CO5650243A2 - Modulador del receptor canabinoide - Google Patents

Modulador del receptor canabinoide

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Publication number
CO5650243A2
CO5650243A2 CO05129098A CO05129098A CO5650243A2 CO 5650243 A2 CO5650243 A2 CO 5650243A2 CO 05129098 A CO05129098 A CO 05129098A CO 05129098 A CO05129098 A CO 05129098A CO 5650243 A2 CO5650243 A2 CO 5650243A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
group
atom
ring
formula
Prior art date
Application number
CO05129098A
Other languages
English (en)
Inventor
Shigenori Ohkawa
Tetsuya Tsukamoto
Yoshihiro Kiyota
Mika Goto
Shouzou Yamamoto
Masato Shimojou
Masaki Seto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CO5650243A2 publication Critical patent/CO5650243A2/es

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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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Abstract

1.- Un modulador del receptor canabinoide, caracterizado porque contiene un compuesto representado por la fórmula (lo) en donde, X es un átomo de oxígeno, un átomo de azufre opcionalmente substituido o un grupo imino opcionalmente substituido, RO es un grupo acilamino opcionalmente substituido, el anillo Ao es un anillo de benceno el cual puede además tener un substituyente además de Ro, y el anillo B es un heterociclo de 5 miembros opcionalmente substituido, o una sal del mismo o un profármaco del mismo.2.- El modulador de conformidad con la reivindicación 1, caracterizado porque el compuesto representado por la Fórmula (lo) o una sal del mismo o un profármaco del mismo es un compuesto representado por la fórmula (I) en donde, X es un átomo de oxígeno, un átomo de azufre opcionalmente substituido o un grupo imino opcionalmente substituido, R1, R2, R3 y R4 son independientemente un átomo de hidrógeno, un grupo hidrocarburo opcionalmente substituido, un grupo heterocíclico opcionalmente substituido, un grupo hidroxilo opcionalmente substituido, un grupo mercapto opcionalmente substituido o un grupo amino opcionalmente substituido, o R2 y R3 pueden tomarse juntos para formar un enlace, o R1 y R2 pueden tomarse con el átomo de carbono adyacente para formar un anillo opcionalmente substituido, Y es -CO-, -SO-, ó SO2-, R5 es un átomo de hidrógeno o un grupo hidrocarburo opcionalmente substituido, R6 es un átomo de hidrógeno, un grupo hidrocarburo opcionalmente substituido, un grupo hidroxilo opcionalmente substituido o un grupo amino opcionalmente substituido, o R5 y R6 pueden tomarse con el átomo de carbono o átomo de azufre adyacente y átomo de nitrógeno para formar un anillo opcionalmente substituido, y el anillo A es un anillo de benceno el cual puede además tener un substituyente además de un grupo representado por la siguiente fórmula en donde, cada uno de los símbolo tiene el mismo significado como se describe arriba, o una sal del mismo o un profármaco del mismo.
CO05129098A 2003-06-26 2005-12-22 Modulador del receptor canabinoide CO5650243A2 (es)

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KR (1) KR101138673B1 (es)
CN (1) CN1816536B (es)
AU (1) AU2004252005B2 (es)
BR (1) BRPI0411740A (es)
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Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
US7993872B2 (en) 2003-06-18 2011-08-09 The Scripps Research Institute Unnatural reactive amino acid genetic code additions
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