JP2008542365A5 - - Google Patents
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- Publication number
- JP2008542365A5 JP2008542365A5 JP2008514586A JP2008514586A JP2008542365A5 JP 2008542365 A5 JP2008542365 A5 JP 2008542365A5 JP 2008514586 A JP2008514586 A JP 2008514586A JP 2008514586 A JP2008514586 A JP 2008514586A JP 2008542365 A5 JP2008542365 A5 JP 2008542365A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- yloxy
- benzyl
- piperidin
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 1-methyl-piperidin-4-yloxy Chemical group 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000019906 panic disease Diseases 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 208000030814 Eating disease Diseases 0.000 claims 3
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 3
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 3
- 101150104680 MCH1 gene Proteins 0.000 claims 3
- 206010027940 Mood altered Diseases 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 206010033664 Panic attack Diseases 0.000 claims 3
- 101100382379 Rattus norvegicus Cap1 gene Proteins 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 230000009286 beneficial effect Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 235000014632 disordered eating Nutrition 0.000 claims 3
- 208000029364 generalized anxiety disease Diseases 0.000 claims 3
- 230000007510 mood change Effects 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
- 230000007823 neuropathy Effects 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000020016 psychiatric disease Diseases 0.000 claims 3
- FDPKGXQCDURRBM-UHFFFAOYSA-N 4-(4-methoxyphenyl)benzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C=C1 FDPKGXQCDURRBM-UHFFFAOYSA-N 0.000 claims 2
- NNJMFJSKMRYHSR-UHFFFAOYSA-N 4-phenylbenzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=CC=C1 NNJMFJSKMRYHSR-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- FICBTMWNFWJNQL-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]methanamine Chemical compound C1CN(C)CCC1OC1=CC=CC(CNCC=2C=CC(Cl)=CC=2)=C1 FICBTMWNFWJNQL-UHFFFAOYSA-N 0.000 claims 1
- CJCOBMTYEDBBSY-UHFFFAOYSA-N 2-phenoxybenzamide Chemical compound NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 CJCOBMTYEDBBSY-UHFFFAOYSA-N 0.000 claims 1
- OAGWHNQUCXPGIV-UHFFFAOYSA-N 3-[4-(dimethylamino)phenyl]-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=CC(C(=O)NCC=2C=C(OC3CCN(C)CC3)C=CC=2)=C1 OAGWHNQUCXPGIV-UHFFFAOYSA-N 0.000 claims 1
- LXWNTLBMNCXRQN-UHFFFAOYSA-N 4'-fluoro-1,1'-biphenyl-4-carboxylic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=C(F)C=C1 LXWNTLBMNCXRQN-UHFFFAOYSA-N 0.000 claims 1
- VXMLQXJQYHWFNO-UHFFFAOYSA-N 4-(3-chlorophenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=C(Cl)C=CC=2)=C1 VXMLQXJQYHWFNO-UHFFFAOYSA-N 0.000 claims 1
- HIZAKWSGPSDQAZ-UHFFFAOYSA-N 4-(4-chlorophenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC(Cl)=CC=2)=C1 HIZAKWSGPSDQAZ-UHFFFAOYSA-N 0.000 claims 1
- CTZYDPNPAYTPAJ-UHFFFAOYSA-N 4-(4-fluoro-3-methylphenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=C(C)C(F)=CC=2)=C1 CTZYDPNPAYTPAJ-UHFFFAOYSA-N 0.000 claims 1
- QTCDZQVGZSUQBS-UHFFFAOYSA-N 4-(4-fluorophenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=C1 QTCDZQVGZSUQBS-UHFFFAOYSA-N 0.000 claims 1
- BVJKDGKGYCBMNN-UHFFFAOYSA-N 4-(4-methoxyphenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(=O)NCC=2C=C(OC3CCN(C)CC3)C=CC=2)C=C1 BVJKDGKGYCBMNN-UHFFFAOYSA-N 0.000 claims 1
- CREKGPKHHFBOBC-UHFFFAOYSA-N 4-(4-methoxyphenyl)-n-methyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(=O)N(C)CC=2C=C(OC3CCN(C)CC3)C=CC=2)C=C1 CREKGPKHHFBOBC-UHFFFAOYSA-N 0.000 claims 1
- SPQOKMMLLGTJJL-UHFFFAOYSA-N 4-(4-methylphenyl)-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC(C)=CC=2)=C1 SPQOKMMLLGTJJL-UHFFFAOYSA-N 0.000 claims 1
- PJDYFSZUHGVJRM-UHFFFAOYSA-N 4-benzyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(CC=3C=CC=CC=3)=CC=2)=C1 PJDYFSZUHGVJRM-UHFFFAOYSA-N 0.000 claims 1
- YLRKXJUMQVWTOI-UHFFFAOYSA-N 4-cyclohexyl-n-methyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C=1C=C(C2CCCCC2)C=CC=1C(=O)N(C)CC(C=1)=CC=CC=1OC1CCN(C)CC1 YLRKXJUMQVWTOI-UHFFFAOYSA-N 0.000 claims 1
- ZXQYZHKJAOBIOV-UHFFFAOYSA-N 4-phenoxy-n-[(3-piperidin-4-yloxyphenyl)methyl]benzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)NCC(C=1)=CC=CC=1OC1CCNCC1 ZXQYZHKJAOBIOV-UHFFFAOYSA-N 0.000 claims 1
- RISSPRUZBRTULC-UHFFFAOYSA-N 4-phenoxy-n-[[3-(1-propylpiperidin-4-yl)oxyphenyl]methyl]benzamide Chemical compound C1CN(CCC)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 RISSPRUZBRTULC-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- KQQFOGNNTZAYAL-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-1-[3-(1-methylpiperidin-4-yl)oxyphenyl]methanamine Chemical compound C1CN(C)CCC1OC1=CC=CC(CNCC=2C=C3OCOC3=CC=2)=C1 KQQFOGNNTZAYAL-UHFFFAOYSA-N 0.000 claims 1
- YVEQXBUNXFOMPK-UHFFFAOYSA-N n-[[3-(1-benzylpiperidin-4-yl)oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)NCC(C=1)=CC=CC=1OC(CC1)CCN1CC1=CC=CC=C1 YVEQXBUNXFOMPK-UHFFFAOYSA-N 0.000 claims 1
- PQANLFYFLBRNSR-UHFFFAOYSA-N n-[[3-(1-cyclopropylpiperidin-4-yl)oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)NCC(C=1)=CC=CC=1OC(CC1)CCN1C1CC1 PQANLFYFLBRNSR-UHFFFAOYSA-N 0.000 claims 1
- AFMXBORFJZKSOK-UHFFFAOYSA-N n-[[3-(1-ethylpiperidin-4-yl)oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C1CN(CC)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 AFMXBORFJZKSOK-UHFFFAOYSA-N 0.000 claims 1
- MRBZBRGOCVOJJT-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-1-(4-phenoxyphenyl)methanamine Chemical compound C1CN(C)CCC1OC1=CC=CC(CNCC=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 MRBZBRGOCVOJJT-UHFFFAOYSA-N 0.000 claims 1
- QAIVOSFJXAMSDU-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-1-(4-phenylphenyl)methanamine Chemical compound C1CN(C)CCC1OC1=CC=CC(CNCC=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 QAIVOSFJXAMSDU-UHFFFAOYSA-N 0.000 claims 1
- RAXRPWHEVIYGCB-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-1-(4-propan-2-ylphenyl)methanamine Chemical compound C1=CC(C(C)C)=CC=C1CNCC1=CC=CC(OC2CCN(C)CC2)=C1 RAXRPWHEVIYGCB-UHFFFAOYSA-N 0.000 claims 1
- BBUSGCSBLGJHHL-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-3-phenoxybenzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=C(OC=3C=CC=CC=3)C=CC=2)=C1 BBUSGCSBLGJHHL-UHFFFAOYSA-N 0.000 claims 1
- KSKVZHOHVWXVIP-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-(4-methylsulfonylphenyl)benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC(=CC=2)S(C)(=O)=O)=C1 KSKVZHOHVWXVIP-UHFFFAOYSA-N 0.000 claims 1
- KAAHTYMQPGOFRE-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-[4-(trifluoromethoxy)phenyl]benzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC(OC(F)(F)F)=CC=2)=C1 KAAHTYMQPGOFRE-UHFFFAOYSA-N 0.000 claims 1
- VMSMZDPNNGYOLL-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-phenylbenzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 VMSMZDPNNGYOLL-UHFFFAOYSA-N 0.000 claims 1
- YNQVBDCUPBKVPE-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-phenylmethoxybenzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(OCC=3C=CC=CC=3)=CC=2)=C1 YNQVBDCUPBKVPE-UHFFFAOYSA-N 0.000 claims 1
- IADYROZDLAWMHG-UHFFFAOYSA-N n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-thiophen-3-ylbenzamide Chemical compound C1CN(C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(=CC=2)C2=CSC=C2)=C1 IADYROZDLAWMHG-UHFFFAOYSA-N 0.000 claims 1
- NQQFNYNBNBXFNX-UHFFFAOYSA-N n-[[3-[(4-methylpiperazin-1-yl)methyl]phenyl]methyl]-4-phenoxybenzamide Chemical compound C1CN(C)CCN1CC1=CC=CC(CNC(=O)C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 NQQFNYNBNBXFNX-UHFFFAOYSA-N 0.000 claims 1
- IGLJXAOHZMBCMN-UHFFFAOYSA-N n-[[3-[1-(2,2-dimethylpropyl)piperidin-4-yl]oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C1CN(CC(C)(C)C)CCC1OC1=CC=CC(CNC(=O)C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 IGLJXAOHZMBCMN-UHFFFAOYSA-N 0.000 claims 1
- SZDZVNAICFHQQD-UHFFFAOYSA-N n-[[3-[1-(oxolan-3-yl)piperidin-4-yl]oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)NCC(C=1)=CC=CC=1OC(CC1)CCN1C1CCOC1 SZDZVNAICFHQQD-UHFFFAOYSA-N 0.000 claims 1
- DCOVPKWLIJKMTM-UHFFFAOYSA-N n-ethyl-n-[[3-(1-ethylpiperidin-4-yl)oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)N(CC)CC(C=1)=CC=CC=1OC1CCN(CC)CC1 DCOVPKWLIJKMTM-UHFFFAOYSA-N 0.000 claims 1
- CVMJFDVTAZFJLW-UHFFFAOYSA-N n-methyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-1-(4-phenoxyphenyl)methanamine Chemical compound C=1C=CC(OC2CCN(C)CC2)=CC=1CN(C)CC(C=C1)=CC=C1OC1=CC=CC=C1 CVMJFDVTAZFJLW-UHFFFAOYSA-N 0.000 claims 1
- GBQVRCQAGWZRJP-UHFFFAOYSA-N n-methyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)N(C)CC(C=1)=CC=CC=1OC1CCN(C)CC1 GBQVRCQAGWZRJP-UHFFFAOYSA-N 0.000 claims 1
- PKMRIBLWFLQQTE-UHFFFAOYSA-N n-methyl-n-[[3-(1-methylpiperidin-4-yl)oxyphenyl]methyl]-4-phenylbenzamide Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)N(C)CC(C=1)=CC=CC=1OC1CCN(C)CC1 PKMRIBLWFLQQTE-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68583205P | 2005-05-31 | 2005-05-31 | |
| PCT/SE2006/000621 WO2006130075A1 (en) | 2005-05-31 | 2006-05-29 | Novel mchr1 antagonists and their use for the treatment of mchr1 mediated conditions and disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008542365A JP2008542365A (ja) | 2008-11-27 |
| JP2008542365A5 true JP2008542365A5 (enExample) | 2009-07-16 |
Family
ID=37481914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514586A Pending JP2008542365A (ja) | 2005-05-31 | 2006-05-29 | 新規なｍｃｈｒ１アンタゴニスト並びにｍｃｈｒ１媒介状態及び障害の処置のためのそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080269275A1 (enExample) |
| EP (1) | EP1891065A4 (enExample) |
| JP (1) | JP2008542365A (enExample) |
| KR (1) | KR20080011677A (enExample) |
| CN (1) | CN101184753A (enExample) |
| AU (1) | AU2006253049B2 (enExample) |
| BR (1) | BRPI0610907A2 (enExample) |
| CA (1) | CA2610671A1 (enExample) |
| IL (1) | IL187248A0 (enExample) |
| MX (1) | MX2007014464A (enExample) |
| NO (1) | NO20076695L (enExample) |
| WO (1) | WO2006130075A1 (enExample) |
| ZA (1) | ZA200709922B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1976828B1 (en) | 2005-12-29 | 2016-12-21 | Celtaxsys, Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| CN101400677A (zh) * | 2006-01-06 | 2009-04-01 | 阿斯利康(瑞典)有限公司 | 化合物 |
| BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| DK2470552T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi Sa | NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE |
| MX2012015102A (es) | 2010-07-06 | 2013-05-01 | Astrazeneca Ab | Agentes terapeuticos 976. |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| CA2906086A1 (en) * | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH377824A (de) * | 1959-08-28 | 1964-05-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen N-heterocyclischen Verbindungen |
| CH377826A (de) * | 1959-08-28 | 1964-05-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen N-heterocyclischen Verbindungen |
| ZA829150B (en) * | 1981-12-14 | 1984-07-25 | American Home Prod | Benzo-fused heterocyclic compounds |
| FR2531704B1 (fr) * | 1982-08-13 | 1985-08-09 | Sanofi Sa | Amides d'acides (hetero)aromatiques n-substitues, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant |
| IL69392A (en) * | 1982-08-13 | 1987-01-30 | Sanofi Sa | N-oxide nicotinamide derivatives,their preparation and pharmaceutical compositions containing them |
| JP2002003370A (ja) * | 1999-09-20 | 2002-01-09 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
| US7115750B1 (en) * | 1999-09-20 | 2006-10-03 | Takeda Pharmaceutical Company Limited | Melanin concentrating hormone antagonist |
| NZ525723A (en) * | 2000-12-22 | 2004-11-26 | Schering Corp | 1,4-di-substituted piperidine antagonists for melanin-concentrating hormone (MCH) and their use in the treatment of obesity or diabetes |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| CA2484209C (en) * | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| US7601868B2 (en) * | 2003-02-12 | 2009-10-13 | Takeda Pharmaceutical Company Limited | Amine derivative |
| US20080161344A1 (en) * | 2004-02-09 | 2008-07-03 | Steenstra Cheryl K | Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues |
-
2006
- 2006-05-29 KR KR1020077027793A patent/KR20080011677A/ko not_active Withdrawn
- 2006-05-29 WO PCT/SE2006/000621 patent/WO2006130075A1/en not_active Ceased
- 2006-05-29 JP JP2008514586A patent/JP2008542365A/ja active Pending
- 2006-05-29 MX MX2007014464A patent/MX2007014464A/es not_active Application Discontinuation
- 2006-05-29 CA CA002610671A patent/CA2610671A1/en not_active Abandoned
- 2006-05-29 BR BRPI0610907-1A patent/BRPI0610907A2/pt not_active IP Right Cessation
- 2006-05-29 AU AU2006253049A patent/AU2006253049B2/en not_active Ceased
- 2006-05-29 US US11/914,400 patent/US20080269275A1/en not_active Abandoned
- 2006-05-29 CN CNA2006800191464A patent/CN101184753A/zh active Pending
- 2006-05-29 EP EP06747815A patent/EP1891065A4/en not_active Withdrawn
-
2007
- 2007-11-08 IL IL187248A patent/IL187248A0/en unknown
- 2007-11-16 ZA ZA200709922A patent/ZA200709922B/xx unknown
- 2007-12-28 NO NO20076695A patent/NO20076695L/no not_active Application Discontinuation
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