HUE030839T2 - Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol - Google Patents

Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol Download PDF

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Publication number
HUE030839T2
HUE030839T2 HUE05752122A HUE05752122A HUE030839T2 HU E030839 T2 HUE030839 T2 HU E030839T2 HU E05752122 A HUE05752122 A HU E05752122A HU E05752122 A HUE05752122 A HU E05752122A HU E030839 T2 HUE030839 T2 HU E030839T2
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HU
Hungary
Prior art keywords
compound
quinazolin
phenyl
ylamino
purin
Prior art date
Application number
HUE05752122A
Other languages
English (en)
Hungarian (hu)
Inventor
Kerry W Fowler
Danwen Huang
Edward A Kesicki
Hua Chee Ooi
Amy R Oliver
Fuqiang Ruan
Jennifer Treiberg
Kamal Deep Puri
Original Assignee
Icos Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE030839(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of HUE030839T2 publication Critical patent/HUE030839T2/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P39/06Free radical scavengers or antioxidants
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical Kinetics & Catalysis (AREA)
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  • Hematology (AREA)
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  • Oncology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
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  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
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HUE05752122A 2004-05-13 2005-05-12 Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol HUE030839T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13

Publications (1)

Publication Number Publication Date
HUE030839T2 true HUE030839T2 (en) 2017-06-28

Family

ID=34969603

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE05752122A HUE030839T2 (en) 2004-05-13 2005-05-12 Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol
HUE13150110A HUE030950T2 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
HUS1700006C HUS1700006I1 (hu) 2004-05-13 2017-02-22 Kinazolinonok mint humán foszfatidilinozitol 3-kináz delta inhibitorai

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE13150110A HUE030950T2 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
HUS1700006C HUS1700006I1 (hu) 2004-05-13 2017-02-22 Kinazolinonok mint humán foszfatidilinozitol 3-kináz delta inhibitorai

Country Status (23)

Country Link
US (14) US7932260B2 (enExample)
EP (4) EP2612862B1 (enExample)
JP (1) JP2007537291A (enExample)
CN (2) CN101031569B (enExample)
AU (2) AU2005245875C1 (enExample)
BE (1) BE2017C002I2 (enExample)
CA (1) CA2566609C (enExample)
CY (3) CY2016046I1 (enExample)
DK (2) DK2612862T3 (enExample)
ES (3) ES2605792T3 (enExample)
FR (1) FR17C1007I2 (enExample)
HR (2) HRP20161751T1 (enExample)
HU (3) HUE030839T2 (enExample)
IL (4) IL179176A (enExample)
LT (3) LT2612862T (enExample)
LU (1) LUC00005I2 (enExample)
ME (2) ME02688B (enExample)
NL (1) NL300867I2 (enExample)
PL (3) PL1761540T3 (enExample)
PT (3) PT2612862T (enExample)
RS (2) RS55546B1 (enExample)
SI (2) SI2612862T1 (enExample)
WO (2) WO2005113556A1 (enExample)

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CA2566609C (en) 2004-05-13 2012-06-26 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
WO2005112935A1 (en) * 2004-05-13 2005-12-01 Vanderbilt University Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
EP1831225A2 (en) * 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
EP1885356A2 (en) * 2005-02-17 2008-02-13 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
GB2431156A (en) * 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
DK2004654T3 (da) 2006-04-04 2013-07-22 Univ California Pyrazolopyrimidin derivater til anvendelse som kinase antagonister
KR20090087027A (ko) 2006-11-13 2009-08-14 일라이 릴리 앤드 캄파니 염증 질환 및 암의 치료를 위한 티에노피리미디논
EP1953163A1 (en) * 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
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US8980901B2 (en) 2015-03-17
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US7932260B2 (en) 2011-04-26
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