ID21654A - Proses derivatisasi selektif taksana - Google Patents

Proses derivatisasi selektif taksana

Info

Publication number
ID21654A
ID21654A IDW990217A ID990217A ID21654A ID 21654 A ID21654 A ID 21654A ID W990217 A IDW990217 A ID W990217A ID 990217 A ID990217 A ID 990217A ID 21654 A ID21654 A ID 21654A
Authority
ID
Indonesia
Prior art keywords
sup
prosecutive
hydroxytaxane
acyloxy
selective derivatization
Prior art date
Application number
IDW990217A
Other languages
English (en)
Indonesian (id)
Inventor
Robert A Holton
Zhuming Zhang
Paul A Clark
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID21654(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of ID21654A publication Critical patent/ID21654A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
IDW990217A 1997-08-18 1998-08-17 Proses derivatisasi selektif taksana ID21654A (id)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes

Publications (1)

Publication Number Publication Date
ID21654A true ID21654A (id) 1999-07-08

Family

ID=27368950

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990217A ID21654A (id) 1997-08-18 1998-08-17 Proses derivatisasi selektif taksana

Country Status (25)

Country Link
US (5) US7288665B1 (pt)
EP (6) EP1170293B1 (pt)
JP (1) JP2001504864A (pt)
KR (1) KR100596989B1 (pt)
CN (3) CN1974563A (pt)
AT (3) ATE326455T1 (pt)
AU (1) AU744987B2 (pt)
BR (1) BR9806145A (pt)
CA (2) CA2597799A1 (pt)
CY (1) CY1105399T1 (pt)
CZ (1) CZ296580B6 (pt)
DE (3) DE69837684T2 (pt)
DK (3) DK0956284T3 (pt)
ES (3) ES2274579T3 (pt)
HU (1) HUP0300425A3 (pt)
ID (1) ID21654A (pt)
IL (3) IL129386A0 (pt)
NO (4) NO325139B1 (pt)
NZ (1) NZ335156A (pt)
PL (3) PL332723A1 (pt)
PT (3) PT1170293E (pt)
RU (1) RU2225402C2 (pt)
SG (1) SG97986A1 (pt)
WO (1) WO1999009021A1 (pt)
ZA (1) ZA987394B (pt)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
NZ514406A (en) 2000-02-02 2005-01-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents
MXPA01009906A (es) 2000-02-02 2003-07-28 Univ Florida State Res Found Taxanos sustituidos con carbonato en c7 como agentes.
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
MXPA01009923A (es) 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.
CA2368534A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
IL145636A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CZ20013520A3 (cs) 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. C10 - Karbamoyloxy substituované taxany jako protinádorová činidla
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
EP2108362B1 (en) 2002-06-26 2013-05-29 MediGene AG A cationic liposomal preparation comprising a taxane
CN101039957A (zh) 2003-05-16 2007-09-19 因特缪恩公司 合成的趋化因子受体配体及其使用方法
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
US7160919B2 (en) 2004-03-05 2007-01-09 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
EP1747209A4 (en) * 2004-05-14 2007-12-12 Immunogen Inc A SIMPLE METHOD OF SYNTHESIZING BACCATINE III COMPOUNDS
WO2006089218A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating angiogenesis
MX2007015595A (es) * 2005-06-10 2008-03-07 Univ Florida State Res Found Procesos para la produccion de compuestos de anillo fusionado policiclico.
AU2006258012B2 (en) * 2005-06-10 2011-04-07 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
RU2448697C2 (ru) 2006-03-22 2012-04-27 Медигене Аг Лечение рака молочной железы, негативного по трем рецепторам
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
PL210984B1 (pl) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Sposób wytwarzania docetakselu
US20100137221A1 (en) * 2007-02-27 2010-06-03 University Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ntn株式会社 潤滑剤劣化検出装置および検出装置付き軸受
CN101274923B (zh) * 2007-03-27 2011-02-02 中国科学院大连化学物理研究所 一种制备紫杉醇,巴卡亭ⅲ及其衍生物的方法
CN101274924B (zh) * 2007-03-27 2010-11-10 中国科学院大连化学物理研究所 一种制备紫杉醇及其衍生物的方法
WO2009040829A1 (en) * 2007-09-27 2009-04-02 Benzochem Lifescience (P) Limited A novel process for the preparation of docetaxel
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
EP2296645B1 (en) 2008-05-22 2014-11-19 Galera Therapeutics, LLC Combination antitumor therapy
US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
CN101863861A (zh) * 2009-04-16 2010-10-20 山东靶点药物研究有限公司 一种简便高效地制备紫杉醇类似物Larotaxel的方法
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
EP2697211A4 (en) 2011-04-01 2014-08-13 Shilpa Medicare Ltd PROCESS FOR THE PREPARATION OF DOCETAXEL AND ITS HYDRATE
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN103159704B (zh) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 卡巴他赛中间体及卡巴他赛中间体的制备方法
EP3539563A1 (en) 2012-07-19 2019-09-18 Redwood Bioscience, Inc. Antibody specific for cd22 and methods of use thereof
EP2916835A4 (en) 2012-11-12 2016-07-27 Redwood Bioscience Inc COMPOUNDS AND METHOD FOR PRODUCING A CONJUGATE
HUE047487T2 (hu) 2013-02-15 2020-04-28 Univ California Kiméra antigénreceptor és eljárások alkalmazására
CN105358531B (zh) 2013-03-14 2017-11-14 利兰-斯坦福大学初级学院的董事会 线粒体醛脱氢酶‑2调节剂和其使用方法
CN103145654A (zh) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 一种多西他赛的半合成方法
WO2014191989A1 (en) * 2013-05-26 2014-12-04 Idd Therapeutics Ltd. Conjugate of a taxane and biotin and uses thereof
CA2927806C (en) 2013-11-27 2023-01-10 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
PL3107899T3 (pl) 2014-02-19 2021-01-25 Aviv Therapeutics, Inc. Policykliczne amidy wiążące mitochondrialną dehydrogenazę aldehydową-2 (aldh2) i ich zastosowanie w leczeniu nowotworów
CA2942101A1 (en) 2014-03-21 2015-09-24 Abbvie Inc. Anti-egfr antibodies and antibody drug conjugates
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (en) 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
US11208632B2 (en) 2016-04-26 2021-12-28 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
KR20230162139A (ko) 2016-06-01 2023-11-28 세르비에 아이피 유케이 리미티드 폴리알킬렌 옥시드-아스파라기나제의 제형, 및 그의 제조 및 사용 방법
RS61828B1 (sr) 2016-06-08 2021-06-30 Abbvie Inc Anti-b7-h3 antitela i antitelske konjugacije lekova
CA3027103A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
US20200147235A1 (en) 2016-06-08 2020-05-14 Abbvie Inc. Anti-cd98 antibodies and antibody drug conjugates
JP2019526529A (ja) 2016-06-08 2019-09-19 アッヴィ・インコーポレイテッド 抗b7−h3抗体及び抗体薬物コンジュゲート
AU2017277914A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-CD98 antibodies and antibody drug conjugates
KR20190130559A (ko) 2017-01-18 2019-11-22 에프1 온콜로지, 인코포레이티드 Axl 또는 ror2에 대한 키메라 항원 수용체 및 이의 사용 방법
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
EP3746085A4 (en) 2018-01-31 2022-03-09 Galera Labs, LLC ANTI-CANCER POLYTHERAPY BY MEANS OF A PENTAAZA MACROCYCLIC CYCLE-TYPE COMPLEX AND AN ANTI-CANCER AGENT BASED ON PLATINUM
US11660266B2 (en) 2018-04-11 2023-05-30 Ohio State Innovation Foundation Methods and compositions for sustained release microparticles for ocular drug delivery
CA3105879A1 (en) 2018-07-18 2020-01-23 Manzanita Pharmaceuticals, Inc. Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof
JP2022527860A (ja) 2019-04-02 2022-06-06 ケンジョッケティ バイオテクノロジー,インク. 排出ポンプ-癌抗原マルチ特異性抗体ならびにそれに関する組成物、試薬、キットおよび方法
KR20220133884A (ko) 2020-01-29 2022-10-05 켄조케티 바이오테크놀러지 인코포레이티드 항-mdr1 항체 및 이의 용도
EP4161650A1 (en) 2020-06-04 2023-04-12 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
AU2021283080A1 (en) 2020-06-04 2022-12-15 Kenjockety Biotechnology, Inc. ABCG2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
AU2021338286A1 (en) 2020-09-02 2023-03-23 Kenjockety Biotechnology, Inc. Anti-ABCC1 antibodies and uses thereof
CA3203652A1 (en) 2020-11-13 2022-05-19 William Robert ARATHOON Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
WO2023114658A1 (en) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569666A (en) * 1896-10-20 Brake-beam
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
JPH01309997A (ja) * 1988-06-09 1989-12-14 Kanto Kasei Kogyo Kk 耐食性に優れた銅−ニッケル−クロム光沢電気めっき方法およびそれにより得られためっき皮膜
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5654447A (en) 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
FR2687145B1 (fr) 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux anhydrides d'acides, leur preparation et leur emplot et
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5416225A (en) 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
ES2134847T3 (es) 1992-04-17 1999-10-16 Abbott Lab Derivados de taxol.
US5440056A (en) 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
US5269442A (en) * 1992-05-22 1993-12-14 The Cornelius Company Nozzle for a beverage dispensing valve
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5478854A (en) 1992-10-01 1995-12-26 Bristol-Myers Squibb Company Deoxy taxols
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5412116A (en) 1992-11-06 1995-05-02 Hauser Chemical Research, Inc. Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates
FR2698363B1 (fr) 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5336684A (en) 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
US5405972A (en) 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
FR2718137B1 (fr) 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
JPH08253465A (ja) * 1995-03-17 1996-10-01 Dai Ichi Seiyaku Co Ltd 四環性化合物
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
FR2743074B1 (fr) * 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
DE69703294T2 (de) * 1996-05-22 2001-05-17 Protarga Inc Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
US5773461A (en) 1996-06-06 1998-06-30 Bristol-Myers Squibb Company 7-deoxy-6-substituted paclitaxels
FR2750989B1 (fr) 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
EP0875508B1 (en) * 1997-05-02 2003-10-22 Pharmachemie B.V. Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position

Also Published As

Publication number Publication date
ES2259646T3 (es) 2006-10-16
CN100351246C (zh) 2007-11-28
ATE360624T1 (de) 2007-05-15
DK1170293T3 (da) 2006-09-11
CY1105399T1 (el) 2010-04-28
HUP0300425A3 (en) 2005-12-28
US6291691B1 (en) 2001-09-18
DE69837684T2 (de) 2007-09-06
DE69836072D1 (de) 2006-11-16
KR20000068782A (ko) 2000-11-25
DK1170292T3 (da) 2007-08-27
PL332723A1 (en) 1999-10-11
ATE341540T1 (de) 2006-10-15
NO20054514L (no) 1999-06-18
EP1170292A2 (en) 2002-01-09
EP1795528A1 (en) 2007-06-13
JP2001504864A (ja) 2001-04-10
HUP0300425A2 (hu) 2003-09-29
EP1170292A3 (en) 2002-04-03
EP0956284A4 (en) 2001-12-05
EP1170292B1 (en) 2007-04-25
SG97986A1 (en) 2003-08-20
IL184321A0 (en) 2007-10-31
NZ335156A (en) 2001-10-26
NO991838D0 (no) 1999-04-16
PL201641B1 (pl) 2009-04-30
DE69837684D1 (de) 2007-06-06
ATE326455T1 (de) 2006-06-15
NO20054513L (no) 1999-06-18
CN1974563A (zh) 2007-06-06
NO325139B1 (no) 2008-02-11
WO1999009021A1 (en) 1999-02-25
PT1170293E (pt) 2006-07-31
PT1170292E (pt) 2007-05-31
US20050272944A1 (en) 2005-12-08
IL184320A0 (en) 2007-10-31
AU9021198A (en) 1999-03-08
KR100596989B1 (ko) 2006-07-07
AU744987B2 (en) 2002-03-07
US6191287B1 (en) 2001-02-20
PL193674B1 (pl) 2007-03-30
EP1170293A2 (en) 2002-01-09
DK0956284T3 (da) 2007-02-12
EP1193262A1 (en) 2002-04-03
CA2268662A1 (en) 1999-02-25
ES2286073T3 (es) 2007-12-01
IL129386A0 (en) 2000-02-17
RU2225402C2 (ru) 2004-03-10
ZA987394B (en) 1999-05-14
ES2274579T3 (es) 2007-05-16
BR9806145A (pt) 2000-01-18
NO20054512L (no) 1999-06-18
NO991838L (no) 1999-06-18
CN1690053A (zh) 2005-11-02
CN1205196C (zh) 2005-06-08
EP1671960A2 (en) 2006-06-21
CZ296580B6 (cs) 2006-04-12
CZ133299A3 (cs) 1999-11-17
DE69834584T2 (de) 2006-11-23
US7288665B1 (en) 2007-10-30
EP1170293B1 (en) 2006-05-17
EP1170293A3 (en) 2002-04-03
CN1239476A (zh) 1999-12-22
PT956284E (pt) 2006-12-29
EP0956284B1 (en) 2006-10-04
DE69836072T2 (de) 2007-01-11
CA2597799A1 (en) 1999-02-25
US6706896B1 (en) 2004-03-16
EP0956284A1 (en) 1999-11-17
DE69834584D1 (de) 2006-06-22

Similar Documents

Publication Publication Date Title
ID21654A (id) Proses derivatisasi selektif taksana
TR199900191T2 (xx) (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.
AR070946A2 (es) Proceso para la preparacion de dihidroxiesteres y derivados de los mismos
DE60117012D1 (de) O-aryl glucosid sglt2 inhibitoren und verfahren
DE69509903T2 (de) Synthese von 4-alkoxy-n-acetylneuraminsäure
DK232483A (da) Fremgangsmaade til fremstilling af ws 6049-forbindelser
IT1275936B1 (it) Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
ATE247475T1 (de) Synthetische gangliosid-derivate
BR9916648A (pt) Processo para preparar ésteres glioxìlicos ou seus hidratos
JPS5424827A (en) Preparation of carbonate ester
JPS52156867A (en) Preparation of piperonal
KR920021571A (ko) 3'및/또는 4'oh기에서 엘사마이신 a의 화학적 변형
WO2001026801A8 (en) Composition of matter tailoring: system i
FI873789A (fi) 13 -alkylgonan-/ 9(11)-5,10-epoxider.
DE69600686D1 (de) Verfahren zur herstellung von butanonderivaten
JPS51138650A (en) Process for preparing optically active trans-cyclopentene-3,5,-diolmon oester
JPS54154754A (en) Beta-lactone derivative of antiesterase active substance delta-hydroxymicolic acid and its preparation
JPS53129441A (en) Aeration method
KR880005080A (ko) 피리딘 유도체의 제조방법
JPS51135894A (en) Process for producing solica-titania catalyst
JPS5398919A (en) Preparation of glucosides
KR900014296A (ko) 만델산 에스테르 화합물의 제조방법
KR910008143A (ko) 수분 활성도 억제 방법에 의한 세팔렉신 제조 방법