|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
EP1065207A1
(en)
*
|
1999-07-02 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
|
|
AU770600B2
(en)
|
1999-10-07 |
2004-02-26 |
Amgen, Inc. |
Triazine kinase inhibitors
|
|
DE19948417A1
(de)
*
|
1999-10-07 |
2001-04-19 |
Morphochem Ag |
Imidazol-Derivate und ihre Verwendung als Arzneimittel
|
|
DK1235830T3
(da)
|
1999-12-10 |
2004-03-29 |
Pfizer Prod Inc |
Pyrrolo[2,3-d]pyrimidin-forbindelser som proteinkinaseinhibitorer
|
|
ATE369844T1
(de)
*
|
2000-01-24 |
2007-09-15 |
Genzyme Corp |
Inhibitoren des jak/stat-weges und deren verwendung zur behandlung von allgemeiner primärer osteoarthritis
|
|
EP1782800B1
(en)
*
|
2000-01-24 |
2013-12-18 |
Genzyme Corporation |
Methods for detecting JAK3 inhibitors
|
|
MY137020A
(en)
*
|
2000-04-27 |
2008-12-31 |
Abbott Lab |
Diazabicyclic central nervous system active agents
|
|
AU784297C
(en)
*
|
2000-06-26 |
2007-01-11 |
Pfizer Products Inc. |
Pyrrolo(2,3-d)pyrimidine compounds as immunosuppressive agents
|
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
|
US6864255B2
(en)
|
2001-04-11 |
2005-03-08 |
Amgen Inc. |
Substituted triazinyl amide derivatives and methods of use
|
|
US7301023B2
(en)
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
HRP20031049A2
(en)
*
|
2001-06-23 |
2004-06-30 |
Aventis Pharma Inc |
Pyrrolopyrimidines as protein kinase inhibitors
|
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
US7323469B2
(en)
|
2001-08-07 |
2008-01-29 |
Novartis Ag |
7H-pyrrolo[2,3-d]pyrimidine derivatives
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
GT200200234A
(es)
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
|
US6642381B2
(en)
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
|
DE60305446T4
(de)
|
2002-01-07 |
2009-07-09 |
Eisai R&D Management Co., Ltd. |
Desazapurine und deren verwendung
|
|
GB0202679D0
(en)
*
|
2002-02-05 |
2002-03-20 |
Glaxo Group Ltd |
Novel compounds
|
|
EP1388541A1
(en)
*
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
|
PL378246A1
(pl)
|
2002-11-26 |
2006-03-20 |
Pfizer Products Inc. |
Sposób leczenia odrzucania przeszczepu
|
|
WO2004093812A2
(en)
*
|
2003-04-22 |
2004-11-04 |
Irm Llc |
Compounds that induce neuronal differentiation in embryonic stem cells
|
|
US7169918B2
(en)
*
|
2003-10-27 |
2007-01-30 |
Genelabs Technologies, Inc. |
Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
|
|
US20050153989A1
(en)
*
|
2004-01-13 |
2005-07-14 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
|
GB0403606D0
(en)
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
|
US8076338B2
(en)
|
2004-04-23 |
2011-12-13 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
|
US20110104186A1
(en)
|
2004-06-24 |
2011-05-05 |
Nicholas Valiante |
Small molecule immunopotentiators and assays for their detection
|
|
MXPA06015237A
(es)
|
2004-06-29 |
2007-12-10 |
Amgen Inc |
Pirrolo[2-3-d]pirimidinas que modulan la actividad de ack1 y lck.
|
|
MX2007001399A
(es)
|
2004-08-02 |
2007-04-18 |
Osi Pharm Inc |
Compuestos que inhiben pirrolopirimidina multi-cinasa aril-amino sustituidas.
|
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
|
FR2880626B1
(fr)
*
|
2005-01-13 |
2008-04-18 |
Aventis Pharma Sa |
Derives de la purine, compositions les contenant et utilisation
|
|
US7423043B2
(en)
|
2005-02-18 |
2008-09-09 |
Lexicon Pharmaceuticals, Inc. |
4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
|
|
BRPI0610278A2
(pt)
|
2005-05-13 |
2010-06-08 |
Irm Llc |
compostos e composições como inibidores de proteìna cinase
|
|
US8163767B2
(en)
|
2005-07-14 |
2012-04-24 |
Astellas Pharma Inc. |
Heterocyclic Janus Kinase 3 inhibitors
|
|
EP2251341A1
(en)
|
2005-07-14 |
2010-11-17 |
Astellas Pharma Inc. |
Heterocyclic Janus kinase 3 inhibitors
|
|
WO2007038215A1
(en)
|
2005-09-22 |
2007-04-05 |
Incyte Corporation |
Tetracyclic inhibitors of janus kinases
|
|
CN101801971A
(zh)
|
2005-09-30 |
2010-08-11 |
沃泰克斯药物股份有限公司 |
可用作janus激酶抑制剂的脱氮嘌呤
|
|
EP2474545B1
(en)
|
2005-12-13 |
2016-11-09 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
US20090163490A1
(en)
*
|
2006-03-11 |
2009-06-25 |
Vernalis (R&D) Ltd. |
Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors
|
|
RU2008143361A
(ru)
*
|
2006-04-05 |
2010-05-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Деазапурины в качестве ингибиторов янус-киназ
|
|
GB0608176D0
(en)
*
|
2006-04-25 |
2006-06-07 |
Astex Therapeutics Ltd |
Pharmaceutical Compounds
|
|
EP2043655A2
(en)
*
|
2006-04-25 |
2009-04-08 |
Astex Therapeutics Limited |
Purine and deazapurine derivatives as pharmaceutical compounds
|
|
WO2008012635A2
(en)
*
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
KR20090077914A
(ko)
*
|
2006-09-11 |
2009-07-16 |
쿠리스 인코퍼레이션 |
항증식제로서의 다작용성 소분자
|
|
WO2008033745A2
(en)
*
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
AR064416A1
(es)
*
|
2006-12-21 |
2009-04-01 |
Cancer Rec Tech Ltd |
Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
|
|
WO2008075007A1
(en)
*
|
2006-12-21 |
2008-06-26 |
Cancer Research Technology Limited |
Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
|
|
WO2008079965A1
(en)
|
2006-12-22 |
2008-07-03 |
Incyte Corporation |
Substituted heterocycles as janus kinase inhibitors
|
|
TW200900061A
(en)
|
2007-01-12 |
2009-01-01 |
Astellas Pharma Inc |
Condensed pyridine compound
|
|
AR065901A1
(es)
*
|
2007-04-02 |
2009-07-08 |
Palau Pharma Sa |
Derivados de pirrolipirimidina
|
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
|
DK2173752T4
(en)
|
2007-06-13 |
2022-08-01 |
Incyte Holdings Corp |
Salte af janus-kinase-inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
GB0713602D0
(en)
*
|
2007-07-12 |
2007-08-22 |
Syngenta Participations Ag |
Chemical compounds
|
|
CA2693715C
(en)
*
|
2007-07-27 |
2015-10-27 |
Janssen Pharmaceutica Nv |
Pyrrolopyrimidines
|
|
CN101772502A
(zh)
*
|
2007-08-08 |
2010-07-07 |
莱西肯医药有限公司 |
作为激酶抑制剂用于治疗癌和炎症的(7H-吡咯并[2,3-d]嘧啶-4-基)哌嗪类化合物
|
|
WO2009030871A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Vernalis R & D Ltd |
Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
|
|
AU2008309383B2
(en)
|
2007-10-11 |
2012-04-19 |
Astrazeneca Ab |
Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors
|
|
KR101580482B1
(ko)
|
2007-11-16 |
2015-12-28 |
인사이트 홀딩스 코포레이션 |
야누스 키나제 억제제로서의 ４－피라졸릴－ｎ－아릴피리미딘－２－아민 및 ４－피라졸릴－ｎ－헤테로아릴피리미딘－２－아민
|
|
US8158616B2
(en)
|
2008-03-11 |
2012-04-17 |
Incyte Corporation |
Azetidine and cyclobutane derivatives as JAK inhibitors
|
|
US8193202B2
(en)
|
2008-04-21 |
2012-06-05 |
Lexicon Pharmaceuticals, Inc. |
LIMK2 inhibitors, compositions comprising them, and methods of their use
|
|
CA2722326A1
(en)
|
2008-04-24 |
2009-10-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
RS53382B
(sr)
|
2008-08-20 |
2014-10-31 |
Zoetis Llc |
Jedinjenja pirol [2,3-d]pirimidina
|
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
|
JOP20190230A1
(ar)
*
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
DE102009005193A1
(de)
*
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
|
|
WO2010085597A1
(en)
|
2009-01-23 |
2010-07-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
EP2396004A4
(en)
|
2009-02-11 |
2012-07-25 |
Reaction Biology Corp |
SELECTIVE KINASE HEMMER
|
|
CA3025627C
(en)
|
2009-04-20 |
2021-08-31 |
Auspex Pharmaceuticals, Inc. |
Piperidine inhibitors of janus kinase 3
|
|
TWI484962B
(zh)
*
|
2009-05-22 |
2015-05-21 |
Incyte Corp |
作為ｊａｋ抑制劑之３－〔４－（７ｈ－吡咯并〔２，３－ｄ〕嘧啶－４－基）－１ｈ－吡唑－１－基〕辛烷或庚腈
|
|
CA2762174C
(en)
*
|
2009-05-22 |
2018-02-20 |
Incyte Corporation |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
TW201105674A
(en)
|
2009-07-08 |
2011-02-16 |
Leo Pharma As |
Novel JAK receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof
|
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
WO2011029046A1
(en)
|
2009-09-04 |
2011-03-10 |
Biogen Idec Ma Inc. |
Bruton's tyrosine kinase inhibitors
|
|
AU2010289321A1
(en)
*
|
2009-09-04 |
2012-04-05 |
The Regents Of The University Of Michigan |
Compositions and methods for treatment of leukemia
|
|
CA2777114C
(en)
|
2009-10-09 |
2018-10-23 |
Incyte Corporation |
Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
MX2012004379A
(es)
|
2009-10-15 |
2012-06-01 |
Pfizer |
Compuestos de pirrolo[2,3-d]pirimidina.
|
|
US9074143B2
(en)
*
|
2009-12-11 |
2015-07-07 |
Uop Llc |
Process for producing hydrocarbon fuel
|
|
ES2461967T3
(es)
|
2009-12-18 |
2014-05-21 |
Pfizer Inc. |
Compuestos de pirrolo[2,3-d]pirimidina
|
|
EP2531508A1
(en)
|
2010-02-05 |
2012-12-12 |
Pfizer Inc. |
Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors
|
|
KR101836538B1
(ko)
*
|
2010-02-18 |
2018-03-08 |
인사이트 홀딩스 코포레이션 |
야누스 키나아제 억제제로서의 사이클로부탄 및 메틸사이클로부탄 유도체
|
|
ME02386B
(me)
|
2010-03-10 |
2016-09-20 |
Incyte Holdings Corp |
Derivati piperidin-4-il azetidina kao inhibitori jak1
|
|
SG185567A1
(en)
|
2010-05-21 |
2012-12-28 |
Incyte Corp |
Topical formulation for a jak inhibitor
|
|
RU2013105450A
(ru)
|
2010-07-09 |
2014-08-20 |
Лео Фарма А/С |
Новые производные гомопиперзина в качестве ингибиторов протеинтирозинкиназ и их фармацевтическое применение
|
|
WO2012022045A1
(en)
*
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
EP2606051B1
(en)
*
|
2010-08-20 |
2016-10-05 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
CN102372717B
(zh)
*
|
2010-08-20 |
2014-06-18 |
和记黄埔医药（上海）有限公司 |
吡咯并嘧啶类化合物及其用途
|
|
TWI401258B
(zh)
*
|
2010-09-08 |
2013-07-11 |
Hutchison Medipharma Ltd |
吡咯並嘧啶類化合物及其用途
|
|
US8933085B2
(en)
|
2010-11-19 |
2015-01-13 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
US9034884B2
(en)
|
2010-11-19 |
2015-05-19 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
|
|
ES2617339T3
(es)
|
2010-12-16 |
2017-06-16 |
Calchan Limited |
Derivados de pirrolopirimidina inhibidores de ASK1
|
|
WO2012088682A1
(en)
*
|
2010-12-29 |
2012-07-05 |
Shanghai Fochon Pharmaceutical Co Ltd. |
2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
|
|
BR112013017184A2
(pt)
*
|
2011-01-07 |
2016-09-20 |
Leo Pharma As |
composto, composição farmacêutica, uso de um composto, e, método para evitar, tratar ou melhorar doenças
|
|
DE102011008352A1
(de)
*
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
|
|
EP2670244B1
(en)
|
2011-02-04 |
2018-04-11 |
Duquesne University of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
PT2675451E
(pt)
|
2011-02-18 |
2015-10-16 |
Incyte Corp |
Terapia de combinação com inibidores mtor/jak
|
|
US9115133B2
(en)
|
2011-03-22 |
2015-08-25 |
Advinus Therapeutics Limited |
Substituted fused tricyclic compounds, compositions and medicinal applications thereof
|
|
CA2831848C
(en)
|
2011-04-01 |
2020-12-22 |
Astrazeneca Ab |
Combination comprising (s)-4-amino-n-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide and a taxane
|
|
BR112013032720A2
(pt)
|
2011-06-20 |
2016-09-13 |
Incyte Corp |
"derivados de azetidinil fenil, piridil ou pirazinil carboxamida como inibidores de jak, composição e uso dos referidos derivados"
|
|
US8895603B2
(en)
*
|
2011-06-29 |
2014-11-25 |
Merck Sharp & Dohme Corp. |
Crystalline forms of a dipeptidyl peptidase-IV inhibitor
|
|
US9233111B2
(en)
|
2011-07-08 |
2016-01-12 |
Novartis Ag |
Pyrrolo pyrimidine derivatives
|
|
US9358229B2
(en)
|
2011-08-10 |
2016-06-07 |
Novartis Pharma Ag |
JAK PI3K/mTOR combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
CN103945849B
(zh)
|
2011-11-30 |
2017-04-26 |
阿斯利康(瑞典)有限公司 |
癌症的联合治疗
|
|
AU2012345732B2
(en)
|
2011-11-30 |
2016-07-14 |
Emory University |
Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
|
|
US8993756B2
(en)
|
2011-12-06 |
2015-03-31 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
|
AR091079A1
(es)
|
2012-05-18 |
2014-12-30 |
Incyte Corp |
Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
EP2867236B1
(en)
*
|
2012-06-29 |
2017-06-14 |
Pfizer Inc |
Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
|
|
JP6318156B2
(ja)
*
|
2012-09-06 |
2018-04-25 |
プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． |
キナーゼをモジュレートするための化合物および方法、ならびにその指標
|
|
WO2014045305A1
(en)
|
2012-09-21 |
2014-03-27 |
Advinus Therapeutics Limited |
Substituted fused tricyclic compounds, compositions and medicinal applications thereof
|
|
US20150284394A1
(en)
*
|
2012-10-26 |
2015-10-08 |
Hoffmann-La Roche Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CN102936251A
(zh)
*
|
2012-11-05 |
2013-02-20 |
上海毕得医药科技有限公司 |
一种吡咯并[2,3-d]嘧啶衍生物的制备方法
|
|
TW202228704A
(zh)
|
2012-11-15 |
2022-08-01 |
美商英塞特控股公司 |
盧梭利替尼之緩釋性劑型
|
|
ES2647525T3
(es)
|
2013-02-22 |
2017-12-22 |
Pfizer Inc. |
Derivados de pirrolo[2,3-d]pirimidina como inhibidores de janus cinasas (JAK)
|
|
PT3489239T
(pt)
|
2013-03-06 |
2021-12-17 |
Incyte Holdings Corp |
Processos e intermediários para a preparação de um inibidor de jak
|
|
WO2014139388A1
(en)
*
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
MY203694A
(en)
|
2013-08-07 |
2024-07-14 |
Incyte Holdings Corp |
Sustained release dosage forms for a jak1 inhibitor
|
|
WO2015083028A1
(en)
|
2013-12-05 |
2015-06-11 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
|
|
EP3083618B1
(en)
|
2013-12-17 |
2018-02-21 |
Pfizer Inc |
Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
ES2750655T3
(es)
|
2014-08-12 |
2020-03-26 |
Pfizer |
Derivados de pirrolo[2,3-d]pirimidina útiles para inhibir la Janus cinasa
|
|
USRE49687E1
(en)
|
2014-09-09 |
2023-10-10 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
CN105524067A
(zh)
*
|
2014-09-28 |
2016-04-27 |
江苏柯菲平医药股份有限公司 |
4-取代吡咯并[2,3-d]嘧啶化合物及其用途
|
|
EP3288943B1
(en)
|
2015-05-01 |
2022-09-28 |
Pfizer Inc. |
Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase
|
|
HK1246593A1
(zh)
|
2015-06-04 |
2018-09-14 |
Kura Oncology, Inc. |
用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物
|
|
AR104020A1
(es)
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
TWI716427B
(zh)
|
2015-07-31 |
2021-01-21 |
日商大鵬藥品工業股份有限公司 |
吡咯并[2,3-d]嘧啶化合物或其鹽
|
|
KR101771219B1
(ko)
*
|
2015-08-21 |
2017-09-05 |
양지화학 주식회사 |
야누스 키나제 1 선택적 억제제 및 그 의약 용도
|
|
CN108137586B
(zh)
|
2015-09-14 |
2021-04-13 |
辉瑞大药厂 |
作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物
|
|
CN108472298B
(zh)
|
2015-11-24 |
2021-04-20 |
深圳阿拉丁医疗科技有限公司 |
选择性激酶抑制剂
|
|
CN107098908B
(zh)
|
2016-02-23 |
2021-01-08 |
欣凯医药科技(上海)有限公司 |
一种吡咯并嘧啶类化合物的制备方法和应用
|
|
CN109640987B
(zh)
|
2016-03-16 |
2022-12-02 |
库拉肿瘤学公司 |
Menin-mll的桥联双环抑制剂及使用方法
|
|
MY201450A
(en)
|
2016-03-16 |
2024-02-22 |
Univ Michigan Regents |
Substituted inhibitors of menin-mll and methods of use
|
|
CN107513067A
(zh)
|
2016-06-16 |
2017-12-26 |
北京赛林泰医药技术有限公司 |
含有取代环戊基的吡咯并嘧啶化合物
|
|
CN107513069A
(zh)
*
|
2016-06-16 |
2017-12-26 |
正大天晴药业集团股份有限公司 |
手性吡咯并嘧啶化合物的制备方法
|
|
WO2018017153A1
(en)
|
2016-07-21 |
2018-01-25 |
Biogen Ma Inc. |
Succinate forms and compositions of bruton's tyrosine kinase inhibitors
|
|
US10316038B2
(en)
|
2017-01-25 |
2019-06-11 |
Aclaris Therapeutics, Inc. |
Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer
|
|
US10799507B2
(en)
|
2017-02-03 |
2020-10-13 |
Leo Pharma A/S |
5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
|
|
CN110691779B
(zh)
|
2017-03-24 |
2023-10-10 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
|
|
CN108794480A
(zh)
*
|
2017-04-28 |
2018-11-13 |
天津药物研究院有限公司 |
吡咯并嘧啶类化合物、其制备方法和用途
|
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
EP3684361A4
(en)
|
2017-09-20 |
2021-09-08 |
Kura Oncology, Inc. |
SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHOD OF USING
|
|
AU2018360059B2
(en)
|
2017-11-03 |
2023-07-13 |
Aclaris Therapeutics, Inc. |
Substituted pyrrolopyrimidine JAK inhibitors and methods of making and using the same
|
|
WO2019090143A1
(en)
|
2017-11-03 |
2019-05-09 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrimidine-5-carboxylate analogs and methods of making the same
|
|
TW201924683A
(zh)
|
2017-12-08 |
2019-07-01 |
美商英塞特公司 |
用於治療骨髓增生性贅瘤的低劑量組合療法
|
|
PL3746429T3
(pl)
|
2018-01-30 |
2022-06-20 |
Incyte Corporation |
Procesy do otrzymywania (1-(3-fluoro-2-(trifluorometylo)izonikotynoilo)piperydyn-4-onu)
|
|
RS65624B1
(sr)
|
2018-03-30 |
2024-07-31 |
Incyte Corp |
Lečenje supurativnog hidradenitisa upotrebom jak inhbitora
|
|
BR112021002479A2
(pt)
|
2018-08-10 |
2021-07-27 |
Aclaris Therapeutics, Inc. |
composto, composição farmacêutica, método para inibir a atividade de itk ou jak3 em uma população de células, método para tratar um distúrbio mediado por itk ou jak3 em um indivíduo necessitando do mesmo e uso de um composto
|
|
GB201818750D0
(en)
*
|
2018-11-16 |
2019-01-02 |
Institute Of Cancer Res Royal Cancer Hospital |
Lox inhibitors
|
|
CN109394768B
(zh)
*
|
2018-12-10 |
2019-08-23 |
牡丹江医学院 |
一种治疗湿疹的药物及其制备方法
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
EP3946606B1
(en)
|
2019-03-27 |
2025-01-01 |
Insilico Medicine IP Limited |
Bicyclic jak inhibitors and uses thereof
|
|
CA3138544A1
(en)
|
2019-05-02 |
2020-11-05 |
Aclaris Therapeutics, Inc. |
Substituted pyrrolopyridines as jak inhibitors
|
|
KR102503349B1
(ko)
|
2019-05-14 |
2023-02-23 |
프로벤션 바이오, 인코포레이티드 |
제1형 당뇨병을 예방하기 위한 방법 및 조성물
|
|
PH12022551052A1
(en)
|
2019-11-22 |
2023-05-29 |
Incyte Corp |
Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
IL298999A
(en)
|
2020-06-11 |
2023-02-01 |
Provention Bio Inc |
Methods and compositions for the prevention of type 1 diabetes
|
|
US20250051337A1
(en)
*
|
2021-09-28 |
2025-02-13 |
Sanford Burnham Prebys Medical Discovery Institute |
Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof
|