AU2001237057A1 - Functionalized encapsulated fluorescent nanocrystals - Google Patents

Functionalized encapsulated fluorescent nanocrystals

Info

Publication number
AU2001237057A1
AU2001237057A1 AU2001237057A AU3705701A AU2001237057A1 AU 2001237057 A1 AU2001237057 A1 AU 2001237057A1 AU 2001237057 A AU2001237057 A AU 2001237057A AU 3705701 A AU3705701 A AU 3705701A AU 2001237057 A1 AU2001237057 A1 AU 2001237057A1
Authority
AU
Australia
Prior art keywords
functionalized
fluorescent nanocrystals
encapsulated fluorescent
encapsulated
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237057A
Inventor
Emilio Barbera-Guillem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocrystal Ltd
Original Assignee
Biocrystal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocrystal Ltd filed Critical Biocrystal Ltd
Publication of AU2001237057A1 publication Critical patent/AU2001237057A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound thereto comprises contacting the functionalized encapsulated fluorescent nanocrystals with a sample so that complexes are formed between the functionalized encapsulated fluorescent nanocrystals and substrate for which the affinity molecule has binding specificity, if the substrate is present; exposing the complexes in the detection system to an excitation light source, and detecting a fluorescence peak emitted from the complexes, if present.
AU2001237057A 2000-02-18 2001-02-16 Functionalized encapsulated fluorescent nanocrystals Abandoned AU2001237057A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18360800P 2000-02-18 2000-02-18
US18360700P 2000-02-18 2000-02-18
US60183608 2000-02-18
US60183607 2000-02-18
US09/783,469 US6761877B2 (en) 2000-02-18 2001-02-14 Functionalized encapsulated fluorescent nanocrystals
US09783469 2001-02-14
PCT/US2001/005108 WO2001061045A1 (en) 2000-02-18 2001-02-16 Functionalized encapsulated fluorescent nanocrystals

Publications (1)

Publication Number Publication Date
AU2001237057A1 true AU2001237057A1 (en) 2001-08-27

Family

ID=27391706

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237057A Abandoned AU2001237057A1 (en) 2000-02-18 2001-02-16 Functionalized encapsulated fluorescent nanocrystals

Country Status (6)

Country Link
US (3) US6761877B2 (en)
EP (1) EP1266032B1 (en)
AT (1) ATE383440T1 (en)
AU (1) AU2001237057A1 (en)
DE (1) DE60132311T2 (en)
WO (1) WO2001061045A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
WO2002029410A2 (en) * 2000-10-06 2002-04-11 Quantum Dot Corporation Cells having a spectral signature, and methods of preparation and use thereof
JP2003028797A (en) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd Fluorescence reader
JP4072994B2 (en) * 2001-10-11 2008-04-09 学校法人日本大学 Magnetic particles
JP3701622B2 (en) 2002-03-27 2005-10-05 日立ソフトウエアエンジニアリング株式会社 Semiconductor nanoparticle fluorescent reagent and fluorescence measuring method
JP3955225B2 (en) * 2002-03-27 2007-08-08 日立ソフトウエアエンジニアリング株式会社 Method for measuring reaction of reaction using semiconductor nanoparticles and method for evaluating quality of semiconductor nanoparticles using the measurement method
JP3847677B2 (en) 2002-07-23 2006-11-22 日立ソフトウエアエンジニアリング株式会社 Semiconductor nanoparticle, method for producing the same, and semiconductor nanoparticle fluorescent reagent
JP2004077389A (en) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd Functional fluorescent reagent containing semiconductor nanoparticle
US20050032246A1 (en) * 2002-11-14 2005-02-10 Mcmaster University Method of immobilizing membrane-associated molecules
US8367324B2 (en) * 2003-11-17 2013-02-05 Canon Kabushiki Kaisha Method for judging change in probe-bearing substrate, probe-bearing substrate and detecting apparatus
JP4528990B2 (en) * 2003-12-09 2010-08-25 学校法人慶應義塾 Lipid bilayer and nano-sized phosphor complex
GB0400235D0 (en) * 2004-01-07 2004-02-11 Univ Sunderland Nanoparticles as agents for imaging finger prints
US20060014175A1 (en) * 2004-05-17 2006-01-19 Imad Naasani Functionalized fluorescent nanocrystal detection system
US7794600B1 (en) * 2004-08-27 2010-09-14 Nanosys, Inc. Purification of nanocrystal solutions by chromatography
US8486371B2 (en) * 2004-09-17 2013-07-16 The Regents Of The University Of Michigan Quantitative two-photon flow cytometry
US20060240227A1 (en) * 2004-09-23 2006-10-26 Zhijun Zhang Nanocrystal coated surfaces
EP1809720B1 (en) * 2004-10-29 2012-05-02 Life Technologies Corporation Functionalized fluorescent nanocrystals, and methods for their preparation and use
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
GB2441666B (en) * 2005-04-25 2010-12-29 Univ Arkansas Doped semiconductor nanocrystals and methods of making same
CA2617513A1 (en) 2005-08-09 2007-02-15 University Of Sunderland Fingerprint analysis using mass spectrometry
US8101430B2 (en) 2005-08-15 2012-01-24 Massachusetts Institute Of Technology Fluorescent sensor based on two fluorescent moieties one of which is a semiconductor nanocrystal and methods of using and making
US8465983B1 (en) * 2005-08-19 2013-06-18 Gabriel P. Lopez Detection and delivery systems utilizing supported lipid bilayers
WO2007030521A1 (en) * 2005-09-06 2007-03-15 Invitrogen Corporation Control of chemical modification
JP4415972B2 (en) * 2005-09-22 2010-02-17 ソニー株式会社 Method for producing metal oxide nanoparticles
US8337721B2 (en) 2005-12-02 2012-12-25 Vanderbilt University Broad-emission nanocrystals and methods of making and using same
PT1962805T (en) 2005-12-08 2016-10-05 Insmed Inc Lipid-based compositions of antiinfectives for treating pulmonary infections
WO2008039912A2 (en) * 2006-09-27 2008-04-03 Evident Technologies Retro-emission systems comprising microlens arrays and luminescent emitters
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
FR2918755B1 (en) * 2007-07-09 2009-10-30 Commissariat Energie Atomique METHOD FOR DETECTING AND QUANTIFYING SOLID - SUPPORTED ANALYTES WITH FLUORESCENT MOLECULES ENCAPSULATED IN IMMUNOLIPOSOMES.
US20090171330A1 (en) * 2007-12-28 2009-07-02 Spectranetics Tunable nanoparticle tags to enhance tissue recognition
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
WO2009152265A1 (en) * 2008-06-10 2009-12-17 The Board Of Trustees Of The University Of Arkansas Indium arsenide nanocrystals and methods of making the same
US20120034156A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
US8895158B2 (en) 2011-08-10 2014-11-25 The Johns Hopkins University Nanoparticle taggants for explosive precursors
WO2013078252A1 (en) 2011-11-22 2013-05-30 Qd Vision, Inc. Quantum dot-containing compositions including an emission stabilizer, products including same, and method
WO2013163407A1 (en) * 2012-04-25 2013-10-31 Trustees Of Tufts College Silk microspheres and methods for surface lubrication
MX2015006681A (en) 2012-11-29 2016-04-06 Insmed Inc Stabilized vancomycin formulations.
US20160145679A1 (en) * 2013-03-01 2016-05-26 Arizona Board Of Regents On Behalf Of Arizona State University Oligonucleotide functionalized quantum dots
US9229611B2 (en) * 2013-03-05 2016-01-05 Oracle International Corporation Automatic management of client data consistency
CA2943049A1 (en) 2014-04-08 2015-10-15 Aradigm Corporation Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria
KR20160144404A (en) 2014-04-08 2016-12-16 아라다임 코포레이션 Liposomes that form drug nanocrystals after freeze-thaw
WO2015175939A1 (en) 2014-05-15 2015-11-19 Insmed Incorporated Methods for treating pulmonary non-tuberculous mycobacterial infections
WO2017147407A1 (en) * 2016-02-25 2017-08-31 Board Of Regents, The University Of Texas System Compositions comprising composite nanocarriers and methods of making and uses thereof
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated Methods for continuous manufacture of liposomal drug products

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614796A (en) * 1983-03-25 1986-09-30 Nippon Shinyaku Co., Ltd. Liposome and method of manufacture therefor
AU7359487A (en) * 1986-05-30 1987-12-22 Johns Hopkins University, The Receptor-targeted drug delivery systems
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5578718A (en) * 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
US5187085A (en) * 1990-09-28 1993-02-16 Applied Biosystems, Inc. Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
YU187991A (en) * 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3- (2) -AMINO-ALI THIOL-MODIFIED, FLUORESCENT-DYED NUCLEOSIDES, NUCLEOTIDS AND OLIGONUCLEOTIDES, PROCESS FOR THEIR OBTAINING AND THEIR USE
US5364759B2 (en) * 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
US5650277A (en) * 1992-07-02 1997-07-22 Diagenetics Ltd. Method of determining the presence and quantifying the number of di- and trinucleotide repeats
US6048616A (en) 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
US5637258A (en) * 1996-03-18 1997-06-10 Nanocrystals Technology L.P. Method for producing rare earth activited metal oxide nanocrystals
JP4245664B2 (en) * 1996-07-29 2009-03-25 ナノスフェアー インコーポレイテッド Method for detecting the target acid using gold nanoparticles with oligonucleotides
DE19724796A1 (en) * 1997-06-06 1998-12-10 Max Delbrueck Centrum Antitumor therapy agents
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
WO2000028089A1 (en) 1998-11-10 2000-05-18 Biocrystal Limited Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6221602B1 (en) * 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6194213B1 (en) * 1999-12-10 2001-02-27 Bio-Pixels Ltd. Lipophilic, functionalized nanocrystals and their use for fluorescence labeling of membranes
US6179912B1 (en) * 1999-12-20 2001-01-30 Biocrystal Ltd. Continuous flow process for production of semiconductor nanocrystals
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals

Also Published As

Publication number Publication date
US7060252B2 (en) 2006-06-13
US20020001716A1 (en) 2002-01-03
EP1266032B1 (en) 2008-01-09
US20060099147A1 (en) 2006-05-11
US6761877B2 (en) 2004-07-13
DE60132311D1 (en) 2008-02-21
EP1266032A4 (en) 2005-01-19
US7244413B2 (en) 2007-07-17
WO2001061045A1 (en) 2001-08-23
ATE383440T1 (en) 2008-01-15
US20050019486A1 (en) 2005-01-27
EP1266032A1 (en) 2002-12-18
DE60132311T2 (en) 2009-01-02

Similar Documents

Publication Publication Date Title
AU2001237057A1 (en) Functionalized encapsulated fluorescent nanocrystals
DE60234382D1 (en) NANO CRYSTALS
AU6779700A (en) Microparticles with multiple fluorescent signals and methods of using same
ATE317122T1 (en) FLUORESCENT POLARIZATION
JP2005513471A5 (en)
ATE342508T1 (en) CAPSULES CONTAINING SOLID PARTICLES OF SIGNAL-GENERATING ORGANIC SUBSTANCES
DE69735532D1 (en) DETERMINATION OF ANTIGENS BY OLIGONUCLEOTIDE ANTIBODY CONJUGATES
AU2001242345A1 (en) Method and device for detecting temperature-dependent parameters, such as association/dissociation parameters and/or the equilibrium constant of complexes that comprise at least two components
DE60136034D1 (en) Molecular modification assays
CA2231186A1 (en) Optical apparatus for performing an immunoassay
CA2366303A1 (en) Semiconductor nanocrystal probes for biological applications
WO2001086299A3 (en) Doped nanoparticles as biolabels
AU3659002A (en) Methods, circuits and compositions of matter for in vivo detection of biomolecule concentrations using fluorescent tags
DE50210457D1 (en) DEVICE FOR REFERENCING FLUORESCENT SIGNALS
PL368690A1 (en) Method for detecting analyte(s) using magnetic colloidal particles
AU7532501A (en) Method for increasing luminescence assay sensitivity
WO2006014576A3 (en) Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals
DE69604920D1 (en) USE OF A PHYCOBILIPROTEIN-PEPTIDE COMPLEX COMPOUND AS A FLUORESCENT LABEL
WO2002035228A3 (en) Method and test kit for detecting analytes in a sample
DE69732034D1 (en) ASSAY METHOD
AU2002245206A1 (en) Dendritic chemiluminescent substrates
AU2002312899A1 (en) Hybrid method for the production of carriers for analyte determination
ATE336572T1 (en) NEW REAGENTS IN CHEMILUMINESCENCE DETECTION METHODS
AU3297000A (en) Method for reducing fluorescence quenching in bioassays
DE60332479D1 (en) HOLO-TRANSCOBALAMIN BINDING PARTNER AND ITS USE IN COBALAMINTEST