JP2009529544A5 - - Google Patents

Download PDF

Info

Publication number
JP2009529544A5
JP2009529544A5 JP2008558611A JP2008558611A JP2009529544A5 JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5 JP 2008558611 A JP2008558611 A JP 2008558611A JP 2008558611 A JP2008558611 A JP 2008558611A JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
optionally substituted
substituents
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008558611A
Other languages
English (en)
Japanese (ja)
Other versions
JP5419468B2 (ja
JP2009529544A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CA2007/000428 external-priority patent/WO2007104162A1/en
Publication of JP2009529544A publication Critical patent/JP2009529544A/ja
Publication of JP2009529544A5 publication Critical patent/JP2009529544A5/ja
Application granted granted Critical
Publication of JP5419468B2 publication Critical patent/JP5419468B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008558611A 2006-03-16 2007-03-16 Ｉａｐのｂｉｒドメインに結合する化合物 Expired - Fee Related JP5419468B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78252306P 2006-03-16 2006-03-16
US60/782,523 2006-03-16
US87699406P 2006-12-26 2006-12-26
US60/876,994 2006-12-26
PCT/CA2007/000428 WO2007104162A1 (en) 2006-03-16 2007-03-16 Iap bir domain binding compounds

Publications (3)

Publication Number Publication Date
JP2009529544A JP2009529544A (ja) 2009-08-20
JP2009529544A5 true JP2009529544A5 (enExample) 2010-04-30
JP5419468B2 JP5419468B2 (ja) 2014-02-19

Family

ID=38509005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008558611A Expired - Fee Related JP5419468B2 (ja) 2006-03-16 2007-03-16 Ｉａｐのｂｉｒドメインに結合する化合物

Country Status (15)

Country Link
US (5) US7579320B2 (enExample)
EP (1) EP2004600A4 (enExample)
JP (1) JP5419468B2 (enExample)
KR (1) KR101446907B1 (enExample)
AU (1) AU2007224932B2 (enExample)
BR (1) BRPI0709610A2 (enExample)
CA (1) CA2581960C (enExample)
IL (1) IL193951A (enExample)
MX (1) MX2008011837A (enExample)
NO (1) NO20083868L (enExample)
NZ (1) NZ571577A (enExample)
PH (1) PH12014502420B1 (enExample)
SG (1) SG170739A1 (enExample)
TW (2) TWI504597B (enExample)
WO (1) WO2007104162A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5230865B2 (ja) 2004-07-15 2013-07-10 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ結合性化合物
MX2007007195A (es) 2004-12-20 2007-10-08 Genentech Inc Inhibidores de pirrolidina de iap.
EA012810B1 (ru) 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
AU2006308453B9 (en) 2005-10-25 2011-12-01 Pharmascience Inc. IAP BIR domain binding compounds
WO2007106192A2 (en) 2005-12-19 2007-09-20 Genentech, Inc. Inhibitors of iap
TWI504597B (zh) * 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
MX2008012053A (es) * 2006-03-21 2008-12-17 Joyant Pharmaceuticals Inc Promotores de apoptosis de molecula pequeña.
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
WO2008014229A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
MX2009000824A (es) * 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
CA2684169C (en) * 2007-04-12 2012-06-19 Joyant Pharmaceuticals, Inc. Smac mimetic dimers and trimers useful as anti-cancer agents
NZ598890A (en) * 2007-04-30 2013-10-25 Genentech Inc Inhibitors of iap
JP2010528587A (ja) * 2007-05-07 2010-08-26 テトラロジック ファーマシューティカルズ コーポレーション アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法
WO2008144925A1 (en) * 2007-05-30 2008-12-04 Aegera Therapeutics Inc. Iap bir domain binding compounds
WO2009132136A1 (en) 2008-04-23 2009-10-29 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
US20110117081A1 (en) * 2008-05-05 2011-05-19 Aegera Therapeutics, Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
US20110171171A1 (en) * 2008-06-27 2011-07-14 Aegera Therapeutics, Inc. Bridged secondary amines and use thereof as iap bir domain binding compounds
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
WO2010015090A1 (en) * 2008-08-07 2010-02-11 Aegera Therapeutics Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
WO2010031171A1 (en) * 2008-09-19 2010-03-25 Aegera Therapeutics, Inc. Iap bir domain binding compounds
US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
EP2493879B1 (en) 2009-10-28 2014-05-14 Joyant Pharmaceuticals, Inc. Dimeric smac mimetics
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
UY33236A (es) 2010-02-25 2011-09-30 Novartis Ag Inhibidores dimericos de las iap
WO2012052758A1 (en) * 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
UY33794A (es) 2010-12-13 2012-07-31 Novartis Ag Inhibidores diméricos de las iap
WO2015196091A1 (en) 2014-06-20 2015-12-23 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
US11357857B2 (en) 2014-06-20 2022-06-14 Comera Life Sciences, Inc. Excipient compounds for protein processing
CA2916970A1 (en) * 2016-01-08 2017-07-08 Pharmascience Inc. A smac mimetic compound for use in the treatment of proliferative diseases
CN110944719A (zh) * 2017-07-25 2020-03-31 合帕吉恩治疗公司 凋亡蛋白的二聚肽抑制剂
CN109407133B (zh) * 2017-08-18 2023-09-22 南京中硼联康医疗科技有限公司 生物剂量计及具有其的中子捕获治疗系统
WO2019180627A1 (en) * 2018-03-21 2019-09-26 Piramal Enterprises Limited AN IMPROVED ASYMMETRIC SYNTHESIS OF alpha-(DIARYLMETHYL) ALKYL AMINES
WO2020027225A1 (ja) 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
CA3120023A1 (en) * 2018-11-29 2020-06-04 Reform Biologics, Llc Excipient compounds for protein processing
AU2020252216B2 (en) * 2019-04-05 2026-02-26 Hepagene Therapeutics (HK) Limited Bivalent antagonists of inhibitors of apoptosis proteins
WO2020223403A1 (en) * 2019-04-29 2020-11-05 The Regents Of The University Of California Anticancer smac derivatives
JP7764027B2 (ja) 2019-07-31 2025-11-05 ファイメクス株式会社 複素環化合物
US20230056604A1 (en) 2020-01-20 2023-02-23 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
EP4308095A4 (en) 2021-03-15 2025-02-19 Maze Therapeutics, Inc. GLYCOGEN SYNTHASE 1 (GYS1) INHIBITORS AND METHODS OF USE THEREOF
JP7260725B1 (ja) * 2021-12-27 2023-04-18 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、及び除去剤

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US93429A (en) * 1869-08-10 Improvement in flasks for vulcanizing rubber plates for setting teeth
US32437A (en) * 1861-05-28 Improvement in steam-plows
US258581A (en) * 1882-05-30 husset
US219140A (en) * 1879-09-02 Improvement in the art of ornamenting metallic foils
US211627A (en) * 1879-01-28 Improvement in perforating-stamps
US69812A (en) * 1867-10-15 Improved refrigerator
US89896A (en) * 1869-05-11 Improvement in bee-hive
US180828A (en) * 1876-08-08 Improvement in horse-powers
US207525A (en) * 1878-08-27 Improvement in car-coupling draw-bars
US93428A (en) * 1869-08-10 Improvement in spurs for excelsior-machines
US25347A (en) * 1859-09-06 Improvement
US194741A (en) * 1877-08-28 Improvement in circular looms
JPH0680077B2 (ja) 1985-02-08 1994-10-12 サントリー株式会社 プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物
JPH04208299A (ja) 1990-11-30 1992-07-29 Ajinomoto Co Inc プロリルエンドペプチターゼ阻害ペプチド
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
AUPN727595A0 (en) * 1995-12-22 1996-01-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic compositions
JP4208299B2 (ja) 1998-08-19 2009-01-14 東レ株式会社 金属板貼合わせ成形加工用ポリエステルフィルム
US6110691A (en) * 2000-01-06 2000-08-29 Board Of Regents, The University Of Texas System Activators of caspases
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
US6992063B2 (en) * 2000-09-29 2006-01-31 The Trustees Of Princeton University Compositions and method for regulating apoptosis
WO2004007529A2 (en) 2002-07-15 2004-01-22 The Trustees Of Princeton University Iap binding compounds
WO2002026775A2 (en) 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions and methods for regulating apoptosis
WO2002030959A2 (en) 2000-10-13 2002-04-18 Abbott Laboratories Peptides derived from smac (diablo) and methods of use therefor
CA2447687A1 (en) * 2001-05-16 2002-12-19 Antexpharma, Inc. Substituted 1-benzazepines and derivatives thereof
EP1421204A4 (en) 2001-05-31 2004-12-15 Univ Princeton IAP-BINDING PEPTIDES AND ASSAYS FOR IDENTIFYING IAP-BINDING COMPOUNDS
ES2278928T3 (es) * 2001-06-19 2007-08-16 Altana Pharma Ag Inhibidores de triptasa.
US20060258581A1 (en) 2001-11-21 2006-11-16 Reed John C Methods and composition for derepressions of IAP-inhibited caspase
WO2003086470A2 (en) 2002-04-17 2003-10-23 Deutsches Krebsforschungszentrum Smac-peptides as therapeutics against cancer and autoimmune diseases
CA2491041A1 (en) 2002-07-02 2004-01-15 Novartis Ag Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
FR2844271A1 (fr) * 2002-09-09 2004-03-12 Oreal Derives bis-paraphenylenediamine a groupement pyrrolidinyle et utilisation de ces derives pour la coloration de fibres keratiniques
RU2379056C2 (ru) * 2002-11-27 2010-01-20 Айрм Ллс Способы и композиции для индукции апоптоза раковых клеток
WO2004066958A2 (en) 2003-01-30 2004-08-12 The Trustees Of Princeton University Caspase-9:bir3 domain of xiap complexes and methods of use
US7067274B2 (en) * 2003-11-13 2006-06-27 Genentech, Inc. Compositions and methods for the screening pro-apoptotic compounds
CN1933847A (zh) 2004-01-16 2007-03-21 密歇根大学董事会 Smac肽模拟物及其应用
EP1713542A2 (en) 2004-02-05 2006-10-25 Novartis AG COMBINATION OF (a) A DNA TOPOISOMERASE INHIBITOR AND (b) AN IAP INHIBITOR
EP1723122B1 (en) * 2004-03-01 2014-11-19 Board of Regents, The University of Texas System Dimeric small molecule potentiators of apoptosis
US7345081B2 (en) 2004-03-23 2008-03-18 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
PL2253614T3 (pl) 2004-04-07 2013-03-29 Novartis Ag Inhibitory IAP
KR100926203B1 (ko) * 2004-07-02 2009-11-09 제넨테크, 인크. Ｉａｐ의 억제제
WO2006010118A2 (en) 2004-07-09 2006-01-26 The Regents Of The University Of Michigan Conformationally constrained smac mimetics and the uses thereof
BRPI0513310A (pt) 2004-07-12 2008-05-06 Idun Pharmaceuticals Inc análogos de tetrapeptìdeo
JP5230865B2 (ja) 2004-07-15 2013-07-10 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ結合性化合物
MX2007007195A (es) 2004-12-20 2007-10-08 Genentech Inc Inhibidores de pirrolidina de iap.
EA012810B1 (ru) * 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
US20070003535A1 (en) 2005-03-17 2007-01-04 Reed John C Methods and compositions for derepression of IAP-inhibited caspase
DE102005017116A1 (de) 2005-04-13 2006-10-26 Novartis Ag Hemmstoffe für Inhibitoren von Apoptose Proteinen (IAP)
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
WO2006128455A2 (en) 2005-05-25 2006-12-07 2Curex Aps Compounds modifying apoptosis
AU2006255084A1 (en) 2005-06-08 2006-12-14 Novartis Ag Organic compounds
CA2617642A1 (en) * 2005-08-09 2007-02-22 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
AU2006308453B9 (en) 2005-10-25 2011-12-01 Pharmascience Inc. IAP BIR domain binding compounds
WO2007106192A2 (en) 2005-12-19 2007-09-20 Genentech, Inc. Inhibitors of iap
US20090005411A1 (en) 2005-12-20 2009-01-01 Novartic Ag Combinations of Organic Compounds
WO2007101347A1 (en) 2006-03-07 2007-09-13 Aegera Therapeutics Inc. Bir domain binding compounds
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
MX2008012053A (es) 2006-03-21 2008-12-17 Joyant Pharmaceuticals Inc Promotores de apoptosis de molecula pequeña.
ES2525585T3 (es) 2006-05-05 2014-12-26 The Regents Of The University Of Michigan Intermedios para la preparación de miméticos de SMAC bivalentes
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
MX2009000824A (es) 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
US20100056495A1 (en) 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014229A2 (en) 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP5452223B2 (ja) 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
US20100143499A1 (en) 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014240A2 (en) 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
PE20110217A1 (es) 2006-08-02 2011-04-01 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
AU2007307763A1 (en) 2006-10-12 2008-04-17 Novartis Ag Pyrrolydine derivatives as IAP inhibitors
RU2009118487A (ru) 2006-10-19 2010-11-27 Новартис АГ (CH) Органические соединения
KR20090087094A (ko) 2006-11-28 2009-08-14 노파르티스 아게 Ｉａｐ 억제제 및 ｆｌｔ3 억제제의 조합물
WO2008085610A1 (en) 2006-11-28 2008-07-17 Novartis Ag Use of iap inhibitors for the treatment of acute myeloid leukemia
BRPI0720049A2 (pt) 2006-12-07 2014-01-07 Novartis Ag Derivados de piridina utilizados como inibidores de xiap
CN101605786A (zh) 2006-12-19 2009-12-16 健泰科生物技术公司 细胞凋亡抑制剂的咪唑并吡啶抑制剂
CA2684169C (en) 2007-04-12 2012-06-19 Joyant Pharmaceuticals, Inc. Smac mimetic dimers and trimers useful as anti-cancer agents
WO2008128171A2 (en) 2007-04-13 2008-10-23 The Regents Of The University Of Michigan Diazo bicyclic smac mimetics and the uses thereof
NZ598890A (en) 2007-04-30 2013-10-25 Genentech Inc Inhibitors of iap
WO2008144925A1 (en) 2007-05-30 2008-12-04 Aegera Therapeutics Inc. Iap bir domain binding compounds
EP2058312A1 (en) 2007-11-09 2009-05-13 Universita' degli Studi di Milano SMAC mimetic compounds as apoptosis inducers

Similar Documents

Publication Publication Date Title
JP2009512719A5 (enExample)
JP2023062187A (ja) 癌を治療するためのｉｒｓ／ｓｔａｔ３二重修飾因子と抗癌剤の組み合わせ
RU2483061C2 (ru) Тетрагидропиранохроменовые ингибиторы гамма-секретазы
JP2009537461A5 (enExample)
EP0622076B1 (en) Inhibitor for restenosis after percutaneous coronary arterioplasty
JP2024501471A5 (enExample)
WO2008124384A2 (en) Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
CN102711686A (zh) 含有低甲基化试剂以及组蛋白脱乙酰基酶抑制剂的药物组合物
KR20210002015A (ko) Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물
KR20210079313A (ko) 암 치료에서 면역 조절을 위한 조합
EP2512469A1 (en) 3-(indolyl)-or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarzinoma
JP2024523126A (ja) Ｎｒｈ、ｎａｒｈ、及びそれらの還元誘導体を用いた免疫関連障害、腎障害、肝障害、溶血性障害、及び酸化的ストレス関連障害の処置
US20110281814A1 (en) Methods and compositions for treating breast cancer
CA2789750A1 (en) Ghrelin receptor agonist for treatment of cachexia
JP2008538362A (ja) タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法
RU2016123855A (ru) Ингибиторы протеинкиназы
JP2016537367A5 (enExample)
JP2026502179A (ja) 置換３，７－ジヒドロ－１ｈ－プリン－２，６－ジオンおよびその使用
EP3888647B1 (en) Ezh1/2 dual inhibitor-containing pharmaceutical composition to be used as combination drug
JP7468829B2 (ja) 癌を処置するための、癌治療剤と組み合わせたＩＲＥ１α阻害剤
AU2022291381B2 (en) Combination mcl-1 inhibitors with anti-cancer agents
US20200237779A1 (en) Combination therapy with a bet inhibitor and a bcl-2 inhibitor
EP2780011B1 (en) Combination therapy for ovarian cancer
US20110009335A1 (en) Anticancer Treatments
RU2016124366A (ru) Ингибиторы протеинкиназы