|
EP1862181A3
(en)
*
|
2003-04-11 |
2010-09-15 |
High Point Pharmaceuticals, LLC |
New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
|
|
DE602004027171D1
(de)
*
|
2003-04-11 |
2010-06-24 |
High Point Pharmaceuticals Llc |
Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
|
|
EP1659881B1
(en)
|
2003-08-06 |
2019-04-03 |
Senomyx Inc. |
Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
|
|
EP1653949A4
(en)
*
|
2003-08-07 |
2009-04-22 |
Merck & Co Inc |
PYRAZOL CARBOXAMIDE AS AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
|
|
GB0326029D0
(en)
*
|
2003-11-07 |
2003-12-10 |
Astrazeneca Ab |
Chemical compounds
|
|
TWI349550B
(en)
*
|
2003-12-26 |
2011-10-01 |
|
A thiazole derivative and adenosine a2a receptor antagonist containing the same
|
|
NZ548212A
(en)
|
2003-12-29 |
2010-07-30 |
Sepracor Inc |
Pyrrole and pyrazole DAAO inhibitors
|
|
US8415354B2
(en)
|
2004-04-29 |
2013-04-09 |
Abbott Laboratories |
Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US7880001B2
(en)
|
2004-04-29 |
2011-02-01 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
US20100222316A1
(en)
|
2004-04-29 |
2010-09-02 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
CA2565630C
(en)
|
2004-05-07 |
2013-05-28 |
Janssen Pharmaceutica N.V. |
Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
WO2006012226A2
(en)
|
2004-06-24 |
2006-02-02 |
Incyte Corporation |
N-substituted piperidines and their use as pharmaceuticals
|
|
MXPA06014573A
(es)
*
|
2004-06-24 |
2007-03-12 |
Incyte Corp |
Compuestos amido y su uso como farmaceuticos.
|
|
JP2008509146A
(ja)
|
2004-08-06 |
2008-03-27 |
メルク エンド カムパニー インコーポレーテッド |
１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−１の阻害剤としてのスルホニル化合物
|
|
DE602005017159D1
(de)
|
2004-08-30 |
2009-11-26 |
Janssen Pharmaceutica Nv |
Oxysteroid-dehydrogenase-inhibitoren
|
|
MY141198A
(en)
|
2004-08-30 |
2010-03-31 |
Janssen Pharmaceutica Nv |
Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
CN101300005B
(zh)
*
|
2004-08-30 |
2013-05-01 |
詹森药业有限公司 |
作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物
|
|
CN101014578B
(zh)
|
2004-09-16 |
2011-01-19 |
安斯泰来制药有限公司 |
三唑衍生物或其盐
|
|
EP1802623A1
(en)
*
|
2004-10-12 |
2007-07-04 |
Novo Nordisk A/S |
11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds
|
|
KR100912146B1
(ko)
*
|
2004-10-27 |
2009-08-14 |
에프. 호프만-라 로슈 아게 |
인돌 또는 벤즈이미다졸 유도체
|
|
EP1807080A1
(en)
*
|
2004-10-29 |
2007-07-18 |
AstraZeneca AB |
Use of unsaturated quionoline or naphtalene derivatives as medicaments
|
|
US8110581B2
(en)
|
2004-11-10 |
2012-02-07 |
Incyte Corporation |
Lactam compounds and their use as pharmaceuticals
|
|
SG161261A1
(en)
*
|
2004-11-10 |
2010-05-27 |
Incyte Corp |
Lactam compounds and their use as pharmaceuticals
|
|
CN101103016A
(zh)
*
|
2004-11-18 |
2008-01-09 |
因塞特公司 |
11-β羟基类固醇脱氢酶1型抑制剂及其使用方法
|
|
CA2594116A1
(en)
|
2005-01-05 |
2006-07-13 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US8198331B2
(en)
|
2005-01-05 |
2012-06-12 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US20090192198A1
(en)
|
2005-01-05 |
2009-07-30 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
KR101496190B1
(ko)
|
2005-01-05 |
2015-02-26 |
애브비 인코포레이티드 |
11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
|
|
FR2880887B1
(fr)
*
|
2005-01-14 |
2009-01-30 |
Merck Sante Soc Par Actions Si |
Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
|
|
CN101384183B
(zh)
|
2005-02-04 |
2012-07-04 |
西诺米克斯公司 |
包含连接有杂芳基部分的化合物及其作为用于食物组合物的新型鲜味调节剂、促味剂和味觉增强剂的应用
|
|
GB0506133D0
(en)
*
|
2005-03-24 |
2005-05-04 |
Sterix Ltd |
Compound
|
|
WO2006105127A2
(en)
*
|
2005-03-31 |
2006-10-05 |
Takeda San Diego, Inc. |
Hydroxysteroid dehydrogenase inhibitors
|
|
WO2006106052A1
(en)
*
|
2005-04-05 |
2006-10-12 |
F. Hoffmann-La Roche Ag |
Pyrazoles
|
|
EP1879881A2
(en)
*
|
2005-04-14 |
2008-01-23 |
Bristol-Myers Squibb Company |
Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
|
|
TW200716576A
(en)
|
2005-06-07 |
2007-05-01 |
Shionogi & Co |
Heterocyclic derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
|
|
RU2383539C2
(ru)
*
|
2005-06-08 |
2010-03-10 |
Джапан Тобакко Инк. |
Гетероциклические соединения
|
|
BRPI0611179A2
(pt)
*
|
2005-06-08 |
2010-08-24 |
Japan Tobacco Inc |
compostos heterocÍclicos, inibidor de 11bhsd1, agente farmacÊutico, uso dos referidos compostos, embalagem comercial e composiÇço farmacÊutica
|
|
KR100970294B1
(ko)
*
|
2005-06-08 |
2010-07-15 |
니뽄 다바코 산교 가부시키가이샤 |
복소환 화합물
|
|
TW200715993A
(en)
|
2005-06-15 |
2007-05-01 |
Senomyx Inc |
Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
|
|
MX2007015863A
(es)
|
2005-06-17 |
2008-04-02 |
Apogee Biotechnology Corp |
Inhibidores de esfingosina cinasa.
|
|
US7605289B2
(en)
|
2005-06-17 |
2009-10-20 |
Amgen, Inc. |
Benzamide derivatives and uses related thereto
|
|
GB0513702D0
(en)
|
2005-07-04 |
2005-08-10 |
Sterix Ltd |
Compound
|
|
GB0514018D0
(en)
*
|
2005-07-07 |
2005-08-17 |
Ionix Pharmaceuticals Ltd |
Chemical compounds
|
|
AU2006272922A1
(en)
|
2005-07-22 |
2007-02-01 |
Amgen Inc. |
Aniline sulfonamide derivatives and their uses
|
|
CN102295636A
(zh)
|
2005-07-29 |
2011-12-28 |
弗·哈夫曼-拉罗切有限公司 |
吲哚-3-基-羰基-哌啶和哌嗪衍生物
|
|
US7345178B2
(en)
*
|
2005-08-04 |
2008-03-18 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7622492B2
(en)
|
2005-08-31 |
2009-11-24 |
Hoffmann-La Roche Inc. |
Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
|
|
GB2429975A
(en)
*
|
2005-09-08 |
2007-03-14 |
Univ Edinburgh |
1,5-substituted-1H-tetrazole 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
CA2621255A1
(en)
*
|
2005-09-21 |
2007-04-05 |
Incyte Corporation |
Amido compounds and their use as pharmaceuticals
|
|
WO2007051811A2
(en)
*
|
2005-11-01 |
2007-05-10 |
Transtech Pharma |
Pharmaceutical use of substituted amides
|
|
EA200801243A1
(ru)
*
|
2005-11-01 |
2008-10-30 |
Транстек Фарма |
Фармацевтическое применение замещенных амидов
|
|
CN102659659B
(zh)
*
|
2005-11-21 |
2014-07-23 |
盐野义制药株式会社 |
具有I型11β羟基类固醇脱氢酶抑制活性的杂环化合物
|
|
EA200870019A1
(ru)
|
2005-12-05 |
2008-12-30 |
Инсайт Корпорейшн |
Лактамовые соединения и способы их применения
|
|
EP1801098A1
(en)
|
2005-12-16 |
2007-06-27 |
Merck Sante |
2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
|
|
US8053603B2
(en)
|
2006-01-06 |
2011-11-08 |
Sunovion Pharmaceuticals Inc. |
Tetralone-based monoamine reuptake inhibitors
|
|
KR101294014B1
(ko)
|
2006-01-06 |
2013-08-09 |
선오비온 파마슈티컬스 인코포레이티드 |
모노아민 재흡수 저해제로서의 시클로알킬아민
|
|
US7998959B2
(en)
|
2006-01-12 |
2011-08-16 |
Incyte Corporation |
Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
|
|
TW200734313A
(en)
*
|
2006-01-17 |
2007-09-16 |
Astrazeneca Ab |
Piperazines and piperidines as mGluR5 potentiators
|
|
WO2007082808A2
(en)
|
2006-01-18 |
2007-07-26 |
F. Hoffmann-La Roche Ag |
Thiazoles as 11 beta-hsd1 inhibitors
|
|
AU2007214594B2
(en)
*
|
2006-02-13 |
2010-11-11 |
F. Hoffmann-La Roche Ag |
Heterobicyclic sulfonamide derivatives for the treatment of diabetes
|
|
EP2007722A1
(en)
*
|
2006-03-21 |
2008-12-31 |
High Point Pharmaceuticals, LLC |
Adamantane derivatives for the treatment of the metabolic syndrome
|
|
CN101405270B
(zh)
|
2006-03-22 |
2013-01-16 |
霍夫曼-拉罗奇有限公司 |
作为11-β-HSD-1的吡唑类
|
|
EP2006286A4
(en)
|
2006-03-30 |
2010-04-07 |
Shionogi & Co |
ISOXAZOLE DERIVATIVE AND ISOTHIAZONE DERIVATIVITY WITH ANTICIPATING EFFECT ON 11 TYPE I BETA HYDROXYSTEROIDDEHYDROGENASE
|
|
DK2816024T3
(en)
|
2006-03-31 |
2017-10-30 |
Sunovion Pharmaceuticals Inc |
CHIRALE AMINER
|
|
EP2010479A1
(en)
*
|
2006-04-07 |
2009-01-07 |
High Point Pharmaceuticals, LLC |
11 beta-hydroxysteroid dehydrogenase type 1 active compounds
|
|
US7435833B2
(en)
|
2006-04-07 |
2008-10-14 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
DK3235811T3
(en)
|
2006-04-21 |
2018-11-12 |
Senomyx Inc |
PROCEDURE FOR THE PREPARATION OF OXALAMIDS
|
|
JP2009535420A
(ja)
|
2006-05-01 |
2009-10-01 |
インサイト・コーポレイション |
１１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
JP2009537564A
(ja)
|
2006-05-17 |
2009-10-29 |
インサイト・コーポレイション |
１１−βヒドロキシルステロイドデヒドロゲナーゼタイプＩの複素環阻害剤およびそれを用いる方法
|
|
TW200808695A
(en)
|
2006-06-08 |
2008-02-16 |
Amgen Inc |
Benzamide derivatives and uses related thereto
|
|
ATE476418T1
(de)
|
2006-06-08 |
2010-08-15 |
Amgen Inc |
Benzamidderivate und assoziierte verwendungen
|
|
WO2007144394A2
(en)
*
|
2006-06-16 |
2007-12-21 |
High Point Pharmaceuticals, Llc. |
Pharmaceutical use of substituted piperidine carboxamides
|
|
TW200811158A
(en)
|
2006-06-27 |
2008-03-01 |
Sanofi Aventis |
Piperidine or pyrrolidine urea derivatives, their preparation and their therapeutic application
|
|
FR2902791B1
(fr)
*
|
2006-06-27 |
2008-08-22 |
Sanofi Aventis Sa |
Derives d'urees de tropane,leur preparation et leur application en therapeutique
|
|
TW200811170A
(en)
*
|
2006-06-27 |
2008-03-01 |
Sanofi Aventis |
Urea derivatives of tropane, their preparation and their therapeutic application
|
|
US7884124B2
(en)
|
2006-06-30 |
2011-02-08 |
Sepracor Inc. |
Fluoro-substituted inhibitors of D-amino acid oxidase
|
|
US8048908B2
(en)
*
|
2006-07-13 |
2011-11-01 |
High Point Pharmaceuticals, Llc |
11β-hydroxysteroid dehydrogenase type 1 active compounds
|
|
EP1878721A1
(en)
*
|
2006-07-13 |
2008-01-16 |
Novo Nordisk A/S |
4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
JP2010500300A
(ja)
|
2006-08-08 |
2010-01-07 |
サノフィ−アベンティス |
アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
|
|
BRPI0719122A2
(pt)
|
2006-08-24 |
2013-12-10 |
Novartis Ag |
Compostos orgânicos
|
|
US7727978B2
(en)
|
2006-08-24 |
2010-06-01 |
Bristol-Myers Squibb Company |
Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
MX2009003080A
(es)
|
2006-09-22 |
2009-04-02 |
Novartis Ag |
Compuestos organicos heterociclicos.
|
|
CA2664682C
(en)
*
|
2006-10-17 |
2012-12-04 |
Reva Medical, Inc. |
N-substituted monomers and polymers
|
|
TW200827346A
(en)
*
|
2006-11-03 |
2008-07-01 |
Astrazeneca Ab |
Chemical compounds
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
CN101547923A
(zh)
*
|
2006-12-07 |
2009-09-30 |
弗·哈夫曼-拉罗切有限公司 |
作为via受体拮抗剂的螺环-哌啶衍生物
|
|
WO2008069518A1
(en)
*
|
2006-12-08 |
2008-06-12 |
Amorepacific Corporation |
Pharmaceutical composition for controlling the function of spihngosylphosphorylcholine
|
|
AU2007336238A1
(en)
|
2006-12-20 |
2008-06-26 |
Novartis Ag |
2-substituted 5-membered heterocycles as SCD inhibitors
|
|
EP1935420A1
(en)
|
2006-12-21 |
2008-06-25 |
Merck Sante |
2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
|
|
CN101563324A
(zh)
*
|
2006-12-22 |
2009-10-21 |
弗·哈夫曼-拉罗切有限公司 |
螺-哌啶衍生物
|
|
CA2673586A1
(en)
|
2006-12-26 |
2008-07-24 |
Amgen Inc. |
N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
|
|
US7902252B2
(en)
|
2007-01-18 |
2011-03-08 |
Sepracor, Inc. |
Inhibitors of D-amino acid oxidase
|
|
TW200836719A
(en)
*
|
2007-02-12 |
2008-09-16 |
Astrazeneca Ab |
Chemical compounds
|
|
AU2011232811B2
(en)
*
|
2007-02-12 |
2012-05-31 |
Astrazeneca Ab |
Pyrazole derivatives as 11-beta-HSD1 inhibitors
|
|
US8334305B2
(en)
*
|
2007-02-23 |
2012-12-18 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
|
|
EP2146952A1
(en)
|
2007-02-23 |
2010-01-27 |
High Point Pharmaceuticals, LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
ZA200904916B
(en)
*
|
2007-02-23 |
2010-09-29 |
High Point Pharmaceuticals Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
US20110003856A1
(en)
*
|
2007-02-23 |
2011-01-06 |
Soren Ebdrup |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
US8153798B2
(en)
*
|
2007-03-09 |
2012-04-10 |
High Point Pharmaceuticals, Llc |
Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
|
|
CA2681934A1
(en)
*
|
2007-03-28 |
2008-10-02 |
High Point Pharmaceuticals, Llc |
11beta-hsd1 active compounds
|
|
JP2010523692A
(ja)
*
|
2007-04-11 |
2010-07-15 |
ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー |
新規合成物
|
|
ES2393230T3
(es)
*
|
2007-04-24 |
2012-12-19 |
High Point Pharmaceuticals, Llc |
Uso farmacéutico de amidas sustituidas
|
|
GB0708186D0
(en)
*
|
2007-04-27 |
2007-06-06 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
AU2008252185B2
(en)
|
2007-05-18 |
2012-02-16 |
Shionogi & Co., Ltd. |
Nitrogen-containing heterocyclic derivative having 11 beta-hydroxysteroid dehydrogenase type I inhibitory activity
|
|
MX2009012685A
(es)
|
2007-05-31 |
2009-12-14 |
Sepracor Inc |
Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
|
|
EP1997805A1
(en)
*
|
2007-06-01 |
2008-12-03 |
Commissariat à l'Energie Atomique |
Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
|
|
CL2008001839A1
(es)
|
2007-06-21 |
2009-01-16 |
Incyte Holdings Corp |
Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
|
|
AU2008277783B2
(en)
*
|
2007-07-17 |
2012-09-20 |
F. Hoffmann-La Roche Ag |
Inhibitors of 11beta-hydroxysteroid dehydrogenase
|
|
JP5451611B2
(ja)
|
2007-07-26 |
2014-03-26 |
ヴァイティー ファーマシューティカルズ，インコーポレイテッド |
１１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
|
|
AU2008284746A1
(en)
|
2007-08-06 |
2009-02-12 |
Dainippon Sumitomo Pharma Co., Ltd. |
Aminopyrazole amide derivative
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
JP5736098B2
(ja)
|
2007-08-21 |
2015-06-17 |
アッヴィ・インコーポレイテッド |
中枢神経系障害を治療するための医薬組成物
|
|
HRP20120837T1
(hr)
|
2007-08-31 |
2012-11-30 |
Astellas Pharma Inc. |
Derivati piperidina
|
|
US8119658B2
(en)
|
2007-10-01 |
2012-02-21 |
Bristol-Myers Squibb Company |
Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
WO2009056881A1
(en)
*
|
2007-10-29 |
2009-05-07 |
Astrazeneca Ab |
Chemical compounds 313
|
|
EA201000701A1
(ru)
*
|
2007-11-06 |
2010-12-30 |
Астразенека Аб |
4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465
|
|
AR069207A1
(es)
|
2007-11-07 |
2010-01-06 |
Vitae Pharmaceuticals Inc |
Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
|
|
US8859580B2
(en)
|
2007-11-16 |
2014-10-14 |
Boehringer Ingelheim International Gmbh |
Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
|
|
ES2322121B1
(es)
*
|
2007-12-10 |
2010-04-19 |
Consejo Superior De Investigaciones Cientificas |
Nuevos derivados de aminoacidos dicarboxilicos y su aplicacion en el tratamiento de enfermedades neurodegenerativas.
|
|
CA2708303A1
(en)
|
2007-12-11 |
2009-06-18 |
Vitae Pharmaceuticals, Inc. |
Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
|
|
TW200934490A
(en)
|
2008-01-07 |
2009-08-16 |
Vitae Pharmaceuticals Inc |
Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
|
|
WO2009094169A1
(en)
|
2008-01-24 |
2009-07-30 |
Vitae Pharmaceuticals, Inc. |
Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
WO2009098501A1
(en)
|
2008-02-04 |
2009-08-13 |
Astrazeneca Ab |
Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl] benzoic acid
|
|
US8598160B2
(en)
|
2008-02-15 |
2013-12-03 |
Vitae Pharmaceuticals, Inc. |
Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
|
|
AU2009231258A1
(en)
*
|
2008-04-04 |
2009-10-08 |
Biomarin Iga Limited |
Compounds for treating muscular dystrophy
|
|
MX2010011591A
(es)
*
|
2008-04-22 |
2010-11-09 |
Astrazeneca Ab |
Pirimidin-5-carboxamidas sustituidas 281.
|
|
TW201004945A
(en)
|
2008-05-01 |
2010-02-01 |
Vitae Pharmaceuticals Inc |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
KR20110002492A
(ko)
|
2008-05-01 |
2011-01-07 |
비타이 파마슈티컬즈, 인코포레이티드 |
11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
|
|
EP2291370B1
(en)
|
2008-05-01 |
2013-11-27 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
US8765780B2
(en)
|
2008-05-13 |
2014-07-01 |
Boehringer Ingelheim International Gmbh |
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
|
|
ES2620657T3
(es)
|
2008-07-03 |
2017-06-29 |
Astellas Pharma Inc. |
Derivado de triazol o sal del mismo
|
|
WO2010003624A2
(en)
|
2008-07-09 |
2010-01-14 |
Sanofi-Aventis |
Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
|
|
EP2349484A2
(en)
*
|
2008-07-15 |
2011-08-03 |
Novartis AG |
Heteroaryl derivatives as dgat1 inhibitors
|
|
US8846668B2
(en)
|
2008-07-25 |
2014-09-30 |
Vitae Pharmaceuticals, Inc. |
Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
WO2010011314A1
(en)
|
2008-07-25 |
2010-01-28 |
Boehringer Ingelheim International Gmbh |
Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
|
|
CA2735204C
(en)
*
|
2008-08-25 |
2017-06-20 |
Boehringer Ingelheim International Gmbh |
Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
CN102137864B
(zh)
*
|
2008-09-01 |
2014-12-31 |
默克专利股份公司 |
作为选择性11-β-羟基甾族化合物脱氢酶1型抑制剂的稠合吡咯烷并-环丙烷衍生物
|
|
CA2738453C
(en)
|
2008-10-23 |
2017-07-04 |
Boehringer Ingelheim International Gmbh |
Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
BRPI0921299A2
(pt)
|
2008-11-21 |
2015-08-25 |
High Point Pharmaceuticals Llc |
Compostos de benzamida adamantila
|
|
WO2010068601A1
(en)
|
2008-12-08 |
2010-06-17 |
Sanofi-Aventis |
A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
|
|
TW201028421A
(en)
*
|
2009-01-15 |
2010-08-01 |
Abbott Lab |
Novel benzenesulfonamides as calcium channel blockers
|
|
US20120041211A1
(en)
*
|
2009-01-30 |
2012-02-16 |
Sythana Suresh Kumar |
Novel process for preparing carboxy-containing pyrazoleamido compounds 597
|
|
JP5679997B2
(ja)
|
2009-02-04 |
2015-03-04 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
|
|
CN102985557B
(zh)
|
2009-03-13 |
2018-06-15 |
安吉奥斯医药品有限公司 |
用于细胞增殖相关病症的方法和组合物
|
|
JP2012521429A
(ja)
*
|
2009-03-23 |
2012-09-13 |
メルク・シャープ・エンド・ドーム・コーポレイション |
疼痛治療用のｐ２ｘ３受容体アンタゴニスト
|
|
JP5756457B2
(ja)
|
2009-04-06 |
2015-07-29 |
アジオス ファーマシューティカルズ， インコーポレイテッド |
ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法
|
|
UA109255C2
(ru)
|
2009-04-30 |
2015-08-10 |
Берінгер Інгельхайм Інтернешнл Гмбх |
Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
|
|
US8703765B2
(en)
|
2009-06-02 |
2014-04-22 |
Boehringer Ingelheim International Gmbh |
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
|
|
ES2350077B1
(es)
|
2009-06-04 |
2011-11-04 |
Laboratorios Salvat, S.A. |
Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
|
|
WO2011011123A1
(en)
|
2009-06-11 |
2011-01-27 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
|
|
PE20120693A1
(es)
|
2009-06-29 |
2012-07-04 |
Agios Pharmaceuticals Inc |
Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
|
|
SG178880A1
(en)
|
2009-08-26 |
2012-04-27 |
Sanofi Sa |
Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
|
|
DK2477983T3
(en)
*
|
2009-09-16 |
2015-06-29 |
Univ Edinburgh |
(4-phenyl-piperidin-1-yl) - [5-1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONFORBINDELSER AND THEIR USE
|
|
TW201118085A
(en)
*
|
2009-10-20 |
2011-06-01 |
Astrazeneca Ab |
Adamantyl iminocarbonyl-substituted pyrimidines as inhibitors of 11-β-HSD1
|
|
WO2011050210A1
(en)
|
2009-10-21 |
2011-04-28 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
AR078887A1
(es)
*
|
2009-11-06 |
2011-12-07 |
Boehringer Ingelheim Int |
Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
|
|
EP2509590B1
(en)
*
|
2009-12-10 |
2019-10-30 |
The Trustees of Columbia University in the City of New York |
Histone acetyltransferase activators and uses thereof
|
|
US10640457B2
(en)
|
2009-12-10 |
2020-05-05 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase activators and uses thereof
|
|
EP2535059A4
(en)
*
|
2010-02-10 |
2014-03-12 |
Public Univ Corp Yokohama City |
USE OF A MSIN3B BINDING COMPOUND FOR SPECIFIC BINDING TO THE NEURONIC RESTRICTIVE SILENCER FACTOR (NRSF)
|
|
WO2011107494A1
(de)
|
2010-03-03 |
2011-09-09 |
Sanofi |
Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2558087A4
(en)
*
|
2010-03-11 |
2013-09-11 |
Univ New York |
AMID COMPOUNDS AS RORYT MODULATORS AND ITS USES
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
RU2569678C2
(ru)
|
2010-04-22 |
2015-11-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ получения циклоалкилкарбоксамидо-индольных соединений
|
|
EP2582698B1
(en)
|
2010-06-16 |
2016-09-14 |
Vitae Pharmaceuticals, Inc. |
Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
|
|
EP2582709B1
(de)
|
2010-06-18 |
2018-01-24 |
Sanofi |
Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
EP2585054A1
(en)
|
2010-06-24 |
2013-05-01 |
Allergan, Inc. |
Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
|
|
WO2011161128A1
(en)
|
2010-06-25 |
2011-12-29 |
Boehringer Ingelheim International Gmbh |
Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
AU2011202542A1
(en)
*
|
2010-07-14 |
2012-02-02 |
Indian Institute Of Science |
Benzothiophene carboxamide compounds, composition and applications thereof
|
|
FR2962649B1
(fr)
*
|
2010-07-19 |
2025-10-24 |
Conservatoire Nat Arts Et Metiers |
Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
|
|
US8513430B2
(en)
|
2010-07-27 |
2013-08-20 |
High Point Pharmaceuticals, Llc |
Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators
|
|
UA112418C2
(uk)
|
2010-09-07 |
2016-09-12 |
Астеллас Фарма Інк. |
Терапевтичний болезаспокійливий засіб
|
|
CA2813671A1
(en)
|
2010-11-02 |
2012-05-10 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical combinations for the treatment of metabolic disorders
|
|
TWI537258B
(zh)
*
|
2010-11-05 |
2016-06-11 |
百靈佳殷格翰國際股份有限公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
|
|
US9221792B2
(en)
|
2010-12-17 |
2015-12-29 |
Agios Pharmaceuticals, Inc |
N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
|
|
WO2012088314A1
(en)
|
2010-12-21 |
2012-06-28 |
Agios Pharmaceuticals, Inc. |
Bicyclic pkm2 activators
|
|
US9969677B2
(en)
|
2010-12-22 |
2018-05-15 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase modulators and uses thereof
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
CN102584741A
(zh)
*
|
2011-01-06 |
2012-07-18 |
中国科学院上海药物研究所 |
酰胺类化合物及其制备方法、组合物和用途
|
|
US8809324B2
(en)
|
2011-03-08 |
2014-08-19 |
Sanofi |
Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
WO2012120054A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2683698B1
(de)
|
2011-03-08 |
2017-10-04 |
Sanofi |
Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
US8846666B2
(en)
|
2011-03-08 |
2014-09-30 |
Sanofi |
Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
|
|
WO2012120055A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2683703B1
(de)
|
2011-03-08 |
2015-05-27 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
KR101332805B1
(ko)
|
2011-03-31 |
2013-11-27 |
한국화학연구원 |
아다만틸기를 갖는 설파마이드 유도체 및 이의 약제학적으로 허용 가능한 염
|
|
CN102241678B
(zh)
*
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
CN104230935A
(zh)
*
|
2011-04-26 |
2014-12-24 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
EP2704720B1
(en)
|
2011-05-03 |
2019-08-07 |
Agios Pharmaceuticals, Inc. |
Pyruvate kinase r activators for use in therapy
|
|
PT3406251T
(pt)
|
2011-05-03 |
2024-01-24 |
Agios Pharmaceuticals Inc |
Ativadores da piruvato-cinase para utilização em terapia
|
|
CN107095864A
(zh)
|
2011-06-10 |
2017-08-29 |
纽约市哥伦比亚大学理事会 |
组蛋白乙酰转移酶激活剂的用途
|
|
CN102827170A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
WO2013018095A1
(en)
*
|
2011-08-01 |
2013-02-07 |
Yissum Research And Development Of The Hebrew University Of Jerusalem Ltd. |
Compounds and compositions for use in augmentation of glucose uptake and insulin secretion
|
|
US8735585B2
(en)
|
2011-08-17 |
2014-05-27 |
Boehringer Ingelheim International Gmbh |
Indenopyridine derivatives
|
|
SG11201400456RA
(en)
*
|
2011-09-09 |
2014-04-28 |
Univ New York |
Amido compounds as ror?tmodulators and uses thereof
|
|
WO2013037390A1
(en)
|
2011-09-12 |
2013-03-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
EP2760862B1
(en)
|
2011-09-27 |
2015-10-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
JP6020459B2
(ja)
|
2011-10-18 |
2016-11-02 |
アステラス製薬株式会社 |
二環式ヘテロ環化合物
|
|
MX358696B
(es)
*
|
2011-12-22 |
2018-08-31 |
Connexios Life Sciences Pvt Ltd |
Derivados de aza adamantano y lo usos de los mismos.
|
|
US9453014B2
(en)
*
|
2011-12-22 |
2016-09-27 |
Connexios Life Sciences Pvt. Ltd. |
Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof
|
|
US9474779B2
(en)
|
2012-01-19 |
2016-10-25 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their methods of use
|
|
JP6285352B2
(ja)
*
|
2012-03-26 |
2018-02-28 |
飯沼 宗和 |
３−デセン酸誘導体およびその用途
|
|
US8889730B2
(en)
|
2012-04-10 |
2014-11-18 |
Pfizer Inc. |
Indole and indazole compounds that activate AMPK
|
|
JP2015129094A
(ja)
*
|
2012-04-16 |
2015-07-16 |
大日本住友製薬株式会社 |
アリールアミノピラゾール誘導体
|
|
JOP20130213B1
(ar)
|
2012-07-17 |
2021-08-17 |
Takeda Pharmaceuticals Co |
معارضات لمستقبلht3-5
|
|
US10092574B2
(en)
|
2012-09-26 |
2018-10-09 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
|
|
GB201218084D0
(en)
|
2012-10-09 |
2012-11-21 |
Univ Aston |
Novel compounds and methods for use in medicine
|
|
WO2014074976A1
(en)
|
2012-11-09 |
2014-05-15 |
Musc Foundation For Research Development |
Compositions and methods for treating neurological diseases or injury
|
|
BR112015022117A2
(pt)
|
2013-03-13 |
2017-07-18 |
Unilever Nv |
precursor da composição cosmética, composição cosmética para a aplicação tópica, método para a administração de um agente cosmético sólido e amida de triciclodecano
|
|
EP2968094B1
(en)
|
2013-03-13 |
2018-05-30 |
Unilever PLC |
Photoprotective compositions with tricyclodecane amides
|
|
JP6364031B2
(ja)
|
2013-03-13 |
2018-07-25 |
ユニリーバー・ナームローゼ・ベンノートシヤープ |
パーソナルケア組成物からのある芳香剤構成成分の長期送達
|
|
WO2014139144A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Agios Pharmaceuticals, Inc. |
Therapeutic compounds and compositions
|
|
JP6064062B2
(ja)
|
2013-03-15 |
2017-01-18 |
ファイザー・インク |
Ａｍｐｋを活性化させるインダゾール化合物
|
|
WO2015003360A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
WO2015003355A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
CN105593215B
(zh)
|
2013-07-11 |
2019-01-15 |
安吉奥斯医药品有限公司 |
用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物
|
|
WO2015010297A1
(en)
|
2013-07-25 |
2015-01-29 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
GB201317363D0
(en)
|
2013-10-01 |
2013-11-13 |
Eisai Ltd |
Novel compounds
|
|
PH12021551647A1
(en)
|
2014-03-14 |
2022-06-06 |
Agios Pharmaceuticals Inc |
Pharmaceutical compositions of therapeutically active compounds
|
|
JP2017511340A
(ja)
*
|
2014-03-31 |
2017-04-20 |
ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク |
ヒストンアセチルトランスフェラーゼ活性剤及びその使用
|
|
PL3925607T5
(pl)
|
2014-04-15 |
2026-06-01 |
Vertex Pharmaceuticals Incorporated |
Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
|
|
MX2016016769A
(es)
|
2014-06-16 |
2017-08-10 |
Univ Lille Ii Droit & Sante |
Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativas.
|
|
JP7055017B2
(ja)
|
2014-09-29 |
2022-04-15 |
武田薬品工業株式会社 |
結晶形の１－（１－メチル－１ｈ－ピラゾール－４－イル）－ｎ－（（１ｒ，５ｓ，７ｓ）－９－メチル－３－オキサ－９－アザビシクロ［３．３．１］ノナン－７－イル）－１ｈ－インドール－３－カルボキサミド
|
|
TWI784255B
(zh)
|
2014-12-18 |
2022-11-21 |
瑞士商赫孚孟拉羅股份公司 |
四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途
|
|
MX384883B
(es)
|
2015-06-11 |
2025-03-14 |
Agios Pharmaceuticals Inc |
Métodos para usar activadores de piruvato cinasa.
|
|
HUE067449T2
(hu)
|
2015-10-15 |
2024-10-28 |
Servier Lab |
Ivozidenib, citarabin és daunorubicin vagy idarubicin kombinációs terápa akut mielogén leukémia kezelésére
|
|
MD3362066T2
(ro)
|
2015-10-15 |
2022-08-31 |
Les Laboratoires Servier Sas |
Terapie combinată pentru tratamentul tumorilor maligne
|
|
US11872207B2
(en)
|
2015-12-24 |
2024-01-16 |
Mcmaster University |
Dronedarone and derivatives thereof for treating cancer
|
|
WO2017106974A1
(en)
|
2015-12-24 |
2017-06-29 |
Mcmaster University |
Compounds for targeting thyroid hormone receptor alpha isoforms and methods of use thereof
|
|
WO2017123826A1
(en)
|
2016-01-14 |
2017-07-20 |
Beth Israel Deaconess Medical Center, Inc. |
Mast-cell modulators and uses thereof
|
|
WO2017205622A1
(en)
*
|
2016-05-25 |
2017-11-30 |
Savant Neglected Diseases, Llc |
Method of making benznidazole
|
|
JOP20170131B1
(ar)
*
|
2016-06-10 |
2021-08-17 |
Lilly Co Eli |
مركبات 1-تيترا هيدروبيرانييل كاربونيل -2،3-ديهيدرو -1 h- اندول لعلاج السرطان
|
|
EP3471714B1
(en)
|
2016-06-21 |
2025-06-11 |
Shifa Biomedical Corporation |
Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
|
|
CN107663159A
(zh)
*
|
2016-07-29 |
2018-02-06 |
上海迪诺医药科技有限公司 |
多环化合物、其药物组合物及应用
|
|
CN110573154A
(zh)
*
|
2017-02-06 |
2019-12-13 |
卡斯西部储备大学 |
调节短链脱氢酶活性的组合物和方法
|
|
EP3375778A1
(en)
*
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
AR111295A1
(es)
|
2017-03-20 |
2019-06-26 |
Forma Therapeutics Inc |
Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
|
|
US10980788B2
(en)
|
2018-06-08 |
2021-04-20 |
Agios Pharmaceuticals, Inc. |
Therapy for treating malignancies
|
|
LT3810283T
(lt)
|
2018-06-21 |
2023-08-25 |
F. Hoffmann-La Roche Ag |
3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3- il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)- 2,2- difluorpropan-1-olio tartrato druskos kietosios formos, jų paruošimo procesas ir jų naudojimo būdai vėžiui gydyti
|
|
BR112021002207A2
(pt)
|
2018-08-10 |
2021-05-04 |
Diapin Therapeutics, Llc |
tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios
|
|
WO2020061255A1
(en)
|
2018-09-19 |
2020-03-26 |
Forma Therapeutics, Inc. |
Activating pyruvate kinase r
|
|
US20200129485A1
(en)
|
2018-09-19 |
2020-04-30 |
Forma Therapeutics, Inc. |
Treating sickle cell disease with a pyruvate kinase r activating compound
|
|
CN109452280B
(zh)
*
|
2018-11-15 |
2021-01-29 |
南开大学 |
一种利用二氧化碳生产杀虫剂的工艺方法
|
|
CN113329754A
(zh)
|
2018-11-20 |
2021-08-31 |
麻雀制药股份有限公司 |
用于施用皮质类固醇的方法
|
|
WO2020106998A1
(en)
|
2018-11-21 |
2020-05-28 |
Case Western Reserve University |
Compositions and methods of modulating short-chain dehydrogenase activity
|
|
WO2020142557A1
(en)
|
2018-12-31 |
2020-07-09 |
Biomea Fusion, Llc |
Irreversible inhibitors of menin-mll interaction
|
|
TW202043205A
(zh)
|
2018-12-31 |
2020-12-01 |
美商拜歐米富士恩有限公司 |
Menin-mll相互作用之抑制劑
|
|
WO2020216378A1
(zh)
*
|
2019-04-26 |
2020-10-29 |
健艾仕生物医药有限公司 |
一种含杂环的化合物、其应用及含其的组合物
|
|
MX2022003025A
(es)
|
2019-09-19 |
2022-04-07 |
Forma Therapeutics Inc |
Activacion de la piruvato cinasa r.
|
|
CN112812077B
(zh)
*
|
2019-11-18 |
2023-08-22 |
中国科学院上海药物研究所 |
苯甲酰胺类化合物及其制备方法、药物组合物和用途
|
|
JP7677983B2
(ja)
|
2020-01-23 |
2025-05-15 |
マイオフォルテ セラピューティクス，インク． |
Ｐｇｄｈ阻害剤、およびその作製と使用の方法
|
|
AU2021224268A1
(en)
|
2020-02-21 |
2022-09-15 |
Case Western Reserve University |
Compositions and methods for treating renal injury
|
|
WO2022036104A1
(en)
*
|
2020-08-12 |
2022-02-17 |
University Of Iowa Research Foundation |
Insulin sensitizers for the treatment of diabetes mellitus
|
|
US12128035B2
(en)
|
2021-03-19 |
2024-10-29 |
Novo Nordisk Health Care Ag |
Activating pyruvate kinase R
|
|
JP7891524B2
(ja)
|
2021-08-11 |
2026-07-16 |
バイオメア フュージョン，インコーポレイテッド |
真性糖尿病に対するメニン－ｍｌｌ相互作用の共有結合性阻害剤
|
|
MX2024002189A
(es)
|
2021-08-20 |
2024-06-11 |
Biomea Fusion Inc |
Forma cristalina de n-[4-[4-(4-morfolinil)-7h-pirrolo[2,3-d]pirimi din-6-il]fenil]-4-[[3(r)-[(1-oxo)-2-propen-1-il)amino]-1-piperidi nil]metil]-2-piridinacarboxamida, un inhibidor irreversible de menina-mll para el tratamiento del cancer.
|
|
IL316907A
(en)
|
2022-05-16 |
2025-01-01 |
Sparrow Pharmaceuticals Inc |
METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOD EXCESS
|
|
WO2024155719A1
(en)
|
2023-01-18 |
2024-07-25 |
Biomea Fusion, Inc. |
Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2- pyridinecarboxamide as a covalentinhibitor of menin-mll interaction
|