AR070946A2 - Proceso para la preparacion de dihidroxiesteres y derivados de los mismos - Google Patents

Proceso para la preparacion de dihidroxiesteres y derivados de los mismos

Info

Publication number
AR070946A2
AR070946A2 ARP080104001A ARP080104001A AR070946A2 AR 070946 A2 AR070946 A2 AR 070946A2 AR P080104001 A ARP080104001 A AR P080104001A AR P080104001 A ARP080104001 A AR P080104001A AR 070946 A2 AR070946 A2 AR 070946A2
Authority
AR
Argentina
Prior art keywords
formula
compound
optionally substituted
substituted hydrocarbyl
preparation
Prior art date
Application number
ARP080104001A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR070946A2 publication Critical patent/AR070946A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Un proceso para la preparacion de un compuesto de formula (5) que comprende a) preparar un compuesto de formula (1); b) hacer reaccionar el compuesto de formula (1) con 2,2-dimetoxipropano para obtener una acetonida; y c)eliminar el grupo R'-(C=O)-; en la cual X representa a un grupo vinculante hidrocarbilo opcionalmente sustituido, R representa a un grupo hidrocarbilo opcionalmente sustituido y R' representa a un grupo hidrocarbilo opcionalmente sustituido, preferentemente un grupo alquilo opcionalmente sustituido; y donde el proceso para la preparacion de los compuestos de formula (1) comprende: ya sea: a) la reduccion estereoselectiva de un compuesto de formula (2) para obtener un compuesto de formula (3) y b) la esterificacion del compuesto de formula (3) en presencia de un compuesto de formula Rö-O-COR' y una enzima lipasa o hidrolasa por medio de lo cual se obtiene compuesto de formula (1); o c) la esterificacion de un compuesto de formula (2) en presencia de un compuesto de formula Rö-O-COR' y una enzima lipasa o hidrolasa por medio de lo cual se obtiene un compuesto de formula (4), y d) la reduccion estereoselectiva de un compuesto de formula (4) para obtener un compuesto de formula (1) en el cual X, R y R' son como se han definido anteriormente, y Rö representa un grupo hidrocarbilo opcionalmente sustituido y R' representa un hidrocarbilo opcionalmente sustituido; y derivados de los mismos.
ARP080104001A 2000-05-09 2008-09-15 Proceso para la preparacion de dihidroxiesteres y derivados de los mismos AR070946A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0011120.3A GB0011120D0 (en) 2000-05-09 2000-05-09 Process

Publications (1)

Publication Number Publication Date
AR070946A2 true AR070946A2 (es) 2010-05-19

Family

ID=9891211

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010102091A AR028074A1 (es) 2000-05-09 2001-05-03 Proceso para la preparacion de dihidroxiesteres y derivados de los mismos
ARP080104001A AR070946A2 (es) 2000-05-09 2008-09-15 Proceso para la preparacion de dihidroxiesteres y derivados de los mismos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP010102091A AR028074A1 (es) 2000-05-09 2001-05-03 Proceso para la preparacion de dihidroxiesteres y derivados de los mismos

Country Status (34)

Country Link
US (4) US7157255B2 (es)
EP (3) EP1726658B1 (es)
JP (1) JP4733901B2 (es)
KR (2) KR100996977B1 (es)
CN (1) CN1196793C (es)
AR (2) AR028074A1 (es)
AT (3) ATE458823T1 (es)
AU (2) AU2001252383B2 (es)
BR (1) BR0110667A (es)
CA (2) CA2408004C (es)
CY (3) CY1105376T1 (es)
CZ (3) CZ302632B6 (es)
DE (3) DE60141424D1 (es)
DK (3) DK1657310T3 (es)
EE (1) EE05062B1 (es)
ES (3) ES2264981T3 (es)
GB (1) GB0011120D0 (es)
HK (3) HK1051708A1 (es)
HU (1) HUP0302216A3 (es)
IL (4) IL152608A0 (es)
IS (1) IS2290B (es)
MX (1) MXPA02010955A (es)
MY (1) MY127751A (es)
NO (1) NO20025377L (es)
NZ (1) NZ522407A (es)
PL (3) PL208359B1 (es)
PT (3) PT1282719E (es)
RU (1) RU2266961C2 (es)
SI (3) SI1282719T1 (es)
SK (2) SK287524B6 (es)
TW (1) TWI240753B (es)
UA (1) UA73774C2 (es)
WO (1) WO2001085975A1 (es)
ZA (1) ZA200208937B (es)

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CN102373250B (zh) * 2011-11-08 2012-08-22 张家港市信谊化工有限公司 阿伐他汀钙侧链中间体的制备方法
CN102618596A (zh) * 2012-03-20 2012-08-01 中国药科大学 一种非水相体系中生物转化制备关附庚素的方法
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CN108530416B (zh) * 2017-11-02 2020-05-12 江苏阿尔法药业有限公司 一种瑞舒伐他汀中间体的制备方法
CN109574830B (zh) * 2019-01-04 2021-04-13 浙江宏元药业股份有限公司 一种瑞舒伐他汀钙中间体及其制备方法和应用
KR102384854B1 (ko) 2021-06-15 2022-04-11 한대성 풀빅산 및 일라이트를 이용한 침대

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Also Published As

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EP1726658A3 (en) 2008-12-24
CZ302674B6 (cs) 2011-08-24
IL152608A0 (en) 2003-06-24
SK286746B6 (sk) 2009-04-06
DE60120685D1 (de) 2006-07-27
ES2264981T3 (es) 2007-02-01
IS6609A (is) 2002-11-07
IL193404A (en) 2010-04-29
HK1096998A1 (en) 2007-06-15
DE60120685T2 (de) 2007-06-14
IL193404A0 (en) 2009-02-11
JP4733901B2 (ja) 2011-07-27
DE60129865D1 (de) 2007-09-20
US20030134900A1 (en) 2003-07-17
DE60129865T2 (de) 2008-05-08
EP1726658B1 (en) 2010-02-24
CZ302632B6 (cs) 2011-08-10
IL193405A0 (en) 2009-02-11
NO20025377D0 (no) 2002-11-08
HK1051708A1 (en) 2003-08-15
ZA200208937B (en) 2003-08-28
KR20030032949A (ko) 2003-04-26
IS2290B (is) 2007-10-15
EP1282719B1 (en) 2006-06-14
DK1657310T3 (da) 2007-10-29
CA2408004A1 (en) 2001-11-15
ATE458823T1 (de) 2010-03-15
DE60141424D1 (de) 2010-04-08
US20060194297A1 (en) 2006-08-31
SK15892002A3 (sk) 2003-04-01
IL152608A (en) 2009-05-04
EP1726658A2 (en) 2006-11-29
AU5238301A (en) 2001-11-20
CY1105376T1 (el) 2010-04-28
EP1657310A1 (en) 2006-05-17
CZ20023675A3 (cs) 2003-02-12
GB0011120D0 (en) 2000-06-28
NO20025377L (no) 2003-01-07
HUP0302216A2 (hu) 2003-10-28
HK1090090A1 (en) 2006-12-15
PT1657310E (pt) 2007-09-26
CA2677945A1 (en) 2001-11-15
MXPA02010955A (es) 2003-05-27
BR0110667A (pt) 2003-03-25
JP2003532427A (ja) 2003-11-05
RU2266961C2 (ru) 2005-12-27
US7732171B2 (en) 2010-06-08
US7888083B2 (en) 2011-02-15
CA2408004C (en) 2010-04-13
PL208359B1 (pl) 2011-04-29
AR028074A1 (es) 2003-04-23
EP1657310B1 (en) 2007-08-08
US20080280336A1 (en) 2008-11-13
ATE369437T1 (de) 2007-08-15
DK1726658T3 (da) 2010-05-17
EE05062B1 (et) 2008-08-15
EP1282719A1 (en) 2003-02-12
CN1196793C (zh) 2005-04-13
TWI240753B (en) 2005-10-01
UA73774C2 (en) 2005-09-15
NZ522407A (en) 2004-06-25
PT1726658E (pt) 2010-04-15
CY1106910T1 (el) 2012-09-26
PT1282719E (pt) 2006-09-29
KR20080042129A (ko) 2008-05-14
WO2001085975A1 (en) 2001-11-15
ES2340190T3 (es) 2010-05-31
ATE330020T1 (de) 2006-07-15
US7416865B2 (en) 2008-08-26
EE200200628A (et) 2004-04-15
PL208379B1 (pl) 2011-04-29
SI1657310T1 (sl) 2007-12-31
ES2289722T3 (es) 2008-02-01
SI1726658T1 (sl) 2010-05-31
SI1282719T1 (sl) 2006-10-31
CY1109991T1 (el) 2014-09-10
HUP0302216A3 (en) 2011-03-28
DK1282719T3 (da) 2006-10-02
PL208377B1 (pl) 2011-04-29
US7157255B2 (en) 2007-01-02
CN1440461A (zh) 2003-09-03
AU2001252383B2 (en) 2005-04-14
MY127751A (en) 2006-12-29
KR100914675B1 (ko) 2009-08-28
IL193405A (en) 2010-04-29
US20100209984A1 (en) 2010-08-19
CZ302675B6 (cs) 2011-08-24
SK287524B6 (sk) 2011-01-04
PL359336A1 (en) 2004-08-23
KR100996977B1 (ko) 2010-11-26

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