|
DE3226768A1
(de)
|
1981-11-05 |
1983-05-26 |
Hoechst Ag, 6230 Frankfurt |
Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
|
|
DE3211676A1
(de)
|
1982-03-30 |
1983-10-06 |
Hoechst Ag |
Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
|
|
US4499082A
(en)
*
|
1983-12-05 |
1985-02-12 |
E. I. Du Pont De Nemours And Company |
α-Aminoboronic acid peptides
|
|
FR2575753B1
(fr)
|
1985-01-07 |
1987-02-20 |
Adir |
Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5496927A
(en)
|
1985-02-04 |
1996-03-05 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
|
IL77748A
(en)
|
1985-02-04 |
1991-11-21 |
Merrell Dow Pharma |
Amino acid and peptide derivatives as peptidase inhibitors
|
|
ATE71934T1
(de)
|
1985-06-07 |
1992-02-15 |
Ici America Inc |
Selektionierte difluorverbindungen.
|
|
US5231084A
(en)
|
1986-03-27 |
1993-07-27 |
Hoechst Aktiengesellschaft |
Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
|
|
NZ223148A
(en)
|
1987-01-16 |
1989-10-27 |
Merrell Dow Pharma |
Peptide derivatives having peptidase inhibition activity
|
|
EP0356595A1
(en)
|
1988-09-01 |
1990-03-07 |
Merrell Dow Pharmaceuticals Inc. |
Novel peptidase inhibitors
|
|
US5736520A
(en)
|
1988-10-07 |
1998-04-07 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
|
ZA897514B
(en)
|
1988-10-07 |
1990-06-27 |
Merrell Dow Pharma |
Novel peptidase inhibitors
|
|
EP0371179A1
(en)
|
1988-10-28 |
1990-06-06 |
Merrell Dow Pharmaceuticals Inc. |
Novel analogs of peptidase substrates
|
|
NZ235155A
(en)
|
1989-09-11 |
1993-04-28 |
Merrell Dow Pharma |
Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical
|
|
JPH06504547A
(ja)
|
1990-12-28 |
1994-05-26 |
ジョージア・テック・リサーチ・コーポレーション |
ペプチドケトアミド、ケト酸およびケトエステル
|
|
JP2668003B2
(ja)
|
1992-06-12 |
1997-10-27 |
ファイザー インク. |
ヒトの心臓キマーゼを含むアンギオテンシンiキマーゼに関する阻害剤
|
|
US5371072A
(en)
|
1992-10-16 |
1994-12-06 |
Corvas International, Inc. |
Asp-Pro-Arg α-keto-amide enzyme inhibitors
|
|
ES2150933T3
(es)
*
|
1992-12-22 |
2000-12-16 |
Lilly Co Eli |
Inhibidores de la proteasa vih utiles para el tratamiento del sida.
|
|
EP1090914B1
(en)
|
1992-12-29 |
2003-01-02 |
Abbott Laboratories |
Retroviral protease inhibiting compounds
|
|
US5384410A
(en)
*
|
1993-03-24 |
1995-01-24 |
The Du Pont Merck Pharmaceutical Company |
Removal of boronic acid protecting groups by transesterification
|
|
US5656600A
(en)
|
1993-03-25 |
1997-08-12 |
Corvas International, Inc. |
α-ketoamide derivatives as inhibitors of thrombosis
|
|
US5672582A
(en)
|
1993-04-30 |
1997-09-30 |
Merck & Co., Inc. |
Thrombin inhibitors
|
|
IL110752A
(en)
|
1993-09-13 |
2000-07-26 |
Abbott Lab |
Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
|
|
US5559158A
(en)
|
1993-10-01 |
1996-09-24 |
Abbott Laboratories |
Pharmaceutical composition
|
|
US5468858A
(en)
|
1993-10-28 |
1995-11-21 |
The Board Of Regents Of Oklahoma State University Physical Sciences |
N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
|
|
IL111991A
(en)
|
1994-01-28 |
2000-07-26 |
Abbott Lab |
Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
|
|
HUT72440A
(en)
|
1994-03-31 |
1996-04-29 |
Bristol Myers Squibb Co |
Imidazole-containing inhibitors of farnesyl protein transferase and pharmaceutical compositions containing them
|
|
US6420522B1
(en)
|
1995-06-05 |
2002-07-16 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
|
US5756466A
(en)
|
1994-06-17 |
1998-05-26 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
|
US5847135A
(en)
|
1994-06-17 |
1998-12-08 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
|
US5716929A
(en)
|
1994-06-17 |
1998-02-10 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
|
US5861267A
(en)
|
1995-05-01 |
1999-01-19 |
Vertex Pharmaceuticals Incorporated |
Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
|
|
US6037157A
(en)
|
1995-06-29 |
2000-03-14 |
Abbott Laboratories |
Method for improving pharmacokinetics
|
|
WO1997019084A1
(en)
|
1995-11-23 |
1997-05-29 |
Merck Sharp & Dohme Limited |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
|
EP0873519A4
(en)
|
1995-12-07 |
2005-04-27 |
Scripps Research Inst |
HIV PROTEASE INHIBITORS
|
|
US5807876A
(en)
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
US6054472A
(en)
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
|
ZA972195B
(en)
|
1996-03-15 |
1998-09-14 |
Du Pont Merck Pharma |
Spirocycle integrin inhibitors
|
|
WO1997040028A1
(en)
|
1996-04-23 |
1997-10-30 |
Vertex Pharmaceuticals Incorporated |
Urea derivatives as inhibitors of impdh enzyme
|
|
US5990276A
(en)
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
|
EP0907659A1
(en)
|
1996-05-10 |
1999-04-14 |
Schering Corporation |
Synthetic inhibitors of hepatitis c virus ns3 protease
|
|
US6153579A
(en)
|
1996-09-12 |
2000-11-28 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
|
AU723414B2
(en)
|
1996-09-25 |
2000-08-24 |
Merck Sharp & Dohme Limited |
Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
|
|
CA2268255A1
(en)
|
1996-10-08 |
1998-04-16 |
Colorado State University Research Foundation |
Catalytic asymmetric epoxidation
|
|
HU227742B1
(en)
*
|
1996-10-18 |
2012-02-28 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
|
|
GB9623908D0
(en)
*
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
DE19648011A1
(de)
|
1996-11-20 |
1998-05-28 |
Bayer Ag |
Cyclische Imine
|
|
DE19648793A1
(de)
|
1996-11-26 |
1998-05-28 |
Basf Ag |
Neue Benzamide und deren Anwendung
|
|
CA2282398A1
(en)
|
1997-03-14 |
1998-09-17 |
Steven M. Ronkin |
Inhibitors of impdh enzyme
|
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
|
GB9708484D0
(en)
|
1997-04-25 |
1997-06-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9711114D0
(en)
|
1997-05-29 |
1997-07-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JP4354632B2
(ja)
|
1997-08-11 |
2009-10-28 |
ベーリンガー インゲルハイム (カナダ) リミテッド |
C型肝炎抑制剤ペプチド
|
|
US6767991B1
(en)
|
1997-08-11 |
2004-07-27 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptides
|
|
NZ503263A
(en)
|
1997-08-11 |
2002-10-25 |
Boehringer Ingelheim Ca Ltd |
Hepatitis C NS3 protease inhibitor peptides and peptide analogues
|
|
US6183121B1
(en)
|
1997-08-14 |
2001-02-06 |
Vertex Pharmaceuticals Inc. |
Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
|
|
US20040058982A1
(en)
|
1999-02-17 |
2004-03-25 |
Bioavailability System, Llc |
Pharmaceutical compositions
|
|
US20020017295A1
(en)
|
2000-07-07 |
2002-02-14 |
Weers Jeffry G. |
Phospholipid-based powders for inhalation
|
|
AU1416099A
(en)
|
1997-11-28 |
1999-06-16 |
Schering Corporation |
Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide
|
|
US6075150A
(en)
|
1998-01-26 |
2000-06-13 |
Cv Therapeutics, Inc. |
α-ketoamide inhibitors of 20S proteasome
|
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
|
ES2281170T3
(es)
|
1998-03-31 |
2007-09-16 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de serina proteasas, particularmente proteasa ns3 del virus de la hepatitis c.
|
|
US6251583B1
(en)
|
1998-04-27 |
2001-06-26 |
Schering Corporation |
Peptide substrates for HCV NS3 protease assays
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
AR022061A1
(es)
|
1998-08-10 |
2002-09-04 |
Boehringer Ingelheim Ca Ltd |
Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
DE19836514A1
(de)
|
1998-08-12 |
2000-02-17 |
Univ Stuttgart |
Modifikation von Engineeringpolymeren mit N-basischen Gruppe und mit Ionenaustauschergruppen in der Seitenkette
|
|
US6117639A
(en)
|
1998-08-31 |
2000-09-12 |
Vertex Pharmaceuticals Incorporated |
Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
|
|
US6686335B1
(en)
|
1998-09-22 |
2004-02-03 |
Cephalon, Inc. |
Hydroxamate-containing cysteine and serine protease inhibitors
|
|
US6025516A
(en)
|
1998-10-14 |
2000-02-15 |
Chiragene, Inc. |
Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
|
|
US6117870A
(en)
|
1998-11-12 |
2000-09-12 |
Fujirebio Kabushiki Kaisha |
Cyclic amide derivatives
|
|
GB9825946D0
(en)
|
1998-11-26 |
1999-01-20 |
Angeletti P Ist Richerche Bio |
Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease
|
|
ES2306646T3
(es)
|
1999-02-09 |
2008-11-16 |
Pfizer Products Inc. |
Composiciones de farmacos basicos con biodisponibilidad incrementada.
|
|
US20020042046A1
(en)
|
1999-02-25 |
2002-04-11 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
|
WO2000056331A1
(en)
|
1999-03-19 |
2000-09-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
US6608027B1
(en)
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
AU5788800A
(en)
*
|
1999-07-07 |
2001-01-22 |
Du Pont Pharmaceuticals Company |
Peptide boronic acid inhibitors of hepatitis c virus protease
|
|
US7122627B2
(en)
*
|
1999-07-26 |
2006-10-17 |
Bristol-Myers Squibb Company |
Lactam inhibitors of Hepatitis C virus NS3 protease
|
|
EP1206449A1
(en)
|
1999-07-26 |
2002-05-22 |
Bristol-Myers Squibb Company |
Lactam inhibitors of hepatitis c virus ns3 protease
|
|
US20020183249A1
(en)
|
1999-08-31 |
2002-12-05 |
Taylor Neil R. |
Method of identifying inhibitors of CDC25
|
|
WO2001016300A2
(en)
|
1999-08-31 |
2001-03-08 |
Basf Aktiengesellschaft |
Method of identifying inhibitors of cdc25
|
|
GB9925955D0
(en)
|
1999-11-02 |
1999-12-29 |
Angeletti P Ist Richerche Bio |
Hcv n33 protease inhibitors
|
|
US6774212B2
(en)
*
|
1999-12-03 |
2004-08-10 |
Bristol-Myers Squibb Pharma Company |
Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease
|
|
US6624290B2
(en)
|
2000-02-08 |
2003-09-23 |
Schering Corporation |
Azapeptides useful in the treatment of Hepatitis C
|
|
US6699855B2
(en)
|
2000-02-29 |
2004-03-02 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus NS3 protease
|
|
EP1268519B1
(en)
*
|
2000-04-03 |
2005-06-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
|
|
DE60137207D1
(de)
|
2000-04-05 |
2009-02-12 |
Schering Corp |
Makrozyklische inhibitoren der ns3-serinprotease des hepatitis c-virus mit stickstoffhaltigen zyklischen p2-gruppen
|
|
SK14952002A3
(sk)
*
|
2000-04-19 |
2003-03-04 |
Schering Corporation |
Makrocyklické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
WO2002002546A1
(en)
|
2000-06-30 |
2002-01-10 |
Seikagaku Corporation |
EPOXYCARBOXYLIC ACID AMIDES, AZIDES AND AMINO ALCOHOLS AND PROCESSES FOR PREPARATION OF α-KETO AMIDES BY USING THEM
|
|
EP1322325A4
(en)
|
2000-07-20 |
2004-09-15 |
Merck & Co Inc |
INHIBITION OF PROCESSING AND REPLICATION OF HEPATITIS C VIRUS
|
|
RU2355700C9
(ru)
|
2000-07-21 |
2010-03-20 |
Шеринг Корпорейшн |
Новые пептиды как ингибиторы ns3-серинпротеазы вируса гепатита с
|
|
AR034127A1
(es)
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
|
NZ523781A
(en)
|
2000-07-21 |
2004-10-29 |
Corvas Int Inc |
Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
EP1301527A2
(en)
|
2000-07-21 |
2003-04-16 |
Corvas International, Inc. |
Peptides as ns3-serine protease inhibitors of hepatitis c virus
|
|
AR029851A1
(es)
*
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
|
US6777400B2
(en)
|
2000-08-05 |
2004-08-17 |
Smithkline Beecham Corporation |
Anti-inflammatory androstane derivative compositions
|
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
|
US6939692B2
(en)
|
2000-09-12 |
2005-09-06 |
Degussa Ag |
Nucleotide sequences coding for the pknB gene
|
|
US6846806B2
(en)
|
2000-10-23 |
2005-01-25 |
Bristol-Myers Squibb Company |
Peptide inhibitors of Hepatitis C virus NS3 protein
|
|
JP2002198723A
(ja)
*
|
2000-11-02 |
2002-07-12 |
Ace Technol Co Ltd |
広帯域指向性アンテナ
|
|
US6602718B1
(en)
|
2000-11-08 |
2003-08-05 |
Becton, Dickinson And Company |
Method and device for collecting and stabilizing a biological sample
|
|
AU2002248147B2
(en)
|
2000-11-20 |
2006-04-06 |
Bristol-Myers Squibb Company |
Hepatitis C tripeptide inhibitors
|
|
HUP0303436A2
(hu)
|
2000-12-12 |
2004-01-28 |
Schering Corp. |
Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
|
|
WO2002048157A2
(en)
|
2000-12-13 |
2002-06-20 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
|
|
AU2002230763A1
(en)
|
2000-12-13 |
2008-01-03 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
US6653295B2
(en)
|
2000-12-13 |
2003-11-25 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus NS3 protease
|
|
JP4848528B2
(ja)
|
2000-12-28 |
2011-12-28 |
株式会社Ihi |
イオン質量分離方法及び装置、並びにイオンドーピング装置
|
|
CN1267446C
(zh)
|
2001-01-22 |
2006-08-02 |
默克公司 |
作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物
|
|
GB0102342D0
(en)
|
2001-01-30 |
2001-03-14 |
Smithkline Beecham Plc |
Pharmaceutical formulation
|
|
CA2436518A1
(en)
|
2001-01-30 |
2002-08-08 |
Vertex Pharmaceuticals Incorporated |
A quantitative assay for nucleic acids
|
|
EP1381673B1
(en)
|
2001-03-27 |
2009-05-13 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods useful for hcv infection
|
|
GB0107924D0
(en)
|
2001-03-29 |
2001-05-23 |
Angeletti P Ist Richerche Bio |
Inhibitor of hepatitis C virus NS3 protease
|
|
CA2450545A1
(en)
|
2001-07-03 |
2003-01-16 |
Altana Pharma Ag |
Process for the production of 3-phenylisoserine
|
|
KR100926244B1
(ko)
*
|
2001-07-11 |
2009-11-12 |
버텍스 파마슈티칼스 인코포레이티드 |
브릿지된 바이사이클릭 세린 프로테아제 억제제
|
|
JP2003055389A
(ja)
|
2001-08-09 |
2003-02-26 |
Univ Tokyo |
錯体及びそれを用いたエポキシドの製法
|
|
US6824769B2
(en)
|
2001-08-28 |
2004-11-30 |
Vertex Pharmaceuticals Incorporated |
Optimal compositions and methods thereof for treating HCV infections
|
|
EP1441720B8
(en)
*
|
2001-10-24 |
2012-03-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine protease, particularly hepatitis c virus ns3-ns4a protease, incorporating a fused ring system
|
|
AU2002360386A1
(en)
|
2001-11-14 |
2003-06-17 |
Teva Pharmaceutical Industries Ltd. |
Amorphous and crystalline forms of losartan potassium and process for their preparation
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
CA2369970A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
AR038375A1
(es)
|
2002-02-01 |
2005-01-12 |
Pfizer Prod Inc |
Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
|
|
MXPA04009938A
(es)
*
|
2002-04-11 |
2004-12-13 |
Vertex Pharma |
Inhibidores de serina proteasas, en particular la proteasa ns3-ns4a del hcv.
|
|
KR100838333B1
(ko)
|
2002-04-25 |
2008-06-13 |
오노 야꾸힝 고교 가부시키가이샤 |
디케토히드라진 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제
|
|
MXPA05001298A
(es)
|
2002-08-01 |
2005-11-04 |
Pharmasset Inc |
Compuestos con el sistema biciclo[4.2.1] nonano para el tratamiento de infecciones por flaviviridae.
|
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
CA2413705A1
(en)
|
2002-12-06 |
2004-06-06 |
Raul Altman |
Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
|
|
US7601709B2
(en)
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US7098231B2
(en)
|
2003-01-22 |
2006-08-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US20040180815A1
(en)
|
2003-03-07 |
2004-09-16 |
Suanne Nakajima |
Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
|
|
JP2006517960A
(ja)
|
2003-02-18 |
2006-08-03 |
ファイザー インコーポレイテッド |
C型肝炎ウイルスの阻害剤、それを使用する組成物および治療法
|
|
EP1601685A1
(en)
|
2003-03-05 |
2005-12-07 |
Boehringer Ingelheim International GmbH |
Hepatitis c inhibiting compounds
|
|
WO2004101602A2
(en)
|
2003-03-05 |
2004-11-25 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibitor peptide analogs
|
|
EP1613620A1
(en)
*
|
2003-04-11 |
2006-01-11 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
CA2521678A1
(en)
*
|
2003-04-11 |
2004-10-28 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
CL2004001161A1
(es)
|
2003-05-21 |
2005-04-08 |
Boehringer Ingelheim Int |
Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c.
|
|
CN102020700A
(zh)
*
|
2003-07-18 |
2011-04-20 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂
|
|
WO2005018330A1
(en)
|
2003-08-18 |
2005-03-03 |
Pharmasset, Inc. |
Dosing regimen for flaviviridae therapy
|
|
PE20050374A1
(es)
|
2003-09-05 |
2005-05-30 |
Vertex Pharma |
Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
|
|
CA2538843A1
(en)
|
2003-09-12 |
2005-03-24 |
Vertex Pharmaceuticals Incorporated |
Animal model for protease activity and liver damage
|
|
TW200526686A
(en)
*
|
2003-09-18 |
2005-08-16 |
Vertex Pharma |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
US6933760B2
(en)
|
2003-09-19 |
2005-08-23 |
Intel Corporation |
Reference voltage generator for hysteresis circuit
|
|
US7642235B2
(en)
|
2003-09-22 |
2010-01-05 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
EP1692157B1
(en)
*
|
2003-10-10 |
2013-04-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
AR045870A1
(es)
|
2003-10-11 |
2005-11-16 |
Vertex Pharma |
Terapia de combinacion para la infeccion de virus de hepatitis c
|
|
EP1677827B1
(en)
|
2003-10-27 |
2008-12-10 |
Vertex Pharmaceuticals Incorporated |
Combinations for hcv treatment
|
|
US8187874B2
(en)
|
2003-10-27 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Drug discovery method
|
|
CN1894276B
(zh)
|
2003-10-27 |
2010-06-16 |
威特克斯医药股份有限公司 |
Hcv ns3-ns4a蛋白酶抗药性突变体
|
|
AU2004285972A1
(en)
|
2003-10-28 |
2005-05-12 |
Vertex Pharmaceuticals, Incorporated |
Preparation of 4,5-dialkyl-3-acyl-pyrrole-2-carboxylic acid derivatives by Fischer-Fink type synthesis and subsequent acylation
|
|
US20050119318A1
(en)
|
2003-10-31 |
2005-06-02 |
Hudyma Thomas W. |
Inhibitors of HCV replication
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
AU2004295702A1
(en)
|
2003-12-01 |
2005-06-16 |
Vertex Pharmaceuticals Incorporated |
Compositions comprising fetal liver cells and methods useful for HCV infection
|
|
CA2549851C
(en)
|
2004-01-21 |
2012-09-11 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis c virus
|
|
CN1938332B
(zh)
|
2004-02-04 |
2011-10-19 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂
|
|
KR20120091276A
(ko)
|
2004-02-20 |
2012-08-17 |
베링거 인겔하임 인터내셔날 게엠베하 |
바이러스 폴리머라제 억제제
|
|
US20050187192A1
(en)
|
2004-02-20 |
2005-08-25 |
Kucera Pharmaceutical Company |
Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
|
|
CN1946692A
(zh)
|
2004-02-27 |
2007-04-11 |
先灵公司 |
作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4-(环戊基)-稠合的脯氨酸化合物
|
|
CA2768700C
(en)
|
2004-03-12 |
2014-04-29 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
|
|
WO2005107745A1
(en)
|
2004-05-06 |
2005-11-17 |
Schering Corporation |
An inhibitor of hepatitis c
|
|
AR049297A1
(es)
*
|
2004-06-08 |
2006-07-12 |
Vertex Pharma |
Una composicion farmaceutica y dispersiones solidas de vx-950 (inhibidor de la proteasa de hcv ns3/4a) y proceso de obtencion
|
|
ATE513844T1
(de)
|
2004-08-27 |
2011-07-15 |
Schering Corp |
Acylsulfonamidverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
|
|
CN102160891A
(zh)
*
|
2004-10-01 |
2011-08-24 |
威特克斯医药股份有限公司 |
Hcv ns3-ns4a蛋白酶抑制
|
|
TWI437990B
(zh)
*
|
2004-10-29 |
2014-05-21 |
Vertex Pharma |
Vx-950之醫藥用途
|
|
US7863274B2
(en)
|
2005-07-29 |
2011-01-04 |
Concert Pharmaceuticals Inc. |
Deuterium enriched analogues of tadalafil as PDE5 inhibitors
|
|
RU2441020C2
(ru)
*
|
2005-08-02 |
2012-01-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Ингибиторы серинпротеазы
|
|
PT1934179E
(pt)
*
|
2005-08-19 |
2010-07-12 |
Vertex Pharma |
PROCESSOS E INTERMEDIáRIOS
|
|
US7964624B1
(en)
|
2005-08-26 |
2011-06-21 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases
|
|
AR055395A1
(es)
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
|
US7705138B2
(en)
*
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
|
EP1991229A2
(en)
|
2006-02-27 |
2008-11-19 |
Vertex Pharmaceuticals Incorporated |
Co-crystals and pharmaceutical compositions comprising the same
|
|
EP2194039A1
(en)
|
2006-03-16 |
2010-06-09 |
Vertex Pharmceuticals Incorporated |
Process for preparing optically enriched compounds
|
|
MX2008011869A
(es)
|
2006-03-16 |
2008-12-03 |
Vertex Pharma |
Procedimientos e intermediarios para preparar compuestos estericos.
|
|
NZ571934A
(en)
|
2006-03-20 |
2012-05-25 |
Vertex Pharma |
Methods of spray drying formulations of vx-950 (telaprevir)
|
|
AU2007226983A1
(en)
|
2006-03-20 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions
|
|
US7651520B2
(en)
*
|
2006-05-30 |
2010-01-26 |
Ostial Solutions, Llc |
Means and method for the accurate placement of a stent at the ostium of an artery
|
|
EP2037887B1
(en)
|
2006-05-31 |
2010-09-15 |
Vertex Pharmaceuticals Incorporated |
Oral controlled release formulations of an interleukin-1 beta converting enzyme inhibitor
|
|
US7708294B2
(en)
|
2006-11-02 |
2010-05-04 |
Gm Global Technology Operations, Inc. |
Detachable dual-use platform apparatus and method
|
|
CN101903392A
(zh)
|
2007-02-27 |
2010-12-01 |
弗特克斯药品有限公司 |
丝氨酸蛋白酶的抑制剂
|
|
US7910587B2
(en)
*
|
2007-04-26 |
2011-03-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl dipeptide hepatitis C virus inhibitors
|
|
US7959488B2
(en)
*
|
2007-10-15 |
2011-06-14 |
Tania Alessandra Talamo |
Brassiere pad system
|