CO6160234A2 - Nuevos compuestos ciclicos fusionados que presentan una accion moduladora de la funcion del recptor gpr40 - Google Patents

Nuevos compuestos ciclicos fusionados que presentan una accion moduladora de la funcion del recptor gpr40

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Publication number
CO6160234A2
CO6160234A2 CO09006709A CO09006709A CO6160234A2 CO 6160234 A2 CO6160234 A2 CO 6160234A2 CO 09006709 A CO09006709 A CO 09006709A CO 09006709 A CO09006709 A CO 09006709A CO 6160234 A2 CO6160234 A2 CO 6160234A2
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Colombia
Prior art keywords
optionally substituted
group
compound according
ring
recruitor
Prior art date
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CO09006709A
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English (en)
Inventor
Tsuneo Yasuma
Nobuyuki Negoro
Masaki Yamashita
Masahiro Itou
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Takeda Pharmaceutical
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Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CO6160234A2 publication Critical patent/CO6160234A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/06—Antihyperlipidemics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/10—Antioedematous agents; Diuretics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Organic Chemistry (AREA)
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  • Pulmonology (AREA)
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Abstract

1.- Un compuesto representado por la fórmula (I):caracterizado porque R1 es R6-SO2- (donde R6 es un sustituyente) o un grupo 1,1-dioxidotetrahidrotiopiranilo opcionalmente sustituido; X es un enlace o un grupo hidrocarbonado divalente; R2 y R3 son iguales o diferentes y cada uno es un átomo de hidrógeno, un átomo de halógeno, un grupo hidrocarbonado opcionalmente sustituido o un grupo hidroxi opcionalmente sustituido; R4 y R5 son iguales o diferentes y cada uno es un grupo alquilo C1-6 opcionalmente sustituido con grupo(s) hidroxi; el anillo A es un anillo bencénico que opcionalmente presenta además sustituyente(s) seleccionados de un átomo de halógeno, un grupo hidrocarbonado opcionalmente sustituido, un grupo hidroxi opcionalmente sustituido y un grupo amino opcionalmente sustituido; el anillo B es un anillo de 5 a 7 miembros; Y es un enlace o CH2; y R es un grupo hidroxi opcionalmente sustituido, o una sal del mismo. 2.- El compuesto de conformidad con la reivindicación 1, caracterizado porque R1 es R6-SO2- (donde R6 es un sustituyente). 3.- El compuesto de conformidad con la reivindicación 2, caracterizado porque R6 es un grupo alquilo C1-6.4.- El compuesto de conformidad con la reivindicación 1, caracterizado porque X es un grupo alquileno C1-6.5.- El compuesto de conformidad con la reivindicación 1, caracterizado porque R2 y R3 son iguales o diferentes y cada uno es un átomo de hidrógeno, un átomo de halógeno o un grupo alquilo C1-6.6.- El compuesto de conformidad con la reivindicación 1, caracterizado porque R4 y R5 son iguales o diferentes y cada uno es un grupo alquilo C1-6. 7.- El compuesto de conformidad con la reivindicación 1, caracterizado porque el anillo A es un anillo bencénico no sustituido.8.- El compuesto de conformidad con la reivindicación 1, caracterizado porque el anillo B es tetrahidrofurano.
CO09006709A 2006-06-27 2009-01-26 Nuevos compuestos ciclicos fusionados que presentan una accion moduladora de la funcion del recptor gpr40 CO6160234A2 (es)

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US (5) US7732626B2 (es)
EP (4) EP2248812B1 (es)
JP (3) JP4401428B2 (es)
KR (1) KR101058772B1 (es)
CN (4) CN103070854A (es)
AR (1) AR061644A1 (es)
AT (1) ATE543815T1 (es)
AU (1) AU2007265966B2 (es)
BR (1) BRPI0713378A8 (es)
CA (2) CA2656003C (es)
CL (1) CL2007001873A1 (es)
CO (1) CO6160234A2 (es)
CR (1) CR10564A (es)
CY (2) CY1112705T1 (es)
DK (2) DK2248812T5 (es)
ES (2) ES2450081T3 (es)
GE (1) GEP20115359B (es)
HK (1) HK1131126A1 (es)
HR (2) HRP20120333T1 (es)
IL (1) IL195947A (es)
JO (1) JO2969B1 (es)
MA (1) MA30537B1 (es)
ME (1) ME00535B (es)
MX (1) MX2008016274A (es)
MY (1) MY154798A (es)
NO (1) NO20090235L (es)
NZ (1) NZ574038A (es)
PE (1) PE20080993A1 (es)
PL (2) PL2041123T3 (es)
PT (2) PT2041123E (es)
RS (2) RS53230B (es)
RU (1) RU2444521C2 (es)
SI (2) SI2041123T1 (es)
TW (1) TWI354668B (es)
UA (1) UA95296C2 (es)
WO (1) WO2008001931A2 (es)
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AU2007265966B2 (en) 2012-05-17
SI2248812T1 (sl) 2014-04-30
US20140080891A1 (en) 2014-03-20
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RS53230B (en) 2014-08-29
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UA95296C2 (uk) 2011-07-25
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AR061644A1 (es) 2008-09-10
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MA30537B1 (fr) 2009-06-01
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US20130267589A1 (en) 2013-10-10
CN103083307A (zh) 2013-05-08
JO2969B1 (en) 2016-03-15
EP2248812A3 (en) 2011-03-16
CA2838448A1 (en) 2008-01-03
KR20090027743A (ko) 2009-03-17
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CR10564A (es) 2012-06-18
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