PT1373259E - Inibidores piridazinona de aldose reductase - Google Patents

Inibidores piridazinona de aldose reductase

Info

Publication number
PT1373259E
PT1373259E PT02716247T PT02716247T PT1373259E PT 1373259 E PT1373259 E PT 1373259E PT 02716247 T PT02716247 T PT 02716247T PT 02716247 T PT02716247 T PT 02716247T PT 1373259 E PT1373259 E PT 1373259E
Authority
PT
Portugal
Prior art keywords
pyridazinone
inhibitors
aldose reductase
aldose
reductase
Prior art date
Application number
PT02716247T
Other languages
English (en)
Inventor
Banavara Lakshman Mylari
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PT1373259E publication Critical patent/PT1373259E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT02716247T 2001-03-30 2002-01-31 Inibidores piridazinona de aldose reductase PT1373259E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28005101P 2001-03-30 2001-03-30

Publications (1)

Publication Number Publication Date
PT1373259E true PT1373259E (pt) 2005-03-31

Family

ID=23071435

Family Applications (2)

Application Number Title Priority Date Filing Date
PT02716247T PT1373259E (pt) 2001-03-30 2002-01-31 Inibidores piridazinona de aldose reductase
PT04023149T PT1491540E (pt) 2001-03-30 2002-01-31 Intermediários úteis na síntese de inibidores piridazinona de aldose reductase

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT04023149T PT1491540E (pt) 2001-03-30 2002-01-31 Intermediários úteis na síntese de inibidores piridazinona de aldose reductase

Country Status (44)

Country Link
US (2) US6579879B2 (pt)
EP (3) EP1373259B1 (pt)
JP (1) JP2004528319A (pt)
KR (1) KR100586138B1 (pt)
CN (1) CN1215067C (pt)
AP (1) AP2002002461A0 (pt)
AR (1) AR035798A1 (pt)
AT (3) ATE286049T1 (pt)
AU (1) AU2002226634B2 (pt)
BG (1) BG108179A (pt)
BR (1) BR0208571A (pt)
CA (1) CA2442476A1 (pt)
CZ (1) CZ20032563A3 (pt)
DE (3) DE60217930T2 (pt)
DK (2) DK1373259T3 (pt)
EA (1) EA006023B1 (pt)
EC (1) ECSP034671A (pt)
EE (1) EE200300470A (pt)
ES (2) ES2274369T3 (pt)
GE (1) GEP20053675B (pt)
HK (1) HK1061678A1 (pt)
HR (1) HRP20030752A2 (pt)
HU (1) HUP0303644A3 (pt)
IL (1) IL156462A0 (pt)
IS (3) IS2205B (pt)
MA (1) MA27003A1 (pt)
MX (1) MXPA03008850A (pt)
MY (1) MY134304A (pt)
NO (1) NO20034345L (pt)
NZ (1) NZ528406A (pt)
OA (1) OA12453A (pt)
PA (1) PA8541801A1 (pt)
PE (1) PE20030007A1 (pt)
PL (1) PL365294A1 (pt)
PT (2) PT1373259E (pt)
SI (1) SI1373259T1 (pt)
SK (1) SK11852003A3 (pt)
TN (1) TNSN02037A1 (pt)
TW (1) TWI245762B (pt)
UA (1) UA73236C2 (pt)
UY (1) UY27237A1 (pt)
WO (1) WO2002079198A1 (pt)
YU (1) YU71403A (pt)
ZA (1) ZA200304671B (pt)

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USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
ES2240657T3 (es) * 2001-02-28 2005-10-16 Pfizer Products Inc. Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
AU2002226634B2 (en) * 2001-03-30 2007-01-25 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
PL371258A1 (en) 2002-01-09 2005-06-13 Pfizer Products Inc. Process and intermediates for pyridazinone antidiabetic agents
US20040092522A1 (en) * 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
US7419981B2 (en) * 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US6872833B2 (en) * 2003-04-14 2005-03-29 Hoffmann-La Roche Inc. Adenosine receptor ligands
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006028565A2 (en) * 2004-06-30 2006-03-16 Whitehead Institute For Biomedical Research Novel methods for high-throughput genome-wide location analysis
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
MX2008009022A (es) * 2006-01-13 2008-09-24 Wyeth Corp 1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina.
ME00535B (me) 2006-06-27 2011-10-10 Takeda Pharmaceuticals Co Fuzionisana ciklična jedinjenja
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
TWI464147B (zh) * 2011-09-15 2014-12-11 Univ Taipei Medical 吲哚氫胺酸和吲哚啉氫胺酸於治療心臟衰竭或神經損傷的用途
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103739547B (zh) * 2014-01-03 2015-09-02 沈阳药科大学 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3283074A4 (en) * 2015-04-14 2018-12-05 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN115160339B (zh) 2016-06-21 2024-05-14 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其使用方法
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US10344002B2 (en) 2016-09-26 2019-07-09 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15 PGDH INHIBITORS WITH CORTICOSTEROIDS AND / OR TNF INHIBITORS AND USES THEREOF
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
MX2020001057A (es) 2017-07-28 2020-11-24 Applied Therapeutics Inc Composiciones y metodos para tratar la galactosemia.
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
JP2022534426A (ja) 2019-05-31 2022-07-29 イケナ オンコロジー, インコーポレイテッド Tead阻害剤およびその使用
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
WO2022120353A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof

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IE47592B1 (en) 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
US4996204A (en) 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
WO1992009594A1 (en) * 1990-11-30 1992-06-11 Tsumura & Co. Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
BR9205810A (pt) 1991-03-28 1994-06-28 Pfizer Acidos piridazinona acéticos
US5834466A (en) 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
AU735729B2 (en) * 1997-09-24 2001-07-12 Orion Corporation Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
AU2002226634B2 (en) * 2001-03-30 2007-01-25 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
AU2002236131B2 (en) * 2001-04-30 2005-04-14 Pfizer Products Inc. Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
PL371258A1 (en) * 2002-01-09 2005-06-13 Pfizer Products Inc. Process and intermediates for pyridazinone antidiabetic agents

Also Published As

Publication number Publication date
DK1373259T3 (da) 2005-03-29
JP2004528319A (ja) 2004-09-16
DE60202452T2 (de) 2006-02-09
ZA200304671B (en) 2004-06-25
EP1491541B1 (en) 2007-01-24
DE60202452D1 (de) 2005-02-03
PT1491540E (pt) 2007-01-31
KR20030088484A (ko) 2003-11-19
TNSN02037A1 (fr) 2005-12-23
PE20030007A1 (es) 2003-01-28
CA2442476A1 (en) 2002-10-10
NZ528406A (en) 2004-03-26
IS2205B (is) 2007-02-15
OA12453A (en) 2006-05-24
HUP0303644A2 (hu) 2004-03-01
EE200300470A (et) 2004-02-16
TWI245762B (en) 2005-12-21
NO20034345D0 (no) 2003-09-29
WO2002079198A1 (en) 2002-10-10
SK11852003A3 (sk) 2004-07-07
CZ20032563A3 (cs) 2004-05-12
DE60216823D1 (de) 2007-01-25
BR0208571A (pt) 2004-03-23
MXPA03008850A (es) 2003-12-04
DE60217930T2 (de) 2007-10-18
NO20034345L (no) 2003-09-29
ES2274369T3 (es) 2007-05-16
ES2231681T3 (es) 2005-05-16
AR035798A1 (es) 2004-07-14
DE60216823T2 (de) 2007-10-04
GEP20053675B (en) 2005-11-25
SI1373259T1 (en) 2005-04-30
CN1215067C (zh) 2005-08-17
AP2002002461A0 (en) 2002-06-30
US20020143017A1 (en) 2002-10-03
HUP0303644A3 (en) 2008-06-30
KR100586138B1 (ko) 2006-06-07
PL365294A1 (en) 2004-12-27
IL156462A0 (en) 2004-01-04
DK1491540T3 (da) 2007-03-26
EP1491541A1 (en) 2004-12-29
AU2002226634B2 (en) 2007-01-25
EP1491540B1 (en) 2006-12-13
ATE348100T1 (de) 2007-01-15
UY27237A1 (es) 2002-12-31
MY134304A (en) 2007-12-31
HRP20030752A2 (en) 2005-06-30
US20030162784A1 (en) 2003-08-28
ECSP034671A (es) 2003-08-29
HK1061678A1 (en) 2004-09-30
UA73236C2 (en) 2005-06-15
DE60217930D1 (de) 2007-03-15
IS8251A (is) 2006-01-23
EP1491540A1 (en) 2004-12-29
PA8541801A1 (es) 2002-10-28
US6849629B2 (en) 2005-02-01
IS6845A (is) 2003-06-16
CN1500087A (zh) 2004-05-26
DE60202452C5 (de) 2006-11-23
ATE352551T1 (de) 2007-02-15
EP1373259B1 (en) 2004-12-29
IS8250A (is) 2006-01-23
US6579879B2 (en) 2003-06-17
EP1373259A1 (en) 2004-01-02
BG108179A (en) 2004-09-30
EA200300673A1 (ru) 2003-12-25
YU71403A (sh) 2006-05-25
MA27003A1 (fr) 2004-12-20
EA006023B1 (ru) 2005-08-25
ATE286049T1 (de) 2005-01-15

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