|
EP1862181A3
(en)
*
|
2003-04-11 |
2010-09-15 |
High Point Pharmaceuticals, LLC |
New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
|
|
EP1618090A1
(en)
*
|
2003-04-11 |
2006-01-25 |
Novo Nordisk A/S |
11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
|
|
CN103275058B
(zh)
|
2003-08-06 |
2016-02-24 |
西诺米克斯公司 |
调味剂、味道调节剂、促味剂、味觉增强剂、鲜味剂或甜味剂和/或增强剂及其用途
|
|
WO2005016877A2
(en)
|
2003-08-07 |
2005-02-24 |
Merck & Co., Inc. |
Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
|
|
GB0326029D0
(en)
*
|
2003-11-07 |
2003-12-10 |
Astrazeneca Ab |
Chemical compounds
|
|
BRPI0418082B8
(pt)
*
|
2003-12-26 |
2021-05-25 |
Kyowa Hakko Kirin Co Ltd |
derivados de tiazol úteis como antagonistas de receptor de adenosina a2a
|
|
RU2361862C2
(ru)
|
2003-12-29 |
2009-07-20 |
Сепракор Инк. |
Пиррольные и пиразольные ингибиторы daao
|
|
US7880001B2
(en)
|
2004-04-29 |
2011-02-01 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
US8415354B2
(en)
|
2004-04-29 |
2013-04-09 |
Abbott Laboratories |
Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US20100222316A1
(en)
|
2004-04-29 |
2010-09-02 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
WO2005108360A1
(en)
|
2004-05-07 |
2005-11-17 |
Janssen Pharmaceutica N.V. |
Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
EP1758882A4
(en)
*
|
2004-06-24 |
2008-01-23 |
Incyte Corp |
AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS
|
|
CA2570637A1
(en)
|
2004-06-24 |
2006-02-02 |
Wenqing Yao |
N-substituted piperidines and their use as pharmaceuticals
|
|
EP1797034B1
(en)
|
2004-08-06 |
2010-06-30 |
Merck Sharp & Dohme Corp. |
Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
|
|
DE602005017159D1
(de)
|
2004-08-30 |
2009-11-26 |
Janssen Pharmaceutica Nv |
Oxysteroid-dehydrogenase-inhibitoren
|
|
JP5137574B2
(ja)
|
2004-08-30 |
2013-02-06 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
11−ベータヒドロキシステロイドヒドロゲナーゼ阻害剤としての三環式ラクタム誘導体
|
|
JP5208505B2
(ja)
*
|
2004-08-30 |
2013-06-12 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのn−2アダマンタニル−2−フェノキシ−アセトアミド誘導体
|
|
MX2007003161A
(es)
|
2004-09-16 |
2007-05-16 |
Astellas Pharma Inc |
Derivado de triazol o una sal del mismo.
|
|
EP1802623A1
(en)
*
|
2004-10-12 |
2007-07-04 |
Novo Nordisk A/S |
11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds
|
|
CA2585030A1
(en)
*
|
2004-10-27 |
2006-05-04 |
F. Hoffmann-La Roche Ag |
New indole or benzimidazole derivatives
|
|
EP1807080A1
(en)
*
|
2004-10-29 |
2007-07-18 |
AstraZeneca AB |
Use of unsaturated quionoline or naphtalene derivatives as medicaments
|
|
AU2005304560C1
(en)
*
|
2004-11-10 |
2013-05-09 |
Incyte Holdings Corporation |
Lactam compounds and their use as pharmaceuticals
|
|
US8110581B2
(en)
|
2004-11-10 |
2012-02-07 |
Incyte Corporation |
Lactam compounds and their use as pharmaceuticals
|
|
BRPI0518281A2
(pt)
*
|
2004-11-18 |
2008-11-18 |
Incyte Corp |
inibidores de 11-beta hidroxilesteràide desidrogenase do tipo i e mÉtodos uso dos mesmos
|
|
EP2835367A1
(en)
|
2005-01-05 |
2015-02-11 |
AbbVie Inc. |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US8198331B2
(en)
|
2005-01-05 |
2012-06-12 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
CN103242192B
(zh)
|
2005-01-05 |
2016-05-04 |
Abbvie公司 |
11-β-羟甾类脱氢酶1型酶的抑制剂
|
|
US20090192198A1
(en)
|
2005-01-05 |
2009-07-30 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
FR2880887B1
(fr)
*
|
2005-01-14 |
2009-01-30 |
Merck Sante Soc Par Actions Si |
Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
|
|
KR101340859B1
(ko)
|
2005-02-04 |
2013-12-13 |
세노믹스, 인코포레이티드 |
연결형 헤테로 아릴 잔기를 포함한 화합물, 및 식용조성물을 위한 신규의 우마미 향미 개선제, 맛 촉진물질 및맛 향상제로서의 그의 용도
|
|
GB0506133D0
(en)
*
|
2005-03-24 |
2005-05-04 |
Sterix Ltd |
Compound
|
|
WO2006105127A2
(en)
*
|
2005-03-31 |
2006-10-05 |
Takeda San Diego, Inc. |
Hydroxysteroid dehydrogenase inhibitors
|
|
ATE519744T1
(de)
|
2005-04-05 |
2011-08-15 |
Hoffmann La Roche |
1h-pyrazol-4-carbonsäure-amide, deren herstellung und verwendung als 11-beta-hydroxysteroid- dehydrogenase-hemmer
|
|
EP2527337A1
(en)
*
|
2005-04-14 |
2012-11-28 |
Bristol-Myers Squibb Company |
Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
|
|
US8952176B2
(en)
|
2005-06-07 |
2015-02-10 |
Shionogi & Co., Ltd. |
Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
|
|
RU2383539C2
(ru)
*
|
2005-06-08 |
2010-03-10 |
Джапан Тобакко Инк. |
Гетероциклические соединения
|
|
AU2006255944B2
(en)
*
|
2005-06-08 |
2010-03-04 |
Japan Tobacco Inc. |
Heterocyclic compound
|
|
BRPI0611179A2
(pt)
*
|
2005-06-08 |
2010-08-24 |
Japan Tobacco Inc |
compostos heterocÍclicos, inibidor de 11bhsd1, agente farmacÊutico, uso dos referidos compostos, embalagem comercial e composiÇço farmacÊutica
|
|
TW200715993A
(en)
|
2005-06-15 |
2007-05-01 |
Senomyx Inc |
Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
|
|
CN101248041B
(zh)
|
2005-06-17 |
2013-11-20 |
艾宝奇生物工艺有限公司 |
鞘氨醇激酶抑制剂
|
|
US7605289B2
(en)
|
2005-06-17 |
2009-10-20 |
Amgen, Inc. |
Benzamide derivatives and uses related thereto
|
|
GB0513702D0
(en)
|
2005-07-04 |
2005-08-10 |
Sterix Ltd |
Compound
|
|
GB0514018D0
(en)
*
|
2005-07-07 |
2005-08-17 |
Ionix Pharmaceuticals Ltd |
Chemical compounds
|
|
JP2009505955A
(ja)
|
2005-07-22 |
2009-02-12 |
アムゲン インコーポレイティッド |
アニリンスルホンアミド誘導体およびそれらの使用
|
|
CN102295636A
(zh)
|
2005-07-29 |
2011-12-28 |
弗·哈夫曼-拉罗切有限公司 |
吲哚-3-基-羰基-哌啶和哌嗪衍生物
|
|
CA2618370A1
(en)
*
|
2005-08-04 |
2007-02-15 |
Sirtris Pharmaceuticals, Inc. |
Oxazolopyridine derivatives as sirtuin modulators
|
|
US7622492B2
(en)
|
2005-08-31 |
2009-11-24 |
Hoffmann-La Roche Inc. |
Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
|
|
GB2429975A
(en)
*
|
2005-09-08 |
2007-03-14 |
Univ Edinburgh |
1,5-substituted-1H-tetrazole 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
WO2007038138A2
(en)
*
|
2005-09-21 |
2007-04-05 |
Incyte Corporation |
Amido compounds and their use as pharmaceuticals
|
|
KR20080069189A
(ko)
*
|
2005-11-01 |
2008-07-25 |
트랜스테크 파르마, 인크. |
치환된 아미드의 약학적 사용
|
|
US20090124598A1
(en)
*
|
2005-11-01 |
2009-05-14 |
Henrik Sune Andersen |
Pharmaceutical use of substituted amides
|
|
CA2630665C
(en)
*
|
2005-11-21 |
2011-03-15 |
Shionogi & Co., Ltd. |
Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i
|
|
TW200804382A
(en)
*
|
2005-12-05 |
2008-01-16 |
Incyte Corp |
Lactam compounds and methods of using the same
|
|
EP1801098A1
(en)
|
2005-12-16 |
2007-06-27 |
Merck Sante |
2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
|
|
BRPI0706365A2
(pt)
|
2006-01-06 |
2011-03-22 |
Sepracor Inc |
Cicloalquilaminas como inibidores da recaptação de monoamina
|
|
US8053603B2
(en)
|
2006-01-06 |
2011-11-08 |
Sunovion Pharmaceuticals Inc. |
Tetralone-based monoamine reuptake inhibitors
|
|
US7998959B2
(en)
|
2006-01-12 |
2011-08-16 |
Incyte Corporation |
Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
|
|
TW200734313A
(en)
*
|
2006-01-17 |
2007-09-16 |
Astrazeneca Ab |
Piperazines and piperidines as mGluR5 potentiators
|
|
KR101081293B1
(ko)
|
2006-01-18 |
2011-11-08 |
에프. 호프만-라 로슈 아게 |
11 베타-에이치에스디1 억제제로서 티아졸
|
|
EP1996563B1
(en)
*
|
2006-02-13 |
2012-03-21 |
F. Hoffmann-La Roche AG |
Heterobicyclic sulfonamide derivatives for the treatment of diabetes
|
|
CA2646588A1
(en)
*
|
2006-03-21 |
2007-09-27 |
High Point Pharmaceuticals, Llc |
Adamantane derivatives for the treatment of the metabolic syndrome
|
|
HRP20151078T1
(hr)
|
2006-03-22 |
2015-11-20 |
F. Hoffmann - La Roche Ag |
Pirazoli kao 11-beta-hsd-1
|
|
JP5240775B2
(ja)
|
2006-03-30 |
2013-07-17 |
塩野義製薬株式会社 |
I型11βヒドロキシステロイド脱水素酵素阻害活性を有するイソキサゾール誘導体およびイソチアゾール誘導体
|
|
EP2816024B8
(en)
|
2006-03-31 |
2018-04-04 |
Sunovion Pharmaceuticals Inc. |
Chiral amines
|
|
US7435833B2
(en)
|
2006-04-07 |
2008-10-14 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
AU2007236049A1
(en)
*
|
2006-04-07 |
2007-10-18 |
High Point Pharmaceuticals, Llc |
11beta-hydroxysteroid dehydrogenase type 1 active compounds
|
|
EP3235811B1
(en)
|
2006-04-21 |
2018-07-25 |
Senomyx, Inc. |
Process of preparing oxalamides
|
|
WO2007130898A1
(en)
|
2006-05-01 |
2007-11-15 |
Incyte Corporation |
TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
US7838544B2
(en)
|
2006-05-17 |
2010-11-23 |
Incyte Corporation |
Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same
|
|
TW200808695A
(en)
|
2006-06-08 |
2008-02-16 |
Amgen Inc |
Benzamide derivatives and uses related thereto
|
|
DE602007008237D1
(de)
|
2006-06-08 |
2010-09-16 |
Amgen Inc |
Benzamidderivate und assoziierte verwendungen
|
|
WO2007144394A2
(en)
*
|
2006-06-16 |
2007-12-21 |
High Point Pharmaceuticals, Llc. |
Pharmaceutical use of substituted piperidine carboxamides
|
|
FR2902791B1
(fr)
*
|
2006-06-27 |
2008-08-22 |
Sanofi Aventis Sa |
Derives d'urees de tropane,leur preparation et leur application en therapeutique
|
|
TW200811170A
(en)
|
2006-06-27 |
2008-03-01 |
Sanofi Aventis |
Urea derivatives of tropane, their preparation and their therapeutic application
|
|
PE20080212A1
(es)
|
2006-06-27 |
2008-04-25 |
Sanofi Aventis |
Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1)
|
|
US7884124B2
(en)
|
2006-06-30 |
2011-02-08 |
Sepracor Inc. |
Fluoro-substituted inhibitors of D-amino acid oxidase
|
|
WO2008006702A1
(en)
*
|
2006-07-13 |
2008-01-17 |
High Point Pharmaceuticals, Llc. |
11beta-hydroxysteroid dehydrogenase type 1 active compounds
|
|
EP1878721A1
(en)
*
|
2006-07-13 |
2008-01-16 |
Novo Nordisk A/S |
4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
AU2007283113A1
(en)
|
2006-08-08 |
2008-02-14 |
Sanofi-Aventis |
Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
|
|
US7727978B2
(en)
*
|
2006-08-24 |
2010-06-01 |
Bristol-Myers Squibb Company |
Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
AU2007288245A1
(en)
|
2006-08-24 |
2008-02-28 |
Novartis Ag |
2- (pyrazin-2-yl) -thiazole and 2- (1h-pyrazol-3-yl) -thiazole derivatives as well as related compounds as stearoyl-CoA desaturase (SCD) inhibitors for the treatment of metabolic, cardiovascular and other disorders
|
|
JP5351025B2
(ja)
|
2006-09-22 |
2013-11-27 |
ノバルティス アーゲー |
ヘテロ環式有機化合物
|
|
CN101528160A
(zh)
*
|
2006-10-17 |
2009-09-09 |
鲁特格斯州立大学 |
N-取代的单体和聚合物
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
TW200827346A
(en)
*
|
2006-11-03 |
2008-07-01 |
Astrazeneca Ab |
Chemical compounds
|
|
KR101050568B1
(ko)
*
|
2006-12-07 |
2011-07-19 |
에프. 호프만-라 로슈 아게 |
V1a 수용체 길항제로서의 스피로-피페리딘 유도체
|
|
WO2008069518A1
(en)
*
|
2006-12-08 |
2008-06-12 |
Amorepacific Corporation |
Pharmaceutical composition for controlling the function of spihngosylphosphorylcholine
|
|
MX2009006728A
(es)
|
2006-12-20 |
2009-09-09 |
Novartis Ag |
Heterociclos de 5 miembros 2-sustituidos como inhibidores de scd.
|
|
EP1935420A1
(en)
|
2006-12-21 |
2008-06-25 |
Merck Sante |
2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
|
|
WO2008077810A2
(en)
*
|
2006-12-22 |
2008-07-03 |
F. Hoffmann-La Roche Ag |
Spiro-piperidine derivatives
|
|
WO2008088540A2
(en)
*
|
2006-12-26 |
2008-07-24 |
Amgen Inc. |
N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
|
|
US7902252B2
(en)
|
2007-01-18 |
2011-03-08 |
Sepracor, Inc. |
Inhibitors of D-amino acid oxidase
|
|
TW200836719A
(en)
*
|
2007-02-12 |
2008-09-16 |
Astrazeneca Ab |
Chemical compounds
|
|
AU2011232811B2
(en)
*
|
2007-02-12 |
2012-05-31 |
Astrazeneca Ab |
Pyrazole derivatives as 11-beta-HSD1 inhibitors
|
|
CA2675669C
(en)
*
|
2007-02-23 |
2015-05-26 |
High Point Pharmaceuticals, Llc |
Novel compounds
|
|
JP2010519240A
(ja)
*
|
2007-02-23 |
2010-06-03 |
ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー |
11−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての、n−アダマンチルベンズアミド
|
|
EP2129652A2
(en)
*
|
2007-02-23 |
2009-12-09 |
High Point Pharmaceuticals, LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
WO2008101885A1
(en)
*
|
2007-02-23 |
2008-08-28 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
BRPI0721430A2
(pt)
|
2007-03-09 |
2013-01-08 |
High Point Pharmaceuticals Llc |
amidas indol e benzimidazol como inibidoras de hidroxiesteràide deidrogenase
|
|
US20100056600A1
(en)
*
|
2007-03-28 |
2010-03-04 |
Soren Ebdrup |
11beta-hsd1 active compounds
|
|
JP2010523692A
(ja)
*
|
2007-04-11 |
2010-07-15 |
ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー |
新規合成物
|
|
ES2393230T3
(es)
*
|
2007-04-24 |
2012-12-19 |
High Point Pharmaceuticals, Llc |
Uso farmacéutico de amidas sustituidas
|
|
GB0708186D0
(en)
*
|
2007-04-27 |
2007-06-06 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
WO2008142986A1
(ja)
|
2007-05-18 |
2008-11-27 |
Shionogi & Co., Ltd. |
I型11βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体
|
|
CA2688493C
(en)
|
2007-05-31 |
2016-04-19 |
Sepracor Inc. |
Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
|
|
EP1997805A1
(en)
*
|
2007-06-01 |
2008-12-03 |
Commissariat à l'Energie Atomique |
Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
|
|
CL2008001839A1
(es)
|
2007-06-21 |
2009-01-16 |
Incyte Holdings Corp |
Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
|
|
KR101158191B1
(ko)
*
|
2007-07-17 |
2012-06-19 |
에프. 호프만-라 로슈 아게 |
11b-하이드록시스테로이드 탈수소효소의 억제제
|
|
US8575156B2
(en)
|
2007-07-26 |
2013-11-05 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
|
|
KR20100044829A
(ko)
|
2007-08-06 |
2010-04-30 |
다이닛본 스미토모 세이야꾸 가부시끼가이샤 |
아미노피라졸 아미드 유도체
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
JP5736098B2
(ja)
|
2007-08-21 |
2015-06-17 |
アッヴィ・インコーポレイテッド |
中枢神経系障害を治療するための医薬組成物
|
|
HRP20120837T1
(hr)
|
2007-08-31 |
2012-11-30 |
Astellas Pharma Inc. |
Derivati piperidina
|
|
US8119658B2
(en)
|
2007-10-01 |
2012-02-21 |
Bristol-Myers Squibb Company |
Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
WO2009056881A1
(en)
*
|
2007-10-29 |
2009-05-07 |
Astrazeneca Ab |
Chemical compounds 313
|
|
EA201000701A1
(ru)
*
|
2007-11-06 |
2010-12-30 |
Астразенека Аб |
4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465
|
|
AR069207A1
(es)
|
2007-11-07 |
2010-01-06 |
Vitae Pharmaceuticals Inc |
Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
|
|
CL2008003407A1
(es)
*
|
2007-11-16 |
2010-01-11 |
Boehringer Ingelheim Int |
Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
|
|
ES2322121B1
(es)
*
|
2007-12-10 |
2010-04-19 |
Consejo Superior De Investigaciones Cientificas |
Nuevos derivados de aminoacidos dicarboxilicos y su aplicacion en el tratamiento de enfermedades neurodegenerativas.
|
|
WO2009075835A1
(en)
|
2007-12-11 |
2009-06-18 |
Vitae Pharmaceutical, Inc |
CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
|
|
TW200934490A
(en)
|
2008-01-07 |
2009-08-16 |
Vitae Pharmaceuticals Inc |
Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
|
|
JP5490020B2
(ja)
|
2008-01-24 |
2014-05-14 |
ヴァイティー ファーマシューティカルズ,インコーポレイテッド |
11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状カルバゼート及びセミカルバジドインヒビター
|
|
KR20100126306A
(ko)
*
|
2008-02-04 |
2010-12-01 |
아스트라제네카 아베 |
4-[4-(2-(아다만틸카르바모일)-5-tert-부틸-피라졸-1-일]벤조산의 신규한 결정형
|
|
US8598160B2
(en)
|
2008-02-15 |
2013-12-03 |
Vitae Pharmaceuticals, Inc. |
Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
|
|
AU2009231258A1
(en)
*
|
2008-04-04 |
2009-10-08 |
Biomarin Iga Limited |
Compounds for treating muscular dystrophy
|
|
JP2011518216A
(ja)
*
|
2008-04-22 |
2011-06-23 |
アストラゼネカ アクチボラグ |
置換ピリミジン−5−カルボキサミド
|
|
WO2009134387A1
(en)
|
2008-05-01 |
2009-11-05 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
NZ588954A
(en)
|
2008-05-01 |
2012-08-31 |
Vitae Pharmaceuticals Inc |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
TW201004945A
(en)
|
2008-05-01 |
2010-02-01 |
Vitae Pharmaceuticals Inc |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
TW200950780A
(en)
|
2008-05-13 |
2009-12-16 |
Boehringer Ingelheim Int |
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
|
|
JP5494482B2
(ja)
|
2008-07-03 |
2014-05-14 |
アステラス製薬株式会社 |
トリアゾール誘導体またはその塩
|
|
UY31968A
(es)
|
2008-07-09 |
2010-01-29 |
Sanofi Aventis |
Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
|
|
TW201006832A
(en)
*
|
2008-07-15 |
2010-02-16 |
Novartis Ag |
Organic compounds
|
|
CN104327062A
(zh)
|
2008-07-25 |
2015-02-04 |
贝林格尔·英格海姆国际有限公司 |
11β-羟基类固醇脱氢酶1的环状抑制剂
|
|
TW201016691A
(en)
|
2008-07-25 |
2010-05-01 |
Boehringer Ingelheim Int |
Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
CA2735204C
(en)
*
|
2008-08-25 |
2017-06-20 |
Boehringer Ingelheim International Gmbh |
Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
BRPI0918288B1
(pt)
|
2008-09-01 |
2018-11-06 |
Merck Patent Gmbh |
derivados de pirrolidino-ciclopropano fundidos, medicamento, composição farmacêutica, e kit
|
|
TW201022266A
(en)
|
2008-10-23 |
2010-06-16 |
Boehringer Ingelheim Int |
Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
MX2011005037A
(es)
|
2008-11-21 |
2011-06-16 |
High Point Pharmaceuticals Llc |
Compuestos de adamantilo benzamida.
|
|
WO2010068601A1
(en)
|
2008-12-08 |
2010-06-17 |
Sanofi-Aventis |
A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
|
|
TW201028421A
(en)
*
|
2009-01-15 |
2010-08-01 |
Abbott Lab |
Novel benzenesulfonamides as calcium channel blockers
|
|
EP2391607A1
(en)
*
|
2009-01-30 |
2011-12-07 |
AstraZeneca AB |
Novel process for preparing carboxy-containing pyrazoleamido compounds 597
|
|
EP2393807B1
(en)
|
2009-02-04 |
2013-08-14 |
Boehringer Ingelheim International GmbH |
Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
|
|
JP6067226B2
(ja)
|
2009-03-13 |
2017-01-25 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
細胞増殖関連疾患のための方法および組成物
|
|
WO2010111060A1
(en)
*
|
2009-03-23 |
2010-09-30 |
Merck Sharp & Dohme Corp. |
P2x3, receptor antagonists for treatment of pain
|
|
EP2417123A2
(en)
|
2009-04-06 |
2012-02-15 |
Agios Pharmaceuticals, Inc. |
Therapeutic compositions and related methods of use
|
|
MA33216B1
(fr)
|
2009-04-30 |
2012-04-02 |
Boehringer Ingelheim Int |
Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
|
|
EP2438049B1
(en)
|
2009-06-02 |
2014-05-14 |
Boehringer Ingelheim International GmbH |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
ES2350077B1
(es)
|
2009-06-04 |
2011-11-04 |
Laboratorios Salvat, S.A. |
Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
|
|
WO2011011123A1
(en)
|
2009-06-11 |
2011-01-27 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
|
|
CR20170071A
(es)
|
2009-06-29 |
2017-03-28 |
Agios Pharmaceuticals Inc |
Compuestos terapeuticos y composiciones
|
|
KR20120060207A
(ko)
|
2009-08-26 |
2012-06-11 |
사노피 |
신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
|
|
KR101702159B1
(ko)
*
|
2009-09-16 |
2017-02-02 |
더 유니버시티 오브 에든버러 |
(4―페닐―피페리딘―1―일)―[5―(1h―피라졸―4―일)―티오펜―3―일]―메탄온 화합물 및 그의 용도
|
|
AR078673A1
(es)
*
|
2009-10-20 |
2011-11-23 |
Astrazeneca Ab |
Pirimidinas sustituidas con adamantiliminocarbonilo como inhibidores de 11-b-hsd1 826
|
|
WO2011050210A1
(en)
|
2009-10-21 |
2011-04-28 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
TWI531571B
(zh)
|
2009-11-06 |
2016-05-01 |
維它藥物公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基-及雜芳基羰基衍生物
|
|
ES2907862T3
(es)
*
|
2009-12-10 |
2022-04-26 |
Univ Columbia |
Activadores de histona acetiltransferasa y usos de los mismos
|
|
US10640457B2
(en)
|
2009-12-10 |
2020-05-05 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase activators and uses thereof
|
|
EP2535059A4
(en)
*
|
2010-02-10 |
2014-03-12 |
Public Univ Corp Yokohama City |
USE OF A MSIN3B BINDING COMPOUND FOR SPECIFIC BINDING TO THE NEURONIC RESTRICTIVE SILENCER FACTOR (NRSF)
|
|
WO2011107494A1
(de)
|
2010-03-03 |
2011-09-09 |
Sanofi |
Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP3002008B8
(en)
|
2010-03-11 |
2018-10-24 |
New York University |
Amido compounds as roryt modulators and uses thereof
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
RU2745977C2
(ru)
|
2010-04-22 |
2021-04-05 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ получения циклоалкилкарбоксамидо-индольных соединений
|
|
JP5860042B2
(ja)
|
2010-06-16 |
2016-02-16 |
ヴァイティー ファーマシューティカルズ,インコーポレイテッド |
置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用
|
|
EP2582709B1
(de)
|
2010-06-18 |
2018-01-24 |
Sanofi |
Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
CA2803920A1
(en)
|
2010-06-24 |
2011-12-29 |
Richard Beard |
Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
|
|
EP2585444B1
(en)
|
2010-06-25 |
2014-10-22 |
Boehringer Ingelheim International GmbH |
Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
|
AU2011202542A1
(en)
*
|
2010-07-14 |
2012-02-02 |
Indian Institute Of Science |
Benzothiophene carboxamide compounds, composition and applications thereof
|
|
FR2962649B1
(fr)
|
2010-07-19 |
2025-10-24 |
Conservatoire Nat Arts Et Metiers |
Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
|
|
US8513430B2
(en)
|
2010-07-27 |
2013-08-20 |
High Point Pharmaceuticals, Llc |
Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators
|
|
UA112418C2
(uk)
|
2010-09-07 |
2016-09-12 |
Астеллас Фарма Інк. |
Терапевтичний болезаспокійливий засіб
|
|
EA201300522A1
(ru)
|
2010-11-02 |
2013-11-29 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Фармацевтические комбинации для лечения метаболических нарушений
|
|
TWI537258B
(zh)
|
2010-11-05 |
2016-06-11 |
百靈佳殷格翰國際股份有限公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物
|
|
EP2651898B1
(en)
|
2010-12-17 |
2015-12-09 |
Agios Pharmaceuticals, Inc. |
Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
|
|
WO2012088314A1
(en)
|
2010-12-21 |
2012-06-28 |
Agios Pharmaceuticals, Inc. |
Bicyclic pkm2 activators
|
|
EP3323813B1
(en)
|
2010-12-22 |
2020-08-26 |
The Trustees of Columbia University in the City of New York |
Histone acetyltransferase modulators and uses thereof
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
CN102584741A
(zh)
*
|
2011-01-06 |
2012-07-18 |
中国科学院上海药物研究所 |
酰胺类化合物及其制备方法、组合物和用途
|
|
EP2683703B1
(de)
|
2011-03-08 |
2015-05-27 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
US8871758B2
(en)
|
2011-03-08 |
2014-10-28 |
Sanofi |
Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
|
|
US8809325B2
(en)
|
2011-03-08 |
2014-08-19 |
Sanofi |
Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
WO2012120058A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2683702B1
(de)
|
2011-03-08 |
2014-12-24 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
US8710050B2
(en)
|
2011-03-08 |
2014-04-29 |
Sanofi |
Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
US8828994B2
(en)
|
2011-03-08 |
2014-09-09 |
Sanofi |
Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
KR101332805B1
(ko)
|
2011-03-31 |
2013-11-27 |
한국화학연구원 |
아다만틸기를 갖는 설파마이드 유도체 및 이의 약제학적으로 허용 가능한 염
|
|
CN102241678B
(zh)
*
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
CN104230935A
(zh)
*
|
2011-04-26 |
2014-12-24 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
CA2834692A1
(en)
|
2011-05-03 |
2012-11-08 |
Agios Pharmaceuticals, Inc. |
Pyruvate kinase activators for use in therapy
|
|
ME03074B
(me)
|
2011-05-03 |
2019-01-20 |
Agios Pharmaceuticals Inc |
Akтivatori piruvat kinaze za upotrebu u terapiji
|
|
CN107095864A
(zh)
|
2011-06-10 |
2017-08-29 |
纽约市哥伦比亚大学理事会 |
组蛋白乙酰转移酶激活剂的用途
|
|
CN102827170A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
US9409904B2
(en)
|
2011-08-01 |
2016-08-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd |
Compounds and compositions for use in augmentation of glucose
|
|
JP2014524438A
(ja)
|
2011-08-17 |
2014-09-22 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
インデノピリジン誘導体
|
|
JP2014528933A
(ja)
*
|
2011-09-09 |
2014-10-30 |
ニューヨーク ユニバーシティ |
RORγtモジュレーターとしてのアミド化合物およびその使用
|
|
WO2013037390A1
(en)
|
2011-09-12 |
2013-03-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
WO2013045413A1
(en)
|
2011-09-27 |
2013-04-04 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
KR101987514B1
(ko)
|
2011-10-18 |
2019-06-10 |
아스텔라스세이야쿠 가부시키가이샤 |
이환식 헤테로환 화합물
|
|
SG11201403266RA
(en)
*
|
2011-12-22 |
2014-07-30 |
Connexios Life Sciences Pvt Ltd |
Derivatives of aza adamantane and uses thereof
|
|
BR112014015301A8
(pt)
*
|
2011-12-22 |
2017-07-04 |
Connexios Life Sciences Pvt Ltd |
derivados de amida cíclica como inibidores de 11 - beta-hidroxiesteroide desidrogenase e seus usos
|
|
US9474779B2
(en)
|
2012-01-19 |
2016-10-25 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their methods of use
|
|
WO2013146437A1
(ja)
*
|
2012-03-26 |
2013-10-03 |
シーシーアイ株式会社 |
3-デセン酸誘導体およびその用途
|
|
US8889730B2
(en)
|
2012-04-10 |
2014-11-18 |
Pfizer Inc. |
Indole and indazole compounds that activate AMPK
|
|
JP2015129094A
(ja)
*
|
2012-04-16 |
2015-07-16 |
大日本住友製薬株式会社 |
アリールアミノピラゾール誘導体
|
|
JOP20130213B1
(ar)
|
2012-07-17 |
2021-08-17 |
Takeda Pharmaceuticals Co |
معارضات لمستقبلht3-5
|
|
US10092574B2
(en)
|
2012-09-26 |
2018-10-09 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
|
|
GB201218084D0
(en)
|
2012-10-09 |
2012-11-21 |
Univ Aston |
Novel compounds and methods for use in medicine
|
|
WO2014074976A1
(en)
|
2012-11-09 |
2014-05-15 |
Musc Foundation For Research Development |
Compositions and methods for treating neurological diseases or injury
|
|
EP2968082B1
(en)
|
2013-03-13 |
2017-02-01 |
Unilever PLC |
Prolonged delivery of certain fragrance components from personal care compositions
|
|
BR112015021886A2
(pt)
|
2013-03-13 |
2017-07-18 |
Unilever Nv |
composição de fotoproteção para cuidados pessoais, método de aumentar a proteção e método para diminuir a produção de sebo na pele
|
|
EA029547B1
(ru)
|
2013-03-13 |
2018-04-30 |
Юнилевер Н.В. |
Косметические композиции с трициклодеканамидами
|
|
CA2905242C
(en)
|
2013-03-15 |
2016-11-29 |
Pfizer Inc. |
Indole compounds that activate ampk
|
|
WO2014139144A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Agios Pharmaceuticals, Inc. |
Therapeutic compounds and compositions
|
|
WO2015003355A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
US9579324B2
(en)
|
2013-07-11 |
2017-02-28 |
Agios Pharmaceuticals, Inc |
Therapeutically active compounds and their methods of use
|
|
WO2015003360A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
CA2917671A1
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
|
|
US20150031627A1
(en)
|
2013-07-25 |
2015-01-29 |
Agios Pharmaceuticals, Inc |
Therapeutically active compounds and their methods of use
|
|
GB201317363D0
(en)
|
2013-10-01 |
2013-11-13 |
Eisai Ltd |
Novel compounds
|
|
PH12021551647A1
(en)
|
2014-03-14 |
2022-06-06 |
Agios Pharmaceuticals Inc |
Pharmaceutical compositions of therapeutically active compounds
|
|
CN106604913A
(zh)
*
|
2014-03-31 |
2017-04-26 |
纽约哥伦比亚大学理事会 |
组蛋白乙酰基转移酶激活剂及其用途
|
|
SG10201913575VA
(en)
|
2014-04-15 |
2020-02-27 |
Vertex Pharma |
Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
|
|
TN2016000550A1
(en)
*
|
2014-06-16 |
2018-04-04 |
Centre Hospitalier Regional Univ De Lille Chru |
Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
|
|
ES2883295T3
(es)
|
2014-09-29 |
2021-12-07 |
Takeda Pharmaceuticals Co |
Forma cristalina de 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]nonan-7-il)-1h-indol-3-carboxamida
|
|
CN112375078B
(zh)
|
2014-12-18 |
2023-12-19 |
豪夫迈·罗氏有限公司 |
四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
|
|
MA44392B1
(fr)
|
2015-06-11 |
2023-10-31 |
Agios Pharmaceuticals Inc |
Procédés d'utilisation d'activateurs de la pyruvate kinase
|
|
ES2897959T3
(es)
|
2015-10-15 |
2022-03-03 |
Servier Lab |
Terapia de combinación para tratar neoplasias malignas
|
|
KR20250126877A
(ko)
|
2015-10-15 |
2025-08-25 |
르 라보레또레 쎄르비에르 |
악성 종양의 치료를 위한 조합물 요법
|
|
EP3393466B1
(en)
|
2015-12-24 |
2021-02-03 |
McMaster University |
Compounds for use in treating cancer
|
|
US11872207B2
(en)
|
2015-12-24 |
2024-01-16 |
Mcmaster University |
Dronedarone and derivatives thereof for treating cancer
|
|
US20190016680A1
(en)
|
2016-01-14 |
2019-01-17 |
Beth Israel Deaconess Medical Center, Inc. |
Mast-cell modulators and uses thereof
|
|
WO2017205622A1
(en)
*
|
2016-05-25 |
2017-11-30 |
Savant Neglected Diseases, Llc |
Method of making benznidazole
|
|
JOP20170131B1
(ar)
*
|
2016-06-10 |
2021-08-17 |
Lilly Co Eli |
مركبات 1-تيترا هيدروبيرانييل كاربونيل -2،3-ديهيدرو -1 h- اندول لعلاج السرطان
|
|
JP7097828B2
(ja)
|
2016-06-21 |
2022-07-08 |
シファ バイオメディカル コーポレーション |
抗プロタンパク質変換酵素サブチリシン ケキシン タイプ9(Subtilisin Kexin Type 9)(抗PCSK9)化合物および心血管疾患の治療および/または予防にこれを使用する方法
|
|
CN107663159A
(zh)
*
|
2016-07-29 |
2018-02-06 |
上海迪诺医药科技有限公司 |
多环化合物、其药物组合物及应用
|
|
US11718589B2
(en)
*
|
2017-02-06 |
2023-08-08 |
Case Western Reserve University |
Compositions and methods of modulating short-chain dehydrogenase
|
|
EP3375778A1
(en)
*
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
PT3448859T
(pt)
|
2017-03-20 |
2019-10-25 |
Forma Therapeutics Inc |
Composições de pirrolopirrole como ativadores de piruvato quinase (pkr).
|
|
US10980788B2
(en)
|
2018-06-08 |
2021-04-20 |
Agios Pharmaceuticals, Inc. |
Therapy for treating malignancies
|
|
IL278063B2
(en)
|
2018-06-21 |
2025-08-01 |
Hoffmann La Roche |
Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
|
|
WO2020033919A1
(en)
|
2018-08-10 |
2020-02-13 |
Diapin Therapeutics, Llc |
Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders
|
|
US12053458B2
(en)
|
2018-09-19 |
2024-08-06 |
Novo Nordisk Health Care Ag |
Treating sickle cell disease with a pyruvate kinase R activating compound
|
|
ES2989438T3
(es)
|
2018-09-19 |
2024-11-26 |
Novo Nordisk Healthcare Ag |
Activación de la piruvato cinasa R
|
|
CN109452280B
(zh)
|
2018-11-15 |
2021-01-29 |
南开大学 |
一种利用二氧化碳生产杀虫剂的工艺方法
|
|
AU2019384074B2
(en)
|
2018-11-20 |
2025-04-10 |
Sparrow Pharmaceuticals, Inc. |
Methods for administering corticosteroids
|
|
KR102921276B1
(ko)
|
2018-11-21 |
2026-02-03 |
케이스 웨스턴 리저브 유니버시티 |
단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
|
|
EA202191852A1
(ru)
|
2018-12-31 |
2022-03-18 |
Биомеа Фьюжн, Ллс |
Необратимые ингибиторы взаимодействия менин-mll
|
|
EP3906029A4
(en)
|
2018-12-31 |
2022-09-21 |
Biomea Fusion, LLC |
INHIBITORS OF MENIN-MLL INTERACTION
|
|
CA3134585A1
(en)
*
|
2019-04-26 |
2020-10-29 |
Xin-Yuan Fu |
Heterocyclic compounds, uses thereof, and compositions containing the same
|
|
CN114615977B
(zh)
|
2019-09-19 |
2025-01-14 |
诺沃挪第克健康护理股份公司 |
丙酮酸激酶r(pkr)活化组合物
|
|
CN112812077B
(zh)
*
|
2019-11-18 |
2023-08-22 |
中国科学院上海药物研究所 |
苯甲酰胺类化合物及其制备方法、药物组合物和用途
|
|
KR20220146458A
(ko)
|
2020-01-23 |
2022-11-01 |
마이오포르테 테라퓨틱스 인코포레이티드 |
Pgdh 억제제 및 그의 제조 및 사용 방법
|
|
US20230295088A1
(en)
*
|
2020-08-12 |
2023-09-21 |
University Of Iowa Research Foundation |
Insulin sensitizers for the treatment of diabetes mellitus
|
|
US12128035B2
(en)
|
2021-03-19 |
2024-10-29 |
Novo Nordisk Health Care Ag |
Activating pyruvate kinase R
|
|
AU2022325861A1
(en)
|
2021-08-11 |
2024-02-29 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-mll interaction for diabetes mellitus
|
|
IL310717A
(en)
|
2021-08-20 |
2024-04-01 |
Biomea Fusion Inc |
Crystalline form of N-[4-[4-(4-morpholinyl)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO ] -2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE, IRREVERSIBLE MENIN-MLL INHIBITOR FOR CANCER TREATMENT
|
|
JP2025517334A
(ja)
|
2022-05-16 |
2025-06-05 |
スパロー ファーマシューティカルズ,インコーポレーテッド |
グルココルチコイド過剰を治療するための方法及び組成物
|
|
TW202430528A
(zh)
|
2023-01-18 |
2024-08-01 |
美商拜歐米富士恩股份有限公司 |
N-[4-[4-(4-嗎啉基)-7h-吡咯並[2,3-d]嘧啶-6-基]苯基]-4-[[3(r)-[(1-氧代-2-丙烯-1-基)氨基]-1-哌啶基]甲基]-2-吡啶甲醯胺的結晶形式作為menin-mll相互作用的共價抑制劑
|