AU2001293189A1 - Compositions and methods for regulating apoptosis - Google Patents

Compositions and methods for regulating apoptosis

Info

Publication number
AU2001293189A1
AU2001293189A1 AU2001293189A AU9318901A AU2001293189A1 AU 2001293189 A1 AU2001293189 A1 AU 2001293189A1 AU 2001293189 A AU2001293189 A AU 2001293189A AU 9318901 A AU9318901 A AU 9318901A AU 2001293189 A1 AU2001293189 A1 AU 2001293189A1
Authority
AU
Australia
Prior art keywords
compositions
methods
regulating apoptosis
apoptosis
regulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293189A
Inventor
Yigong Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of AU2001293189A1 publication Critical patent/AU2001293189A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
AU2001293189A 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis Abandoned AU2001293189A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60/236,574 2000-09-29
US25683000P 2000-12-20 2000-12-20
US60/256,830 2000-12-20
PCT/US2001/030567 WO2002026775A2 (en) 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis

Publications (1)

Publication Number Publication Date
AU2001293189A1 true AU2001293189A1 (en) 2002-04-08

Family

ID=34806773

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293189A Abandoned AU2001293189A1 (en) 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis

Country Status (2)

Country Link
AU (1) AU2001293189A1 (en)
WO (1) WO2002026775A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002030959A2 (en) * 2000-10-13 2002-04-18 Abbott Laboratories Peptides derived from smac (diablo) and methods of use therefor
EP1421204A4 (en) * 2001-05-31 2004-12-15 Univ Princeton Iap binding peptides and assays for identifying compounds that bind iap
JPWO2003070947A1 (en) * 2002-02-19 2005-06-09 株式会社 ビーエフ研究所 Apoptosis-promoting substance and inhibitory substance interacting with CGI-94 and screening method thereof
EP1354953A1 (en) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1354952A1 (en) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1495124A2 (en) * 2002-04-17 2005-01-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1378515A1 (en) * 2002-07-01 2004-01-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Peptides for inducing apoptosis in tumor cells
ES2318167T3 (en) * 2002-07-15 2009-05-01 The Trustees Of Princeton University IAP UNION COMPOUNDS.
WO2004072641A1 (en) * 2003-02-07 2004-08-26 Genentech, Inc. Compositions and methods for enhancing apoptosis
AU2005218555B2 (en) 2004-03-01 2008-01-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
EP1740173A4 (en) 2004-03-23 2009-05-27 Genentech Inc Azabicyclo-octane inhibitors of iap
ES2524449T3 (en) 2004-07-02 2014-12-09 Genentech, Inc. IAP inhibitors
EP1773766B1 (en) 2004-07-15 2014-04-02 Tetralogic Pharmaceuticals Corporation Iap binding compounds
CN101146803A (en) 2004-12-20 2008-03-19 健泰科生物技术公司 Pyrrolidine inhibitors of IAP
DK1851200T3 (en) 2005-02-25 2014-04-14 Tetralogic Pharm Corp DIMER IAP INHIBITORS
JP4954983B2 (en) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド BIR domain binding compound
RU2418807C2 (en) 2005-10-25 2011-05-20 Аегера Терапьютикс Инк. Compounds binding iap bir domains
CN101374829A (en) 2005-12-19 2009-02-25 健泰科生物技术公司 Inhibitors of IAP
TWI504597B (en) 2006-03-16 2015-10-21 Pharmascience Inc Iap bir domain binding compounds
EP2049563B1 (en) 2006-07-24 2014-03-12 Tetralogic Pharmaceuticals Corporation Dimeric iap antagonists
AR064235A1 (en) 2006-07-24 2009-03-25 Tetralogic Pharmaceuticals Cor IAP ANTAGONIST DIPEPTIDES, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND THE USE OF THEM FOR THE TREATMENT OF CANCER
NZ577150A (en) 2006-12-19 2012-04-27 Genentech Inc Imidazopyridine inhibitors of iap
NZ598890A (en) 2007-04-30 2013-10-25 Genentech Inc Inhibitors of iap
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
AU2009279924B2 (en) 2008-08-02 2014-10-02 Genentech, Inc. Inhibitors of IAP
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
BR112012020113A2 (en) 2010-02-12 2016-06-07 Pharmascience Inc iap bir domain binding compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
US20020132786A1 (en) * 2000-08-24 2002-09-19 Alnemri Emad S. IAP binding peptide or polypeptide and methods of using the same
WO2002030959A2 (en) * 2000-10-13 2002-04-18 Abbott Laboratories Peptides derived from smac (diablo) and methods of use therefor

Also Published As

Publication number Publication date
WO2002026775A2 (en) 2002-04-04
WO2002026775A3 (en) 2003-01-23

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