JP2007537197A5 - - Google Patents

Info

Publication number

JP2007537197A5

JP2007537197A5 JP2007512091A JP2007512091A JP2007537197A5 JP 2007537197 A5 JP2007537197 A5 JP 2007537197A5 JP 2007512091 A JP2007512091 A JP 2007512091A JP 2007512091 A JP2007512091 A JP 2007512091A JP 2007537197 A5 JP2007537197 A5 JP 2007537197A5

Authority

JP

Japan

Prior art keywords

nucleic acid

tumor

associated antigen

antibody

group

Prior art date

2005-05-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000007523 nucleic acids Chemical class 0.000 claims 112
• 108020004707 nucleic acids Proteins 0.000 claims 101
• 102000039446 nucleic acids Human genes 0.000 claims 101
• 206010028980 Neoplasm Diseases 0.000 claims 58
• 239000000427 antigen Substances 0.000 claims 55
• 102000036639 antigens Human genes 0.000 claims 55
• 108091007433 antigens Proteins 0.000 claims 55
• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 238000000034 method Methods 0.000 claims 20
• 239000003795 chemical substances by application Substances 0.000 claims 16
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 102000004169 proteins and genes Human genes 0.000 claims 12
• 108090000623 proteins and genes Proteins 0.000 claims 12
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
• 210000004027 cell Anatomy 0.000 claims 10
• 230000000295 complement effect Effects 0.000 claims 9
• 229920001184 polypeptide Polymers 0.000 claims 9
• 102000004196 processed proteins & peptides Human genes 0.000 claims 9
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 238000001514 detection method Methods 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 210000004698 lymphocyte Anatomy 0.000 claims 6
• 230000002159 abnormal effect Effects 0.000 claims 4
• 239000000032 diagnostic agent Substances 0.000 claims 4
• 229940039227 diagnostic agent Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 3
• 208000029742 colonic neoplasm Diseases 0.000 claims 3
• 231100000433 cytotoxic Toxicity 0.000 claims 3
• 230000001472 cytotoxic effect Effects 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 239000000523 sample Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 108020004511 Recombinant DNA Proteins 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 239000004615 ingredient Substances 0.000 claims 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 102000053602 DNA Human genes 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 230000030833 cell death Effects 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 210000000170 cell membrane Anatomy 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 238000010276 construction Methods 0.000 claims 1
• 230000001461 cytolytic effect Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000037841 lung tumor Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 208000023958 prostate neoplasm Diseases 0.000 claims 1
• 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1