JP2006522325A - コンパートメント化スクリーニングによる選択 - Google Patents

コンパートメント化スクリーニングによる選択 Download PDF

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JP2006522325A
JP2006522325A JP2006506048A JP2006506048A JP2006522325A JP 2006522325 A JP2006522325 A JP 2006522325A JP 2006506048 A JP2006506048 A JP 2006506048A JP 2006506048 A JP2006506048 A JP 2006506048A JP 2006522325 A JP2006522325 A JP 2006522325A
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compound
microcapsule
microcapsules
microbead
target
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JP2006522325A5 (https=
Inventor
グリフィズ，アンドルー・デイヴィッド
アベル，クリス
ホルフェルダー，フロリアン
マストロバティスタ，エンリコ
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Medical Research Council
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Medical Research Council
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2006506048A 2003-03-31 2004-03-31 コンパートメント化スクリーニングによる選択 Withdrawn JP2006522325A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0307403.6A GB0307403D0 (en) 2003-03-31 2003-03-31 Selection by compartmentalised screening
PCT/GB2004/001362 WO2004088314A1 (en) 2003-03-31 2004-03-31 Selection by compartmentalised screening

Related Child Applications (1)

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JP2011114932A Division JP2011221028A (ja) 2003-03-31 2011-05-23 コンパートメント化スクリーニングによる選択

Publications (2)

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JP2006522325A true JP2006522325A (ja) 2006-09-28
JP2006522325A5 JP2006522325A5 (https=) 2007-05-24

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JP2006506048A Withdrawn JP2006522325A (ja) 2003-03-31 2004-03-31 コンパートメント化スクリーニングによる選択
JP2011114932A Withdrawn JP2011221028A (ja) 2003-03-31 2011-05-23 コンパートメント化スクリーニングによる選択
JP2014246570A Withdrawn JP2015092164A (ja) 2003-03-31 2014-12-05 コンパートメント化スクリーニングによる選択
JP2018105794A Pending JP2018194552A (ja) 2003-03-31 2018-06-01 コンパートメント化スクリーニングによる選択

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JP2011114932A Withdrawn JP2011221028A (ja) 2003-03-31 2011-05-23 コンパートメント化スクリーニングによる選択
JP2014246570A Withdrawn JP2015092164A (ja) 2003-03-31 2014-12-05 コンパートメント化スクリーニングによる選択
JP2018105794A Pending JP2018194552A (ja) 2003-03-31 2018-06-01 コンパートメント化スクリーニングによる選択

Country Status (7)

Country Link
US (5) US9448172B2 (https=)
EP (4) EP1608976B1 (https=)
JP (4) JP2006522325A (https=)
AU (2) AU2004225691B2 (https=)
CA (1) CA2520548C (https=)
GB (1) GB0307403D0 (https=)
WO (1) WO2004088314A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP4829240B2 (ja) * 2004-10-12 2011-12-07 メディカル リサーチ カウンシル マイクロ流体制御による区画化されたスクリーニング
JP2018524568A (ja) * 2015-06-03 2018-08-30 スフィア フルイディクス リミテッドＳｐｈｅｒｅ Ｆｌｕｉｄｉｃｓ Ｌｉｍｉｔｅｄ システムおよび方法
JP2022505803A (ja) * 2018-10-24 2022-01-14 ナンナ セラピューティクス リミテッド タグなしコード化化学ライブラリスクリーニング用のマイクロビーズ

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