ATE239801T1 - Mikropartikel mit multiplen fluoreszenz-signalen - Google Patents

Mikropartikel mit multiplen fluoreszenz-signalen

Info

Publication number
ATE239801T1
ATE239801T1 AT99904191T AT99904191T ATE239801T1 AT E239801 T1 ATE239801 T1 AT E239801T1 AT 99904191 T AT99904191 T AT 99904191T AT 99904191 T AT99904191 T AT 99904191T AT E239801 T1 ATE239801 T1 AT E239801T1
Authority
AT
Austria
Prior art keywords
fluorescent
microparticles
methods
nanoparticles
particles
Prior art date
Application number
AT99904191T
Other languages
English (en)
Inventor
Mark B Chandler
Don Chandler
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corp filed Critical Luminex Corp
Application granted granted Critical
Publication of ATE239801T1 publication Critical patent/ATE239801T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82BNANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1012Calibrating particle analysers; References therefor
    • G01N2015/1014Constitution of reference particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99904191T 1998-01-22 1999-01-22 Mikropartikel mit multiplen fluoreszenz-signalen ATE239801T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7216098P 1998-01-22 1998-01-22
PCT/US1999/001315 WO1999037814A1 (en) 1998-01-22 1999-01-22 Microparticles with multiple fluorescent signals

Publications (1)

Publication Number Publication Date
ATE239801T1 true ATE239801T1 (de) 2003-05-15

Family

ID=22105965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904191T ATE239801T1 (de) 1998-01-22 1999-01-22 Mikropartikel mit multiplen fluoreszenz-signalen

Country Status (9)

Country Link
US (1) US6268222B1 (de)
EP (1) EP1049807B1 (de)
JP (1) JP3468750B2 (de)
KR (1) KR100593712B1 (de)
AT (1) ATE239801T1 (de)
AU (1) AU2464299A (de)
CA (1) CA2318779C (de)
DE (1) DE69907630T2 (de)
WO (1) WO1999037814A1 (de)

Families Citing this family (370)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951716B2 (en) * 1995-03-13 2005-10-04 Mark Hechinger Anti-platelet immunoglobulin bead positive control
US6933106B2 (en) * 1995-03-13 2005-08-23 Mark Hechinger Platelet immunoglobulin bead suspension and flow cytometry
KR19990008052A (ko) * 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6933331B2 (en) 1998-05-22 2005-08-23 Nanoproducts Corporation Nanotechnology for drug delivery, contrast agents and biomedical implants
US6632526B1 (en) * 1997-10-14 2003-10-14 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
AU3555599A (en) * 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6423410B1 (en) * 1998-09-04 2002-07-23 Mds Proteomics, Inc. Ultrasonically generated paramagnetic polymer particles
US7116407B2 (en) * 1998-12-15 2006-10-03 Union Biometrica, Inc. System for axial pattern analysis of multicellular organisms
JP3978961B2 (ja) * 1998-12-25 2007-09-19 特種製紙株式会社 偽造防止用紙に使用する蛍光発色粒子、その製造方法、及び蛍光発色粒子を使用した偽造防止用紙
US6696304B1 (en) 1999-02-24 2004-02-24 Luminex Corporation Particulate solid phase immobilized protein quantitation
US6261782B1 (en) 1999-04-06 2001-07-17 Yale University Fixed address analysis of sequence tags
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
WO2000063695A1 (en) 1999-04-16 2000-10-26 Tibotec N.V. Encoding of microcarriers
US6423818B1 (en) * 1999-07-30 2002-07-23 Takehisa Matsuda Coumarin endcapped absorbable polymers
CA2383264A1 (en) 1999-08-13 2001-02-22 Yale University Binary encoded sequence tags
ATE324588T1 (de) 1999-08-17 2006-05-15 Luminex Corp Verkapselung von fluoreszierenden partikeln
US6649414B1 (en) * 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
US7316899B2 (en) * 2000-01-31 2008-01-08 The Board Of Regents Of The University Of Texas System Portable sensor array system
CA2309575A1 (en) * 2000-05-26 2001-11-26 James E. Guillet Internally cross-linked macromolecules
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001272993B2 (en) 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US20020019004A1 (en) * 2000-08-03 2002-02-14 Albert Orfao Method for isolating molecules, cells and other particles which are specifically bound to a large particle
WO2002016506A2 (en) * 2000-08-24 2002-02-28 Sendx Medical, Inc. The use of a multiple dye system to enhance the spectral properties of dyed microparticles in an immunoassay
WO2002020695A1 (de) 2000-09-08 2002-03-14 Nanosolutions Gmbh Dotierte nanopartikel
US7241399B2 (en) 2000-09-08 2007-07-10 Centrum Fuer Angewandte Nanotechnologie (Can) Gmbh Synthesis of nanoparticles
US7465540B2 (en) 2000-09-21 2008-12-16 Luminex Corporation Multiple reporter read-out for bioassays
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
CA2425775C (en) 2000-10-19 2012-02-28 Tibotec Bvba Method and device for the manipulation of microcarriers for an identification purpose
WO2002039083A2 (en) * 2000-11-08 2002-05-16 Science & Technology Corporation @ Unm Fluorescence and fret based assays for biomolecules on beads
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
CA2431201A1 (en) * 2000-12-13 2002-08-01 Bio-Rad Laboratories, Inc. Standard diluent for multiplex assays
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2002251739A1 (en) * 2001-01-05 2002-07-30 The General Hospital Corporation Activatable imaging probes
US20030165865A1 (en) * 2001-01-29 2003-09-04 Hinkel Christopher A. Methods of analysis of nucleic acids
US20020127586A1 (en) * 2001-01-31 2002-09-12 Novozymes A/S Method of analyzing granular composition by fluorescene analysis
US20020115116A1 (en) * 2001-02-22 2002-08-22 Yong Song Multiplex protein interaction determinations using glutathione-GST binding
US7122383B2 (en) 2001-03-16 2006-10-17 Qtl Biosystems, Llc Fluorescent polymer superquenching-based bioassays
US7189767B2 (en) * 2001-03-30 2007-03-13 Rohm And Haas Company Colorants, dispersants, dispersions, and inks
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20030082584A1 (en) * 2001-06-29 2003-05-01 Liang Shi Enzymatic ligation-based identification of transcript expression
US20030170695A1 (en) * 2001-06-29 2003-09-11 Liang Shi Enzymatic ligation-based identification of nucleotide sequences
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US6855426B2 (en) * 2001-08-08 2005-02-15 Nanoproducts Corporation Methods for producing composite nanoparticles
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
CN100436574C (zh) * 2001-09-06 2008-11-26 基因描绘系统有限公司 复制细胞的快速检测
US7064309B2 (en) 2001-09-17 2006-06-20 The Boeing Company Method for detecting foreign object debris
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
WO2003084982A2 (en) * 2001-11-14 2003-10-16 Luminex Corporation Functionalized compositions for improved immobilization
FR2832507B1 (fr) * 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
AU2002364701B8 (en) * 2001-11-20 2006-06-22 Alkermes, Inc. Compositions for sustained action product delivery
EP1448800A4 (de) * 2001-11-21 2007-05-16 Applera Corp Digitaler assay
US20030109067A1 (en) * 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US7241629B2 (en) * 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
WO2003056301A2 (en) * 2001-12-21 2003-07-10 Centocor, Inc. A novel screening method for molecular antagonist using flow-cytometry
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US6792019B2 (en) * 2002-02-28 2004-09-14 Texas Instruments Incorporated Driver with tail currents in discrete subranges
WO2003075016A1 (en) * 2002-03-07 2003-09-12 Cambridge University Technical Services Limited (Cuts) Scd fingerprints
AU2002330390A1 (en) * 2002-03-20 2003-09-29 Hosokawa Micron Corporation Method of manufacturing chemical-containing composite particles
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20030215791A1 (en) * 2002-05-20 2003-11-20 Applied Spectral Imaging Ltd. Method of and system for multiplexed analysis by spectral imaging
WO2003102216A2 (en) 2002-05-31 2003-12-11 Diversa Corporation Multiplexed systems for nucleic acid sequencing
US7244784B2 (en) * 2002-06-14 2007-07-17 Rohm And Haas Company Aqueous nanoparticle dispersions
AU2003204606A1 (en) * 2002-06-14 2004-01-15 Rohm And Haas Company Water-based adhesives
EP1371688B1 (de) 2002-06-14 2008-10-22 Rohm And Haas Company Farbmittel, Dispergiermittel und Dispersionen enthaltend polymere Nanopartikel
US7091275B1 (en) 2002-06-14 2006-08-15 Rohm And Haas Company Aqueous polymeric composition containing polymeric nanoparticles and treatments prepared therefrom
EP1371679B1 (de) * 2002-06-14 2008-04-09 Rohm And Haas Company Wässrige Zusammensetzung enthaltend Polymernanopartikel
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
AU2003256742A1 (en) * 2002-07-24 2004-02-09 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
JP4087200B2 (ja) * 2002-09-17 2008-05-21 ユニバーサル・バイオ・リサーチ株式会社 粒子複合体及び該粒子複合体の作製方法
US8394944B2 (en) * 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
CN1497015A (zh) * 2002-09-30 2004-05-19 ��������ķ������ 改进的塑料组合物
CN1283739C (zh) * 2002-09-30 2006-11-08 罗姆和哈斯公司 喷墨油墨用聚合物粘合剂
CN1225515C (zh) * 2002-09-30 2005-11-02 罗姆和哈斯公司 含有交联的纳米颗粒的耐破损涂层、薄膜和制品
CN1325580C (zh) * 2002-09-30 2007-07-11 罗姆和哈斯公司 聚合纳米颗粒配方及其在改进涂层的抗积尘性方面的应用
US20040086867A1 (en) * 2002-10-30 2004-05-06 Jian Han Method for detecting nucleic acid
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
TW200418992A (en) * 2002-11-12 2004-10-01 Becton Dickinson Co Diagnosis of sepsis or sirs using biomarker profiles
MXPA05005031A (es) * 2002-11-12 2005-11-17 Becton Dickinson Co Diagnostico de la sepsis o sirs usando perfiles de biomarcadores.
CA2505843A1 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7708974B2 (en) 2002-12-10 2010-05-04 Ppg Industries Ohio, Inc. Tungsten comprising nanomaterials and related nanotechnology
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
WO2004064751A2 (en) * 2003-01-16 2004-08-05 St. Johns University New York Nanoparticle based stabilization of ir fluorescent dyes
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
CN1771335A (zh) * 2003-02-13 2006-05-10 加州大学评议会 使用集光多生色团检测和分析多核苷酸-结合蛋白相互作用的方法和组合物
WO2004074452A2 (en) * 2003-02-19 2004-09-02 The Regents Of The University Of California Multiplex mapping of protein interactions
ITMI20030339A1 (it) * 2003-02-26 2004-08-27 Pranha 50 Ltda Metodo, apparato e dispositivi per il risanamento di condotte mediante introduzione di tubi in materiale plastico.
WO2004081571A1 (fr) * 2003-03-13 2004-09-23 Chengdu Kuachang Medical Industrial Limited Procede et dispositif de detection de polypeptides, et compose ligand comprenant des nanoparticules
WO2004090548A1 (en) * 2003-03-13 2004-10-21 Chengdu Kuachang Medical Industrial Limited Device for analysis or separation containing an active nanostructured carrier, its preparation method and applications
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
EP1624306A4 (de) * 2003-04-30 2008-12-24 Chengdu Kuachang Medical Ind L Zur trennung oder analyse verwendete nanostrukturen enthaltende vorrichtung sowie herstellung und anwendung davon
EP1627025B1 (de) * 2003-05-09 2016-10-12 Applied Biosystems, LLC Fluoreszierende kunststoffe mit gehalt an lipidlöslichen rhodaminfarbstoffen
WO2004101709A1 (en) 2003-05-09 2004-11-25 Applera Corporation Phenyl xanthene dyes
US8012768B2 (en) * 2003-07-18 2011-09-06 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
US7260485B2 (en) * 2003-07-18 2007-08-21 Luminex Corporation Method and systems for distinguishing between materials having similar spectra
CA2532790C (en) 2003-07-18 2017-01-17 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
WO2005012548A2 (en) * 2003-08-01 2005-02-10 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
US7692773B2 (en) * 2003-08-05 2010-04-06 Luminex Corporation Light emitting diode based measurement systems
US7069191B1 (en) 2003-08-06 2006-06-27 Luminex Corporation Methods for reducing the susceptibility of a peak search to signal noise
KR101135138B1 (ko) 2003-08-13 2012-04-16 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의제어 방법
US7550557B2 (en) * 2003-08-29 2009-06-23 Louisiana Tech University Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7544770B2 (en) * 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7348399B2 (en) * 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules
WO2005020933A2 (en) * 2003-09-02 2005-03-10 University Of South Florida Nanoparticles for drug-delivery
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US20050084513A1 (en) * 2003-10-21 2005-04-21 Board Of Regents Nanocoating for improving biocompatibility of medical implants
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
AU2004286253A1 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
NZ547495A (en) 2003-10-29 2008-05-30 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
EP1695082A2 (de) * 2003-12-11 2006-08-30 Board of Regents, The University of Texas System Verfahren und vorrichtung für die analyse von speichel unter verwendung eines sensorarrays
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
CA2550902C (en) * 2003-12-22 2013-06-25 Versamatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US7390628B2 (en) * 2003-12-23 2008-06-24 University Of Florida Research Foundation, Inc. Microparticle-based diagnostic methods
US7323696B2 (en) 2004-01-09 2008-01-29 Applera Corporation Phosphor particle coded beads
US7551763B2 (en) * 2004-01-14 2009-06-23 Luminex Corporation Methods for altering one or more parameters of a measurement system
US7362432B2 (en) * 2004-01-14 2008-04-22 Luminex Corp. Method and systems for dynamic range expansion
US20050277205A1 (en) * 2004-02-20 2005-12-15 Ki-Bum Lee Multicomponent magnetic nanorods for biomolecular separations
US7422696B2 (en) * 2004-02-20 2008-09-09 Northwestern University Multicomponent nanorods
US7229778B2 (en) * 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
JP2005265654A (ja) 2004-03-19 2005-09-29 Hitachi Maxell Ltd 複合化粒子
EP1580559B1 (de) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methoden zur Verringerung der Varianz der Analytkonzentrationen von komplexen Probenmischungen
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2005094381A2 (en) * 2004-04-01 2005-10-13 Rules-Based Medicine, Inc. Universal shotgun assay
WO2005106462A2 (en) * 2004-04-26 2005-11-10 Drexel University Methods for use of fluorescent nanoparticles to determine free volume and to detect and deliver materials to repair cracks in polymers and polymer composites
US7465543B1 (en) 2004-05-21 2008-12-16 The United States Of America, As Represented By The Secretary Of Agriculture Multiplex DNA identification of clinical yeasts using flow cytometry
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
ATE406462T1 (de) * 2004-08-18 2008-09-15 Hoffmann La Roche Verfahren zur messung einer nukleinsäureamplifikation in real time beinhaltend die positionierung eines reaktionsgefässes relativ zu einer detektionseinheit
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
CN103951595B (zh) 2004-10-12 2015-10-14 卢米尼克斯股份有限公司 形成染色的微球体和染色的微球体群的方法
EP1802973B1 (de) * 2004-10-12 2010-05-05 Luminex Corporation Verfahren zur veränderung der oberflächeneigenschaften von mikrokügelchen
US20060084184A1 (en) * 2004-10-19 2006-04-20 Renovar Incorporated Reagents for urine-based immunological assays
GB2420850A (en) 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
WO2006066169A1 (en) * 2004-12-17 2006-06-22 Luminex Corporation Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore
WO2006074471A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006074482A2 (en) * 2005-01-10 2006-07-13 The Regents Of The University Of California Methods and kits for strand-specific polynucleotide detection with cationic multichromophores
JP4452188B2 (ja) * 2005-01-17 2010-04-21 凸版印刷株式会社 カラービーズ製造装置、カラービーズ製造方法及びバイオ分析装置
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
EP1842211B1 (de) 2005-01-20 2010-08-04 Luminex Corporation Mikrokugeln mit fluoreszente und magnetische eigenschaften
CA2495138C (en) * 2005-01-20 2012-10-23 Alison Jane Basile Multiplexed analysis for determining a serodiagnosis of viral infection
WO2006083932A2 (en) 2005-01-31 2006-08-10 The Regents Of The University Methods and compositions for aggregant detection
DE102005007374A1 (de) * 2005-02-17 2006-08-24 Universität Ulm Nanopartikel und deren Verwendung
US20070053950A1 (en) * 2005-02-28 2007-03-08 Gajanan Shukla P Composition of polymer microcapsules of biocide for coating material
EP1869463A4 (de) 2005-04-15 2010-05-05 Becton Dickinson Co Sepsisdiagnose
WO2006112771A1 (en) * 2005-04-18 2006-10-26 Ge Healthcare Bio-Sciences Ab Magnetic beads
US7507588B2 (en) * 2005-04-20 2009-03-24 Becton, Dickinson And Company Multiplex microparticle system
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2006129796A1 (ja) * 2005-06-03 2006-12-07 Tokyo University Of Agriculture And Technology 磁性粒子保持担体、およびその調製方法
JP4652902B2 (ja) * 2005-06-23 2011-03-16 株式会社日立ソリューションズ 安定保存された担体微小粒子
EP1904846A4 (de) * 2005-06-29 2009-03-18 Rules Based Medicine Inc Verfahren und kits zur diagnose von akutem koronarsyndrom
NO20053373D0 (no) 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
EP2261635B1 (de) 2005-09-21 2017-05-03 Luminex Corporation Verfahren und systeme für die bilddatenverarbeitung
CN101528912B (zh) * 2005-09-26 2014-08-27 快速微型生物系统公司 包含生长培养基的盒
WO2007037282A1 (ja) 2005-09-27 2007-04-05 Eisai R & D Management Co., Ltd. 微小粒子に自己集合体を形成させる方法及び標的分析物の検出方法
US20070072309A1 (en) * 2005-09-29 2007-03-29 General Electric Company Analytical compositions including nanometer-sized transducers, methods to make thereof, and devices therefrom
DE102005047609A1 (de) * 2005-10-05 2007-04-12 Giesecke & Devrient Gmbh Echtheitssicherung von Wertdokumenten mittels Merkmalsstoffen
KR100795100B1 (ko) 2005-10-31 2008-01-17 한국과학기술연구원 단백질 키나아제에 의한 단백질 인산화의 영상화를 위한고분자 나노 입자 및 그의 용도
US7572643B2 (en) * 2005-11-21 2009-08-11 E. I. Du Pont De Nemours And Company Nanoparticle composite-coated glass microspheres for use in bioassays
US20070119950A1 (en) * 2005-11-30 2007-05-31 Auslander Judith D Document edge encoding using multi-spectral encoding tags
US7926730B2 (en) * 2005-11-30 2011-04-19 Pitney Bowes Inc. Combined multi-spectral document markings
JP4902183B2 (ja) * 2005-12-06 2012-03-21 日立マクセル株式会社 機能性赤外蛍光粒子
JP5537034B2 (ja) 2005-12-23 2014-07-02 ナノストリング テクノロジーズ,インコーポレーテッド ナノレポーターならびにその作製方法および使用方法
US20070239483A1 (en) * 2006-01-09 2007-10-11 Biophysical Corporation Methods for individualized health assessment service
EP1984738A2 (de) * 2006-01-11 2008-10-29 Raindance Technologies, Inc. Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und kontrolle von nanoreaktoren
US8309025B1 (en) 2006-01-26 2012-11-13 Luminex Corporation Methods and systems for determining composition and completion of an experiment
AU2007211085A1 (en) 2006-01-27 2007-08-09 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US20070190536A1 (en) * 2006-02-16 2007-08-16 Academia Sinica Method for using biomaterials as reagent for nano-patterning
JP4748542B2 (ja) * 2006-02-24 2011-08-17 古河電気工業株式会社 フローサイトメトリーによる生体分子の定量システム、及び定量方法
US20070207513A1 (en) * 2006-03-03 2007-09-06 Luminex Corporation Methods, Products, and Kits for Identifying an Analyte in a Sample
CA2643169A1 (en) * 2006-03-17 2007-09-27 Vivacta Ltd A chemical sensing device
US9182398B2 (en) 2006-04-01 2015-11-10 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
US8124943B1 (en) 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
WO2007120762A2 (en) * 2006-04-14 2007-10-25 Cambrios Technologies Corporation Fluorescent particles bound to multifunctional scaffolds and their uses
US7795040B2 (en) * 2006-04-17 2010-09-14 Luminex Corporation Methods, particles, and kits for determining activity of a kinase
WO2007131171A1 (en) * 2006-05-05 2007-11-15 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of hypothyroidism
EP4190448A3 (de) 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
CA2657970A1 (en) * 2006-05-17 2007-11-29 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US20080277626A1 (en) * 2006-05-23 2008-11-13 Evident Technologies, Inc. Quantum dot fluorescent inks
US8296088B2 (en) * 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
WO2007143615A2 (en) * 2006-06-02 2007-12-13 Luminex Corporation Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
WO2008021540A2 (en) * 2006-08-17 2008-02-21 The Regents Of The University Of California Customized lithographic particles
US7501290B2 (en) * 2006-09-13 2009-03-10 Hanley Brian P Intraplexing method for improving precision of suspended microarray assays
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US8062609B2 (en) 2006-11-10 2011-11-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
WO2008064336A2 (en) 2006-11-22 2008-05-29 Inivitrogen Corporation Autoimmune disease biomarkers
US9456983B1 (en) * 2006-12-08 2016-10-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition with enhanced vessel targeting
KR101433208B1 (ko) 2006-12-13 2014-08-22 루미넥스 코포레이션 실시간으로 pcr의 다중 분석을 위한 시스템과 방법
WO2008089059A1 (en) * 2007-01-12 2008-07-24 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of galactosemia
WO2008094709A2 (en) * 2007-02-01 2008-08-07 Trustees Of Columbia University In The City Of New York Methods and compositions for treating t-cell leukemia
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008100791A1 (en) * 2007-02-16 2008-08-21 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
EP1961825A1 (de) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Verfahren zur Vorhersage des Auftretens von Metastasen bei Brustkrebspatienten
AU2008239495A1 (en) * 2007-02-27 2008-10-23 Northwestern University Molecule attachment to nanoparticles
DE102007010860B4 (de) * 2007-03-01 2014-05-15 PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Verfahren zur Identifikation eines Partikels mit zwei oder mehr monodispers eingebetteten Fluorophoren
WO2008109797A1 (en) * 2007-03-08 2008-09-12 Rules-Based Medicine, Inc. Methods for rapid disease screening
US20080260725A1 (en) * 2007-03-29 2008-10-23 Ulhas Naik Tag and target delivery system
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
DE102007031137A1 (de) 2007-06-13 2008-12-18 Attomol Gmbh Molekulare Diagnostika Verfahren und Sonden/Primärsystem zum "real time" Nachweis eines Nukleinsäuretargets
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
EP2173820A2 (de) * 2007-07-24 2010-04-14 Northwestern University Beschichtete kolloidale materialien
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
CN101965508B (zh) * 2007-09-17 2013-11-27 卢米尼克斯股份有限公司 识别流中的微粒的系统和方法
US8871687B2 (en) * 2007-09-28 2014-10-28 Quest Diagnostics Investments Incorporated Nucleic acid sequencing by single-base primer extension
WO2009064489A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Process for directing assemblies of particulate dispersions using surface roughness
US20090170214A1 (en) * 2007-12-27 2009-07-02 Luminex Corporation Luminescent Reporter Modality for Analyzing an Assay
CN101939648B (zh) * 2008-01-07 2013-09-04 卢米耐克斯公司 生物靶标的免疫磁性捕获和成像
CA2711373C (en) * 2008-01-07 2014-10-28 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
ES2658852T3 (es) 2008-01-18 2018-03-12 Visen Medical, Inc. Agentes de imaginología fluorescentes
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
JP4582224B2 (ja) 2008-05-02 2010-11-17 ソニー株式会社 マイクロビーズ作製方法及びマイクロビーズ
JP4561869B2 (ja) 2008-05-08 2010-10-13 ソニー株式会社 マイクロビーズ自動識別方法及びマイクロビーズ
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US20100075322A1 (en) * 2008-08-22 2010-03-25 Hooper Dennis G Methods and Compositions for Identifying Mycotoxins and Fungal Species
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
US20100068729A1 (en) * 2008-09-12 2010-03-18 Rules-Based Medicine, Inc. Method and kits for the diagnosis of diabetes
EP2340300B1 (de) 2008-09-24 2013-12-18 Straus Holdings Inc. Verfahren zur erkennung von analyten
JP5375005B2 (ja) 2008-09-30 2013-12-25 ソニー株式会社 マイクロビーズ作製方法
US8541154B2 (en) 2008-10-06 2013-09-24 Xerox Corporation Toner containing fluorescent nanoparticles
US8222313B2 (en) * 2008-10-06 2012-07-17 Xerox Corporation Radiation curable ink containing fluorescent nanoparticles
US8586141B2 (en) * 2008-10-06 2013-11-19 Xerox Corporation Fluorescent solid ink made with fluorescent nanoparticles
US8147714B2 (en) * 2008-10-06 2012-04-03 Xerox Corporation Fluorescent organic nanoparticles and a process for producing fluorescent organic nanoparticles
US8236198B2 (en) * 2008-10-06 2012-08-07 Xerox Corporation Fluorescent nanoscale particles
WO2010048572A1 (en) 2008-10-23 2010-04-29 Cornell University A novel anti-viral method
EP2350651B1 (de) * 2008-11-10 2015-01-14 Luminex Corporation Verfahren zur herstellung makroporöser kügelchen
JP5529505B2 (ja) * 2008-11-13 2014-06-25 ベクトン・ディキンソン・アンド・カンパニー 蛍光分析装置のための機器セットアップシステム
US8415161B2 (en) 2008-11-13 2013-04-09 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US8343775B2 (en) * 2009-05-06 2013-01-01 Hanley Brian P Method and device for affinity differential intraplexing
EP2258865A1 (de) * 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Lysinspezifische Demethylase 1 (LSD1) ist ein Biomarker für Brustkrebs
EP2449379B1 (de) 2009-07-02 2017-05-17 Sloan-Kettering Institute for Cancer Research Fluoreszente nanopartikel auf silicabasis
US12161734B2 (en) 2009-07-02 2024-12-10 Sloan-Kettering Institute For Cancer Research Multimodal silica-based nanoparticles
JP5589616B2 (ja) 2009-09-15 2014-09-17 ソニー株式会社 マイクロビーズ解析方法及びマイクロビーズ解析装置
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
EP2486409A1 (de) 2009-10-09 2012-08-15 Universite De Strasbourg Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung
JP2011085587A (ja) * 2009-10-15 2011-04-28 Becton Dickinson & Co 蛍光分析装置のための機器セットアップシステム
WO2011079064A1 (en) * 2009-12-23 2011-06-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods and kits for identyfing human adenovirus serotypes
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US8927271B1 (en) 2010-01-21 2015-01-06 Jack T. Johansen Compositions and methods for detecting target analytes
EP4435111A1 (de) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digitale analytanalyse
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US8747677B2 (en) 2010-04-09 2014-06-10 Luminex Corporation Magnetic separation device
US8274656B2 (en) 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
US8767069B2 (en) 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
KR20130102033A (ko) * 2010-09-03 2013-09-16 가부시키가이샤 아데카 색 변환 필터
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US9525092B2 (en) 2010-11-05 2016-12-20 Pacific Light Technologies Corp. Solar module employing quantum luminescent lateral transfer concentrator
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
JP5900489B2 (ja) * 2011-03-25 2016-04-06 コニカミノルタ株式会社 免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2757378B1 (de) * 2011-09-09 2019-03-27 Konica Minolta, Inc. Verfahren zum Nachweis biologischer Stoffe
CN108192952A (zh) 2011-09-29 2018-06-22 露美内克丝公司 水解探针
WO2013059338A1 (en) 2011-10-18 2013-04-25 Luminex Corporation Methods and systems for image data processing
CA2854000C (en) 2011-11-07 2023-01-24 Rapid Micro Biosystems, Inc. A cell culturing device allowing filtration therein
US9159872B2 (en) 2011-11-09 2015-10-13 Pacific Light Technologies Corp. Semiconductor structure having nanocrystalline core and nanocrystalline shell
US20130112942A1 (en) 2011-11-09 2013-05-09 Juanita Kurtin Composite having semiconductor structures embedded in a matrix
ES2648899T3 (es) 2011-12-09 2018-01-08 Institut Pasteur Inmunoensayo de cribado múltiplex
CA2858119A1 (en) * 2011-12-09 2013-06-13 Sietzema SIETZE Method for detection of bacteria in milk
JP2015511012A (ja) 2012-03-06 2015-04-13 ライフ テクノロジーズ コーポレーション 全身性エリテマトーデスのためのバイオマーカー
EP4060016A1 (de) 2012-04-16 2022-09-21 Rapid Micro Biosystems, Inc. Zellkultivierungsvorrichtung
CN104541152B (zh) 2012-06-15 2017-08-25 卢米尼克斯股份有限公司 使用拟合选择标准的高斯残差的图像归一化装置、系统和方法
WO2014011881A2 (en) 2012-07-11 2014-01-16 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US10519434B2 (en) 2012-07-13 2019-12-31 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US8759075B2 (en) * 2012-07-13 2014-06-24 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US9425365B2 (en) 2012-08-20 2016-08-23 Pacific Light Technologies Corp. Lighting device having highly luminescent quantum dots
AU2014257365B2 (en) 2012-09-04 2019-01-24 Liquet Technologies, Inc. Tissue removal devices, systems and methods
US8889457B2 (en) 2012-12-13 2014-11-18 Pacific Light Technologies Corp. Composition having dispersion of nano-particles therein and methods of fabricating same
US8956821B2 (en) 2013-02-06 2015-02-17 Medical Service Consultation International, Llc Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins
WO2014134280A1 (en) 2013-02-28 2014-09-04 The Terasaki Family Foundation Methods, compositions and kits to recycle internally dyed particles
EP2966445B1 (de) * 2013-03-08 2018-06-20 Konica Minolta, Inc. Färbemittel zum färben von gewebe, herstellungsverfahren für färbemittel für gewebe und kit mit färbemittel zur gewebefärbung
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN105247042B (zh) 2013-03-15 2021-06-11 普林斯顿大学理事会 用于高通量纯化的方法和设备
CN110186835B (zh) 2013-03-15 2022-05-31 Gpb科学有限公司 颗粒的片上微流体处理
WO2014145606A1 (en) 2013-03-15 2014-09-18 Sloan-Kettering Institute For Cancer Research Multimodal silica-based nanoparticles
WO2014205083A1 (en) 2013-06-19 2014-12-24 Luminex Corporation Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
EP4697022A2 (de) 2013-08-09 2026-02-18 Luminex Corporation Sonden zur verbesserten schmelzunterscheidung und multiplexierung in nukleinsäuretests
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10001487B2 (en) 2014-04-08 2018-06-19 Hirosaki University Glucose derivative, and cell imaging method and imaging agent using said derivative
WO2015168374A1 (en) 2014-05-01 2015-11-05 Diomics Corporation Devices and kits for collection, storage and analysis of samples and methods of production and use thereof
RU2016144055A (ru) 2014-05-29 2018-07-02 Мемориал Слоун Кеттеринг Кэнсэ Сентр Конъюгаты лекарственного средства с наночастицами
CN105219373B (zh) * 2014-06-05 2019-06-25 中翰盛泰生物技术股份有限公司 一种载体颗粒及其制备方法
US20160025603A1 (en) 2014-07-22 2016-01-28 Diomics Corporation Airborne agent collectors, methods, systems and devices for monitoring airborne agents
EP3180449B1 (de) 2014-08-11 2019-10-09 Luminex Corporation Sonden zur verbesserten schmelzunterscheidung und multiplexierung in nukleinsäuretests
EP3179912B1 (de) 2014-08-15 2020-10-14 Diomics Corporation Filme zur entnahme und analyse biologischer analyten sowie verfahren zur herstellung
US11867696B2 (en) 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
US11971354B2 (en) 2015-04-08 2024-04-30 Molecular Devices, Llc Methods and systems for fluorescence detection using infrared dyes
US10571396B2 (en) * 2015-04-08 2020-02-25 Molecular Devices, Llc Methods and systems for fluorescence detection
WO2016166295A1 (de) 2015-04-15 2016-10-20 Attomol Gmbh Molekulare Diagnostika Verfahren zum reaktionsraumbegrenzten nachweis von einem oder mehreren analyten in einer probe
CA2985126A1 (en) 2015-05-29 2016-12-08 Cornell University Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis
EP3341893A4 (de) 2015-08-24 2019-03-06 GPB Scientific, LLC Verfahren und vorrichtungen zur mehrstufigen zellreinigung und -konzentration
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10845305B1 (en) * 2015-11-20 2020-11-24 Verily Life Sciences Llc Method for increasing sensor resolution by spectrally stacking responsive dyes
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
DE102015225457B4 (de) * 2015-12-16 2017-07-20 BSH Hausgeräte GmbH Sensorvorrichtung zum Bestimmen zumindest einer Eigenschaft einer Flüssigkeit, wasserführendes Haushaltsgerät mit der Sensorvorrichtung sowie Verfahren zum Bestimmen zumindest einer Eigenschaft einer Flüssigkeit
ES2862533T3 (es) 2016-03-30 2021-10-07 Macroarray Diagnostics Gmbh Matriz de antígenos
JP2020520953A (ja) 2017-05-25 2020-07-16 メモリアル スローン ケタリング キャンサー センター ジルコニウム−89で標識した超小型ナノ粒子およびその方法
JP7393328B2 (ja) 2017-09-01 2023-12-06 ジーピービー・サイエンティフィック・インコーポレイテッド マイクロ流体を使用した治療的に活性な細胞を調製する方法
CN108531550A (zh) * 2018-02-01 2018-09-14 武汉尚码生物科技有限公司 一种微粒载体的标记和鉴别方法及其应用
JP7347849B2 (ja) 2018-04-19 2023-09-20 ファースト ライト ダイアグノスティクス, インコーポレイテッド 標的の検出
EP3803394A4 (de) 2018-05-24 2022-06-08 The University of Melbourne Kreislaufbiomarker für plazentale oder fetale gesundheit
EP3591406A1 (de) * 2018-07-06 2020-01-08 Euroimmun Medizinische Labordiagnostika AG Vorrichtung und verfahren zur antikörperdetektion
US20210349082A1 (en) 2018-10-04 2021-11-11 First Light Diagnostics, Inc. Analysis instrument
KR102205473B1 (ko) * 2018-12-21 2021-01-21 칸트사이언스 주식회사 세포 내 pH 측정방법
US10914731B2 (en) 2019-02-21 2021-02-09 Qinxue DING Method of removing non-specific binding signals using microparticle assay
US12042281B2 (en) 2019-07-17 2024-07-23 Terumo Cardiovascular Systems Corporation Fluorescent nanomaterial sensors and related methods
US20220259332A1 (en) * 2019-07-19 2022-08-18 Washington University Particle-based method for defining a gut microbiota in humans or other animal species
CA3206950A1 (en) * 2021-01-29 2022-08-04 Flowmetric Life Sciences, Inc. Detecting sars-cov-2 and other infective agents
WO2022221693A1 (en) * 2021-04-15 2022-10-20 Cornell University Aluminosilicate nanoparticle sensors and uses thereof
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
WO2024192141A1 (en) 2023-03-13 2024-09-19 Dana-Farber Cancer Institute, Inc. Treatment of cancers having a drug-resistant mesenchymal cell state
CN117607286A (zh) * 2023-11-09 2024-02-27 国家毒品实验室浙江分中心(浙江省毒品技术中心) 一种精神活性物质检测方法、荧光探针及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045431B (en) * 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4717655A (en) * 1982-08-30 1988-01-05 Becton, Dickinson And Company Method and apparatus for distinguishing multiple subpopulations of cells
US5093234A (en) 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US4987539A (en) 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US6632526B1 (en) * 1997-10-14 2003-10-14 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same

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US6268222B1 (en) 2001-07-31
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CA2318779C (en) 2009-08-25
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