MXPA01009906A - Taxanos sustituidos con carbonato en c7 como agentes. - Google Patents
Taxanos sustituidos con carbonato en c7 como agentes.Info
- Publication number
- MXPA01009906A MXPA01009906A MXPA01009906A MXPA01009906A MXPA01009906A MX PA01009906 A MXPA01009906 A MX PA01009906A MX PA01009906 A MXPA01009906 A MX PA01009906A MX PA01009906 A MXPA01009906 A MX PA01009906A MX PA01009906 A MXPA01009906 A MX PA01009906A
- Authority
- MX
- Mexico
- Prior art keywords
- antitumor agents
- carbonate substituted
- substituted taxanes
- taxanes
- carbonate
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000005587 carbonate group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17967100P | 2000-02-02 | 2000-02-02 | |
PCT/US2001/003554 WO2001057030A1 (en) | 2000-02-02 | 2001-02-02 | C7 carbonate substituted taxanes as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA01009906A true MXPA01009906A (es) | 2003-07-28 |
Family
ID=22657501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA01009906A MXPA01009906A (es) | 2000-02-02 | 2001-02-02 | Taxanos sustituidos con carbonato en c7 como agentes. |
Country Status (25)
Country | Link |
---|---|
US (3) | US6780879B2 (es) |
EP (1) | EP1165552A1 (es) |
JP (1) | JP2003522170A (es) |
KR (1) | KR20010112395A (es) |
CN (1) | CN1362958A (es) |
AU (1) | AU776122B2 (es) |
BG (1) | BG64890B1 (es) |
BR (1) | BR0104351A (es) |
CA (1) | CA2368540A1 (es) |
CZ (1) | CZ20013429A3 (es) |
GE (1) | GEP20043226B (es) |
HK (1) | HK1047934A1 (es) |
HU (1) | HUP0200756A3 (es) |
IL (1) | IL145637A0 (es) |
MX (1) | MXPA01009906A (es) |
NO (1) | NO20014755L (es) |
NZ (1) | NZ514380A (es) |
PL (1) | PL350315A1 (es) |
RO (1) | RO121271B1 (es) |
RU (1) | RU2265019C2 (es) |
SK (1) | SK13702001A3 (es) |
TR (1) | TR200102857T1 (es) |
UA (1) | UA74331C2 (es) |
WO (1) | WO2001057030A1 (es) |
ZA (1) | ZA200108051B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2265019C2 (ru) * | 2000-02-02 | 2005-11-27 | Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. | Таксаны, фармацевтические композиции, способы ингибирования |
US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
WO2004013093A2 (en) | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
SV2006002010A (es) * | 2004-02-13 | 2006-08-23 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
EP1848423A4 (en) * | 2005-02-14 | 2008-12-31 | Univ Florida State Res Found | C10 CYCLOPROPYL ESTER SUBSTITUTED TAXAN COMPOSITIONS |
EP2276755A4 (en) * | 2008-03-31 | 2011-05-04 | Univ Florida State Res Found | C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
ES2230790T3 (es) | 1992-01-15 | 2005-05-01 | E.R. SQUIBB & SONS, INC. | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos. |
FR2687150B1 (fr) | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5698712A (en) | 1992-03-06 | 1997-12-16 | Indena S.P.A. | Baccatine III derivatives |
US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
US5319112A (en) | 1992-08-18 | 1994-06-07 | Virgnia Tech Intellectual Properties, Inc. | Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol |
US5470866A (en) | 1992-08-18 | 1995-11-28 | Virginia Polytechnic Institute And State University | Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol |
IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them |
CA2111527C (en) | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
DE69433297T2 (de) * | 1993-02-05 | 2004-10-21 | Bryn Mawr College Bryn Mawr | Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten |
US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
DE69433146T2 (de) * | 1993-06-11 | 2004-06-09 | Pharmacia & Upjohn Co., Kalamazoo | Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen |
IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
CA2174350A1 (en) * | 1993-10-20 | 1995-04-27 | Richard B. Greenwald | 2'- and/or 7- substituted taxoids |
FR2711369B1 (fr) | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
US5824701A (en) * | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
JPH10508022A (ja) | 1994-10-28 | 1998-08-04 | ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク | タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用 |
US5801191A (en) * | 1995-06-01 | 1998-09-01 | Biophysica Foundation | Taxoids |
TW354293B (en) | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
US6545168B1 (en) | 1996-05-06 | 2003-04-08 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
RU2265019C2 (ru) | 2000-02-02 | 2005-11-27 | Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. | Таксаны, фармацевтические композиции, способы ингибирования |
TR200102855T1 (tr) * | 2000-02-02 | 2002-06-21 | Florida State University Research Foundation, Inc | Antitümör ajanları olarak C10 karbonat ikameli taksanlar. |
HUP0200995A3 (en) | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | Taxane formulations having improved solubility |
US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
-
2001
- 2001-02-02 RU RU2001129502/04A patent/RU2265019C2/ru not_active IP Right Cessation
- 2001-02-02 HU HU0200756A patent/HUP0200756A3/hu unknown
- 2001-02-02 CZ CZ20013429A patent/CZ20013429A3/cs unknown
- 2001-02-02 JP JP2001557862A patent/JP2003522170A/ja active Pending
- 2001-02-02 IL IL14563701A patent/IL145637A0/xx unknown
- 2001-02-02 NZ NZ514380A patent/NZ514380A/en unknown
- 2001-02-02 MX MXPA01009906A patent/MXPA01009906A/es active IP Right Grant
- 2001-02-02 CA CA002368540A patent/CA2368540A1/en not_active Withdrawn
- 2001-02-02 BR BR0104351-0A patent/BR0104351A/pt not_active IP Right Cessation
- 2001-02-02 WO PCT/US2001/003554 patent/WO2001057030A1/en active IP Right Grant
- 2001-02-02 GE GEAP20016128A patent/GEP20043226B/en unknown
- 2001-02-02 US US09/776,137 patent/US6780879B2/en not_active Expired - Fee Related
- 2001-02-02 AU AU34793/01A patent/AU776122B2/en not_active Ceased
- 2001-02-02 SK SK1370-2001A patent/SK13702001A3/sk unknown
- 2001-02-02 KR KR1020017012603A patent/KR20010112395A/ko active IP Right Grant
- 2001-02-02 UA UA2001106732A patent/UA74331C2/uk unknown
- 2001-02-02 TR TR2001/02857T patent/TR200102857T1/xx unknown
- 2001-02-02 PL PL01350315A patent/PL350315A1/xx not_active Application Discontinuation
- 2001-02-02 RO ROA200101084A patent/RO121271B1/ro unknown
- 2001-02-02 EP EP01906952A patent/EP1165552A1/en not_active Withdrawn
- 2001-02-02 CN CN01800313A patent/CN1362958A/zh active Pending
- 2001-10-01 ZA ZA200108051A patent/ZA200108051B/xx unknown
- 2001-10-01 BG BG105966A patent/BG64890B1/bg unknown
- 2001-10-01 NO NO20014755A patent/NO20014755L/no not_active Application Discontinuation
-
2003
- 2003-01-07 HK HK03100166.5A patent/HK1047934A1/zh unknown
- 2003-12-22 US US10/743,581 patent/US6992104B2/en not_active Expired - Fee Related
-
2005
- 2005-03-17 US US11/082,380 patent/US7226944B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RO121271B1 (ro) | 2007-02-28 |
TR200102857T1 (tr) | 2002-06-21 |
AU776122B2 (en) | 2004-08-26 |
BG105966A (en) | 2002-07-31 |
US6780879B2 (en) | 2004-08-24 |
RU2265019C2 (ru) | 2005-11-27 |
EP1165552A1 (en) | 2002-01-02 |
UA74331C2 (uk) | 2005-12-15 |
US20050165051A1 (en) | 2005-07-28 |
SK13702001A3 (sk) | 2002-06-04 |
NZ514380A (en) | 2005-03-24 |
CN1362958A (zh) | 2002-08-07 |
CZ20013429A3 (cs) | 2002-04-17 |
BR0104351A (pt) | 2002-01-02 |
GEP20043226B (en) | 2004-04-26 |
NO20014755D0 (no) | 2001-10-01 |
BG64890B1 (bg) | 2006-08-31 |
NO20014755L (no) | 2001-11-29 |
AU3479301A (en) | 2001-08-14 |
PL350315A1 (en) | 2002-12-02 |
US6992104B2 (en) | 2006-01-31 |
IL145637A0 (en) | 2002-06-30 |
US20040138267A1 (en) | 2004-07-15 |
JP2003522170A (ja) | 2003-07-22 |
CA2368540A1 (en) | 2001-08-09 |
KR20010112395A (ko) | 2001-12-20 |
ZA200108051B (en) | 2003-12-01 |
US7226944B2 (en) | 2007-06-05 |
WO2001057030A1 (en) | 2001-08-09 |
HK1047934A1 (zh) | 2003-03-14 |
HUP0200756A3 (en) | 2005-02-28 |
HUP0200756A2 (hu) | 2002-07-29 |
US20020065304A1 (en) | 2002-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |