间体的制备方法
EP2702045B1 (en) * 2011-04-26 2017-10-18 Mylan Laboratories Ltd. Novel process for the preparation of etravirine
KR102033802B1 (ko) 2011-10-07 2019-10-17 길리애드 사이언시즈, 인코포레이티드 항-바이러스 뉴클레오티드 유사체의 제조 방법
EP2634180A1 (en) 2012-03-01 2013-09-04 Lonza Ltd. Enzymatic process for the preparation of butyrolactones
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
US9936723B2 (en) 2014-02-12 2018-04-10 Senomyx, Inc. Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
LT3236972T (lt) 2014-12-26 2021-11-10 Emory University Antivirusiniai n4-hidroksicitidino dariniai
JP6435907B2 (ja) * 2015-02-16 2018-12-12 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN108610227B (zh) * 2016-12-10 2021-02-09 中国科学院大连化学物理研究所 一种制备双环芳香化合物的方法
LT3706762T (lt) 2017-12-07 2024-12-27 Emory University N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai
AU2020211600A1 (en) 2019-01-25 2021-07-22 Brown University Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026749A1 (en) * 1993-05-14 1994-11-24 Merck & Co., Inc. Hiv protease inhibitors
AU1369001A (en) * 1995-12-13 2001-03-22 Abbott Laboratories Retroviral protease inhibiting compounds
WO2001046120A1 (en) 1999-12-23 2001-06-28 Aerojet Fine Chemicals Llc Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
WO2002060905A2 (en) * 2000-10-24 2002-08-08 Glaxo Group Ltd Process for preparing intermediates of hiv protease inhibitors
CN1561570A (zh) 2001-07-20 2005-01-05 皇家菲利浦电子有限公司 振荡电路、具有这种振荡电路的变换器以及具有这种变换器的预调节器
US20050239054A1 (en) * 2002-04-26 2005-10-27 Arimilli Murty N Method and compositions for identifying anti-HIV therapeutic compounds
EA008775B1 (ru) * 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция
CA2543294A1 (en) * 2003-10-24 2005-05-26 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds

Also Published As

Publication number Publication date
EP1999133A2 (en) 2008-12-10
EP2570416A1 (en) 2013-03-20
NZ571302A (en) 2011-11-25
PL1999133T3 (pl) 2014-01-31
SI1999133T1 (sl) 2013-10-30
HRP20080554B1 (hr) 2014-11-21
NZ596074A (en) 2013-03-28
AP2013006690A0 (en) 2013-01-31
EA016140B1 (ru) 2012-02-28
HK1180311A1 (en) 2013-10-18
NO342965B1 (no) 2018-09-10
EA020088B1 (ru) 2014-08-29
SG170794A1 (en) 2011-05-30
US20130172295A1 (en) 2013-07-04
HRP20140626A2 (hr) 2014-11-07
AU2007245194A1 (en) 2007-11-08
IL194122A (en) 2016-08-31
NO342102B1 (no) 2018-03-26
JP2009531441A (ja) 2009-09-03
ZA200808046B (en) 2009-06-24
JP5430395B2 (ja) 2014-02-26
HRP20080554A2 (hr) 2009-02-28
KR101429300B1 (ko) 2014-08-11
KR20140021047A (ko) 2014-02-19
CA2647316C (en) 2013-05-28
NO20084547L (no) 2008-12-22
US20120258935A1 (en) 2012-10-11
AP2008004641A0 (en) 2008-10-31
US20080004242A1 (en) 2008-01-03
US20110065631A1 (en) 2011-03-17
KR20080108322A (ko) 2008-12-12
AU2007245194B2 (en) 2013-03-14
CN101448838A (zh) 2009-06-03
WO2007126812A2 (en) 2007-11-08
CN101448838B (zh) 2012-07-04
IL225167A (en) 2016-03-31
WO2007126812A3 (en) 2007-12-21
EA201100994A1 (ru) 2012-03-30
AP2757A (en) 2013-09-30
EP1999133B1 (en) 2013-08-21
UA97241C2 (uk) 2012-01-25
PT1999133E (pt) 2013-10-16
ES2430557T3 (es) 2013-11-21
NO20180086A1 (no) 2008-12-22
DK1999133T3 (da) 2013-11-25
MX2008012398A (es) 2008-12-17
HK1126756A1 (en) 2009-09-11
EP2570416B1 (en) 2016-03-16
EA200802074A1 (ru) 2009-02-27
KR101395377B1 (ko) 2014-05-14
JP2013082717A (ja) 2013-05-09
US8431745B2 (en) 2013-04-30
BRPI0710199A2 (pt) 2012-03-06
US8173623B2 (en) 2012-05-08
CN102516259B (zh) 2014-12-10
CA2647316A1 (en) 2007-11-08
CN102516259A (zh) 2012-06-27

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