UA74331C2 - С7-карбонатзаміщені таксани, фармацевтична композиція на їх основі (варіанти) та спосіб інгібування росту пухлин (варіанти) - Google Patents

С7-карбонатзаміщені таксани, фармацевтична композиція на їх основі (варіанти) та спосіб інгібування росту пухлин (варіанти)

Info

Publication number
UA74331C2
UA74331C2 UA2001106732A UA2001106732A UA74331C2 UA 74331 C2 UA74331 C2 UA 74331C2 UA 2001106732 A UA2001106732 A UA 2001106732A UA 2001106732 A UA2001106732 A UA 2001106732A UA 74331 C2 UA74331 C2 UA 74331C2
Authority
UA
Ukraine
Prior art keywords
variants
taxanes
carbonate
sustituted
tumors
Prior art date
Application number
UA2001106732A
Other languages
English (en)
Russian (ru)
Inventor
Роберт А. Холтон
Original Assignee
Флоріда Стейт Юніверсіті Рісерч Фаундейшн, Інк.
Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Флоріда Стейт Юніверсіті Рісерч Фаундейшн, Інк., Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. filed Critical Флоріда Стейт Юніверсіті Рісерч Фаундейшн, Інк.
Publication of UA74331C2 publication Critical patent/UA74331C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Таксани, що мають карбонатний замісник при С(7), гідроксизамісник при С(10) та ряд замісників при С(2), С(9), С(14) та в боковому ланцюзі.
UA2001106732A 2000-02-02 2001-02-02 С7-карбонатзаміщені таксани, фармацевтична композиція на їх основі (варіанти) та спосіб інгібування росту пухлин (варіанти) UA74331C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967100P 2000-02-02 2000-02-02
PCT/US2001/003554 WO2001057030A1 (en) 2000-02-02 2001-02-02 C7 carbonate substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
UA74331C2 true UA74331C2 (uk) 2005-12-15

Family

ID=22657501

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001106732A UA74331C2 (uk) 2000-02-02 2001-02-02 С7-карбонатзаміщені таксани, фармацевтична композиція на їх основі (варіанти) та спосіб інгібування росту пухлин (варіанти)

Country Status (25)

Country Link
US (3) US6780879B2 (uk)
EP (1) EP1165552A1 (uk)
JP (1) JP2003522170A (uk)
KR (1) KR20010112395A (uk)
CN (1) CN1362958A (uk)
AU (1) AU776122B2 (uk)
BG (1) BG64890B1 (uk)
BR (1) BR0104351A (uk)
CA (1) CA2368540A1 (uk)
CZ (1) CZ20013429A3 (uk)
GE (1) GEP20043226B (uk)
HK (1) HK1047934A1 (uk)
HU (1) HUP0200756A3 (uk)
IL (1) IL145637A0 (uk)
MX (1) MXPA01009906A (uk)
NO (1) NO20014755L (uk)
NZ (1) NZ514380A (uk)
PL (1) PL350315A1 (uk)
RO (1) RO121271B1 (uk)
RU (1) RU2265019C2 (uk)
SK (1) SK13702001A3 (uk)
TR (1) TR200102857T1 (uk)
UA (1) UA74331C2 (uk)
WO (1) WO2001057030A1 (uk)
ZA (1) ZA200108051B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
RU2265019C2 (ru) * 2000-02-02 2005-11-27 Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. Таксаны, фармацевтические композиции, способы ингибирования
KR20050032110A (ko) * 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
EP1848423A4 (en) * 2005-02-14 2008-12-31 Univ Florida State Res Found C10 CYCLOPROPYL ESTER SUBSTITUTED TAXAN COMPOSITIONS
US8242166B2 (en) * 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
DE69333675T2 (de) 1992-01-15 2006-02-02 E.R. Squibb & Sons, Inc. Enzymatische Verfahren zur Trennung von Enantiomerengemischen von Verbindungen, die als Zwischenprodukte zur Herstellung von Taxanen nützlich sind
FR2687150B1 (fr) 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
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US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
NO310238B1 (no) 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
BR9405687C1 (pt) * 1993-02-05 2001-08-07 Bryn Mawr College Processo quìmico utilizável na produção de análogos de taxol e, composto quìmico
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US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
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US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
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JP2003522171A (ja) * 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン

Also Published As

Publication number Publication date
HUP0200756A3 (en) 2005-02-28
BG105966A (en) 2002-07-31
KR20010112395A (ko) 2001-12-20
US20050165051A1 (en) 2005-07-28
RU2265019C2 (ru) 2005-11-27
HK1047934A1 (zh) 2003-03-14
RO121271B1 (ro) 2007-02-28
SK13702001A3 (sk) 2002-06-04
AU3479301A (en) 2001-08-14
NZ514380A (en) 2005-03-24
US20040138267A1 (en) 2004-07-15
NO20014755D0 (no) 2001-10-01
BR0104351A (pt) 2002-01-02
ZA200108051B (en) 2003-12-01
IL145637A0 (en) 2002-06-30
WO2001057030A1 (en) 2001-08-09
JP2003522170A (ja) 2003-07-22
HUP0200756A2 (hu) 2002-07-29
NO20014755L (no) 2001-11-29
TR200102857T1 (tr) 2002-06-21
GEP20043226B (en) 2004-04-26
US6992104B2 (en) 2006-01-31
US6780879B2 (en) 2004-08-24
MXPA01009906A (es) 2003-07-28
US20020065304A1 (en) 2002-05-30
PL350315A1 (en) 2002-12-02
BG64890B1 (bg) 2006-08-31
AU776122B2 (en) 2004-08-26
CA2368540A1 (en) 2001-08-09
US7226944B2 (en) 2007-06-05
CN1362958A (zh) 2002-08-07
EP1165552A1 (en) 2002-01-02
CZ20013429A3 (cs) 2002-04-17

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