JP2005535574A5 - - Google Patents
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- JP2005535574A5 JP2005535574A5 JP2003584048A JP2003584048A JP2005535574A5 JP 2005535574 A5 JP2005535574 A5 JP 2005535574A5 JP 2003584048 A JP2003584048 A JP 2003584048A JP 2003584048 A JP2003584048 A JP 2003584048A JP 2005535574 A5 JP2005535574 A5 JP 2005535574A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- compound
- ring
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(*)C(C)C1CCCC1 Chemical compound CC(*)C(C)C1CCCC1 0.000 description 17
- GDBCVIHZQYAWLU-UHFFFAOYSA-N CC(C(CCC1CC23N(C)CCC2)N1C3=O)=O Chemical compound CC(C(CCC1CC23N(C)CCC2)N1C3=O)=O GDBCVIHZQYAWLU-UHFFFAOYSA-N 0.000 description 1
- VTOITISQJGMVSQ-UHFFFAOYSA-N CC(C(CCC1CCCC2NC)N1C2=O)=O Chemical compound CC(C(CCC1CCCC2NC)N1C2=O)=O VTOITISQJGMVSQ-UHFFFAOYSA-N 0.000 description 1
- TUFWJBPCWWPJJX-UHFFFAOYSA-N CC(C(CCC1NCC2NC)N1C2=O)=O Chemical compound CC(C(CCC1NCC2NC)N1C2=O)=O TUFWJBPCWWPJJX-UHFFFAOYSA-N 0.000 description 1
- HJNGFPBZCZRPJX-UHFFFAOYSA-N CC(C(CCC1NCCC2NC)N1C2=O)=O Chemical compound CC(C(CCC1NCCC2NC)N1C2=O)=O HJNGFPBZCZRPJX-UHFFFAOYSA-N 0.000 description 1
- JCIZAGNGBHWOES-UHFFFAOYSA-N CC(C(CCC1SCC2NC)N1C2=O)=O Chemical compound CC(C(CCC1SCC2NC)N1C2=O)=O JCIZAGNGBHWOES-UHFFFAOYSA-N 0.000 description 1
- RECBQSVGWIRVQV-UHFFFAOYSA-N CC(C(CCC1SCCC2NC)N1C2=O)=O Chemical compound CC(C(CCC1SCCC2NC)N1C2=O)=O RECBQSVGWIRVQV-UHFFFAOYSA-N 0.000 description 1
- QFXDFUFPSSTROV-UHFFFAOYSA-N CC(C(CCCC1CC23N(C)CCC2)N1C3=O)=O Chemical compound CC(C(CCCC1CC23N(C)CCC2)N1C3=O)=O QFXDFUFPSSTROV-UHFFFAOYSA-N 0.000 description 1
- ZXJCQACFSYGMPO-UHFFFAOYSA-N CC(C(CCSC1CC23N(C)CCC2)N1C3=[U])=O Chemical compound CC(C(CCSC1CC23N(C)CCC2)N1C3=[U])=O ZXJCQACFSYGMPO-UHFFFAOYSA-N 0.000 description 1
- RXSWFHPGDPYGRL-IDKOKCKLSA-N CC(C(CC[C@@H]1CCC2NC)N1C2=O)=O Chemical compound CC(C(CC[C@@H]1CCC2NC)N1C2=O)=O RXSWFHPGDPYGRL-IDKOKCKLSA-N 0.000 description 1
- NQIMYAPMJDMGFM-UHFFFAOYSA-N CC(C(CSC1CC23N(C)CCC2)N1C3=O)=O Chemical compound CC(C(CSC1CC23N(C)CCC2)N1C3=O)=O NQIMYAPMJDMGFM-UHFFFAOYSA-N 0.000 description 1
- DVGMAZIZBADOBU-UHFFFAOYSA-N CC(C)(CC(C)=O)CNC Chemical compound CC(C)(CC(C)=O)CNC DVGMAZIZBADOBU-UHFFFAOYSA-N 0.000 description 1
- XQIUXEOBOCSGFV-UHFFFAOYSA-N CC1=CC=CCC1C[Sc](C)C Chemical compound CC1=CC=CCC1C[Sc](C)C XQIUXEOBOCSGFV-UHFFFAOYSA-N 0.000 description 1
- QVVPJFZQUZTCKD-UHFFFAOYSA-O CCC(C)C(C(C(NC(C)CC)=N)=O)NC(C(C)(CC1C2CCCC1)N2C(C(C)(C(C)(C)C)NC(C(C1CCCCC1)NC(C([NH3+])=CC=N)=O)=O)=O)=O Chemical compound CCC(C)C(C(C(NC(C)CC)=N)=O)NC(C(C)(CC1C2CCCC1)N2C(C(C)(C(C)(C)C)NC(C(C1CCCCC1)NC(C([NH3+])=CC=N)=O)=O)=O)=O QVVPJFZQUZTCKD-UHFFFAOYSA-O 0.000 description 1
- SUNIXXUMZRROKD-OWDBQKORSA-N CCC(C1)[C@]1(C(C(NC1C=C1)=O)=O)NC([C@](C1)(C1C(CCC1)C2C1C(C)(C)[C@@H]1NC([C@H](C3CCCCC3)NC(c3nccnc3)=O)=O)N2C1=O)=O Chemical compound CCC(C1)[C@]1(C(C(NC1C=C1)=O)=O)NC([C@](C1)(C1C(CCC1)C2C1C(C)(C)[C@@H]1NC([C@H](C3CCCCC3)NC(c3nccnc3)=O)=O)N2C1=O)=O SUNIXXUMZRROKD-OWDBQKORSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37184602P | 2002-04-11 | 2002-04-11 | |
| PCT/US2003/011459 WO2003087092A2 (en) | 2002-04-11 | 2003-04-11 | Inhibitors of serine proteases, particularly hepatitis c virus ns3 - ns4 protease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009128587A Division JP2009185081A (ja) | 2002-04-11 | 2009-05-28 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535574A JP2005535574A (ja) | 2005-11-24 |
| JP2005535574A5 true JP2005535574A5 (enExample) | 2006-06-01 |
Family
ID=29250748
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584048A Pending JP2005535574A (ja) | 2002-04-11 | 2003-04-11 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
| JP2009128587A Pending JP2009185081A (ja) | 2002-04-11 | 2009-05-28 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
| JP2010151000A Pending JP2010241821A (ja) | 2002-04-11 | 2010-07-01 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009128587A Pending JP2009185081A (ja) | 2002-04-11 | 2009-05-28 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
| JP2010151000A Pending JP2010241821A (ja) | 2002-04-11 | 2010-07-01 | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7273885B2 (enExample) |
| EP (2) | EP1497282A2 (enExample) |
| JP (3) | JP2005535574A (enExample) |
| KR (2) | KR20040099425A (enExample) |
| CN (2) | CN100381440C (enExample) |
| AU (2) | AU2003223602B8 (enExample) |
| CA (1) | CA2481369C (enExample) |
| IL (1) | IL164455A0 (enExample) |
| MX (1) | MXPA04009938A (enExample) |
| NO (2) | NO20044889L (enExample) |
| NZ (2) | NZ561851A (enExample) |
| PL (1) | PL373399A1 (enExample) |
| RU (1) | RU2004133044A (enExample) |
| SG (1) | SG159385A1 (enExample) |
| TW (1) | TW200403236A (enExample) |
| WO (1) | WO2003087092A2 (enExample) |
| ZA (1) | ZA200408243B (enExample) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| AU2001251165A1 (en) * | 2000-04-03 | 2001-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| MXPA04003825A (es) * | 2001-10-24 | 2004-07-08 | Vertex Pharma | Inhibidores de serina proteasa, en particular la ns3-ns4a proteasa del virus de hepatitis c, que incorpora un sistema de anillo fusionado. |
| EP1497282A2 (en) * | 2002-04-11 | 2005-01-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis c virus ns3-ns4 protease |
| US20050090450A1 (en) | 2003-04-11 | 2005-04-28 | Farmer Luc J. | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| AU2011203054B2 (en) * | 2003-04-11 | 2012-04-26 | Vertex Pharmaceuticals, Incorporated | Inhibitors of Serine Proteases, Particularly HCV NS3-NS4A Protease |
| US7109172B2 (en) | 2003-07-18 | 2006-09-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| MY148123A (en) * | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| EP1664091A1 (en) * | 2003-09-18 | 2006-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| US7365092B2 (en) * | 2003-10-10 | 2008-04-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| NZ546663A (en) | 2003-10-10 | 2010-01-29 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
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| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US20080267915A1 (en) * | 2004-10-01 | 2008-10-30 | Vertex Pharmaceuticals | Hcv Ns3-Ns4a Protease Inhibition |
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| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
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| AR055105A1 (es) | 2005-07-29 | 2007-08-08 | Tibotec Pharm Ltd | Inhibidores macrociclicos del virus de la hepatitis c |
| EP1919904B1 (en) | 2005-07-29 | 2014-01-08 | Janssen R&D Ireland | Macrocyclic inhibitors of hepatitis c virus |
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| ATE496042T1 (de) | 2005-07-29 | 2011-02-15 | Tibotec Pharm Ltd | Makrocyclische inhibitoren des hepatitis-c-virus |
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| JO2768B1 (en) * | 2005-07-29 | 2014-03-15 | تيبوتيك فارماسيوتيكالز ليمتد | Large cyclic inhibitors of hepatitis C virus |
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2003
- 2003-04-11 EP EP03719741A patent/EP1497282A2/en not_active Withdrawn
- 2003-04-11 NZ NZ561851A patent/NZ561851A/en not_active IP Right Cessation
- 2003-04-11 PL PL03373399A patent/PL373399A1/xx not_active Application Discontinuation
- 2003-04-11 TW TW092108412A patent/TW200403236A/zh unknown
- 2003-04-11 NZ NZ575692A patent/NZ575692A/en not_active IP Right Cessation
- 2003-04-11 WO PCT/US2003/011459 patent/WO2003087092A2/en not_active Ceased
- 2003-04-11 RU RU2004133044/04A patent/RU2004133044A/ru not_active Application Discontinuation
- 2003-04-11 CN CNB03809665XA patent/CN100381440C/zh not_active Expired - Fee Related
- 2003-04-11 EP EP12160782A patent/EP2468744A2/en not_active Withdrawn
- 2003-04-11 US US10/412,600 patent/US7273885B2/en not_active Expired - Fee Related
- 2003-04-11 SG SG200700139-9A patent/SG159385A1/en unknown
- 2003-04-11 AU AU2003223602A patent/AU2003223602B8/en not_active Ceased
- 2003-04-11 KR KR10-2004-7016168A patent/KR20040099425A/ko not_active Withdrawn
- 2003-04-11 MX MXPA04009938A patent/MXPA04009938A/es active IP Right Grant
- 2003-04-11 CN CNA2008100823499A patent/CN101245097A/zh active Pending
- 2003-04-11 CA CA2481369A patent/CA2481369C/en not_active Expired - Fee Related
- 2003-04-11 JP JP2003584048A patent/JP2005535574A/ja active Pending
- 2003-04-11 KR KR1020117004808A patent/KR20110028665A/ko not_active Ceased
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2004
- 2004-10-10 IL IL16445504A patent/IL164455A0/xx unknown
- 2004-10-12 ZA ZA200408243A patent/ZA200408243B/en unknown
- 2004-11-10 NO NO20044889A patent/NO20044889L/no unknown
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2007
- 2007-07-23 US US11/880,629 patent/US20070292933A1/en not_active Abandoned
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2009
- 2009-05-28 JP JP2009128587A patent/JP2009185081A/ja active Pending
- 2009-06-03 US US12/477,581 patent/US20100173851A1/en not_active Abandoned
- 2009-10-30 AU AU2009233604A patent/AU2009233604A1/en not_active Abandoned
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2010
- 2010-07-01 JP JP2010151000A patent/JP2010241821A/ja active Pending
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2011
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