JP2009512719A5 - - Google Patents
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- Publication number
- JP2009512719A5 JP2009512719A5 JP2008536890A JP2008536890A JP2009512719A5 JP 2009512719 A5 JP2009512719 A5 JP 2009512719A5 JP 2008536890 A JP2008536890 A JP 2008536890A JP 2008536890 A JP2008536890 A JP 2008536890A JP 2009512719 A5 JP2009512719 A5 JP 2009512719A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkynyl
- cycloalkyl
- alkenyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000753 cycloalkyl group Chemical group 0.000 claims 30
- 125000000623 heterocyclic group Chemical group 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 24
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 24
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 17
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 102000009058 Death Domain Receptors Human genes 0.000 claims 7
- 108010049207 Death Domain Receptors Proteins 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 5
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 5
- 108700012411 TNFSF10 Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000003607 modifier Substances 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- 229940044601 receptor agonist Drugs 0.000 claims 5
- 239000000018 receptor agonist Substances 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000007801 affinity label Substances 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- 239000004305 biphenyl Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 102100032187 Androgen receptor Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100038595 Estrogen receptor Human genes 0.000 claims 1
- 229940122440 HIV protease inhibitor Drugs 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 229940113306 Ligase inhibitor Drugs 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 229940122054 Peroxisome proliferator-activated receptor delta agonist Drugs 0.000 claims 1
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 1
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
- 229940123468 Transferase inhibitor Drugs 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000037012 chymotrypsin-like activity Effects 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000000091 immunopotentiator Effects 0.000 claims 1
- 108010093036 interleukin receptors Proteins 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000436 ligase inhibitor Substances 0.000 claims 1
- 229950001869 mapatumumab Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000036457 multidrug resistance Effects 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 0 C*(C)NC(N*C1CC1)=O Chemical compound C*(C)NC(N*C1CC1)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72972705P | 2005-10-25 | 2005-10-25 | |
| US83066206P | 2006-07-14 | 2006-07-14 | |
| PCT/CA2006/001721 WO2007048224A1 (en) | 2005-10-25 | 2006-10-20 | Iap bir domain binding compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009512719A JP2009512719A (ja) | 2009-03-26 |
| JP2009512719A5 true JP2009512719A5 (enExample) | 2009-12-03 |
Family
ID=37965208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536890A Pending JP2009512719A (ja) | 2005-10-25 | 2006-10-20 | Ｉａｐｂｉｒドメイン結合化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7589118B2 (enExample) |
| EP (1) | EP1951698A4 (enExample) |
| JP (1) | JP2009512719A (enExample) |
| KR (1) | KR20080067357A (enExample) |
| AU (1) | AU2006308453B9 (enExample) |
| BR (1) | BRPI0617751A2 (enExample) |
| CA (1) | CA2564872C (enExample) |
| IL (1) | IL190936A0 (enExample) |
| RU (1) | RU2418807C2 (enExample) |
| WO (1) | WO2007048224A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2475207T3 (es) * | 2004-07-15 | 2014-07-10 | Tetralogic Pharmaceuticals Corporation | Compuestos de unión a IAP |
| DK1836201T4 (da) | 2004-12-20 | 2013-11-11 | Genentech Inc | Pyrrolidininhibitorer af IAP. |
| PL1851200T3 (pl) | 2005-02-25 | 2014-06-30 | Tetralogic Pharm Corp | Dimeryczne inhibitory IAP |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| KR20080067357A (ko) | 2005-10-25 | 2008-07-18 | 에게라 쎄라퓨틱스 인코포레이티드 | Ｉａｐ ｂｉｒ 도메인 결합 화합물 |
| CA2632807A1 (en) * | 2005-12-19 | 2007-09-20 | Genentech, Inc. | Inhibitors of iap |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| EP1996184A4 (en) * | 2006-03-21 | 2010-09-22 | Joyant Pharmaceuticals Inc | SMALL MOLECULAR APOPTOSIS PROMOTERS |
| WO2007131366A1 (en) | 2006-05-16 | 2007-11-22 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| US20100113326A1 (en) * | 2006-07-24 | 2010-05-06 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014229A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014263A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap antagonists |
| EP2049524A2 (en) * | 2006-07-24 | 2009-04-22 | Tetralogic Pharmaceuticals Corporation | Iap inhibitors |
| US20100143499A1 (en) * | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| TWI432212B (zh) * | 2007-04-30 | 2014-04-01 | Genentech Inc | Ｉａｐ抑制劑 |
| US20110008802A1 (en) * | 2007-05-07 | 2011-01-13 | Tetralogic Pharmaceuticals Corp. | TNFalpha GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS |
| WO2008144925A1 (en) * | 2007-05-30 | 2008-12-04 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| US20120141496A1 (en) * | 2007-12-17 | 2012-06-07 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| AU2009203971A1 (en) * | 2008-01-11 | 2009-07-16 | Genentech, Inc. | Inhibitors of IAP |
| WO2009136290A1 (en) * | 2008-05-05 | 2009-11-12 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| WO2009155709A1 (en) * | 2008-06-27 | 2009-12-30 | Aegera Therapeutics Inc. | Bridged secondary amines and use thereof as iap bir domain binding compounds |
| JP2011529962A (ja) | 2008-08-02 | 2011-12-15 | ジェネンテック， インコーポレイテッド | Ｉａｐのインヒビター |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| US8779280B2 (en) * | 2009-08-18 | 2014-07-15 | Lg Electronics Inc. | Solar cell and method of manufacturing the same |
| JP5529282B2 (ja) | 2009-10-28 | 2014-06-25 | ジョイアント ファーマスーティカルズ、インク． | 二量体Ｓｍａｃ模倣薬 |
| SG182724A1 (en) | 2010-02-12 | 2012-08-30 | Pharmascience Inc | Iap bir domain binding compounds |
| UY33236A (es) * | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| US8263578B2 (en) | 2010-03-18 | 2012-09-11 | Innopharma, Inc. | Stable bortezomib formulations |
| US9061037B2 (en) * | 2010-03-18 | 2015-06-23 | Innopharma, Inc. | Stable bortezomib formulations |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| CA2850330A1 (en) | 2011-09-30 | 2013-04-04 | Tetralogic Pharmaceuticals Corporation | Smac mimetic (birinapant) for use in the treatment of proliferative diseases (cancer) |
| EP3013329B1 (en) | 2013-06-25 | 2020-08-05 | The Walter and Eliza Hall Institute of Medical Research | Smac mimetics for the treatment of persistent intracellular hbv infection |
| CA2950911C (en) | 2014-06-04 | 2023-10-10 | Sanford-Burnham Medical Research Institute | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| AU2020252216B2 (en) * | 2019-04-05 | 2026-02-26 | Hepagene Therapeutics (HK) Limited | Bivalent antagonists of inhibitors of apoptosis proteins |
| JP7764027B2 (ja) | 2019-07-31 | 2025-11-05 | ファイメクス株式会社 | 複素環化合物 |
| CA3166980A1 (en) | 2020-01-20 | 2021-07-29 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| CN119677743A (zh) * | 2023-02-08 | 2025-03-21 | 成都先导药物开发股份有限公司 | 杂环化合物及其用途 |
| KR102848239B1 (ko) * | 2023-04-13 | 2025-08-19 | 성신여자대학교 연구 산학협력단 | 비천연 아미노산을 포함하는 htra 표적 테트라펩타이드 프로브 |
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| US5750646A (en) * | 1987-09-24 | 1998-05-12 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| GB9016810D0 (en) | 1990-07-31 | 1990-09-12 | Wellcome Found | Peptides |
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| US6110691A (en) | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
| US6608026B1 (en) | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
| AU2001293189A1 (en) | 2000-09-29 | 2002-04-08 | Trustees Of Princeton University | Compositions and methods for regulating apoptosis |
| US6992063B2 (en) | 2000-09-29 | 2006-01-31 | The Trustees Of Princeton University | Compositions and method for regulating apoptosis |
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| CA2449168A1 (en) | 2001-05-31 | 2002-12-05 | The Trustees Of Princeton University | Iap binding peptides and assays for identifying compounds that bind iap |
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| WO2003086470A2 (en) | 2002-04-17 | 2003-10-23 | Deutsches Krebsforschungszentrum | Smac-peptides as therapeutics against cancer and autoimmune diseases |
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| EP1578777B1 (en) | 2002-07-15 | 2008-11-26 | The Trustees of Princeton University | Iap binding compounds |
| BR0316737A (pt) | 2002-11-27 | 2005-12-13 | Irm Llc | Métodos e composições para induzir apoptose em células cancerosas |
| US20040180828A1 (en) | 2003-01-30 | 2004-09-16 | Yigong Shi | Caspase-9 : BIR domain of XIAP complexes and methods of use |
| EP1715882A4 (en) | 2004-01-16 | 2009-04-08 | Univ Michigan | SMAC-PEPTIDOMIMETIKA AND ITS USES |
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| US7309792B2 (en) * | 2004-03-01 | 2007-12-18 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
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| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| EP1996184A4 (en) * | 2006-03-21 | 2010-09-22 | Joyant Pharmaceuticals Inc | SMALL MOLECULAR APOPTOSIS PROMOTERS |
| CN101484151B (zh) | 2006-05-05 | 2012-11-21 | 密执安州立大学董事会 | 二价smac模拟物及其应用 |
| WO2007131366A1 (en) | 2006-05-16 | 2007-11-22 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| US20100143499A1 (en) | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100113326A1 (en) | 2006-07-24 | 2010-05-06 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014229A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100056495A1 (en) | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014263A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap antagonists |
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| WO2008057172A2 (en) | 2006-10-19 | 2008-05-15 | Novartis Ag | Organic compounds |
| PT2089024E (pt) | 2006-11-28 | 2011-08-31 | Novartis Ag | Combinação de inibidores de iap e inibidores de flt3 |
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| CN101595093A (zh) | 2006-12-07 | 2009-12-02 | 诺瓦提斯公司 | 有机化合物 |
| CN101605786A (zh) | 2006-12-19 | 2009-12-16 | 健泰科生物技术公司 | 细胞凋亡抑制剂的咪唑并吡啶抑制剂 |
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| EP2139490B1 (en) | 2007-04-13 | 2014-07-02 | The Regents of the University of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| TWI432212B (zh) | 2007-04-30 | 2014-04-01 | Genentech Inc | Ｉａｐ抑制劑 |
| WO2008144925A1 (en) | 2007-05-30 | 2008-12-04 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
| WO2009136290A1 (en) | 2008-05-05 | 2009-11-12 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| CA2724720A1 (en) | 2008-05-16 | 2009-11-19 | Novartis Ag | Immunomodulation by iap inhibitors |
| TW201011006A (en) | 2008-06-16 | 2010-03-16 | Nuevolution As | IAP binding compounds |
| WO2009155709A1 (en) | 2008-06-27 | 2009-12-30 | Aegera Therapeutics Inc. | Bridged secondary amines and use thereof as iap bir domain binding compounds |
| JP2011529962A (ja) | 2008-08-02 | 2011-12-15 | ジェネンテック， インコーポレイテッド | Ｉａｐのインヒビター |
| US20120009141A1 (en) | 2008-08-07 | 2012-01-12 | Pharmascience Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| AU2009293403A1 (en) | 2008-09-17 | 2010-03-25 | Tetralogic Pharmaceuticals Corp. | IAP inhibitors |
| WO2010031171A1 (en) | 2008-09-19 | 2010-03-25 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
-
2006
- 2006-10-20 KR KR1020087012374A patent/KR20080067357A/ko not_active Withdrawn
- 2006-10-20 RU RU2008120408/04A patent/RU2418807C2/ru not_active IP Right Cessation
- 2006-10-20 JP JP2008536890A patent/JP2009512719A/ja active Pending
- 2006-10-20 CA CA2564872A patent/CA2564872C/en not_active Expired - Fee Related
- 2006-10-20 AU AU2006308453A patent/AU2006308453B9/en not_active Ceased
- 2006-10-20 EP EP06790872A patent/EP1951698A4/en not_active Withdrawn
- 2006-10-20 US US11/583,816 patent/US7589118B2/en not_active Expired - Fee Related
- 2006-10-20 BR BRPI0617751-4A patent/BRPI0617751A2/pt not_active IP Right Cessation
- 2006-10-20 WO PCT/CA2006/001721 patent/WO2007048224A1/en not_active Ceased
- 2006-12-01 US US11/606,883 patent/US7547724B2/en not_active Expired - Fee Related
- 2006-12-04 US US11/607,964 patent/US8063095B2/en not_active Expired - Fee Related
- 2006-12-04 US US11/607,998 patent/US7795298B2/en not_active Expired - Fee Related
-
2008
- 2008-04-17 IL IL190936A patent/IL190936A0/en unknown
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