JP2006516190A5 - - Google Patents

Download PDF

Info

Publication number
JP2006516190A5
JP2006516190A5 JP2004554414A JP2004554414A JP2006516190A5 JP 2006516190 A5 JP2006516190 A5 JP 2006516190A5 JP 2004554414 A JP2004554414 A JP 2004554414A JP 2004554414 A JP2004554414 A JP 2004554414A JP 2006516190 A5 JP2006516190 A5 JP 2006516190A5
Authority
JP
Japan
Prior art keywords
nucleic acid
tumor
associated antigen
antibody
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004554414A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006516190A (ja
Filing date
Publication date
Priority claimed from DE10254601A external-priority patent/DE10254601A1/de
Application filed filed Critical
Publication of JP2006516190A publication Critical patent/JP2006516190A/ja
Publication of JP2006516190A5 publication Critical patent/JP2006516190A5/ja
Pending legal-status Critical Current

Links

JP2004554414A 2002-11-22 2003-11-21 腫瘍において示差的に発現する遺伝子産物およびその利用 Pending JP2006516190A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10254601A DE10254601A1 (de) 2002-11-22 2002-11-22 Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
PCT/EP2003/013091 WO2004047863A2 (de) 2002-11-22 2003-11-21 In tumoren differentiell exprimierte genprodukte und deren verwendung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2010032059A Division JP5726422B2 (ja) 2002-11-22 2010-02-17 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2011001695A Division JP5904478B2 (ja) 2002-11-22 2011-01-07 腫瘍において示差的に発現する遺伝子産物およびその利用

Publications (2)

Publication Number Publication Date
JP2006516190A JP2006516190A (ja) 2006-06-29
JP2006516190A5 true JP2006516190A5 (https=) 2007-03-22

Family

ID=32240310

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2004554414A Pending JP2006516190A (ja) 2002-11-22 2003-11-21 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2010032059A Expired - Lifetime JP5726422B2 (ja) 2002-11-22 2010-02-17 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2011001695A Expired - Fee Related JP5904478B2 (ja) 2002-11-22 2011-01-07 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2012228760A Pending JP2013046626A (ja) 2002-11-22 2012-10-16 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2014225894A Expired - Fee Related JP6182127B2 (ja) 2002-11-22 2014-11-06 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2016023703A Pending JP2016104800A (ja) 2002-11-22 2016-02-10 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2017151213A Pending JP2017206551A (ja) 2002-11-22 2017-08-04 腫瘍において示差的に発現する遺伝子産物およびその利用

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2010032059A Expired - Lifetime JP5726422B2 (ja) 2002-11-22 2010-02-17 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2011001695A Expired - Fee Related JP5904478B2 (ja) 2002-11-22 2011-01-07 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2012228760A Pending JP2013046626A (ja) 2002-11-22 2012-10-16 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2014225894A Expired - Fee Related JP6182127B2 (ja) 2002-11-22 2014-11-06 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2016023703A Pending JP2016104800A (ja) 2002-11-22 2016-02-10 腫瘍において示差的に発現する遺伝子産物およびその利用
JP2017151213A Pending JP2017206551A (ja) 2002-11-22 2017-08-04 腫瘍において示差的に発現する遺伝子産物およびその利用

Country Status (20)

Country Link
US (7) US7527933B2 (https=)
EP (27) EP2399998A3 (https=)
JP (7) JP2006516190A (https=)
KR (7) KR20170031804A (https=)
CN (4) CN101966337A (https=)
AU (2) AU2003282101B2 (https=)
BR (1) BR0316435A (https=)
CA (2) CA3000243C (https=)
CY (1) CY1117786T1 (https=)
DE (1) DE10254601A1 (https=)
ES (2) ES2675785T3 (https=)
HU (1) HUE027825T2 (https=)
IL (7) IL168168A (https=)
MX (2) MXPA05005423A (https=)
NZ (4) NZ578130A (https=)
PL (3) PL219093B1 (https=)
PT (1) PT2400018T (https=)
SG (3) SG2012077905A (https=)
SI (1) SI2400018T1 (https=)
WO (1) WO2004047863A2 (https=)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
DE10344799A1 (de) * 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
DE102004023187A1 (de) * 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
AU2011256897B2 (en) * 2004-05-18 2013-09-19 Astellas Pharma Inc. Genetic products differentially expressed in tumors and the use thereof
DE102004024617A1 (de) * 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
JP4772684B2 (ja) * 2004-08-30 2011-09-14 武田薬品工業株式会社 スクリーニング方法
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102005013846A1 (de) * 2005-03-24 2006-10-05 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
EP1790664A1 (en) * 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
AU2016202322B2 (en) * 2005-11-24 2018-03-08 Astellas Pharma Inc. Monoclonal antibodies against claudin-18 for treatment of cancer
AU2014208256B2 (en) * 2005-11-24 2016-01-14 Astellas Pharma Inc. Monoclonal antibodies against claudin-18 for treatment of cancer
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP2530167A1 (en) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Microfluidic Devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008039941A2 (en) 2006-09-27 2008-04-03 The Government Of The Usa As Represented By The Secretary Of The Dpt. Of Health And Human Services Scgb3a2 as a growth factor and anti-apoptotic agent
ES2629749T3 (es) * 2006-10-04 2017-08-14 Dana-Farber Cancer Institute, Inc. Inmunidad tumoral
US7951781B2 (en) * 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP1997832A1 (en) * 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
EP2060583A1 (en) * 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US20110206736A1 (en) * 2008-09-23 2011-08-25 Thomas Jefferson University Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
SG10201407757XA (en) 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8840902B2 (en) * 2010-03-16 2014-09-23 Biontech Ag Tumor vaccination involving a humoral immune response against self-proteins
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3412778A1 (en) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP3351641A1 (en) 2011-04-08 2018-07-25 Tufts Medical Center, Inc. Pepducin design and use
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
CN102526703B (zh) * 2012-01-18 2013-11-13 广东医学院司法鉴定中心 一种鼻咽癌相关易感基因yh1蛋白的制备方法及其应用
WO2013120089A1 (en) 2012-02-10 2013-08-15 Raindance Technologies, Inc. Molecular diagnostic screening assay
AU2013251312B2 (en) 2012-04-27 2018-03-22 Takeda Pharmaceutical Company Limited Anti-GCC antibody molecules and use of same to test for susceptibility to GCC-targeted therapy
EP2844768B1 (en) 2012-04-30 2019-03-13 Raindance Technologies, Inc. Digital analyte analysis
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
WO2013174404A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
JP6499079B2 (ja) 2012-11-13 2019-04-10 バイオエヌテック アーゲーBioNTech AG クローディンを発現するガン疾患を処置するための剤
WO2014127785A1 (en) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014172288A2 (en) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Digital analyte analysis
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
RU2678773C2 (ru) 2014-02-13 2019-02-01 Басф Се Порошок и гранула, способ получения такого порошка и гранулы и их применение
WO2015124138A1 (de) * 2014-02-20 2015-08-27 Rheinische Friedrich-Wilhelms-Universität Bonn Tumor-assoziierte antigene und genprodukte in der diagnose und therapie
WO2016149261A1 (en) * 2015-03-16 2016-09-22 Personal Genome Diagnostics, Inc. Systems and methods for analyzing nucleic acid
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017083618A1 (en) 2015-11-13 2017-05-18 Oasis Pharmaceuticals, LLC Protease-activated receptor-2 modulators
CN105463094B (zh) * 2015-12-29 2018-09-07 北京泱深生物信息技术有限公司 直肠腺癌的诊治标记物
US11927591B2 (en) 2016-08-02 2024-03-12 Georgetown University Methods of identifying novel proteins and antigens in cancer cells
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
MX2020012607A (es) * 2018-05-23 2021-01-29 Pfizer Anticuerpos especificos para gucy2c y sus usos.
KR20210050547A (ko) 2018-08-27 2021-05-07 난징 산홈 팔마세우티칼 컴퍼니 리미티드 항-클라우딘18.2 항체 및 이의 용도
SG11202108398YA (en) 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
US20230030674A1 (en) 2019-12-06 2023-02-02 Sotio Biotech A.S. Humanized cldn18.2 antibodies
WO2021130291A1 (en) 2019-12-23 2021-07-01 SOTIO a.s. Tumor-specific claudin 18.2 antibodies
WO2021238831A1 (en) * 2020-05-25 2021-12-02 Mabspace Biosciences (Suzhou) Co., Limited Anti-cldn18.2 antibodies and diagnostic uses thereof
GB2613718A (en) * 2020-08-31 2023-06-14 World Biotech Regenerative Medical Group Ltd Personalized immunogenic compositions and methods for producing and using same
CN114181944B (zh) * 2020-09-14 2023-10-03 中国科学院动物研究所 突变基因及构建短肢性侏儒症小型猪模型的方法和用途
WO2022122709A1 (en) 2020-12-07 2022-06-16 Sotio Biotech A.S. Antibody-drug conjugates based on humanized cldn18.2 antibodies
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法
TW202241519A (zh) 2020-12-23 2022-11-01 捷克商舒迪安生物技術公司 腫瘤特異性密連蛋白18﹒2抗體藥物結合物

Family Cites Families (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4954617A (en) 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
ATE243754T1 (de) 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US4956556A (en) 1988-11-14 1990-09-11 Siemens Analytical X-Ray Instruments, Inc. Radiation scintillation detector
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US6020145A (en) 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
EP0507868A4 (en) 1989-12-27 1992-11-04 Us Commerce Diagnostic probe for detecting human stomach cancer
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5589579A (en) * 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
WO2000075316A1 (en) 1999-06-02 2000-12-14 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
WO2001004311A1 (en) 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5677139A (en) 1995-04-21 1997-10-14 President And Fellows Of Harvard College In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
EP1876241A3 (en) * 1996-01-11 2008-07-30 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
WO1998020143A1 (en) * 1996-11-05 1998-05-14 Abbott Laboratories Reagents and methods useful for detecting diseases of the lung
WO2000073348A2 (en) 1999-06-02 2000-12-07 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
WO2002000690A2 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US7368531B2 (en) 1997-03-07 2008-05-06 Human Genome Sciences, Inc. Human secreted proteins
US20070224663A1 (en) 1997-03-07 2007-09-27 Human Genome Sciences, Inc. Human Secreted Proteins
US7411051B2 (en) 1997-03-07 2008-08-12 Human Genome Sciences, Inc. Antibodies to HDPPA04 polypeptide
WO2000078961A1 (en) 1999-06-23 2000-12-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030073129A1 (en) 1998-09-01 2003-04-17 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030022298A1 (en) 1997-09-15 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020127584A1 (en) 1997-09-18 2002-09-12 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030027272A1 (en) 1997-09-18 2003-02-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030166104A1 (en) 1997-09-18 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20050196832A1 (en) 1997-09-18 2005-09-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030008352A1 (en) 1997-09-18 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030022293A1 (en) 1997-09-18 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7160985B2 (en) * 1997-10-29 2007-01-09 Genentech, Inc. Pro180 polypeptide
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US20030022835A1 (en) 1998-04-29 2003-01-30 Genesis Research And Development Corporation Limited Compositions isolated from skin cells and methods for their use
US20030040471A1 (en) 1998-04-29 2003-02-27 Watson James D. Compositions isolated from skin cells and methods for their use
US6852318B1 (en) * 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
JP3428441B2 (ja) 1998-05-15 2003-07-22 エーザイ株式会社 タイトジャンクション構成膜蛋白質クローディンファミリー
CA2328138A1 (en) * 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging lung cancer
US7319008B2 (en) 1998-06-02 2008-01-15 Genentech, Inc. Nucleic acid underexpressed in melanoma
US7351543B2 (en) 1998-06-02 2008-04-01 Genentech, Inc. Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma
EP1084142A4 (en) * 1998-06-11 2005-01-19 Smithkline Beecham Corp GPR35A RECEIVER
EP1092026A2 (en) * 1998-07-02 2001-04-18 Incyte Pharmaceuticals, Inc. Neurotransmission associated proteins
EP1104486A4 (en) 1998-08-04 2002-07-17 Diadexus Llc NEW METHOD FOR DIAGNOSIS, FOLLOW-UP, AND IMAGE OF LUNG CANCER
US20030166132A1 (en) 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6936697B2 (en) 1998-09-01 2005-08-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030082626A1 (en) 1998-09-01 2003-05-01 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030109672A1 (en) 1998-09-01 2003-06-12 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
NZ531664A (en) 1998-09-01 2005-07-29 Genentech Inc Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family
US20050181478A1 (en) 1998-09-01 2005-08-18 Baker Kevin P. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU5922999A (en) 1998-09-16 2000-04-03 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2343001A1 (en) 1998-09-16 2000-03-23 Zymogenetics, Inc. Stomach polypeptide zsig28
US6355623B2 (en) * 1998-09-24 2002-03-12 Hopital-Sainte-Justine Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
AU766279B2 (en) 1998-10-06 2003-10-16 Curagen Corporation Novel secreted proteins and polynucleotides encoding them
US7399834B2 (en) 1998-10-07 2008-07-15 Genentech, Inc. Anti-PRO1558 antibodies
AU1450900A (en) 1998-10-21 2000-05-08 Arch Development Corporation Methods of treatment of type 2 diabetes
EP1124850A4 (en) * 1998-10-28 2005-10-19 Human Genome Sciences Inc 12 HUMAN SECRETED PROTEINS
US20030009013A1 (en) 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7026449B2 (en) 1999-01-05 2006-04-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7507404B2 (en) 1999-03-08 2009-03-24 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1263948A2 (en) 1999-03-08 2002-12-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
KR100553300B1 (ko) 1999-03-08 2006-02-20 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
AU764092B2 (en) 1999-03-23 2003-08-07 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000058473A2 (en) 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
US20080286821A1 (en) 1999-05-14 2008-11-20 Eaton Dan L Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU3246100A (en) 1999-06-02 2000-12-28 Genentech Inc. Methods and compositions for inhibiting neoplastic cell growth
JP2004522402A (ja) 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸
EP1208195A2 (en) 1999-06-15 2002-05-29 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6321400A (en) * 1999-08-17 2001-03-13 Protegene Inc. Human proteins having hydrophobic domains and dnas encoding these proteins
CA2380355A1 (en) * 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7442776B2 (en) * 1999-10-08 2008-10-28 Young David S F Cancerous disease modifying antibodies
AU1205901A (en) * 1999-10-14 2001-04-23 Board Of Trustees Of The University Of Arkansas, The Tumor antigen derived gene-16 (tadg-16): a novel extracellular serine protease and uses thereof
CA2491433A1 (en) 1999-12-01 2001-06-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6380362B1 (en) 1999-12-23 2002-04-30 Genesis Research & Development Corporation Ltd. Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
CA2390685C (en) 2000-01-06 2008-04-22 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
WO2001055301A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US20040018969A1 (en) 2000-01-31 2004-01-29 Rosen Craig A. Nucleic acids, proteins, and antibodies
EP1251863A4 (en) * 2000-01-31 2005-03-02 Human Genome Sciences Inc 22 HUMAN SECRETED PROTEINS
WO2001055326A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
JP2003525599A (ja) * 2000-02-17 2003-09-02 ディアデクサス インコーポレーテッド 肺癌特異的遺伝子による肺癌の診断、モニタリング、病期分類、イメージングおよび治療の方法
CA2401070A1 (en) * 2000-02-22 2001-08-30 Corixa Corporation Compositions and methods for diagnosis and therapy of malignant mesothelioma
AU6802801A (en) * 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001070979A2 (en) 2000-03-21 2001-09-27 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and method for identification, assessment, prevention and therapy of ovarian cancer
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
EP2213743A1 (en) 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albumin fusion proteins
AU2001260847A1 (en) 2000-05-24 2001-12-03 Genesis Research And Development Corporation Limited Compositions isolated from skin cells and methods for their use
US6822082B2 (en) 2000-06-30 2004-11-23 Zymogenetics, Inc. Polynucleotides for mammalian secreted protein, Z1055G2P
EP1301524A1 (en) * 2000-06-30 2003-04-16 Human Genome Sciences, Inc. B7-like polynucleotides, polypeptides, and antibodies
AU2001273150A1 (en) * 2000-07-20 2002-02-05 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EA013564B1 (ru) 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
ES2284678T3 (es) 2000-08-15 2007-11-16 Immunex Corporation Polipeptidos de claudinas.
WO2002014500A2 (en) * 2000-08-16 2002-02-21 Chiron Corporation Human genes and gene expression products
US7442765B2 (en) 2000-08-24 2008-10-28 Genentech, Inc. Secreted transmembrane polypeptides and nucleic acids encoding the same
JP2004520814A (ja) 2000-08-28 2004-07-15 ディアデクサス インコーポレーテッド 肺特異的遺伝子に関する組成物および方法
ATE549347T1 (de) 2000-09-08 2012-03-15 Schering Corp Gene von säugetiere, und damit verbundene reagentien, methoden
WO2002022684A2 (en) * 2000-09-15 2002-03-21 Incyte Genomics, Inc. Transporters and ion channels
US7829276B2 (en) 2000-09-18 2010-11-09 Thomas Jefferson University Methods of using CRCA-1 as a stomach and esophageal cancer marker
JP2004520821A (ja) * 2000-10-26 2004-07-15 ディアデクサス インコーポレーテッド 肺特異的遺伝子およびタンパク質に関する組成物および方法
AU2002220265A1 (en) * 2000-11-03 2002-05-15 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
WO2002061087A2 (en) 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
AU2002255478A1 (en) 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
WO2002066682A2 (en) 2001-01-29 2002-08-29 Phase-1 Molecular Toxicology, Inc. Rat toxicologically relevant genes and uses thereof
JP3948702B2 (ja) * 2001-02-14 2007-07-25 社団法人畜産技術協会 ウシのClaudin−16欠損症タイプ2の遺伝子診断法
CN1516706A (zh) * 2001-02-26 2004-07-28 阿伦纳药品公司 人g蛋白偶联受体的内源性和非内源性形式
WO2002074237A2 (en) * 2001-03-19 2002-09-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of kidney cancer
US20030152939A1 (en) 2001-04-09 2003-08-14 Glennda Smithson Novel secreted proteins and polynucleotides encoding them
US20060084794A1 (en) 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
JP2003000249A (ja) 2001-05-10 2003-01-07 Daiichi Fine Chemical Co Ltd クローディンによるMT−MMPsを介したproMMP−2活性化
AU2002330714A1 (en) 2001-05-30 2003-01-02 Biomedical Center In silico screening for phenotype-associated expressed sequences
WO2002098891A2 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. GADs AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
JP2004533840A (ja) 2001-07-06 2004-11-11 ジェネンテック・インコーポレーテッド ファージディスプレイによるpdzドメインリガンド
WO2004045535A2 (en) 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
AU2002321903A1 (en) 2001-08-03 2003-02-24 Arbor Vita Corporation Molecular interactions in cells
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
CA2379661A1 (en) 2002-03-28 2003-09-28 Kursad Turksen Paracellular drug delivery system
WO2003101283A2 (en) 2002-06-04 2003-12-11 Incyte Corporation Diagnostics markers for lung cancer
WO2004029629A1 (en) 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
EP1553975B8 (en) 2002-09-27 2023-04-12 Xencor, Inc. Optimized fc variants and methods for their generation
WO2004032961A1 (en) 2002-10-10 2004-04-22 Merck Patent Gmbh Bispecific anti-erb-b antibodies and their use in tumor therapy
BRPI0315295C1 (pt) 2002-10-17 2021-05-25 Genmab As anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
EP1430902A1 (en) 2002-12-20 2004-06-23 Mondobiotech Laboratories Anstalt Pharmaceutical composition of interferon gamma with molecular diagnostics for the improved treatment of asthma bronchiale
CA2512729C (en) 2003-01-09 2014-09-16 Macrogenics, Inc. Identification and engineering of antibodies with variant fc regions and methods of using same
WO2004063355A2 (en) 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
US7393531B2 (en) * 2003-01-21 2008-07-01 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of MCSP
RU2005137325A (ru) 2003-05-31 2006-09-10 Микромет Аг (De) Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам
JP2008501621A (ja) 2003-05-31 2008-01-24 マイクロメット アクツィエン ゲゼルシャフト B細胞関連疾患を処置するための二重特異性抗cd3、抗cd19抗体構築物を含む薬学的組成物
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2005032495A2 (en) 2003-10-03 2005-04-14 Bayer Pharmaceuticals Corporation Gene expression profiles and methods of use
MXPA06004035A (es) 2003-10-16 2006-08-31 Micromet Ag Aglutinantes cd3 de-inmunizados multi-especificos.
DE10354601B3 (de) 2003-11-21 2005-06-23 Chiropro Gmbh Gelenkprothese für Fingerglieder
WO2005052182A2 (en) 2003-11-26 2005-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method of analyzing plasma membrane protein content of cells
EP1709084A4 (en) 2003-12-23 2008-05-28 Nono Inc POLYPEPTIDES FOR MODULATING BINDING OF TRP-CHANNEL PROTEINS AND TRP-ASSOCIATED PROTEINS
WO2005076939A2 (en) 2004-02-09 2005-08-25 University Of Kentucky Research Foundation Assay and method for diagnosing and treating alzheimer’s disease
CA2557181A1 (en) 2004-02-26 2005-09-09 Ohio University Diagnosis of hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in muscle cells
KR20060134216A (ko) 2004-04-16 2006-12-27 에미스페어 테크놀로지스, 인코포레이티드 활성제 전달을 위한 8-(2-히드록시페녹시)옥틸디에탄올아민및 그의 염
US20050255041A1 (en) 2004-05-13 2005-11-17 Arius Research, Inc. Cancerous disease modifying antibodies
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US20060141528A1 (en) 2004-05-21 2006-06-29 Aebersold Rudolf H Compositions and methods for quantification of serum glycoproteins
WO2006023121A1 (en) 2004-07-27 2006-03-02 Ohio University Diagnosis of hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in white adipose tissue (13)
DE102004042822A1 (de) 2004-08-31 2006-03-16 Technische Universität Dresden Verbindungen und Methoden zur Behandlung, Diagnose und Prognose bei Pankreaserkrankungen
FR2876705B1 (fr) 2004-10-19 2008-12-12 Biomerieux Sa Procede pour le diagnostic d'une intolerance a l'aspirine
US20070072175A1 (en) 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
WO2007005800A1 (en) 2005-06-30 2007-01-11 Abbott Laboratories Endoprosthesis having foot extensions
AU2006276813A1 (en) 2005-07-01 2007-02-15 Arbor Vita Corporation Methods and compositions for diagnosis and treatment of influenza
EP1922410A2 (en) 2005-08-15 2008-05-21 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
WO2007027867A2 (en) 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1930414B1 (en) 2005-09-08 2012-07-18 Medinet Co., Ltd. Method for activation treatment of antigen-presenting cell
EP2402758B1 (en) 2005-09-19 2014-09-10 Janssen Diagnostics, LLC Methods and uses for identifying the origin of a carcinoma of unknown primary origin
DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP1938104A2 (en) 2005-10-17 2008-07-02 Institute for Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
JP5399712B2 (ja) 2005-12-21 2014-01-29 アムゲン リサーチ (ミュンヘン) ゲーエムベーハー 可溶性ceaに対する抵抗性を有する医薬組成物
AU2007213920B2 (en) 2006-02-09 2013-08-29 Amgen Research (Munich) Gmbh Treatment of metastatic breast cancer
ES2582652T3 (es) 2006-02-10 2016-09-14 Genentech, Inc. Anticuerpos anti-FGF19 y métodos de uso de los mismos
AU2007233237A1 (en) 2006-03-29 2007-10-11 Genentech, Inc. Diagnostics and treatments for tumors
US20100129929A1 (en) 2006-07-27 2010-05-27 Roberto Polakewicz Tyrosine Phosphorylation Sites
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US8450057B2 (en) 2006-08-14 2013-05-28 The Brigham And Women's Hospital, Inc. Diagnostic tests using gene expression ratios
WO2008082730A2 (en) 2006-09-19 2008-07-10 Novartis Ag Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors
JP2010505897A (ja) 2006-10-11 2010-02-25 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ インフルエンザターゲット
WO2008073303A2 (en) 2006-12-07 2008-06-19 Switchgear Genomics Transcriptional regulatory elements of biological pathways, tools, and methods
EP2104734A2 (en) 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
JP5666136B2 (ja) 2007-02-01 2015-02-12 ジャンセン ダイアグノスティックス,エルエルシー 原発不明がんの原発巣を同定するための方法および材料
EP1970384A1 (en) 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
EP2145902A3 (en) 2007-04-19 2010-09-29 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
EP1997832A1 (en) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
AU2008261951A1 (en) 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
JPWO2008152822A1 (ja) 2007-06-15 2010-08-26 株式会社メディネット 医薬
US20090274698A1 (en) 2007-07-06 2009-11-05 Shripad Bhagwat Combination anti-cancer therapy
US20100292303A1 (en) 2007-07-20 2010-11-18 Birrer Michael J Gene expression profile for predicting ovarian cancer patient survival
WO2009035497A2 (en) 2007-08-08 2009-03-19 Savidge Tor C Disease related cysteine modifications and uses thereof
EP2036987A1 (en) 2007-09-17 2009-03-18 Siemens Healthcare Diagnostics GmbH Molecular markers for tumor cell content in tissue samples
WO2009038090A1 (ja) 2007-09-19 2009-03-26 Suntory Holdings Limited セサミン類とアラキドン酸類を含有する組成物
WO2009047362A2 (en) 2007-10-12 2009-04-16 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Method for opening tight junctions
WO2009102367A2 (en) 2007-11-19 2009-08-20 The Regents Of The University Of Colorado Tight junction protein modulators and uses thereof
MX2010008099A (es) 2008-01-28 2010-08-04 Medimmune Ltd Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
EP2304053A1 (en) 2008-06-02 2011-04-06 NSABP Foundation, Inc. Identification and use of prognostic and predictive markers in cancer treatment
WO2009155609A1 (en) 2008-06-20 2009-12-23 Oklahoma Medical Research Foundation IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE
EP2316026A1 (en) 2008-07-25 2011-05-04 Merck Patent GmbH Method of determination of receptor binding saturation effected by monoclonal antibodies
WO2010046889A1 (en) 2008-10-23 2010-04-29 Quark Pharmaceuticals, Inc. Methods for delivery of sirna to bone marrow cells and uses thereof
CN101381524A (zh) 2008-10-24 2009-03-11 南开大学 单层氧化石墨与水溶性高分子增强复合材料
PL2918604T3 (pl) 2008-11-07 2018-05-30 Amgen Research (Munich) Gmbh Leczenie pediatrycznej ostrej białaczki limfoblastycznej
US20110286916A1 (en) 2008-11-20 2011-11-24 Jose Miguel Aste-Amezaga Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
GB0904957D0 (en) 2009-03-23 2009-05-06 Univ Erasmus Medical Ct Tumour gene profile
WO2010120526A2 (en) 2009-03-31 2010-10-21 Emory University Methods and systems for screening for and diagnosing dna methylation associated with autism spectrum disorders
CN101584860A (zh) 2009-04-27 2009-11-25 西安杰诺瓦生物科技有限公司 重组人Claudin18.2肿瘤疫苗及其制备方法
WO2010141093A2 (en) 2009-06-04 2010-12-09 The University Of Maryland, Baltimore Co-signaling methods for treating cancers
EP2483813A1 (en) 2009-10-01 2012-08-08 Chipdx LLC System and method for classification of patients
DK3305813T3 (da) 2009-11-11 2020-04-20 Astellas Pharma Inc Antistoffer, der er specifikke for claudin 6 (cldn6)
WO2011068839A1 (en) 2009-12-01 2011-06-09 Compendia Bioscience, Inc. Classification of cancers
WO2011090005A1 (ja) 2010-01-19 2011-07-28 協和発酵キリン株式会社 大腸癌の治療用医薬および治療方法
US8840902B2 (en) 2010-03-16 2014-09-23 Biontech Ag Tumor vaccination involving a humoral immune response against self-proteins
EP2366709A1 (en) 2010-03-16 2011-09-21 BioNTech AG Tumor vaccination involving a humoral immune response against self-proteins
US8945847B2 (en) 2010-05-24 2015-02-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for ascertaining biosafety of an agent
CA2801107A1 (en) 2010-06-07 2011-12-15 F. Hoffman-La Roche Ag Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
WO2011163627A2 (en) 2010-06-24 2011-12-29 Integrated Diagnostics, Inc. Organ specific diagnostic panels and methods for identification of organ specific panel proteins
WO2012070014A2 (en) 2010-11-26 2012-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells
CN103119180A (zh) 2011-01-12 2013-05-22 森永乳业株式会社 产生具有免疫调节作用的乳的食物的筛选方法
DE102011005235B4 (de) 2011-03-08 2017-05-24 Sirs-Lab Gmbh Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
WO2013174403A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2013174404A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014025199A2 (ko) 2012-08-09 2014-02-13 주식회사 한독 스테필로코칼 엔테로톡신 유래의 초항원 변이체 및 이에 표적 특이적 폴리펩타이드가 연결된 융합단백질 및 그 용도
WO2014025198A2 (ko) 2012-08-09 2014-02-13 주식회사 한독 Lfa3 변이체 및 상기 변이체 또는 lfa3 cd2 결합영역과 이에 표적 특이적 폴리펩타이드가 연결된 융합단백질 및 그 용도
EP2888391A4 (en) 2012-08-24 2016-09-14 Univ Utah Res Found COMPOSITIONS AND METHODS RELATING TO BLOOD-BASED BIOMARKERS FOR BREAST CANCER
US9856532B2 (en) 2012-09-07 2018-01-02 Institute For Systems Biology Markers and methods for detecting posttraumatic stress disorder (PTSD)
US20140073524A1 (en) 2012-09-07 2014-03-13 Institute For Systems Biology Markers and methods for detecting posttraumatic stress disorder (ptsd)
JP6499079B2 (ja) 2012-11-13 2019-04-10 バイオエヌテック アーゲーBioNTech AG クローディンを発現するガン疾患を処置するための剤
WO2014127785A1 (en) * 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014146672A1 (en) * 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
JP6241403B2 (ja) 2014-10-24 2017-12-06 横浜ゴム株式会社 リン酸変性ポリマー

Similar Documents

Publication Publication Date Title
JP2006516190A5 (https=)
JP2007537197A5 (https=)
JP2007506417A5 (https=)
JP2010047597A5 (https=)
ES2277432T3 (es) Compuestos y metodos para terapia y diagnosis de cancer de pulmon.
CA2443617C (en) Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions
JP2008537546A5 (https=)
CN112969713A (zh) 结合结构域
EP1992640A1 (en) Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
EP2523687B1 (en) Methods for diagnosis and treatment of cutaneous T cell lymphomas using the NKp46 receptor
EP1051489A2 (en) Compounds for therapy and diagnosis of lung cancer and methods for their use
WO2004001004A2 (en) Membrane associated tumor endothelium markers
JP2008249727A (ja) 前立腺ガンの免疫診断のための化合物およびそれらの使用方法
JP2008508861A5 (https=)
JP2006526992A (ja) 癌を検出し、癌の進行をモニタリングする方法
RU2008114318A (ru) Идентификация опухолевых антигенов для диагностики и терапии
CA2506737C (en) Methods and kits for diagnosing and treating b-cell chronic lymphocytic leukemia (b-cll)
JP2004501613A (ja) 乳腺癌の診断、モニタリング、ステージング、イメージング及び処置のための組成物並びに方法
JP2004527240A (ja) 癌細胞の増殖を調節するのに有用なポリヌクレオチド
JP4025645B2 (ja) Pibf濃度測定によるガン患者の検査方法
CA2398064A1 (en) 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer
JP2012525121A5 (https=)
JP2002539804A5 (https=)
US6284241B1 (en) Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
US8282918B2 (en) Polynucleotides encoding RPA4/RPA32 hybrid polypeptides