NO20074324L - Substituerte arylamin sammensetniger og deres andvendelse som 5-HT6 modulatorer - Google Patents

Substituerte arylamin sammensetniger og deres andvendelse som 5-HT6 modulatorer

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Publication number
NO20074324L
NO20074324L NO20074324A NO20074324A NO20074324L NO 20074324 L NO20074324 L NO 20074324L NO 20074324 A NO20074324 A NO 20074324A NO 20074324 A NO20074324 A NO 20074324A NO 20074324 L NO20074324 L NO 20074324L
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Norway
Prior art keywords
alkyl
aryl
substituted
heteroaryl
hydrogen
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NO20074324A
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English (en)
Inventor
Dale S Dhanoa
Oren Becker
Silvia Noiman
Yael Marantz
Rosa E Melendez
Laurence Wu
Ashis K Saha
Mercedes Lobera
Anurag Sharadendu
Xiang Y Yu
Merav Fichman
Pini Orbach
Sharon Shacham
Srinivasa Rao Cheruku
Hanock Senderowitz
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Epix Delaware Inc
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Publication of NO20074324L publication Critical patent/NO20074324L/no

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

Oppfinnelsen angår nye 5-HT6 reseptor antagonister. Nye arylamin forbindelser med formel: og farmasøytisk akseptable salter og/eller estere derav, der - n er 0, 1, 2, 3, eller 4; - A, når til stede er en lavere alkyl gruppe; - R] er hydrogen eller substituert eller usubstituerte alkyl eller aryl; - R_2 er hydrogen; halo; nitro; cyano, lavere alkoksy; karboksylat salt syre eller alkyl ester derav; et sulfon; haloalkyl eller haloalkoksy; acetaldehyd; karboksamid; karbomyl; alkoksyaminkarbonyl; eller substituert arylalkylamin: - R3 og R4 er uavhengig hydrogen, substituert eller usubstituert alkyl, aryl, alkylaryl, heteroaryl eller alkylheteroaryl, eller tatt sammen danner R;, og R4 en substituert eller usubstituert aryl, alkylaryl, heteroaryl eller alkylheteroaryl gruppe; - B, når til stede, er lavere alkyl; og - X og Y er uavhengig C eller N; og anvendelse av disse forbindelsene og deres farmasøytiske sammensetninger, for eksempel i behandling, modulering og/eller forebygging av fysiologiske tilstander forbundet med serotonin virkning, slik som i behandling av fedme, og fedme-relaterte forstyrrelser for eksempel kardiovaskulær sykdom, fordøyelsessykdom, respiratorisk sykdom, cancer og type II diabetes; og fysiologiske forstyrrelser slik som schizofreni blir beskrevet.
NO20074324A 2005-01-25 2007-08-24 Substituerte arylamin sammensetniger og deres andvendelse som 5-HT6 modulatorer NO20074324L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64695705P 2005-01-25 2005-01-25
US70185305P 2005-07-22 2005-07-22
PCT/US2006/002718 WO2006081332A1 (en) 2005-01-25 2006-01-25 Substituted arylamine compounds and their use as 5-ht6 modulators

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NO20074324L true NO20074324L (no) 2007-10-25

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US (2) US7968538B2 (no)
EP (1) EP1856075A1 (no)
JP (2) JP5186219B2 (no)
KR (1) KR20070097590A (no)
AU (1) AU2006209216A1 (no)
BR (1) BRPI0606110A2 (no)
CA (1) CA2595607C (no)
IL (1) IL184705A0 (no)
MA (1) MA29429B1 (no)
MX (1) MX2007008279A (no)
NO (1) NO20074324L (no)
NZ (1) NZ556761A (no)
RU (1) RU2440996C2 (no)
WO (1) WO2006081332A1 (no)

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US7968538B2 (en) 2011-06-28
RU2007132161A (ru) 2009-03-10
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MX2007008279A (es) 2008-02-15
US20120115850A1 (en) 2012-05-10
WO2006081332A1 (en) 2006-08-03
MA29429B1 (fr) 2008-05-02
CA2595607A1 (en) 2006-08-03
IL184705A0 (en) 2007-12-03
JP2012111784A (ja) 2012-06-14
CA2595607C (en) 2014-07-15
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