|
EP1862181A3
(en)
*
|
2003-04-11 |
2010-09-15 |
High Point Pharmaceuticals, LLC |
New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
|
|
DE602004027171D1
(de)
*
|
2003-04-11 |
2010-06-24 |
High Point Pharmaceuticals Llc |
Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
|
|
NZ545747A
(en)
|
2003-08-06 |
2010-06-25 |
Senomyx Inc |
T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
|
|
CN1832741A
(zh)
*
|
2003-08-07 |
2006-09-13 |
默克公司 |
作为11-β-羟甾类脱氢酶-1抑制剂的吡唑甲酰胺类
|
|
GB0326029D0
(en)
*
|
2003-11-07 |
2003-12-10 |
Astrazeneca Ab |
Chemical compounds
|
|
JP4638355B2
(ja)
*
|
2003-12-26 |
2011-02-23 |
協和発酵キリン株式会社 |
チアゾール誘導体
|
|
AU2004312530A1
(en)
|
2003-12-29 |
2005-07-21 |
Sepracor Inc. |
Pyrrole and pyrazole DAAO inhibitors
|
|
US8415354B2
(en)
|
2004-04-29 |
2013-04-09 |
Abbott Laboratories |
Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
US7880001B2
(en)
|
2004-04-29 |
2011-02-01 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
US20100222316A1
(en)
|
2004-04-29 |
2010-09-02 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
NZ551077A
(en)
|
2004-05-07 |
2009-05-31 |
Janssen Pharmaceutica Nv |
Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
US8071624B2
(en)
|
2004-06-24 |
2011-12-06 |
Incyte Corporation |
N-substituted piperidines and their use as pharmaceuticals
|
|
US20050288317A1
(en)
*
|
2004-06-24 |
2005-12-29 |
Wenqing Yao |
Amido compounds and their use as pharmaceuticals
|
|
CN1993320A
(zh)
|
2004-08-06 |
2007-07-04 |
默克公司 |
作为11-β-羟基类固醇脱氢酶-1的抑制剂的磺酰化合物
|
|
CN101039908B
(zh)
|
2004-08-30 |
2010-06-23 |
詹森药业有限公司 |
作为11-β羟甾类脱氢酶抑制剂的三环内酰胺衍生物
|
|
DE602005017159D1
(de)
|
2004-08-30 |
2009-11-26 |
Janssen Pharmaceutica Nv |
Oxysteroid-dehydrogenase-inhibitoren
|
|
KR101197674B1
(ko)
*
|
2004-08-30 |
2012-11-07 |
얀센 파마슈티카 엔.브이. |
11-베타 하이드록시스테로이드 탈수소효소 저해제로서의 n-2 아다만타닐-2-페녹시-아세트아미드 유도체
|
|
EP1790641A4
(en)
|
2004-09-16 |
2009-08-26 |
Astellas Pharma Inc |
DERIVATIVE OF TRIAZOLE OR SALT OF SAID DERIVATIVE
|
|
EP1802623A1
(en)
*
|
2004-10-12 |
2007-07-04 |
Novo Nordisk A/S |
11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds
|
|
RU2394027C2
(ru)
*
|
2004-10-27 |
2010-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Новые индольные или бензимидазольные производные
|
|
EP1807080A1
(en)
*
|
2004-10-29 |
2007-07-18 |
AstraZeneca AB |
Use of unsaturated quionoline or naphtalene derivatives as medicaments
|
|
US8110581B2
(en)
|
2004-11-10 |
2012-02-07 |
Incyte Corporation |
Lactam compounds and their use as pharmaceuticals
|
|
CA2585797C
(en)
*
|
2004-11-10 |
2015-01-06 |
Incyte Corporation |
Lactam compounds and their use as pharmaceuticals
|
|
CN101103016A
(zh)
*
|
2004-11-18 |
2008-01-09 |
因塞特公司 |
11-β羟基类固醇脱氢酶1型抑制剂及其使用方法
|
|
US8198331B2
(en)
|
2005-01-05 |
2012-06-12 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
AU2006203918B2
(en)
|
2005-01-05 |
2011-05-19 |
Abbvie Inc. |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
US20090192198A1
(en)
|
2005-01-05 |
2009-07-30 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
CA2594098C
(en)
*
|
2005-01-05 |
2014-04-01 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
|
|
FR2880887B1
(fr)
*
|
2005-01-14 |
2009-01-30 |
Merck Sante Soc Par Actions Si |
Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
|
|
CA2597134C
(en)
|
2005-02-04 |
2015-05-26 |
Senomyx, Inc. |
Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
|
|
GB0506133D0
(en)
*
|
2005-03-24 |
2005-05-04 |
Sterix Ltd |
Compound
|
|
JP5140577B2
(ja)
*
|
2005-03-31 |
2013-02-06 |
タケダ カリフォルニア インコーポレイテッド |
ヒドロキシステロイドデヒドロゲナーゼ阻害剤
|
|
BRPI0610459A2
(pt)
*
|
2005-04-05 |
2010-06-22 |
Hoffmann La Roche |
composto, processo para a sua preparação, composições farmacêuticas que o compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróides-11b e utilização do composto
|
|
EP2527337A1
(en)
*
|
2005-04-14 |
2012-11-28 |
Bristol-Myers Squibb Company |
Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
|
|
US8952176B2
(en)
|
2005-06-07 |
2015-02-10 |
Shionogi & Co., Ltd. |
Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
|
|
CA2610172A1
(en)
*
|
2005-06-08 |
2006-12-14 |
Japan Tobacco Inc. |
Heterocyclic compound
|
|
BRPI0611179A2
(pt)
*
|
2005-06-08 |
2010-08-24 |
Japan Tobacco Inc |
compostos heterocÍclicos, inibidor de 11bhsd1, agente farmacÊutico, uso dos referidos compostos, embalagem comercial e composiÇço farmacÊutica
|
|
RU2383539C2
(ru)
*
|
2005-06-08 |
2010-03-10 |
Джапан Тобакко Инк. |
Гетероциклические соединения
|
|
TW200715993A
(en)
|
2005-06-15 |
2007-05-01 |
Senomyx Inc |
Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
|
|
ES2528451T3
(es)
*
|
2005-06-17 |
2015-02-10 |
Apogee Biothechnology Corporation |
Inhibidores de esfingosina cinasa
|
|
US7605289B2
(en)
|
2005-06-17 |
2009-10-20 |
Amgen, Inc. |
Benzamide derivatives and uses related thereto
|
|
GB0513702D0
(en)
|
2005-07-04 |
2005-08-10 |
Sterix Ltd |
Compound
|
|
GB0514018D0
(en)
*
|
2005-07-07 |
2005-08-17 |
Ionix Pharmaceuticals Ltd |
Chemical compounds
|
|
AU2006272922A1
(en)
|
2005-07-22 |
2007-02-01 |
Amgen Inc. |
Aniline sulfonamide derivatives and their uses
|
|
CA2616937A1
(en)
|
2005-07-29 |
2007-02-08 |
F. Hoffman-La Roche Ag |
Indol-3-yl-carbonyl-piperidin and piperazin derivatives
|
|
US20070037865A1
(en)
*
|
2005-08-04 |
2007-02-15 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7622492B2
(en)
|
2005-08-31 |
2009-11-24 |
Hoffmann-La Roche Inc. |
Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
|
|
GB2429975A
(en)
*
|
2005-09-08 |
2007-03-14 |
Univ Edinburgh |
1,5-substituted-1H-tetrazole 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
CA2621255A1
(en)
*
|
2005-09-21 |
2007-04-05 |
Incyte Corporation |
Amido compounds and their use as pharmaceuticals
|
|
US20090124598A1
(en)
*
|
2005-11-01 |
2009-05-14 |
Henrik Sune Andersen |
Pharmaceutical use of substituted amides
|
|
AU2006310519A1
(en)
*
|
2005-11-01 |
2007-05-10 |
High Point Pharmaceuticals, Llc |
Pharmaceutical use of substituted amides
|
|
EP1953145B1
(en)
|
2005-11-21 |
2015-11-04 |
Shionogi & Co., Ltd. |
Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i
|
|
WO2007067504A2
(en)
|
2005-12-05 |
2007-06-14 |
Incyte Corporation |
Lactam compounds and methods of using the same
|
|
EP1801098A1
(en)
|
2005-12-16 |
2007-06-27 |
Merck Sante |
2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
|
|
US8053603B2
(en)
|
2006-01-06 |
2011-11-08 |
Sunovion Pharmaceuticals Inc. |
Tetralone-based monoamine reuptake inhibitors
|
|
CA2636324C
(en)
|
2006-01-06 |
2012-03-20 |
Sepracor Inc. |
Cycloalkylamines as monoamine reuptake inhibitors
|
|
WO2007084314A2
(en)
|
2006-01-12 |
2007-07-26 |
Incyte Corporation |
MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
|
|
TW200734313A
(en)
*
|
2006-01-17 |
2007-09-16 |
Astrazeneca Ab |
Piperazines and piperidines as mGluR5 potentiators
|
|
AU2007207055B2
(en)
*
|
2006-01-18 |
2011-06-02 |
F. Hoffmann-La Roche Ag |
Thiazoles as 11 beta-HSD1 inhibitors
|
|
RU2407740C2
(ru)
*
|
2006-02-13 |
2010-12-27 |
Ф.Хоффманн-Ля Рош Аг |
Гетеробициклические сульфонамидные производные для лечения диабета
|
|
US20100168083A1
(en)
*
|
2006-03-21 |
2010-07-01 |
Soren Ebdrup |
Adamantane derivatives for the treatment of the metabolic syndrome
|
|
ES2548002T3
(es)
*
|
2006-03-22 |
2015-10-13 |
F. Hoffmann-La Roche Ag |
Pirazoles como 11beta-SD1
|
|
JP5240775B2
(ja)
*
|
2006-03-30 |
2013-07-17 |
塩野義製薬株式会社 |
I型11βヒドロキシステロイド脱水素酵素阻害活性を有するイソキサゾール誘導体およびイソチアゾール誘導体
|
|
AU2007233041B2
(en)
|
2006-03-31 |
2013-05-02 |
Sepracor Inc. |
Preparation of chiral amides and amines
|
|
WO2007115935A1
(en)
*
|
2006-04-07 |
2007-10-18 |
High Point Pharmaceuticals, Llc |
11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
|
|
US7435833B2
(en)
*
|
2006-04-07 |
2008-10-14 |
Abbott Laboratories |
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
|
|
EP2010009B1
(en)
|
2006-04-21 |
2017-06-14 |
Senomyx, Inc. |
Processes for preparing solid flavorant compositions
|
|
EP2013163A1
(en)
|
2006-05-01 |
2009-01-14 |
Incyte Corporation |
Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
EP2018378A2
(en)
|
2006-05-17 |
2009-01-28 |
Incyte Corporation |
Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same
|
|
DE602007008237D1
(de)
|
2006-06-08 |
2010-09-16 |
Amgen Inc |
Benzamidderivate und assoziierte verwendungen
|
|
TW200808695A
(en)
|
2006-06-08 |
2008-02-16 |
Amgen Inc |
Benzamide derivatives and uses related thereto
|
|
CA2655282A1
(en)
*
|
2006-06-16 |
2007-12-21 |
High Point Pharmaceuticals, Llc |
Pharmaceutical use of substituted piperidine carboxamides
|
|
PE20080344A1
(es)
*
|
2006-06-27 |
2008-06-09 |
Sanofi Aventis |
Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1
|
|
FR2902791B1
(fr)
*
|
2006-06-27 |
2008-08-22 |
Sanofi Aventis Sa |
Derives d'urees de tropane,leur preparation et leur application en therapeutique
|
|
PE20080212A1
(es)
|
2006-06-27 |
2008-04-25 |
Sanofi Aventis |
Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1)
|
|
US7884124B2
(en)
|
2006-06-30 |
2011-02-08 |
Sepracor Inc. |
Fluoro-substituted inhibitors of D-amino acid oxidase
|
|
EP1878721A1
(en)
*
|
2006-07-13 |
2008-01-16 |
Novo Nordisk A/S |
4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
CA2657078A1
(en)
*
|
2006-07-13 |
2008-01-17 |
High Point Pharmaceuticals, Llc |
11beta-hydroxysteroid dehydrogenase type 1 active compounds
|
|
AU2007283113A1
(en)
|
2006-08-08 |
2008-02-14 |
Sanofi-Aventis |
Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
|
|
JP2010501567A
(ja)
|
2006-08-24 |
2010-01-21 |
ノバルティス アクチエンゲゼルシャフト |
代謝系、心血管系および他の障害の処置のためのステアロイル−CoA不飽和化酵素(SCD)阻害剤としての2−(ピラジン−2−イル)−チアゾールおよび2−(1H−ピラゾール−3−イル)チアゾール誘導体ならびに関連化合物
|
|
US7727978B2
(en)
*
|
2006-08-24 |
2010-06-01 |
Bristol-Myers Squibb Company |
Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
JP5351025B2
(ja)
|
2006-09-22 |
2013-11-27 |
ノバルティス アーゲー |
ヘテロ環式有機化合物
|
|
CN101541355B
(zh)
*
|
2006-10-17 |
2012-08-08 |
雷瓦医药公司 |
N-取代的单体和聚合物
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
TW200827346A
(en)
*
|
2006-11-03 |
2008-07-01 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2008068185A1
(en)
*
|
2006-12-07 |
2008-06-12 |
F. Hoffmann-La Roche Ag |
Spiro-piperidine derivatives as via receptor antagonists
|
|
WO2008069518A1
(en)
*
|
2006-12-08 |
2008-06-12 |
Amorepacific Corporation |
Pharmaceutical composition for controlling the function of spihngosylphosphorylcholine
|
|
KR20090091337A
(ko)
|
2006-12-20 |
2009-08-27 |
노파르티스 아게 |
Scd 억제제로서의 2-치환 5-원 헤테로사이클
|
|
EP1935420A1
(en)
|
2006-12-21 |
2008-06-25 |
Merck Sante |
2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
|
|
KR20090082502A
(ko)
|
2006-12-22 |
2009-07-30 |
에프. 호프만-라 로슈 아게 |
스피로-피페리딘 유도체
|
|
AU2007343726A1
(en)
*
|
2006-12-26 |
2008-07-24 |
Amgen Inc. |
N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
|
|
US7902252B2
(en)
|
2007-01-18 |
2011-03-08 |
Sepracor, Inc. |
Inhibitors of D-amino acid oxidase
|
|
TW200836719A
(en)
*
|
2007-02-12 |
2008-09-16 |
Astrazeneca Ab |
Chemical compounds
|
|
AU2011232811B2
(en)
*
|
2007-02-12 |
2012-05-31 |
Astrazeneca Ab |
Pyrazole derivatives as 11-beta-HSD1 inhibitors
|
|
CA2675669C
(en)
|
2007-02-23 |
2015-05-26 |
High Point Pharmaceuticals, Llc |
Novel compounds
|
|
WO2008101907A2
(en)
*
|
2007-02-23 |
2008-08-28 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
EP2146952A1
(en)
|
2007-02-23 |
2010-01-27 |
High Point Pharmaceuticals, LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
WO2008101886A1
(en)
|
2007-02-23 |
2008-08-28 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
EA200970841A1
(ru)
*
|
2007-03-09 |
2010-04-30 |
ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Фармацевтическое применение замещенных амидов
|
|
EP2141990A4
(en)
*
|
2007-03-28 |
2011-07-06 |
High Point Pharmaceuticals Llc |
ACTIVE COMPOUNDS ON 11BETA-HSD1
|
|
JP2010523692A
(ja)
*
|
2007-04-11 |
2010-07-15 |
ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー |
新規合成物
|
|
CA2685036A1
(en)
*
|
2007-04-24 |
2008-11-06 |
High Point Pharmaceuticals, Llc |
Pharmaceutical use of substituted amides
|
|
GB0708186D0
(en)
*
|
2007-04-27 |
2007-06-06 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
BRPI0811191A2
(pt)
|
2007-05-18 |
2014-10-29 |
Shionogi & Co |
Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1
|
|
JP5420534B2
(ja)
|
2007-05-31 |
2014-02-19 |
サノビオン ファーマシューティカルズ インク |
モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
|
|
EP1997805A1
(en)
*
|
2007-06-01 |
2008-12-03 |
Commissariat à l'Energie Atomique |
Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
|
|
CL2008001839A1
(es)
|
2007-06-21 |
2009-01-16 |
Incyte Holdings Corp |
Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
|
|
CN101743226B
(zh)
*
|
2007-07-17 |
2012-10-10 |
霍夫曼-拉罗奇有限公司 |
11β-羟基类固醇脱氢酶抑制剂
|
|
JP5470557B2
(ja)
|
2007-07-26 |
2014-04-16 |
ヴァイティー ファーマシューティカルズ,インコーポレイテッド |
11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤の合成
|
|
AU2008284746A1
(en)
|
2007-08-06 |
2009-02-12 |
Dainippon Sumitomo Pharma Co., Ltd. |
Aminopyrazole amide derivative
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
JP5736098B2
(ja)
|
2007-08-21 |
2015-06-17 |
アッヴィ・インコーポレイテッド |
中枢神経系障害を治療するための医薬組成物
|
|
AU2008292420A1
(en)
|
2007-08-31 |
2009-03-05 |
Astellas Pharma Inc. |
Piperidine derivative
|
|
US8119658B2
(en)
|
2007-10-01 |
2012-02-21 |
Bristol-Myers Squibb Company |
Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
WO2009056881A1
(en)
*
|
2007-10-29 |
2009-05-07 |
Astrazeneca Ab |
Chemical compounds 313
|
|
EA201000701A1
(ru)
*
|
2007-11-06 |
2010-12-30 |
Астразенека Аб |
4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465
|
|
AR069207A1
(es)
|
2007-11-07 |
2010-01-06 |
Vitae Pharmaceuticals Inc |
Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
|
|
CL2008003407A1
(es)
|
2007-11-16 |
2010-01-11 |
Boehringer Ingelheim Int |
Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
|
|
ES2322121B1
(es)
*
|
2007-12-10 |
2010-04-19 |
Consejo Superior De Investigaciones Cientificas |
Nuevos derivados de aminoacidos dicarboxilicos y su aplicacion en el tratamiento de enfermedades neurodegenerativas.
|
|
JP5490014B2
(ja)
|
2007-12-11 |
2014-05-14 |
ヴァイティー ファーマシューティカルズ,インコーポレイテッド |
11β−ヒドロキシステロイドデヒドロゲナーゼ1型の環状尿素阻害剤
|
|
TW200934490A
(en)
|
2008-01-07 |
2009-08-16 |
Vitae Pharmaceuticals Inc |
Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
|
|
US8592409B2
(en)
|
2008-01-24 |
2013-11-26 |
Vitae Pharmaceuticals, Inc. |
Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
|
|
US7951833B2
(en)
*
|
2008-02-04 |
2011-05-31 |
Astrazeneca Ab |
Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471
|
|
CA2715290A1
(en)
|
2008-02-15 |
2009-08-20 |
Vitae Pharmaceuticals, Inc. |
Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
US20100305120A1
(en)
*
|
2008-04-04 |
2010-12-02 |
Biomarin Iga Limited |
Compounds for treating muscular dystrophy
|
|
WO2009130496A1
(en)
*
|
2008-04-22 |
2009-10-29 |
Astrazeneca Ab |
Substituted pyrimidin-5-carboxamides 281
|
|
US8138178B2
(en)
|
2008-05-01 |
2012-03-20 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
WO2009134392A1
(en)
|
2008-05-01 |
2009-11-05 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
CA2723034A1
(en)
|
2008-05-01 |
2009-11-05 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
EP2288596B1
(en)
|
2008-05-13 |
2016-11-30 |
Boehringer Ingelheim International GmbH |
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
|
|
SMT201700154T1
(it)
|
2008-07-03 |
2017-05-08 |
Astellas Pharma Inc |
Derivato di triazolo o suo sale
|
|
UY31968A
(es)
|
2008-07-09 |
2010-01-29 |
Sanofi Aventis |
Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
|
|
JP5401544B2
(ja)
*
|
2008-07-15 |
2014-01-29 |
ノバルティス アーゲー |
Dgat1阻害剤としてのヘテロアリール誘導体
|
|
KR20110050459A
(ko)
|
2008-07-25 |
2011-05-13 |
비타이 파마슈티컬즈, 인코포레이티드 |
11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
|
|
TW201016691A
(en)
|
2008-07-25 |
2010-05-01 |
Boehringer Ingelheim Int |
Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
EP2318403B1
(en)
*
|
2008-08-25 |
2015-12-23 |
Boehringer Ingelheim International GmbH |
Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
MX2011002181A
(es)
|
2008-09-01 |
2011-03-30 |
Merck Patent Gmbh |
Derivados fusionados de pirrolidino-ciclopropano como inhibidores selectivos de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1.
|
|
US8829027B2
(en)
|
2008-10-23 |
2014-09-09 |
Boehringer Ingelheim International Gmbh |
Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
|
|
EA020496B1
(ru)
|
2008-11-21 |
2014-11-28 |
ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Производное адамантилбензамида, фармацевтическая композиция, включающая его, и его применение
|
|
WO2010068601A1
(en)
|
2008-12-08 |
2010-06-17 |
Sanofi-Aventis |
A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
|
|
TW201028421A
(en)
*
|
2009-01-15 |
2010-08-01 |
Abbott Lab |
Novel benzenesulfonamides as calcium channel blockers
|
|
JP2012516327A
(ja)
*
|
2009-01-30 |
2012-07-19 |
アストラゼネカ アクチボラグ |
カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法
|
|
JP5679997B2
(ja)
|
2009-02-04 |
2015-03-04 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
|
|
MX346801B
(es)
|
2009-03-13 |
2017-03-31 |
Agios Pharmaceuticals Inc |
Métodos y composiciones para trastornos relacionados con la proliferación celular.
|
|
ES2660892T3
(es)
*
|
2009-03-23 |
2018-03-26 |
Merck Sharp & Dohme Corp. |
Antagonistas del receptor P2X3 para el tratamiento del dolor
|
|
JP5756457B2
(ja)
|
2009-04-06 |
2015-07-29 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
ピルビン酸キナーゼm2調節剤、治療組成物および関連する使用方法
|
|
US8680093B2
(en)
|
2009-04-30 |
2014-03-25 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
|
|
JP5670440B2
(ja)
|
2009-06-02 |
2015-02-18 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
|
|
ES2350077B1
(es)
|
2009-06-04 |
2011-11-04 |
Laboratorios Salvat, S.A. |
Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
|
|
EP2440537A1
(en)
|
2009-06-11 |
2012-04-18 |
Vitae Pharmaceuticals, Inc. |
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
|
|
SG177434A1
(en)
|
2009-06-29 |
2012-02-28 |
Agios Pharmaceuticals Inc |
Therapeutic compounds and compositions
|
|
BR112012003973A2
(pt)
|
2009-08-26 |
2015-09-08 |
Sanofi Sa |
hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso
|
|
ES2540547T3
(es)
*
|
2009-09-16 |
2015-07-10 |
The University Of Edinburgh |
Compuestos de (4-fenil-piperidin-1-il)-[5-(1H-pirazol-4-il)-tiofen-3-il]-metanona y su uso
|
|
US20110092526A1
(en)
*
|
2009-10-20 |
2011-04-21 |
Astrazeneca Ab |
Adamantyl Iminocarbonyl-Substituted Pyrimidines As Inhibitors Of 11-Beta-HSD1 826
|
|
WO2011050210A1
(en)
|
2009-10-21 |
2011-04-28 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
UY33001A
(es)
|
2009-11-06 |
2011-05-31 |
Boehringer Ingelheim Int |
Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
|
|
US10640457B2
(en)
|
2009-12-10 |
2020-05-05 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase activators and uses thereof
|
|
WO2011072243A1
(en)
*
|
2009-12-10 |
2011-06-16 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase activators and uses thereof
|
|
WO2011099502A1
(ja)
*
|
2010-02-10 |
2011-08-18 |
公立大学法人横浜市立大学 |
神経選択的転写抑制因子NRSFに特異的に結合するmSin3B に結合する化合物の利用
|
|
WO2011107494A1
(de)
|
2010-03-03 |
2011-09-09 |
Sanofi |
Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
PT3002008T
(pt)
|
2010-03-11 |
2018-12-24 |
Univ New York |
Compostos de amido como moduladores roryt e suas utilizações
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
CA2797118C
(en)
|
2010-04-22 |
2021-03-30 |
Vertex Pharmaceuticals Incorporated |
Process of producing cycloalkylcarboxamido-indole compounds
|
|
EP2582698B1
(en)
|
2010-06-16 |
2016-09-14 |
Vitae Pharmaceuticals, Inc. |
Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
|
|
US8933024B2
(en)
|
2010-06-18 |
2015-01-13 |
Sanofi |
Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
AU2011270872A1
(en)
|
2010-06-24 |
2013-01-31 |
Allergan, Inc. |
Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
|
|
JP5813106B2
(ja)
|
2010-06-25 |
2015-11-17 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|
|
AU2011202542A1
(en)
*
|
2010-07-14 |
2012-02-02 |
Indian Institute Of Science |
Benzothiophene carboxamide compounds, composition and applications thereof
|
|
FR2962649B1
(fr)
|
2010-07-19 |
2025-10-24 |
Conservatoire Nat Arts Et Metiers |
Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
|
|
WO2012015715A1
(en)
|
2010-07-27 |
2012-02-02 |
High Point Pharmaceuticals, Llc |
Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta hsd1 modulators
|
|
UA112418C2
(uk)
|
2010-09-07 |
2016-09-12 |
Астеллас Фарма Інк. |
Терапевтичний болезаспокійливий засіб
|
|
EA201300522A1
(ru)
|
2010-11-02 |
2013-11-29 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Фармацевтические комбинации для лечения метаболических нарушений
|
|
TWI537258B
(zh)
|
2010-11-05 |
2016-06-11 |
百靈佳殷格翰國際股份有限公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物
|
|
WO2012083246A1
(en)
|
2010-12-17 |
2012-06-21 |
Agios Pharmaceuticals, Inc. |
Novel n- (4- (azetidine - 1 - carbonyl) phenyl) - (hetero - ) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
|
|
MX336022B
(es)
|
2010-12-21 |
2016-01-06 |
Agios Pharmaceuticals Inc |
Activadores de pkm2 bicíclicos.
|
|
EP2654428B1
(en)
|
2010-12-22 |
2018-02-14 |
The Trustees of Columbia University in the City of New York |
Histone acetyltransferase modulators and usese thereof
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
CN102584741A
(zh)
*
|
2011-01-06 |
2012-07-18 |
中国科学院上海药物研究所 |
酰胺类化合物及其制备方法、组合物和用途
|
|
EP2683701B1
(de)
|
2011-03-08 |
2014-12-24 |
Sanofi |
Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8895547B2
(en)
|
2011-03-08 |
2014-11-25 |
Sanofi |
Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
|
|
WO2012120052A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2683705B1
(de)
|
2011-03-08 |
2015-04-22 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8710050B2
(en)
|
2011-03-08 |
2014-04-29 |
Sanofi |
Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
US8809325B2
(en)
|
2011-03-08 |
2014-08-19 |
Sanofi |
Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
|
|
WO2012120053A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120050A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
KR101332805B1
(ko)
|
2011-03-31 |
2013-11-27 |
한국화학연구원 |
아다만틸기를 갖는 설파마이드 유도체 및 이의 약제학적으로 허용 가능한 염
|
|
CN104230935A
(zh)
*
|
2011-04-26 |
2014-12-24 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
CN102241678B
(zh)
*
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
PT2704721T
(pt)
|
2011-05-03 |
2018-06-14 |
Agios Pharmaceuticals Inc |
Ativadores da piruvato-cinase para utilização em terapia
|
|
CA2834692A1
(en)
|
2011-05-03 |
2012-11-08 |
Agios Pharmaceuticals, Inc. |
Pyruvate kinase activators for use in therapy
|
|
US9809532B2
(en)
|
2011-06-10 |
2017-11-07 |
The Trustees Of Columbia University In The City Of New York |
Uses of histone acetyltransferase activators
|
|
CN102827170A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
US9409904B2
(en)
|
2011-08-01 |
2016-08-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd |
Compounds and compositions for use in augmentation of glucose
|
|
US8735585B2
(en)
|
2011-08-17 |
2014-05-27 |
Boehringer Ingelheim International Gmbh |
Indenopyridine derivatives
|
|
JP2014528933A
(ja)
*
|
2011-09-09 |
2014-10-30 |
ニューヨーク ユニバーシティ |
RORγtモジュレーターとしてのアミド化合物およびその使用
|
|
WO2013037390A1
(en)
|
2011-09-12 |
2013-03-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
WO2013045413A1
(en)
|
2011-09-27 |
2013-04-04 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
US9266840B2
(en)
|
2011-10-18 |
2016-02-23 |
Astellas Pharma Inc. |
Bicyclic heterocyclic compound
|
|
AU2012367780B2
(en)
*
|
2011-12-22 |
2017-04-06 |
Connexios Life Sciences Pvt. Ltd. |
Derivatives of aza adamantane and uses thereof
|
|
BR112014015301A8
(pt)
*
|
2011-12-22 |
2017-07-04 |
Connexios Life Sciences Pvt Ltd |
derivados de amida cíclica como inibidores de 11 - beta-hidroxiesteroide desidrogenase e seus usos
|
|
US9474779B2
(en)
|
2012-01-19 |
2016-10-25 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their methods of use
|
|
WO2013146437A1
(ja)
*
|
2012-03-26 |
2013-10-03 |
シーシーアイ株式会社 |
3-デセン酸誘導体およびその用途
|
|
US8889730B2
(en)
|
2012-04-10 |
2014-11-18 |
Pfizer Inc. |
Indole and indazole compounds that activate AMPK
|
|
JP2015129094A
(ja)
*
|
2012-04-16 |
2015-07-16 |
大日本住友製薬株式会社 |
アリールアミノピラゾール誘導体
|
|
JOP20130213B1
(ar)
|
2012-07-17 |
2021-08-17 |
Takeda Pharmaceuticals Co |
معارضات لمستقبلht3-5
|
|
US10092574B2
(en)
|
2012-09-26 |
2018-10-09 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
|
|
GB201218084D0
(en)
*
|
2012-10-09 |
2012-11-21 |
Univ Aston |
Novel compounds and methods for use in medicine
|
|
US9861596B2
(en)
*
|
2012-11-09 |
2018-01-09 |
Musc Foundation For Research Development |
Compositions and methods for treating neurological diseases or injury
|
|
EP2968094B1
(en)
|
2013-03-13 |
2018-05-30 |
Unilever PLC |
Photoprotective compositions with tricyclodecane amides
|
|
US9883997B2
(en)
|
2013-03-13 |
2018-02-06 |
Conopco, Inc. |
Cosmetic compositions with tricyclodecane amides
|
|
EP2968082B1
(en)
|
2013-03-13 |
2017-02-01 |
Unilever PLC |
Prolonged delivery of certain fragrance components from personal care compositions
|
|
CA2905242C
(en)
|
2013-03-15 |
2016-11-29 |
Pfizer Inc. |
Indole compounds that activate ampk
|
|
WO2014139144A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Agios Pharmaceuticals, Inc. |
Therapeutic compounds and compositions
|
|
WO2015003360A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
WO2015003355A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
WO2015006591A1
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
|
|
US9579324B2
(en)
|
2013-07-11 |
2017-02-28 |
Agios Pharmaceuticals, Inc |
Therapeutically active compounds and their methods of use
|
|
US20150031627A1
(en)
|
2013-07-25 |
2015-01-29 |
Agios Pharmaceuticals, Inc |
Therapeutically active compounds and their methods of use
|
|
GB201317363D0
(en)
|
2013-10-01 |
2013-11-13 |
Eisai Ltd |
Novel compounds
|
|
UA121211C2
(uk)
|
2014-03-14 |
2020-04-27 |
Аджіос Фармасьютикалз, Інк. |
Фармацевтична композиція, що містить тверду дисперсію, та спосіб лікування гострої мієлогенної/мієлоїдної лейкемії (гмл)
|
|
CA2944613A1
(en)
*
|
2014-03-31 |
2015-10-08 |
The Trustees Of Columbia University In The City Of New York |
Histone acetyltransferase activators and uses thereof
|
|
CA2944140C
(en)
|
2014-04-15 |
2022-10-04 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
|
|
ES2880313T3
(es)
*
|
2014-06-16 |
2021-11-24 |
Univ Lille |
Compuestos, composición farmacéutica y su uso en el tratamiento de enfermedades neurodegenerativas
|
|
JP7055017B2
(ja)
|
2014-09-29 |
2022-04-15 |
武田薬品工業株式会社 |
結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド
|
|
CN107108611B
(zh)
|
2014-12-18 |
2020-09-25 |
豪夫迈·罗氏有限公司 |
四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
|
|
SI3307271T1
(sl)
|
2015-06-11 |
2023-11-30 |
Agios Pharmaceuticals, Inc. |
Postopki za uporabo aktivatorjev piruvat kinaze
|
|
DK3362066T3
(da)
|
2015-10-15 |
2021-11-22 |
Les Laboratoires Servier Sas |
Kombinationsterapi til behandling af maligniteter
|
|
MD3362065T2
(ro)
|
2015-10-15 |
2024-08-31 |
Servier Lab |
Terapie combinată care conține ivosidenib, citarabină și daunorubicina sau idarubicina pentru tratarea leucemiei acute mielogene
|
|
US11872207B2
(en)
|
2015-12-24 |
2024-01-16 |
Mcmaster University |
Dronedarone and derivatives thereof for treating cancer
|
|
EP3393466B1
(en)
|
2015-12-24 |
2021-02-03 |
McMaster University |
Compounds for use in treating cancer
|
|
US20190016680A1
(en)
|
2016-01-14 |
2019-01-17 |
Beth Israel Deaconess Medical Center, Inc. |
Mast-cell modulators and uses thereof
|
|
WO2017205622A1
(en)
*
|
2016-05-25 |
2017-11-30 |
Savant Neglected Diseases, Llc |
Method of making benznidazole
|
|
JOP20170131B1
(ar)
*
|
2016-06-10 |
2021-08-17 |
Lilly Co Eli |
مركبات 1-تيترا هيدروبيرانييل كاربونيل -2،3-ديهيدرو -1 h- اندول لعلاج السرطان
|
|
CA3027223A1
(en)
|
2016-06-21 |
2017-12-28 |
Shifa Biomedical Corporation |
Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
|
|
CN107663159A
(zh)
*
|
2016-07-29 |
2018-02-06 |
上海迪诺医药科技有限公司 |
多环化合物、其药物组合物及应用
|
|
CN110573154A
(zh)
*
|
2017-02-06 |
2019-12-13 |
卡斯西部储备大学 |
调节短链脱氢酶活性的组合物和方法
|
|
EP3375778A1
(en)
*
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
JP6594570B2
(ja)
|
2017-03-20 |
2019-10-23 |
フォーマ セラピューティクス,インコーポレイテッド |
ピルビン酸キナーゼ(pkr)活性化剤としてのピロロピロール組成物
|
|
US10980788B2
(en)
|
2018-06-08 |
2021-04-20 |
Agios Pharmaceuticals, Inc. |
Therapy for treating malignancies
|
|
AU2019290545B2
(en)
|
2018-06-21 |
2022-04-14 |
F. Hoffmann-La Roche Ag |
Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
|
|
WO2020061255A1
(en)
|
2018-09-19 |
2020-03-26 |
Forma Therapeutics, Inc. |
Activating pyruvate kinase r
|
|
WO2020061378A1
(en)
|
2018-09-19 |
2020-03-26 |
Forma Therapeutics, Inc. |
Treating sickle cell disease with a pyruvate kinase r activating compound
|
|
CN109452280B
(zh)
*
|
2018-11-15 |
2021-01-29 |
南开大学 |
一种利用二氧化碳生产杀虫剂的工艺方法
|
|
MX2021005801A
(es)
|
2018-11-20 |
2021-08-05 |
Sparrow Pharmaceuticals Inc |
Metodos para administrar corticosteroides.
|
|
SG11202105345TA
(en)
|
2018-11-21 |
2021-06-29 |
Univ Case Western Reserve |
Compositions and methods of modulating short-chain dehydrogenase activity
|
|
US11084825B2
(en)
|
2018-12-31 |
2021-08-10 |
Biomea Fusion, Llc |
Substituted pyridines as irreversible inhibitors of menin-MLL interaction
|
|
US11174263B2
(en)
|
2018-12-31 |
2021-11-16 |
Biomea Fusion, Inc. |
Inhibitors of menin-MLL interaction
|
|
WO2020216378A1
(zh)
*
|
2019-04-26 |
2020-10-29 |
健艾仕生物医药有限公司 |
一种含杂环的化合物、其应用及含其的组合物
|
|
AU2020350763A1
(en)
|
2019-09-19 |
2022-04-07 |
Novo Nordisk Health Care Ag |
Pyruvate kinase R (PKR) activating compositions
|
|
CN112812077B
(zh)
*
|
2019-11-18 |
2023-08-22 |
中国科学院上海药物研究所 |
苯甲酰胺类化合物及其制备方法、药物组合物和用途
|
|
CA3168494A1
(en)
|
2020-01-23 |
2021-07-29 |
Roopa Rai |
Pgdh inhibitors and methods of making and using
|
|
WO2022036104A1
(en)
*
|
2020-08-12 |
2022-02-17 |
University Of Iowa Research Foundation |
Insulin sensitizers for the treatment of diabetes mellitus
|
|
US12128035B2
(en)
|
2021-03-19 |
2024-10-29 |
Novo Nordisk Health Care Ag |
Activating pyruvate kinase R
|
|
WO2023018825A1
(en)
|
2021-08-11 |
2023-02-16 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-mll interaction for diabetes mellitus
|
|
MX2024002189A
(es)
|
2021-08-20 |
2024-06-11 |
Biomea Fusion Inc |
Forma cristalina de n-[4-[4-(4-morfolinil)-7h-pirrolo[2,3-d]pirimi din-6-il]fenil]-4-[[3(r)-[(1-oxo)-2-propen-1-il)amino]-1-piperidi nil]metil]-2-piridinacarboxamida, un inhibidor irreversible de menina-mll para el tratamiento del cancer.
|
|
IL316907A
(en)
|
2022-05-16 |
2025-01-01 |
Sparrow Pharmaceuticals Inc |
METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOD EXCESS
|
|
TW202430528A
(zh)
|
2023-01-18 |
2024-08-01 |
美商拜歐米富士恩股份有限公司 |
N-[4-[4-(4-嗎啉基)-7h-吡咯並[2,3-d]嘧啶-6-基]苯基]-4-[[3(r)-[(1-氧代-2-丙烯-1-基)氨基]-1-哌啶基]甲基]-2-吡啶甲醯胺的結晶形式作為menin-mll相互作用的共價抑制劑
|