EA201000701A1 - 4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465 - Google Patents

4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465

Info

Publication number
EA201000701A1
EA201000701A1 EA201000701A EA201000701A EA201000701A1 EA 201000701 A1 EA201000701 A1 EA 201000701A1 EA 201000701 A EA201000701 A EA 201000701A EA 201000701 A EA201000701 A EA 201000701A EA 201000701 A1 EA201000701 A1 EA 201000701A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzoic acid
adamanthylkarbamoil
tret
pyrazole
butyl
Prior art date
Application number
EA201000701A
Other languages
English (en)
Inventor
Мартин Пакер
Джеймс Стюарт Скотт
Эндрю Стокер
Пол Роберт Оуэн Уиттамор
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2008/000454 external-priority patent/WO2008099145A1/en
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201000701A1 publication Critical patent/EA201000701A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описаны 4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота и ее фармацевтически приемлемые соли и конкретная кристаллическая форма агента (форма 1); их применение в ингибировании 11βHSD1 (11-β-гидроксистероиддегидрогеназа 1-го типа), способы их получения и содержащие их фармацевтические композиции.
EA201000701A 2007-11-06 2008-11-05 4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465 EA201000701A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98573507P 2007-11-06 2007-11-06
PK10808 2008-02-04
PCT/GB2008/000454 WO2008099145A1 (en) 2007-02-12 2008-02-11 Pyrazole derivatives as 11-beta-hsd1 inhibitors
US8230408P 2008-07-21 2008-07-21
PCT/GB2008/051029 WO2009060232A1 (en) 2007-11-06 2008-11-05 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid - 465

Publications (1)

Publication Number Publication Date
EA201000701A1 true EA201000701A1 (ru) 2010-12-30

Family

ID=42759138

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000701A EA201000701A1 (ru) 2007-11-06 2008-11-05 4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465

Country Status (17)

Country Link
US (1) US20110060022A1 (ru)
EP (1) EP2217232A1 (ru)
JP (1) JP2011502978A (ru)
KR (1) KR20100095439A (ru)
CN (1) CN101909621A (ru)
AU (1) AU2008326226B2 (ru)
BR (1) BRPI0819177A2 (ru)
CA (1) CA2703781A1 (ru)
CO (1) CO6270318A2 (ru)
CR (1) CR11415A (ru)
DO (1) DOP2010000135A (ru)
EA (1) EA201000701A1 (ru)
EC (1) ECSP10010159A (ru)
IL (1) IL205455A0 (ru)
MX (1) MX2010005048A (ru)
WO (1) WO2009060232A1 (ru)
ZA (1) ZA201003031B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006316087B2 (en) 2005-11-21 2011-03-10 Shionogi & Co., Ltd. Heterocyclic compound having inhibitory activity on 11-beta-hydroxysteroid dehydrogenase type I
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200836719A (en) * 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
BRPI0811191A2 (pt) 2007-05-18 2014-10-29 Shionogi & Co Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1
KR20100126306A (ko) * 2008-02-04 2010-12-01 아스트라제네카 아베 4-[4-(2-(아다만틸카르바모일)-5-ｔｅｒｔ-부틸-피라졸-1-일]벤조산의 신규한 결정형
CA2719936A1 (en) * 2008-04-22 2009-10-29 Astrazeneca Ab Substituted pyrimidin-5-carboxamides 281

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005528395A (ja) 2002-04-05 2005-09-22 ザ ユニバーシティ オブ エディンバラ 組成物
EP1615698B1 (en) * 2003-04-11 2010-09-29 High Point Pharmaceuticals, LLC New amide derivatives and pharmaceutical use thereof
WO2006132436A1 (ja) * 2005-06-08 2006-12-14 Japan Tobacco Inc. 複素環化合物

Also Published As

Publication number Publication date
ECSP10010159A (es) 2010-06-29
JP2011502978A (ja) 2011-01-27
CO6270318A2 (es) 2011-04-20
MX2010005048A (es) 2010-07-28
KR20100095439A (ko) 2010-08-30
CR11415A (es) 2010-08-27
DOP2010000135A (es) 2010-06-30
CA2703781A1 (en) 2009-05-14
WO2009060232A1 (en) 2009-05-14
CN101909621A (zh) 2010-12-08
BRPI0819177A2 (pt) 2015-05-05
EP2217232A1 (en) 2010-08-18
ZA201003031B (en) 2011-10-26
AU2008326226B2 (en) 2011-10-20
IL205455A0 (en) 2010-12-30
AU2008326226A1 (en) 2009-05-14
US20110060022A1 (en) 2011-03-10

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